death drugs and rock amp roll

... decomposition and evaporation of isobutyl nitrite throughout the procedure (from the sampling until injection to GC, and from the standard solution to a test specimen) In principle, the sampling, ... µg) and isobutyl alcohol (injected amount 10 µg); they appeared at 3.4 and 7.4 of retention times, respectively The solvent acetone appeared at about The detection limits of isobutyl nitrite and ... nitrite (A) and isobutyl alcohol (B) um between the hydrolysis and esterification [7] Under the present HS conditions, the decomposition of alkyl nitrites by hydrolysis is minimized, and the esterification...

Ngày tải lên: 18/10/2013, 00:15

... in environmental and biological samples using gas chromatography/negative-ion chemical ionization mass spectrometry and tandem mass spectrometry J Mass Spectrom 30:1133–1143 VX and its decomposition ... NaCl and mL acetonitrilei, shaken and centrifuged The resulting acetonitrile layer is transferred to another test tube To the remaining aqueous phase, mL acetonitrile is again added, shaken and ... metabolism and decomposition in human bodies The detection limits of DAEMS in serum are about 50 ng/mL in the scan mode and about ng/mL in the SIM mode > Figure 2.3 shows a TIC, mass chromatograms and...

Ngày tải lên: 18/10/2013, 00:15

... d3- and d10- substitution products of the acid are used When ∆9-THC11-oic acid-d3 is used, the mass spectrum shows ions at m/z 433, 418 and 374 with the Derivatization-2, and at m/z 491, 476 and ... as eluting solvent for getting each cannabinoid standard ∆9-THC, CBD and CBN are separately dissolved in ethanol to prepare 0.05–0.5 mg/mL standard solution for each compound b 5α-Cholestane ... spectra of ∆9-THC, CBD, CBN and 5α-cholestane (IS) are shown in > Fig 2.3 ⊡ Figure 2.3 EI mass spectra of ∆9-THC, CBD, CBN and 5α-cholestane 189 190 Cannabinoids and their metabolites GC/MS analysis...

Ngày tải lên: 24/10/2013, 19:15

... morphine, heroin and codeine The thick and thin arrows show the main and minor metabolic pathways, respectively ⊡ Figure 3.1 196 Morphine and its analogues GC and GC/MS analysis • • • • • Standard solutions ... sampled not later than h after the heroin intake [4] HPLC analysis Reagents and their preparation • • Standard solutions of morphine for a calibration curve (2, and 20 µg/mL): see “Reagents and ... added to it The blank urine and calibration samples are processed in the same way These samples are equally treated according to the above steps iii–vi Assessment and some comments on the methods...

Ngày tải lên: 24/10/2013, 19:15

... wide-bore and medium-bore capillary columns With the medium-bore capillary column, a big and broad peak due to mesitylene appears The detection limits are about 0.3 and 0.1 µg/mL for wide-bore and ... headache, dyspnea, tachypnea, tachycardia and hypertension mental derangement, listlessness and metabolic acidosis coma, convulsive attack and hypotension death A poisoning case [4] An unidentified ... addition of 0.5 mL of concentrated sulfuric acid f and 0.5 mL of mesitylene Nitrate and nitrite compounds iv The mixture is vortex-mixed for and centrifuged at 3,000 rpm for v A 0.2-mL volume...

Ngày tải lên: 24/10/2013, 19:15

... B, C and D v To cuvettes A and B, a 0.5-mL volume each of distilled water is added To cuvettes C and D, a 0.5-mL volume each of % potassium ferricyanide solution is added vi To cuvettes A and ... allowing the cuvettes to stand for min, the absorbances of cuvettes B and D at 630 nm are read using cuvettes A and C as references, respectively These readings are A2 and A4, respectively x The ... S-2-diisopropylaminoethyl methylphosphonothiolate 619 OHMA 181 OHnorBZP 171, 179, 183 oleandrigenin 519 oleander poisoning 524 oleander toxins 519 oleandrin 519, 521, 523, 525 on-column derivatization 238 on-column...

Ngày tải lên: 24/10/2013, 19:15

... after sampling, and processed for extraction and derivatization procedure Good recoveries of cocaine and its metabolites can be obtained with a mixed type extraction column (Bond Elut Certify®) and ... 100 ng EME and 200 ng BE had been added 211 212 Cocaine and its metabolites ⊡ Figure 4.2 Mass spectra of the authentic cocaine and its metabolites and tablets of 3,4-methylenedioxymethamphetamine ... For autopsy specimens, the postmortem interval (period between death and autopsy) and the in vitro interval (period between sampling and analysis) are variable; the hydrolytic rate of cocaine shows...

Ngày tải lên: 29/10/2013, 01:15

... 214 and at m/z 285 (M+) plus 217 were used for detection of IS and pentazocine, respectively When SIM with a single ion is made, ions at m/z 217 and 271 (M+) should be used for pentazocine and ... cases of pentazocine poisoning, its concentrations were 9.2 and 3.3 µg/mL in blood, 43 and 34 µg/g in the liver, and not detectable and 4.5 µg/mL in urine, respectively [12] The blood concentrations ... and tripelennamine, T,s and Blues J Forensic Sci 28:489–495 3) Kintz P, Tracqui A, Lugnier AJ et al (1990) Simultaneous screening and quantification of several nonopiate narcotic analgesics and...

Ngày tải lên: 29/10/2013, 02:15

... diethylamide (LSD) Toxicity, and concentrations in blood and urine The acute toxicity of LSD is generally low; it does almost not cause death In this chapter, detection and identification methods ... (ed) (1992) Standard Methods of Chemical Analysis in Poisoning – With Commentary – Nanzando, Tokyo, p 43 and p 151 (in Japanese) 3) Cody JT (2000) Hallucinogens In: Bogusz MJ (ed) Handbook of Analytical ... of LSD, 2-oxo-LSD, 3-, 13- and 14-hydroxy-LSDs and an N-de-ethyl-LSD are known [3] After oral ingestion of 160 µg LSD, the maximum blood concentration of LSD was ng/mL and its half-life is said...

Ngày tải lên: 08/11/2013, 01:15

... determination of amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine, 3,4-methylenedioxymethamphetamine, and 3,4-methylenedioxyethylamphetamine in urine by solid-phase extraction and GC-MS: ... MDMA=3,4-methylenedioxymethamphetamine; MDA=3,4-methylenedioxyamphetamine; MDEA=3,4-methylenedioxyethylamphetamine; MA=methamphetamine; AP=amphetamine 235 236 3,4-Methylenedioxyamphetamines ⊡ Figure ... GC/MS and LC/MS analyses of MDAs in the forms of tablets and those for GC/MS analysis of MDAs and their main metabolites 4-hydroxy-3-methoxymethamphetamine (HMMA) and 4-hydroxy-3-methoxyamphetamine...

Ngày tải lên: 08/11/2013, 01:15

... fluid, vitreous humor and urine than in blood Villain et al [21] and Elliott [31] have tentatively set positive cutoff limits of GHB at 50 and 30 µg/mL for postmortem blood, and 10 and 20 µg/mL for ... (PCP) and at m/z 246 plus 232 plus 218 (IS) were used at the retention time of 4–12 The amounts of PCP and IS spiked into mL blank whole blood were 25 and 100 ng, respectively Poisoning case, and ... concentrations in blood and the liver ranged from 2.0 to 19.0 µg/mL and from 1.7 to 32.7 µg/g, respectively [28] Cravey et al reported nine PCP-related deaths; the concentrations in blood and the livers...

Ngày tải lên: 08/11/2013, 01:15

... TIC and MCs for phenothiazine drugs obtained by GC/MS Panels A and B show a TIC and an MC for the authentic compounds, respectively; panels C and D those for extracts of human whole blood and ... mL and toxic level 0.05 µg/mL; promazine: therapeutic levels 0.1–0.4 µg/mL and toxic levels 2–3 µg/mL; thioridazine: therapeutic levels 0.2–1 µg/mL and toxic level µg/mL [10] The therapeutic and ... water and 0.5 mL of M sodium bicarbonate solution After well mixing, the mixture is centrifuged at 3,000 rpm for 10 For IS, one of other phenothiazine drugs is selected A 1-mL volume of methanol and...

Ngày tải lên: 15/12/2013, 12:15

... TICs and SIM chromatograms by GC/MS for the authentic standards of butyrophenone drugs (100 ng/mL each) (A) and for a serum extract from a poisoned patient (B) m/z 224: haloperidol (HP) and reduced ... haloperidol (HP) and bromperidol (BP) (100 ng/mL each) (A) and for a serum extract from a poisoned patient (B) m/z 376.5: HP; m/z 378.5: HP and RHP; m/z 422.4: BP=IS Poisoning cases, and toxic and fatal ... Poisoning cases, and toxic and fatal concentrations ⊡ Figure 2.3 HPLC-DAD chromatograms for the authentic haloperidol (HP) and reduced haloperidol (RHP) (100 ng/mL each) (A) and for a serum extract...

Ngày tải lên: 15/12/2013, 12:15

... separated; but mianserin and setiptiline could 275 276 Tricyclic and tetracyclic antidepressants ⊡ Figure 3.3 Chromatograms for tricyclic and tetracyclic antidepressants and carbamazepine obtained ... lofepramine Poisoning cases, and toxic and fatal concentrations In > Table 3.1, the therapeutic and toxic blood concentrations of each compound are shown [4] For all drugs, the toxic levels were ... discovered in her room; the death due to drug poisoning was suspected As her past history, hypotension, depression and insomnia were disclosed; antidepressants and antianxiety drugs had been prescribed...

Ngày tải lên: 15/12/2013, 12:15

... is dissolved in 50 µL methanol and a 2-µL aliquot is injected into GC/MSe i Assessment and some comments on the method The recovery rates of the drugs from blood and urine were not less than 60 ... chlordizepoxide, between flutoprazepam and bromazepam and between flurazepam and nitrazepam could not be achieved; the peak of tofisopam showed tailing The separation of other drugs was relatively good The ... etizolam and brotizolam for both blood and urine The detection limits of these 13 drugs were 1–5 ng/mL For nitrazepam, mexazolam, nimetazepam, clonazepam, bromazepam, tofisopam, estazolam and triazolam,...

Ngày tải lên: 15/12/2013, 12:15

... of the mobile phase, and a 10-µL aliquot is injected into HPLC Bromisovalum ⊡ Figure 5.2 HPLC chromatograms for blood extracts in the presence and absence of bromisovalum and IS The concentration ... As over-the-counter drugs containing bromisovalum, Rislon (100 mg bromisovalum per tablet, Sato Pharmaceutical, Tokyo, Japan) and Wutt (83 mg bromisovalum, 50 mg apronalide and 8.3 mg diphenhydramine ... Matsubara et al [14], and 31.5 and 40.8 µg/mL by Yashiki et al [15] Poisoning cases Many cases of poisoning by bromisovalum were reported In this section, representative clinical and medicolegal cases...

Ngày tải lên: 15/12/2013, 12:15

... phenobarbital, promethazine and Survived and fatal poisoning cases chlorpromazine) and one capsule of Insumin (flurazepam) were found From the stomach contents, phenobarbital, promethazine and chlorpromazine ... concentrations in blood, the liver and kidney were: phenobarbital, 98.0, 106 and 105 µg/g; promethazine, 5.05, 38.2 and 6.92 µg/g; chlorpromazine, 1.68, 22.1 and 3.03 µg/g, respectively Case [28]: ... bromisovalum and levomepromazine were detected The drug concentrations in blood, the liver, brain and urine were: amobarbital, 25, 47, 30 and µg/mL (g); bromisovalum, 37, 70, 57 and µg/mL (g);...

Ngày tải lên: 15/12/2013, 12:15

... hydroxyzine as IS conversely Poisoning cases, and toxic and fatal concentrations The drugs reported to have caused deaths are diphenhydramine, dimenhydrinate and hydroxyzine The estimated fatal doses ... of chlorpheniramine and its metabolites didemethylchlorpheniramine and demethylchlorpheniramine is described Reagents and their preparation • • • Chlorpheniramine maleate and brompheniramine ... widely used as an anxiolytic drug Poisoning cases, and toxic and fatal concentrations Reagents and preparation • • • Hydroxyzine dihydrochloride and triprolidine hydrochloride can be obtained from...

Ngày tải lên: 15/12/2013, 12:15

... the detection limits and colors of the spots observed under ultraviolet light and after spraying five kinds of reagents The screening by TLC is simple and rapid for unchanged drugs Reversed phase ... analgesic and antipyretic drugs Jpn J Forensic Toxicol 14:246–252 4) Shinozuka T, Takei S, Kuroda N et al (1996) Simultaneous determination of propionic acid analgesic and antipyretic drugs in ... detection of non-steroidal anti-inflammatory drugs and their methabolites in urine as part of a systematic toxicological analysis procedure for acidic drugs and poisons by gas chromatography- mass...

Ngày tải lên: 15/12/2013, 12:15

... min); IS: internal standard (theophylline) (20 µg/mL, 5.1 min) HPLC analysis of APAP and its metabolites in urine HPLC analysis of APAP and its metabolites in urine [4] Reagents and their preparation ... UV and amperometric detection J Chromatogr 227:453–462 5) Jung D, Zafar NU (1985) Micro high-performance liquid chromatographic assay of acetaminophen and its major metabolites in plasma and ... internal standards, and gas chromatography-mass spectrometry J Anal Toxicol 25:198–202 24) Heitmeier S, Blaschke G (1999) Direct determination of paracetamol and its metabolites in urine and serum...

Ngày tải lên: 15/12/2013, 12:15