deadly tumor and model systemfor solid tumor cancer stem cells

... of breast cancer cells, molecular tumor classification methods, in vitro cancer models, breast cancer and microenvironment, breast cancer stem cells, gene regulation in breast cancer, and mechanism ... Telmer and Eva Turley Breast Cancer Stem Cells 235 Chapter 11 The Microenvironment of Breast Cancer Stem Cells Deepak Kanojia and Hexin Chen Chapter 12 Involvement of Mesenchymal Stem Cells in ... itself, and that pure in vitro models also need assistance of in vivo ones 22 Breast Cancer – Focusing Tumor Microenvironment, Stem Cells and Metastasis Models for investigation on breast cancer...

Ngày tải lên: 27/06/2014, 17:20

... overexpression P63+ basal /stem cells were transformed into AR+ or ARcancer cells but rarely into ChgA+ neuroendocrine cancer cells Conventional human prostate cancer cells include malignant cells of luminal, ... P63+ basal /stem cells and to examine whether these cancer cells can maintain stem cell characteristics after metastasis More importantly, we intended to elucidate whether P63 + basal /stem cells can ... been reported in some androgen-refractory prostate cancers [13,41] Therefore, both AR + and AR - cells were capable of forming androgen-independent prostate cancer cells as the tumorigenesis progresses...

Ngày tải lên: 10/08/2014, 05:21

... Stem Cells to Overcome Drug Resistance 401 Miaorong She and Xilin Chen Chapter 21 Cancer Stem Cells and Chemoresistance Suebwong Chuthapisith Chapter 22 Cancer Stem Cells in Drug Resistance and ... transformation from normal stem cells to cancer stem cells? ” The authors suggest that cancer stemloid (or stem cell-like cancer cells) ” might be more precise than CSCs when referring to cells “exist[ing] ... Cruz and Isidro Sanchez-Garcia Part Stem Cells in Specific Tumors 61 Chapter Breast Cancer Stem Cells 63 Marco A Velasco-Velázquez, Xuanmao Jiao and Richard G Pestell Chapter Glioma Stem Cells: ...

Ngày tải lên: 12/08/2014, 06:20

... normal stem cells to cancer stem cells Adult normal stem cells represent one purported origin of cancer stem cells What causes the transformation from normal stem cells to cancer stem cells? ... checkpoint activation and apoptosis in cancer stem cells Another possible reason for increased genomic instability in cancer stem cells is malignant transformation of aged stem cells Stem cells have a ... isolated cancer stem cells may be more accurately referred to as cancer stemloids (or stem cell-like cancer cells) (Blagosklonny, 2007) Although these cells may exist only as a minority within the cancer...

Ngày tải lên: 12/08/2014, 06:20

... [62] Murine and human hematopoietic stem cells [63-64], murine neural stem cells [65], normal and malignant human mammary stem cells [66], and normal and malignant human colorectal stem cells [62,67] ... factors For instance, Wnt ligands are produced and released from both stem cells and niche cells, BMP and Shh are released from niche cells and epithelial cells respectively, and Notch signaling is ... www.adultpdf.com 80 Cancer Stem Cells Theories and Practice Discovery of neural and glioma stem cells The discovery of adult neural stem cells paved the way for the glioma stem cell field Until...

Ngày tải lên: 12/08/2014, 06:20

... www.adultpdf.com Cancer Stem Cells in Lung Cancer: Distinct Differences between Small Cell and Non-Small Cell Lung Carcinomas 133 [90] Li, L., Neaves, W.B (2006) Normal stem cells and cancer stem cells: ... www.adultpdf.com Prostate and Colon Cancer Stem Cells as a Target for Anti -Cancer Drug Development 139 Cancer models The relevance of the in vivo and in vitro cancer models to patient tumors remains to ... 126 Cancer Stem Cells Theories and Practice Table Cancer stem cell markers in small cell lung carcinoma amd non-small cell lung carcinoma This is trial version www.adultpdf.com Cancer Stem Cells...

Ngày tải lên: 12/08/2014, 06:20

... the tumor (Papagiannakopoulos and Kosik, 2008) According to this cancer stem cell hypothesis, cancer stem cells are tumorinitiating cells that proliferate uniquely through self-renewal Cancer stem ... the skin and primitive neuroectodermal tumors of the central nervous system Cancer Res 58, 1798–1803 (1998) Reya T, Morrison SJ, Clarke MF, Weissman IL Stem cells, cancer, and cancer stem cells ... 306 Cancer Stem Cells Theories and Practice Conclusion In this chapter, we explore the connection between microRNAs and cancer stem cells Abnormal miRNA expression profiles of oncogenic and/ or tumor...

Ngày tải lên: 12/08/2014, 06:20

... review this issue with depth Stem cells and cancer stem cell theory Stem Cells In order to understand cancer stem cells a brief description of normal adult stem cells and the environment in which ... metastasis, and immunosurveillance avoidance in tumors This is trial version www.adultpdf.com Cancer Stem Cells as a New Opportunity for Therapeutic Intervention 381 Cancer Stem Cells Cancer Stem Cells ... such as; if tumors start with mutations in adult stem cells or if a more differentiated cell could acquire stem cell properties and develop and maintain the tumor bulk These tumor stem cells just...

Ngày tải lên: 12/08/2014, 06:20

... marker for human hematopoietic stem and progenitor cells Blood 1997, 90:5002-5012 22 Wu Y, Wu PY: CD133 as a marker for cancer stem cells: progresses and concerns Stem Cells Dev 2009, 18:1127-1134 ... cancer stem and progenitor cells Stem Cells Dev 2009, 18:17-25 Ginestier C, Hur MH, Charafe-Jauffret E, Monville F, Dutcher J, et al: ALDH1 is a marker of normal and malignant human mammary stem ... significance of cancer stem cell-defining molecules Mol Cancer Ther 9:2450-2457 43 Todaro M, Alea MP, Di Stefano AB, Cammareri P, Vermeulen L, et al: Colon cancer stem cells dictate tumor growth and resist...

Ngày tải lên: 13/08/2014, 15:21

... of tumor cells [3] that are defined by the expression of CD34+CD38- surface antigens and have been termed leukemic stem cells Similar tumor- initiating cells have also been found in 'solid' cancers, ... primitive cancer cells PTL induces apoptosis in primitive cancer cells Percent viability of prostate cancer cells and cells from a patient with BPH treated with increasing concentrations of PTL Cells ... signature Stem cells Stem cells (c) Committed basal Committed basal Stem Committed cells basal (d) Malignancy signature Tumour Birnie et al R83.3 Gleason included Benign Figure Distinctive stem cell and...

Ngày tải lên: 14/08/2014, 08:21

... normal stem cells and cancer stem cells, there are mechanistic differences in some cancers Interestingly, the mechanistic differences in selfrenewal between normal stem cells and cancer stem cells ... multi-potential stem cells, tissue-specific stem cells, progenitor cells, mature cells, and cancer cells described the direct isolation of populations containing cancer stem cells in various ... cancer stem cells Self-renewal and differentiation potentials are the features of stem cells Origin of cancer stem cells Self-renewal and differentiation potentials are the features of stem cells...

Ngày tải lên: 20/06/2014, 07:20

... Foundation and Cancer Research Ireland References Li C, Heidt DG, Dalerba P, Burant CF, Zhang L, Adsay V, Wicha M, Clarke MF, Simeone M: Identification of pancreatic cancer stem cells Cancer Res ... undifferentiated NTera2 and 2102Ep mature Expression of miRNA biosynthesis genes andEC cells miRExpression of miRNA biosynthesis genes and mature miRNAs in undifferentiated NTera2 and 2102Ep EC cells The relative ... differentiated and miRNA biosynthesis Differentiation status NTera2 and 2102Ep cells gene expresDifferentiation status and miRNA biosynthesis gene expression in differentiated NTera2 and 2102Ep cells...

Ngày tải lên: 20/06/2014, 07:20

... progenitor or stem cells and the transplantation of adult-derived neural progenitor and stem cells [39] Self-renewing multipotent neural progenitor and stem cells have been isolated and characterized ... residual stem cells The existence of stem cells in the adult brain suggests that it has the potential for self-repair and that newborn neuronal cells may contribute to the functioning, and physioand ... ectopic granule-like cells and MF sprouting [52] Hence, neurogenesis is enhanced in the DG and SVZ in animal models of epilepsy and seizure-induced ectopic granule-like cells and MF sprouting arises...

Ngày tải lên: 08/08/2014, 17:20

... AK1C3 [19] and CD44 [20] have been proposed to be the markers of cancer stem cells Their expression in tumor cells could correlate with their aggressive biological behavior, drug resistance and poor ... SCLC comparisons and thus specific to LCNEC Interestingly, AK1C1, AK1C3, AL1A1, and CD44 have been reported to be biomarkers of cancer stem cells (see Discussion) In Table BASP and SEGN are significantly ... variety of malignant tumor cells In particular, AK1C1, and AK1C3 are reported in human non-small cell lung carcinoma (A549) cells [21], and a high expression of AL1A1 in lung cancer cell lines,...

Ngày tải lên: 10/08/2014, 09:22

... phenotype of liver cancer stem cells, as distinguished from normal hepatic stem cells and from oncogene and tumor suppressor gene mutations The gene and protein networks directly targeted and affected ... cancer due to aberrant differentiation According to the hierarchical model of cancer, the origin of the cancer stem cells may be long-lived somatic stem cells Therefore, markers of “normal” stem ... demonstrating the existence of SP cells in both fetal liver cells and in primary rodent HCC cancer cells induced by chemical carcinogens Since the HCC cancer cells and fetal liver cells used in our study...

Ngày tải lên: 10/08/2014, 10:20

... right, tumors developed from × 105 and × 106 MCF-7 cells and from × 103 and × 104 BCSCs 24-well plates on top of irradiated NIH/3T3 feeder cells At day 3, the number of adherent cells increased, and ... Xenograft tumor cells Unsorted breast cancer cells 3/3 1/3 0/3 0/3 - - - - ESA+CD44+CD24-/low BCSCs - - - 3/3 3/3 1/3 0/3 0/3 MCF-7 cells gave rise to new tumors when at least × 105 cells were ... (105 cells) By contrast, ESA+CD44 + CD24-/low cells formed tumors when × 103 cells were injected per animal Tumor specimens were retrieved and subsequently passaged into recipient mice, and the...

Ngày tải lên: 10/08/2014, 10:20

... MF, Weisman IL: Stem cells, cancer and cancer stem cells Nature 2001, 414:105-111 15 Shipitsin M, Polyak K: The cancer stem cell hypothesis: in search of definitions, markers, and relevance Lab ... Vormoor J: Understanding the cancer stem cell Br J Cancer 2010, 103:439-445 11 Lindeman GJ, Visrader JE: Insights into the cell of origin in breast cancer and breast cancer stem cells Asia Pac J ... of stem cells is calculated by assuming one stem cell per 57 000 non -stem cells [28] A greater proportion of stem cells would result in a less dramatic difference Naugler Theoretical Biology and...

Ngày tải lên: 13/08/2014, 16:20

... differentiated cells is undone The resultant cells, known colloquially as induced pluripotent stem cells (iPSCs), become akin to pluripotent embryonic stem cells (ESCs) and pluripotent cells of the ... (Figure and 3): Oct4, Sox2, Klf4, and c-Myc (OSKM)48 These converted cells, which share morphological and pluripotent characteristics with ESCs, are known as induced pluripotent stem cells (iPSCs) ... ribonucleic acid N1SKM Nr5a1, Sox2, Klf4 and c-Myc N2SKM Nr5a2, Sox2, Klf4 and c-Myc N2SK Nr5a2, Sox2 and Klf4 OSK Oct4, Sox2 and Klf4 OSKM Oct4, Sox2, Klf4 and c-Myc xvi PBST Phosphate buffered...

Ngày tải lên: 09/09/2015, 18:56