... of breast cancer cells, molecular tumor classification methods, in vitro cancer models, breast cancerand microenvironment, breast cancerstem cells, gene regulation in breast cancer, and mechanism ... Telmer and Eva Turley Breast CancerStemCells 235 Chapter 11 The Microenvironment of Breast CancerStemCells Deepak Kanojia and Hexin Chen Chapter 12 Involvement of Mesenchymal StemCells in ... itself, and that pure in vitro models also need assistance of in vivo ones 22 Breast Cancer – Focusing Tumor Microenvironment, StemCellsand Metastasis Models for investigation on breast cancer...
... overexpression P63+ basal /stem cells were transformed into AR+ or ARcancer cells but rarely into ChgA+ neuroendocrine cancercells Conventional human prostate cancercells include malignant cells of luminal, ... P63+ basal /stem cellsand to examine whether these cancercells can maintain stem cell characteristics after metastasis More importantly, we intended to elucidate whether P63 + basal /stem cells can ... been reported in some androgen-refractory prostate cancers [13,41] Therefore, both AR + and AR - cells were capable of forming androgen-independent prostate cancercells as the tumorigenesis progresses...
... StemCells to Overcome Drug Resistance 401 Miaorong She and Xilin Chen Chapter 21 CancerStemCellsand Chemoresistance Suebwong Chuthapisith Chapter 22 CancerStemCells in Drug Resistance and ... transformation from normal stemcells to cancerstem cells? ” The authors suggest that cancer stemloid (or stem cell-like cancer cells) ” might be more precise than CSCs when referring to cells “exist[ing] ... Cruz and Isidro Sanchez-Garcia Part StemCells in Specific Tumors 61 Chapter Breast CancerStemCells 63 Marco A Velasco-Velázquez, Xuanmao Jiao and Richard G Pestell Chapter Glioma Stem Cells: ...
... normal stemcells to cancerstemcells Adult normal stemcells represent one purported origin of cancerstemcells What causes the transformation from normal stemcells to cancerstem cells? ... checkpoint activation and apoptosis in cancerstemcells Another possible reason for increased genomic instability in cancerstemcells is malignant transformation of aged stemcellsStemcells have a ... isolated cancerstemcells may be more accurately referred to as cancer stemloids (or stem cell-like cancer cells) (Blagosklonny, 2007) Although these cells may exist only as a minority within the cancer...
... [62] Murine and human hematopoietic stemcells [63-64], murine neural stemcells [65], normal and malignant human mammary stemcells [66], and normal and malignant human colorectal stemcells [62,67] ... factors For instance, Wnt ligands are produced and released from both stemcellsand niche cells, BMP and Shh are released from niche cellsand epithelial cells respectively, and Notch signaling is ... www.adultpdf.com 80 CancerStemCells Theories and Practice Discovery of neural and glioma stemcells The discovery of adult neural stemcells paved the way for the glioma stem cell field Until...
... www.adultpdf.com CancerStemCells in Lung Cancer: Distinct Differences between Small Cell and Non-Small Cell Lung Carcinomas 133 [90] Li, L., Neaves, W.B (2006) Normal stemcellsandcancerstem cells: ... www.adultpdf.com Prostate and Colon CancerStemCells as a Target for Anti -Cancer Drug Development 139 Cancer models The relevance of the in vivo and in vitro cancer models to patient tumors remains to ... 126 CancerStemCells Theories and Practice Table Cancerstem cell markers in small cell lung carcinoma amd non-small cell lung carcinoma This is trial version www.adultpdf.com CancerStem Cells...
... review this issue with depth Stemcellsandcancerstem cell theory StemCells In order to understand cancerstemcells a brief description of normal adult stemcellsand the environment in which ... metastasis, and immunosurveillance avoidance in tumors This is trial version www.adultpdf.com CancerStemCells as a New Opportunity for Therapeutic Intervention 381 CancerStemCellsCancerStemCells ... such as; if tumors start with mutations in adult stemcells or if a more differentiated cell could acquire stem cell properties and develop and maintain the tumor bulk These tumorstemcells just...
... marker for human hematopoietic stemand progenitor cells Blood 1997, 90:5002-5012 22 Wu Y, Wu PY: CD133 as a marker for cancerstem cells: progresses and concerns StemCells Dev 2009, 18:1127-1134 ... cancerstemand progenitor cellsStemCells Dev 2009, 18:17-25 Ginestier C, Hur MH, Charafe-Jauffret E, Monville F, Dutcher J, et al: ALDH1 is a marker of normal and malignant human mammary stem ... significance of cancerstem cell-defining molecules Mol Cancer Ther 9:2450-2457 43 Todaro M, Alea MP, Di Stefano AB, Cammareri P, Vermeulen L, et al: Colon cancerstemcells dictate tumor growth and resist...
... of tumorcells [3] that are defined by the expression of CD34+CD38- surface antigens and have been termed leukemic stemcells Similar tumor- initiating cells have also been found in 'solid' cancers, ... primitive cancercells PTL induces apoptosis in primitive cancercells Percent viability of prostate cancercellsandcells from a patient with BPH treated with increasing concentrations of PTL Cells ... signature StemcellsStemcells (c) Committed basal Committed basal Stem Committed cells basal (d) Malignancy signature Tumour Birnie et al R83.3 Gleason included Benign Figure Distinctive stem cell and...
... normal stemcellsandcancerstem cells, there are mechanistic differences in some cancers Interestingly, the mechanistic differences in selfrenewal between normal stemcellsandcancerstemcells ... multi-potential stem cells, tissue-specific stem cells, progenitor cells, mature cells, andcancercells described the direct isolation of populations containing cancerstemcells in various ... cancerstemcells Self-renewal and differentiation potentials are the features of stemcells Origin of cancerstemcells Self-renewal and differentiation potentials are the features of stem cells...
... Foundation andCancer Research Ireland References Li C, Heidt DG, Dalerba P, Burant CF, Zhang L, Adsay V, Wicha M, Clarke MF, Simeone M: Identification of pancreatic cancerstemcellsCancer Res ... undifferentiated NTera2 and 2102Ep mature Expression of miRNA biosynthesis genes andEC cells miRExpression of miRNA biosynthesis genes and mature miRNAs in undifferentiated NTera2 and 2102Ep EC cells The relative ... differentiated and miRNA biosynthesis Differentiation status NTera2 and 2102Ep cells gene expresDifferentiation status and miRNA biosynthesis gene expression in differentiated NTera2 and 2102Ep cells...
... progenitor or stemcellsand the transplantation of adult-derived neural progenitor andstemcells [39] Self-renewing multipotent neural progenitor andstemcells have been isolated and characterized ... residual stemcells The existence of stemcells in the adult brain suggests that it has the potential for self-repair and that newborn neuronal cells may contribute to the functioning, and physioand ... ectopic granule-like cellsand MF sprouting [52] Hence, neurogenesis is enhanced in the DG and SVZ in animal models of epilepsy and seizure-induced ectopic granule-like cellsand MF sprouting arises...
... AK1C3 [19] and CD44 [20] have been proposed to be the markers of cancerstemcells Their expression in tumorcells could correlate with their aggressive biological behavior, drug resistance and poor ... SCLC comparisons and thus specific to LCNEC Interestingly, AK1C1, AK1C3, AL1A1, and CD44 have been reported to be biomarkers of cancerstemcells (see Discussion) In Table BASP and SEGN are significantly ... variety of malignant tumorcells In particular, AK1C1, and AK1C3 are reported in human non-small cell lung carcinoma (A549) cells [21], and a high expression of AL1A1 in lung cancer cell lines,...
... phenotype of liver cancerstem cells, as distinguished from normal hepatic stemcellsand from oncogene andtumor suppressor gene mutations The gene and protein networks directly targeted and affected ... cancer due to aberrant differentiation According to the hierarchical model of cancer, the origin of the cancerstemcells may be long-lived somatic stemcells Therefore, markers of “normal” stem ... demonstrating the existence of SP cells in both fetal liver cellsand in primary rodent HCC cancercells induced by chemical carcinogens Since the HCC cancercellsand fetal liver cells used in our study...
... right, tumors developed from × 105 and × 106 MCF-7 cellsand from × 103 and × 104 BCSCs 24-well plates on top of irradiated NIH/3T3 feeder cells At day 3, the number of adherent cells increased, and ... Xenograft tumorcells Unsorted breast cancercells 3/3 1/3 0/3 0/3 - - - - ESA+CD44+CD24-/low BCSCs - - - 3/3 3/3 1/3 0/3 0/3 MCF-7 cells gave rise to new tumors when at least × 105 cells were ... (105 cells) By contrast, ESA+CD44 + CD24-/low cells formed tumors when × 103 cells were injected per animal Tumor specimens were retrieved and subsequently passaged into recipient mice, and the...
... MF, Weisman IL: Stem cells, cancerandcancerstemcells Nature 2001, 414:105-111 15 Shipitsin M, Polyak K: The cancerstem cell hypothesis: in search of definitions, markers, and relevance Lab ... Vormoor J: Understanding the cancerstem cell Br J Cancer 2010, 103:439-445 11 Lindeman GJ, Visrader JE: Insights into the cell of origin in breast cancerand breast cancerstemcells Asia Pac J ... of stemcells is calculated by assuming one stem cell per 57 000 non -stem cells [28] A greater proportion of stemcells would result in a less dramatic difference Naugler Theoretical Biology and...
... differentiated cells is undone The resultant cells, known colloquially as induced pluripotent stemcells (iPSCs), become akin to pluripotent embryonic stemcells (ESCs) and pluripotent cells of the ... (Figure and 3): Oct4, Sox2, Klf4, and c-Myc (OSKM)48 These converted cells, which share morphological and pluripotent characteristics with ESCs, are known as induced pluripotent stemcells (iPSCs) ... ribonucleic acid N1SKM Nr5a1, Sox2, Klf4 and c-Myc N2SKM Nr5a2, Sox2, Klf4 and c-Myc N2SK Nr5a2, Sox2 and Klf4 OSK Oct4, Sox2 and Klf4 OSKM Oct4, Sox2, Klf4 and c-Myc xvi PBST Phosphate buffered...