database resources for proteomics based analysis of cancer

... understanding of the underlying biology of lesion formation In this regard, cerebral cavernous malformation as a genetic disorder offers unique opportunities to understand the biology of vascular malformations ... two types of malformations are not linked genetically [16], and familial cases of CCM are not generally associated with venous malformations Although these clinical features define CCMs for physicians, ... trichrome stain of surgically excised cavernous malformation (A) Low-magnification view of CCM and surrounding brain Hyalinized caverns of varying size are observed, surrounded by a rim of collagen...

Ngày tải lên: 15/03/2014, 10:20

... ezrin, radixin, moesin) domain of PTPH1 is necessary for the inhibition of Mek, Erk, Jnk and AP-1 and also for localization of the phosphatase on the plasma membrane of Jurkat T cells [14] These ... recorded and mean values of left and right paws were used as reaction index for the individual animal A cut-off of 25 seconds was used to avoid tissue damage in case of absence of response Automated ... accommodation and care of animals were in accordance with the provisions of EEC Council Directive 86/609 Animals were allowed to acclimate for week before the beginning of the experiments All...

Ngày tải lên: 11/08/2014, 03:20

... Chourmouzis, Forest Science Department, University of British Columbia, for useful comment on the early draft of the manuscript, and J Lavery, Forest Science Department, University of British Columbia, for ... role of climate as the major determinant of tree growth, and the concerns about the impact of climatic change on forest growth, the aim of the present study was to quantify the influence of local ... number of study stands in each location is indicated adjusted by adding a 100 m to the measured elevation for every degree of latitude north of the reference latitude of 49° N This adjustment was based...

Ngày tải lên: 08/08/2014, 14:21

... oblique rotation for our data, four factors emerged, accounting for 41.8% of variance explained, and that these factors were effectively one-half of each of the two domains of the data for college ... (Cronbach’s alpha values) of the questionnaire for the responses of all 624 participants are as follows: (i) for the 25 items, 0.91; (ii) for the 10 anxiety items, 0.85; and (iii) for the 15 depression ... by comparing the “goodness - of - fit” (GOF) indices of the various models We used the maximum likelihood method of estimation (MLE) There are three broad types of GOF measures Hooper et al [54]...

Ngày tải lên: 11/08/2014, 16:22

... potential importance for scientific outcome, potential for development of evidencebased medicine recommendations, and availability of evidence For each topic we outlined a preliminary set of key questions ... to the field of ARF: definition/classification system for ARF; clinical outcome measures for ARF studies; physiological end-points for ARF studies; animal models of ARF; techniques for assessing ... http://ccforum.com/content/8/4/R204 Figure The cycle of patient care and sites of potential errors Any step in this continuous cycle of assessing and caring for a patient can be a site of error,...

Ngày tải lên: 12/08/2014, 20:20

... disease pathogenesis Familial forms of AD, with an autosomal dominant mode of inheritance, account for < 2% of all AD cases Onset is most often before 65 years of age, and the penetrance is nearly ... [54] A substantial amount of CAA is often found in transgenic mice with the Swedish mutation, which is likely to be because of the high rate of synthesis and accumulation of Ab1-40 In Tg2576, more ... number of animals needed for experiments LaFerla et al developed 3xTg-AD by coinjecting transgenes encoding both APP695-Swedish and Tau isoform 4R0N with the P301L mutation into pronuclei of PS-1...

Ngày tải lên: 16/02/2014, 09:20

... consequence of the presence of the same kind of spectrum for 4N complexes of GGH, where the a carbon of the His residue is the sole source of chirality [10] However, while positions of the component ... the rate of its formation The Ni(II) for Cu(II) exchange rates for peptides are of the order of 10)6 s)1 in Tris (again somewhat slower for VIHN, in accordance with the steric shielding of Ni(II)-N ... Fig Kinetics of Ni(II) substitution at site I of HSA by Cu(II) at pH 7.4 in 100 mM phosphate buer Left panel, kinetic plots of the loss of Ni(II) complex (h, De at 410 nm), formation of Cu(II) complex...

Ngày tải lên: 22/02/2014, 04:20

... than the performance of the CCM model of Klein and Manning (2002) running off of Penn treebank word classes Again, if we modify the gold standard so as to make determiners the head of NPs, then ... ordered (head, dependent) pairs of words, but the score of a dependency can optionally condition on other characteristics of the structure, most often the direction of the dependency (whether the ... right) Some notation before we present specific models: a dependency d is a pair h, a of a head and argument, which are words in a sentence s, in a corpus S For uniformity of notation with section...

Ngày tải lên: 23/03/2014, 19:20

... expression profiles reveal that established glioma cell lines are poorly representative of primary human gliomas Mol Cancer Res 2008, 6:21-30 Page of (page number not for citation purposes) Journal of ... determinants of malignancy in a mouse model for oligodendroglioma Cancer Research 2003, 63:1589-1595 Donehower LA: The p53-deficient mouse: a model for basic and applied cancer studies Seminars in Cancer ... significance of a tumor Page of (page number not for citation purposes) Journal of Translational Medicine 2009, 7:84 expressing RCAS antigens has yet to be addressed, and because all of these models...

Ngày tải lên: 18/06/2014, 15:20

... comparison of general anxiety and depression scores with expected scores of the general population was a clear strength of study, since assessing symptoms based only on cut-off points may be of little ... disease [9,10] The management of these disorders is therefore complicated for the caregivers, creating a lot of uncertainty and distress when interpreting signs and symptoms for the individuals at risk ... Committee for Medical Research Ethics in Western Norway in September 2004 Page of 10 is well suited as a screening tool for general anxiety and depression, also in HCM patients, with a cut-off score of...

Ngày tải lên: 20/06/2014, 15:20

... approach analysis of formation of the immunological synapse, a specific supramolecular pattern of receptors involved in immune cell communication, in vivo [42,43] Two-photon microscopy One of the ... is a rich arsenal of procedures for imaging within almost all major organs of mice or rats Almost all were developed originally for microvascular research and then adapted for inflammation research ... signs of inflammation The groundwork for further studies on the dynamics of lymphocyte interactions in the synovium has thus been established 168 Most of the work in intravital imaging of leukocytes...

Ngày tải lên: 09/08/2014, 01:22

... synovial transduction efficacy of AAV5 is far higher than that of AAV2 vectors, and thus the former is the vector of choice for future gene therapy trials The number of gene therapy trials in RA ... provided proof of principle and demonstrate the efficacy of a diseaseregulable expression system in arthritis However, this promoter may not be suitable for RA because the Tat is a foreign immunogenic ... [61] For future clinical application, novel disease-regulable promoters must be developed that are based on expression of endogenous genes at the site of injury/inflammation and that express no foreign,...

Ngày tải lên: 09/08/2014, 01:24

... FGF8b has the highest capacity among these isoforms on NIH3T3 cell transformation [12] FGF signaling is transduced through the formation of a complex of a growth factor, a proteoglycan, and a high-affinity ... FGF8f specifically out of the four human FGF8 isoforms, and showed little binding to other members of the FGF family Neutralizing activity of KM1334 was shown by the blocking of FGF8b binding to ... TS and IM are employees of Kyowa Hakko Kogyo MK was an employee of Kyowa Hakko Kogyo MU, TT, TS, AT and IM applied for a patent of an anti-FGF8 antibody for treatment of OA (WO2003/057251) IM...

Ngày tải lên: 09/08/2014, 10:23

... to determine expression patterns of a panel of relevant genes in a large number of distinct colonies of the susceptible mouse strain BALB/c Although induction of disease by the usual immunisation ... the validity of previous studies of the PGIA model in different laboratories, and throws down the gauntlet as a challenge to research groups that use inbred strains of mice as models for other human ... Robinson same inbred strain of mouse, the universally studied BALB/c, which is the most susceptible to PGIA The goal of the research was to compare the incidence and severity of PGIA and proteoglycan-induced...

Ngày tải lên: 09/08/2014, 14:20

... 14 The Scientific Basis of Rheumatology: A Decade of Progress This article is part of a special collection of reviews, The Scientific Basis of Rheumatology: A Decade of Progress, published to ... background of the mice [17] More recently, a major amplifying role of the alternative pathway was identified in the passive CIA model performed in a series of mice genetically deficient in components of ... further identification of its role in subgroups of RA with a distinct T cell signature Increasing support for a pathogenic role of autoantibodies in RA has shifted the interest of researchers to passive...

Ngày tải lên: 09/08/2014, 14:22

... heritabilities For a given value of 71, the log likelihood can be written in a form analogous to !2!, with the use of p matrices of the form of M and with Y! an n x p matrix Y with the ith column of Y ... idea of scaling and transformation carries over to other methods of estimation, for example, using first and/or second differentials of likelihoods strategy in p = Formulae for derivatives of the ... dimension of search It is useful to think of a composite matrix of y and y i , of the form Y! _ [yi Y2] with so that the vector of observations is y yi+ y* We wish to maximize the log-likelihood of...

Ngày tải lên: 09/08/2014, 18:21

... shown in table Data analysis Initial analysis of the joint item pool was conducted in stages First, we computed exploratory factor analyses for categorical data for each scale and for pooled items ... chi-square test statistic of model fit Unlike Maximum Likelihood (ML) estimation for factor analysis of continuous scores, our use of Muthén’s categorical data factor analysis methodology provides ... is based on the initial Mplus and FACTOR results, supports the hypothesis of a general distress factor for depression and anxiety which accounts for a large proportion of the communality of depression...

Ngày tải lên: 11/08/2014, 16:21

... performers, with a score range of 12-16 (n = 6) Average performers, with a score range of 17-21 (n = 22) High performers, with a score range of 22-26 (n = 35) Item Analyses For the purpose of ... understand the need for maintenance treatment Q25 Knowledge of different kinds of treatments Q18 Knowledge of the magnitude of therapeutic efficacy of treatments Q20 Knowledge of common side-effects ... of visits over last months 1/10 ± 2.4 HAM-D score at enrolment 0/4 2.38 ± Page of 15 (page number not for citation purposes) Page of 15 Item Percentage of responses for each item Percentage of...

Ngày tải lên: 11/08/2014, 17:20

... a sample of 60 drug users Methods Recruitment of Study Population Inclusion criteria for participation in the study included anyone who was at least 18 years of age and had a history of illicit ... entered into a Microsoft Access database and exported to SPSS version 12.0 for analysis The primary outcomes were recent (past 12 months) self-sustained overdose experience and number of recently witnessed ... Correlates of recent overdose (Table 2) included a greater number of lifetime previous overdoses (median of 5), a higher SCL-90 subscale score for somatization, stronger expectations of personally...

Ngày tải lên: 11/08/2014, 18:20