data processing and analysis for protein microarrays

Báo cáo khoa học: Recent insights into cerebral cavernous malformations: animal models of CCM and the human phenotype pptx

Ngày tải lên : 15/03/2014, 10:20

... NP_665859) Protein sequences or predicted protein sequences for a variety of vertebrate and nonvertebrate species were included if similarity was detected by BLASTp algorithm across a full-length protein ... E8.5 [33], and developmental arrest and death ensue Prior to developmental arrest, cardiac and neural development proceeds normally Cavernous malformations are vascular lesions that form predominantly ... processes that have been disrupted, resulting in the vascular malformation Between observational and genetic studies in humans and biochemical and cellular studies at the bench lies a gap This minireview...

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Báo cáo y học: " Characterization of protein tyrosine phosphatase H1 knockout mice in animal models of local and systemic inflammation" docx

Ngày tải lên : 11/08/2014, 03:20

... phase Histological Analysis At sacrifice paws were collected and placed in 4% formalin Paws were then incubated for 10-15 days in Shandon TBD2 decalcifier (Thermo-Scientific) and subsequently cut ... understand the possible role of this phosphatase in the inflammatory process and in particular in cytokine expression and release Thus, CBA analysis was performed on the plasma of LPS- and vehicle-treated ... therapeutics for the prevention and treatment of human diseases Authors' contributions The study was devised by CP and VM and carried out by CP DL performed the behavioral tests (Von Frey, Hargreaves and...

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Báo cáo khoa học: "Tree-ring characteristics of subalpine fir (Abies lasiocarpa (Hook.) Nutt.) in relation to elevation and climatic fluctuations" docx

Ngày tải lên : 08/08/2014, 14:21

... identification and interpretation for the Vancouver Forest Region, Land Manage Handbook No 28, B.C Min For. , Victoria, B.C 1994 [27] Grissino-Mayer H., Holmes R., Fritts H.C., International Tree Ring Data ... chronologies [14, 46] using the ARSTAN program − for two data sets (low- and high-elevation trees) and four tree-ring variables (RW, LW, LW%, and MXD) for the 47-year (1946 – 1992) period While the ... maximum, and minimum temperature and monthly total precipitation data for the same period from climate stations in Prince George and Revelstoke, respectively (Environment Canada, Historical and Statistical...

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Báo cáo y học: " Dimensional and hierarchical models of depression using the Beck Depression Inventory-II in an Arab college student sample" pot

Ngày tải lên : 11/08/2014, 16:22

... questionnaire for the responses of all 624 participants are as follows: (i) for the 25 items, 0.91; (ii) for the 10 anxiety items, 0.85; and (iii) for the 15 depression items, 0.86 Data analysis Data ... contributions FAA conceived the study and supervised collection of data FAA and JUO designed the study and analyzed the data FAA and JUO drafted the manuscript All authors read and approved the manuscript ... the general factor for BDI items 1-18 were 0.35 -0.59 (i.e., accounted for 12.3% -35% of variance explained), 0.27 for BDI-II items 20 and 21(i.e., 7.3% variance) and 0.11 for item 19 (i.e.,...

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Báo cáo khoa học: "Acute renal failure – definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group" doc

Ngày tải lên : 12/08/2014, 20:20

... the individual reports from the workgroups and each report was edited to conform to a uniform style and for length Finally, each report was submitted for comments to independent international ... for ARF studies; physiological end-points for ARF studies; animal models of ARF; techniques for assessing and achieving fluid balance in ARF; and information technology in acute dialysis We selected ... catheterization Information technology and acute dialysis The goals of information technology in its application to acute dialysis therapy are to improve our understanding of current practice and to improve...

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Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx

Ngày tải lên : 16/02/2014, 09:20

... leading to hemorrhage and perivascular microgliosis and astrocytosis The Dutch and Iowa mutations both reduce the negative charge of Ab and stimulate the formation of amyloid ﬁbrils and attachment to ... alternative splicing and normal APP processing In these Py8.9 mice, proper APP protein synthesis and alternative splicing was demonstrated, but the brain was devoid of neuropathology and the levels ... aggregation and degradation, but also APP processing The Dutch (E693Q) [73] and Iowa (D694N) [74] mutations are associated with CAA and diffuse Ab deposits, resulting in hemorrhagic strokes and ⁄ or...

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Tài liệu Báo cáo Y học: Short peptides are not reliable models of thermodynamic and kinetic properties of the N-terminal metal binding site in serum albumin doc

Ngày tải lên : 22/02/2014, 04:20

... complexes of VIHN [11] and the DAHam complexes of Cu(II) and Ni(II) [31] were studied previously Tables and thus present only the novel data: protonation constants for DAHKam and VIHN, and stability constants ... 7.4, and therefore they were not taken under consideration for kinetic experiments Spectroscopic data presented in Table (positions of CD spectral extrema for Cu(II) and Ni(II) complexes, and ... order kinetic constants kobs (s)1) for Ni(II) binding and Ni(II) Cu(II) exchange for model peptides and albumins in 100 mM Tris and phosphate buers at 25 C Standard deviations on the last digits...

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Báo cáo khoa học: "Corpus-Based Induction of Syntactic Structure: Models of Dependency and Constituency" pdf

Ngày tải lên : 23/03/2014, 19:20

... pattern would be that stocks and treasuries both frequently occur before the words fell and rose, and might therefore be put into the same class Clark (2001) and Klein and Manning (2002) show that ... English (WSJ) Paskin 01 RANDOM Charniak and Carroll 92-inspired ADJACENT DMV English (WSJ10) RANDOM ADJACENT DMV German (NEGRA10) RANDOM ADJACENT DMV Chinese (CTB10) RANDOM ADJACENT DMV Dir Undir ... benchmark for unsupervised systems for the time being (though see below for speciﬁc issues) Similar head-ﬁnding rules were used for Chinese experiments The NEGRA corpus, however, does supply hand-annotated...

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báo cáo hóa học:" Immunological considerations of modern animal models of malignant primary brain tumors" doc

Ngày tải lên : 18/06/2014, 15:20

... the manuscript idea, and helped prepared the manuscript AK, MR, and SF helped with literature searches and manuscript preparation and editing DJ helped edit the manuscript and contributed insight ... p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation Nature 2008, 455:1129-1133 Huse JT, Holland EC: Genetically engineered mouse models of brain cancer and ... oligodenroglioma or astrocytoma-like tumors in mice Holland and colleagues reported that virus expressing EGFRvIII (a common mutant form of EGFR), and used to infect INK4a-ARF null astrocytes or glial...

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báo cáo hóa học:" General anxiety, depression, and physical health in relation to symptoms of heart-focused anxietya cross sectional study among patients living with the risk of serious arrhythmias and sudden cardiac death" doc

Ngày tải lên : 20/06/2014, 15:20

... activity The PCS is standardized for the general population with a mean score of 50 and a 10 points standard deviation The questionnaire is generic and multidimensional, and suitable for administration ... medication (beta blockers for LQTS), devices (implantable cardioverter defibrillators for LQTS and HCM), and lifestyle modifications (restrictions of intense sports for LQTS and HCM) [8] Because of ... depression, and physical health) The most negative and significant correlation coefficient was between avoidance and physical health (r = -0.44) Attention and general anxiety (r = 0.45), and fear and...

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Báo cáo y học: " In vivo imaging approaches in animal models of rheumatoid arthritis" pot

Ngày tải lên : 09/08/2014, 01:22

... vivo Intravital microscopy Fortunately for immunologists and rheumatologists interested in surgical procedures for in vivo imaging, there is a rich arsenal of procedures for imaging within almost ... ultrasound may be enhanced, and the mechanism of contract agent accumulation is better understood and specific targeting strategies for contrast agents developed for clinical use Microscopy approaches ... mesenteries and the skin [24–28] Each of these preparations has unique strengths and caveats, and most show some effects of surgical trauma that must be considered in interpreting the results For example,...

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Báo cáo y học: " Gene therapy in animal models of rheumatoid arthritis: are we ready for the patients" pdf

Ngày tải lên : 09/08/2014, 01:24

... best vector for gene delivery The obtained clinical data for should provide us with an outline of the strategy (target, vector choice and delivery route) for RA and provide new insights for further ... proinflammatory cytokines IL-1β, IL-6 and TNF-α [88] and of degrading proteinases [89] At least for p21, it has been shown that it also can inactivate NF-κB and activator protein- 1, showing that these ... type II membrane proteins and activate death receptors for transduction of apoptotic signals Activated lymphocytes and synoviocytes from RA patients express TRAIL receptors, and adenoviral TRAIL...

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Báo cáo y học: "Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis" doc

Ngày tải lên : 09/08/2014, 10:23

... different protein isoforms (FGF8a to FGF8h) in mice, and to four isoforms (FGF8a, FGF8b, FGF8e, and FGF8f) in humans [10,11] FGF8b has the highest capacity among these isoforms on NIH3T3 cell transformation ... the original idea for the study The experimental study was designed and carried out by MU, TT, and TS Pathological analysis was performed by MK AT provided information on FGF8 and reviewed the ... 100 ng/ml FGF8 and various concentrations of anti-FGF8 antibody (Ab) (1, and 10 μg/ml) for 48 hours Concentrations of (a) promatrix metalloproteinase-3 (proMMP3) and (b) prostaglandin E2 (PGE2)...

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Báo cáo y học: "Colony variability under the spotlight in animal models of arthritis" pps

Ngày tải lên : 09/08/2014, 14:20

... susceptible to PGIA The goal of the research was to compare the incidence and severity of PGIA and proteoglycan-induced spondylitis and to determine expression patterns of a panel of relevant genes in ... differences in incidence and severity, the sub-lines of BALB/c mice showed modest but significant differences in immune parameters such as cytokine and antibody responses and clinical scores when ... affects the immune response and disease pathology In conclusion, the present report strengthens the validity of previous studies of the PGIA model in different laboratories, and throws down the gauntlet...

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Báo cáo y học: "Lessons from animal models of arthritis over the past decade" pot

Ngày tải lên : 09/08/2014, 14:22

... our understanding of arthritic processes and concomitant cartilage and bone destruction, and have provided novel insights and treatment targets However, final proof of the use of data determined ... in clinics; time will tell whether model data are predictable for certain targets and, as such, clinical data will help shape and define the models TNF and IL-6 are good examples of molecules ... of the classic arthritis models and this holds as well for the more novel models such as KRN and SKG arthritis and passive GPI/KRN arthritis In fact, both T cell- and IC-driven murine models appear...

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Báo cáo sinh học: "Estimating variances and covariances for bivariate animal models using scaling and transformation" pot

Ngày tải lên : 09/08/2014, 18:21

... with and var(e l ) l and var(e I and e and e are uncorrelated, and the ) e Q ’;1 fixed effects #i and (3 have no elements in common, and the random effects u , i 2 l , l u e and e normally distributed ... scaled versions of Yl and y have homogeneous contributions for e and e as in l , model 1, but also for Ub scaling factors, a and b for the contributions of Ub to y , i and y are introduced This ... canonical transformations and estimated rotations Acta Agric Scand A 42, 191-197 Lin CY, Smith SP (1990) Transformation of multitrait to unitrait mixed model analysis of data with multiple random effects...

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Báo cáo y học: " General and Specific Components of Depression and Anxiety in an Adolescent Population" pdf

Ngày tải lên : 11/08/2014, 16:21

... were r = 79 for the depressed mood and worrying factor; r = 86 for the depressed mood and somatic/information processing factor; and r = 78 for the worrying and somatic/information processing ... Confirmatory latent structure analysis for the first-order models Preliminary exploratory factor analysis for ordinal data showed a reasonable model fit for a two-factor and three-factor solution ... computed exploratory factor analyses for categorical data for each scale and for pooled items under promax rotation using Mplus [24] A similar analysis using ULS was performed using the freeware programme...

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Báo cáo y học: " The development of a knowledge test of depression and its treatment for patients suffering from non-psychotic depression: a psychometric assessment" ppt

Ngày tải lên : 11/08/2014, 17:20

... least two occasions for standard treatment and standard psycho-education as a part of standard clinical care prior to recruitment Patients with chronic or recent alcohol and illicit drug abuse, ... depression and its treatment on a 5-point Likert scale (from = irrelevant to = highly relevant) Data Collection and Analysis Responses from psychiatry experts were used to provide evidence for face and ... validity as presented in correlation analysis, and factor analysis For the patients, each item on the MCQ test was scored correct (1) or incorrect (0) and then summed for a total score Results The demographics...

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báo cáo khoa học: " Psychosocial and contextual correlates of opioid overdose risk among drug users in St. Petersburg, Russia" pot

Ngày tải lên : 11/08/2014, 18:20

... self-reported data were collected and therefore are open to the vulnerabilities of social desirability bias, interviewer bias, and recall bias We made every effort to be empathic and non-judgmental and ... perceived distress concerning the given domain Data Analyses Data were entered into a Microsoft Access database and exported to SPSS version 12.0 for analysis The primary outcomes were recent (past ... instruments, performing data analyses, and writing the manuscript TCG participated in developing the study design, helping to create the study instruments, performing data analyses, and writing the...

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Báo cáo y học: " First Siena International Conference on Animal Models of " pptx

Ngày tải lên : 12/08/2014, 18:20

... exposure to cigarette smoke and adenovirus infection increased levels of neutrophils and alveolar macrophages, whereas only the former increased CD4+ lymphocytes and only the latter increased ... and capacity after elastase treatment This increase was partly reversed by retinoid treatment, but reversals of elastase-induced changes in forced expiratory volume/forced vital capacity or forced ... inhibitor; and, in a multidose lipopolysaccharide model, they demonstrated efficacy of the steroid, fluticasone Dr Tralau-Stewart stressed the need to look for improved methodologies and protocols, and...

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