data methods and field sites

... proteins BCL2, BCL2L1, and BIRC5, and up-regulation of the pro-apoptotic protein BIM We showed previously that BCL2 and BIM were regulated by BRAF and INK4A [1, 61] BCL2L1 and BIRC5 are highly ... assay to direct BRAFi and MEKi treatment Comprehensive and standardized INK4A molecular assays have not been established in the context of BRAFi and MEKi treatment Technical and clini‐ cal validation ... shown to inhibit ERK pathway activation and subsequent suppression of melanoma cell proliferation and survival in vitro and in vivo [19-21] Our previous data revealed that the inhibition of mutant...

Ngày tải lên: 18/02/2014, 04:20

... (“khat”) Major Data Sources in the United States This chapter evaluates data from a number of sources to identify national and regional trends and patterns of use of MA and amphetamine The data are ... impacted by MA and amphetamines (i.e., Mexico, Canada, Central and South America, the Caribbean, Europe, Africa, Asia, and Oceania) Data and main findings from peer-reviewed journal articles and national ... unodc.org/unodc/en /data- and- analysis/WDR.html • Patterns and Trends of Amphetamine-Type Stimulants (ATS) and Other Drugs of Abuse in East Asia and the Pacific (2006)— UNODC Regional Centre for East Asia and...

Ngày tải lên: 06/03/2014, 09:21

... Social and Analytical Approaches 381 Chapter 13 Proposals for the Treatment of Users of Alcohol and Other Drugs: A Psychoanalytic Reading 383 Cynara Teixeira Ribeiro and Andréa Hortélio Fernandes ... Addicts 403 Andrea Leonardi, Sonia Scavelli and Gianluca Ciuffardi Chapter 15 Research and Intervention for Drug-Addicted Mothers and Their Children: New Perspectives 425 Paolo Stocco, Alessandra Simonelli, ... Lacoste, David Belin, Cynara Teixeira Ribeiro, Andréa Hortélio Fernandes, Andrea Leonardi, Sonia Scavelli, Gianluca Ciuffardi, Paolo Stocco, Alessandra Simonelli, Nicoletta Capra, Francesca De...

Ngày tải lên: 16/03/2014, 21:20

... both in quality and the amount of exercise and number of sessions per week, and changes in technique and tactics are other factors Pressing in several parts of the pitch and offside and double marking ... conditions, and research on environmental factors (field, equipment, type of training) allow a more specific and individual technical and athletic training, choice of appropriate equipment, and, in ... players, mainly because of the contact between hands and ball (fisting, two-handed catches, dive, punting, and release), which is optimised by footwork and body position Biomechanical studies on kicking...

Ngày tải lên: 24/03/2014, 02:21

... illness and proposed treatment, its potential benefits and risks and their likelihood, the available alternatives and their benefits and risks), there is a limited and logical set of actions and ... rather than the process; (c) ‘‘rational reasons’’ standard; (d) ‘‘the ability to understand’’ standard; and (e) the ‘‘actual understanding’’ standard, which the authors felt ‘‘reduces competency ... ability to understand and appreciate the nature and consequences of health care decisions, including the benefits and risks of and alternatives to any proposed health care, and to reach an informed...

Ngày tải lên: 29/03/2014, 00:21

... dead (red stained) cells was calculated from 10-20 different randomly selected fields for each condition assayed Methods Cell cultures and treatments Caspase activity assays Human colorectal carcinoma ... comparisons by ANOVA and post hoc Dunnett’s test Plots in (D) illustrate the inverse (3BrP and IA) and direct (5-FU) correlation that exists between the bioenergetic signature of the cells and the death-response ... correlates, both in vivo and in vitro, with the rate of glucose utilization by cancer cells and tumors [9,11] Moreover, according to large cohort studies of colon [10,19], lung [9,14] and breast [16,20]...

Ngày tải lên: 18/06/2014, 19:20

... dead (red stained) cells was calculated from 10-20 different randomly selected fields for each condition assayed Methods Cell cultures and treatments Caspase activity assays Human colorectal carcinoma ... comparisons by ANOVA and post hoc Dunnett’s test Plots in (D) illustrate the inverse (3BrP and IA) and direct (5-FU) correlation that exists between the bioenergetic signature of the cells and the death-response ... correlates, both in vivo and in vitro, with the rate of glucose utilization by cancer cells and tumors [9,11] Moreover, according to large cohort studies of colon [10,19], lung [9,14] and breast [16,20]...

Ngày tải lên: 20/06/2014, 03:20

... referral hospitals, and subsequently rolled out treatment to district hospitals and health centres [19] HIV testing is provided by more than 500 static and mobile VCT clinics and through "opt-out" ... using a data- entry programme that generates standard anonymized monthly reports All referral slips were stored in a locked cupboard to ensure patient confidentiality Quantitative methods Data were ... International AIDS Society 2009, 12:31 national and international recommendations regarding strengthened linkages between testing and treatment sites are met, and that access to ART is improved The potential...

Ngày tải lên: 20/06/2014, 08:20

... designed and coordinated the study, participated in data cleaning and data analysis, and was the lead author on this paper ED performed data cleaning and data analysis SM contributed to data analysis, ... purchases and not those made by government-funded HIV/AIDS treatment programmes through such countries as Brazil, South Africa and Thailand Similarly, we had no access to comprehensive and reliable data ... Tuberculosis and Malaria’s Price & Quality Reporting Tool, and UNITAID as provided by the Clinton Health Access Initiative [11-14] Antiretroviral transactional data was systematically cleaned and validated...

Ngày tải lên: 20/06/2014, 08:20

... NFG and NGT IFG and/ or IGT DM-Undiagnosed 4,5 * 5,3 NFG and NGT 4,5 DM-Diagnosed * DM-Undiagnosed DM-Diagnosed * * 3,5 3,5 2,5 2,5 2 NFG and NGT IFG and/ or IGT DM-Undiagnosed DM-Diagnosed NFG and ... means for triglycerides) and lipoprotein concentrations and 95% CIs (vertical bars) in men (figure 1-a, c, e and g) and women (figure 1-b, d, f and h) by ethnicities and glucose categories.* ... and Mohamed Fadhel Najjar Chapter 17 Dyslipidemia and Mental Illness D Saravane Chapter 18 Dyslipidemia Induced by Stress 367 Fernanda Klein Marcondes, Vander José das Neves, Rafaela Costa, Andrea...

Ngày tải lên: 27/06/2014, 13:20

... acquisition of data, draft and revision ofthe manuscript, and analysis and interpretation of data TS participated in study design, revision ofthe manuscript, and interpretation of data J-AN participated ... ofthe manuscript, and analysis and interpretation of data PG participated in study design, acquisition of data, revision ofthe manuscript, and interpretation of data All authors read and approved ... concomitant methotrexate (MTX) or other DMARDs and patient characteristics at treatment initiation Figure Materials and methods Patients Data were collected in a database following a structured clinical...

Ngày tải lên: 09/08/2014, 08:23

... patients treated with whole pelvis RT and adjuvant androgen deprivation therapy (2%) and prostate only (1% with androgen deprivation therapy and 2% without androgen deprivation therapy) [3] The ... ≤100 ng/ml and an estimated risk of lymph node involvement >15% based on pre-treatment PSA value and Gleason score [2] were randomized between PO vs WP radiotherapy and neoadjuvant and concurrent ... planning CT and MRI, for target volume definition, treatment planning and plan evaluation The prostate and seminal vesicles were contoured in the planning CT and the planning MRI and the sum...

Ngày tải lên: 09/08/2014, 09:22

... known death receptors is the type TNF receptor (TNFR1) and a related protein called Fas (CD95) and their ligands are called TNF and Fas ligand (FasL) respectively [17] These death receptors have ... and Bcl-W and to exhibit cytotoxicity in lymphoma, small cell lung carcinoma cell line and primary patient-derived cells Oltersdorf et al., 2005 [69] ATF4, ATF3 and NOXA reported to bind to and ... inhibitors and Hsp90 inhibitors and gene therapy attempted in targeting Survivin in cancer therapy Pennati et al., 2007 [97] Cyclopeptidic Smac mimetics and report to bind to XIAP and cIAP-1/2 and restore...

Ngày tải lên: 10/08/2014, 10:21

... ACR20, 50, and 70 scores for adalumimab were 57%, 39%, and 23% respectively versus 15%, 6%, and 1% for placebo PASI50, 75 and 90 scores for adalumimab and placebo respectively were 75%, 59%, and 42% ... as far as the signs and symptoms of arthritis, but also in dactylitis and enthesitis and in skin involvement Moreover, improvements in functional status and quality of life, and attenuation in ... between afflicted skin and synovium [29] The cytokine network in the psoriatic skin and synovium is dominated by monocyte and T-cell derived cytokines: IL-1β, IL-2, IL-10, IFN-γ and TNF-α [30] In...

Ngày tải lên: 11/08/2014, 10:23

... manuscript MPB and FC carried out data acquisition ML participated in the design of the study and data analysis DZ contributed to the study design LC was involved in the design and coordination ... cytokine and chemokine secretion as well Competing interests The author(s) declare that they have no competing interests Authors' contributions KHH was involved in data acquisition, data analysis, and ... HLA-restricted optimal peptide panel (Figures 4B and 4C) and Gag p55 peptide pools (data not shown); VL decrease is defined as the difference between TI#1 and TI#2 VL plateaus; increase in the magnitude...

Ngày tải lên: 11/08/2014, 10:23

... prescriptions of SSRIs and suicide rates suggests that the decrease of SSRI prescriptions for children and adolescents, both in the United States and the Netherlands, after U.S and European regulatory ... On the other hand, many studies confirm the reciprocal connection between the increased use of antidepressants and the decline of suicide For example, in a study conducted in Scandinavia, victims ... disorder Improved understanding of the risks and detection of early clinical warning signs while using antidepressants is therefore vital for these patients The understanding of the precise mechanisms...

Ngày tải lên: 11/08/2014, 10:23

... manuscript to BioMed Central and take full advantage of: • Convenient online submission • Thorough peer review Authors’ contributions SW and PS clinically diagnosed and managed our patient including ... between the duration of tamsulosin intake and severity of IFIS [3] The Muller’s muscle is a smooth muscle that lies just deep to the orbital septum in both upper and lower eye lids Its primary function ... associated with tamsulosin J Cataract Refract Surg 2005, 31:664-673 Cheung CMG, Awan MAR, Sandramouli S: Prevalence and clinical findings of tamsulosin-associated intra-operative floppy iris syndrome...

Ngày tải lên: 11/08/2014, 11:23

... enabled us to explore the social and public health contexts of heroin dependence from two interrelating angles: distribution of methadone clients on one hand, and the utilization of clinic services ... http://www.harmreductionjournal.com/content/7/1/14 Page of Figure Comparison of mean centre and standard deviation of residential buildings of Tai Po District and the residence locations of methadone treatment users in the ... http://www.harmreductionjournal.com/content/7/1/14 Authors' contributions NSW conducted field study, collated the data, generated the maps, conducted all statistical analyses, and prepared the first draft of the manuscript HL provided...

Ngày tải lên: 11/08/2014, 18:20