... relevant: “We are not at the end, nor at the beginning, we are not at the beginning of the end but perhaps we are at the end of the beginning” Competing interests None declared References van Zanten ... quality of nursing care on duration of weaning from mechanical ventilation [6] That study demonstrated that as the quality of nursing care was reduced the duration of weaning was increased, but ... if we are willing to accept that this role is as important as our better defined clinical role In conclusion, although the time spent on nondrug costs of intravenous antibiotic therapy may seem...
Ngày tải lên: 12/08/2014, 20:20
... procalcitonin, interleukin and interleukin in critically ill patiens admitted with suspected sepsis Am J Respir Crit Care Med 2001, 164:396-402 Christ-Crain M, Stolz D, Bingisser R, Müller C, Miedinger ... antibiotic therapy for patients with pulmonary infiltrates in the intensive care unit A proposed solution for indiscriminate antibiotic prescription Am J Respir Crit Care Med 2000, 162:505-511 Yu V, Singh ... in surgical intensive care patients as well with daily PCT guidance To date, there is no evidence in the literature for this approach in a surgical intensive care setting In a study by Chastre...
Ngày tải lên: 13/08/2014, 16:21
Báo cáo y học: "Procalcitonin to guide duration of antibiotic therapy in intensive care patients: some research questions" pptx
... Procalcitonin to guide duration of antibiotic therapy in intensive care patients: a randomized prospective controlled trial Crit Care 2009, 13:R83 Hausfater P: Procalcitonin measurement in adult clinical ... adult clinical practice [in French] Rev Med Interne 2007, 28:296-305 McLean A: Procalcitonin: seeking a niche Crit Care 2009, 13: 149 Christ-Crain M, Müller B: Procalcitonin and pneumonia: is it ... Critical Care Vol 13 No Kahn Competing interests SS has received payments from BRAHMS AG for speaking engagements References Hochreiter M, Köhler T, Schweiger AM, Keck FS, Bein B, von Spiegel...
Ngày tải lên: 13/08/2014, 18:22
Occupational therapy interventions and physical activity interventions to promote the mental wellbeing of older people in primary care and residential care pdf
... health? Maintaining mental wellbeing • sleep as an activity • keeping mentally active • memory Maintaining physical wellbeing • nutrition • pain • keeping physically active Occupation in the home ... and older living at home, in the community, in supported housing or in residential care homes • they included interventions and activities that promote or sustain mental wellbeing in older people, ... should include: − meeting or maintaining healthcare needs (for example, eye, hearing and foot care) − nutrition (for example, healthy eating on a budget) − personal care (for example, shopping,...
Ngày tải lên: 05/03/2014, 18:20
gene therapy in the treatment of cancer
... protein tyrosine kinases Breast cancer src, yes, fgr fps/fes, abl Nonreceptor protein tyrosine kinases Colon cancer raf, pim0-1, mos, cot Cytoplasmic protein-serine kinases Small-cell lung cancer ... GENE THERAPY IN THE TREATMENT OF CANCER now in development Such inhibition results not only in growth inhibition in vitro but also results in growth inhibition of tumors in animal models of carcinogenesis ... administered intradermally In a long-term clinical trial, idiotype vaccination resulted in tumor regression in cancer patients and cancer immunity in patients in remission Thus, idiotype vaccination,...
Ngày tải lên: 10/04/2014, 22:11
báo cáo hóa học:" Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer" doc
... these CHK1 inhibitors in combination with gemcitabine would be more effective in treating pancreatic cancer patients than gemcitabine alone Moreover, in vivo experiments demonstrating that inhibitors ... sensitizing target for improving Figure Validation of CHK1 as a sensitizing target to gemcitabine in pancreatic cancer cells Validation of CHK1 as a sensitizing target to gemcitabine in pancreatic cancer ... therapies involving gemcitabine and other agents, such as axitinib, cisplatin, and fluorouracil are currently being studied [26-28] Our approach to identifying combination partners for gemcitabine involves...
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học:" Long term outcomes of antiretroviral therapy in a large HIV/AIDS care clinic in urban South Africa: a prospective cohort study" docx
... http://www.jiasociety.org/content/12/1/38 Routine HIV care, treatment and data collection Patients are referred to the clinic from voluntary counseling and testing clinics, hospitals, prenatal care facilities, other ART clinics or ... suppression was defined as achieving viral load below 400 copies per ml Initial virologic success was defined as achieving a viral suppression within six months of HAART initiation in patients with ... slope of CD4 increase to change over time, the first model included the main variable of months since HAART initiation, indicator variables for baseline CD4 count, and static changepoints at months...
Ngày tải lên: 20/06/2014, 08:20
ADVANCES IN CANCER THERAPY potx
... thestateofcurrentknowledgeandlatestresearchfindingsintheareaofcancertherapy. For this purpose research articles, clinical investigations and review papers that are thoughttoimprovethereadersunderstandingofcancertherapydevelopmentsand/or ... like, for example, delineating the killing mechanisms of MCC 18 Advances in Cancer Therapy These conflicting reports might indicate that there seem to be other factors determining the relationship ... marks cargo proteins for endosomal sorting Monoubiquitination appears to mark cargo proteins for protein sorting within the MVBs In yeast, recruitment of ubiquitinated cargo proteins depends on...
Ngày tải lên: 27/06/2014, 17:20
Báo cáo khoa học: "Intraoperative radiation therapy in the treatment of early-stage breast cancer utilizing xoft axxent electronic brachytherapy" ppt
... source It can be inserted through a single incision at the time of surgery or post-lumpectomy using ultrasound guidance Initial results regarding cosmesis and local control using the MS catheter ... breast is inflated with exactly 40 cc, 50cc, 60 cc, or 70 A CEDandinserted through a small incision in the lateral cc A CED is inserted through a small incision in the lateral breast and inflated ... was then inserted into the lumpectomy cavity through a small incision in the lateral breast and inflated with exactly 40 cc of saline (Figure 1) The conformity of the CED to the surrounding breast...
Ngày tải lên: 09/08/2014, 04:21
Báo cáo khoa học: "Early clinical experience with volumetric modulated arc therapy in head and neck cancer patients" ppsx
... USA) Based on the original investigation of K Otto (10), RapidArc(r) was recently introduced in clinical practice in several institutes after an intensive validation at planning level where it was ... In patient receiving Cetuximab, administration was initiated one week before RT at loading dose of 400 mg/ mq of body surface area over a period of 120 minutes, followed by weekly 60 minute infusion ... Volume (GTV) was defined as the gross extent of tumour shown by imaging, including all involved (positive) lymph nodes MRI, and in few cases FDG-PET, were used in the delineation of GTV On the...
Ngày tải lên: 09/08/2014, 09:20
Báo cáo khoa học: "Early prediction of response to radiotherapy and androgen-deprivation therapy in prostate cancer by repeated functional MRI: a preclinical study" pptx
... when using a BPNN, care should also be taken when training the network, in order not to under- or overtrain it [25] Since our RMSE function (Figure 4A) from training, testing and validating the ... needing knowledge on the combination of underlying biological information The presented results were obtained in a preclinical study in prostate cancer xenografts, and suggest that the combination ... cannula with saline-diluted Gd-DTPA (Magnevist ® , Schering, Berlin, Germany) was inserted into the tail vein Dynamic T1-weighted (T1W) imaging was acquired by performing 20 minutes of dynamic...
Ngày tải lên: 09/08/2014, 09:20
Bacteria in cancer therapy: a novel experimental strategy ppsx
... hIL-12: Human interleukin-12; IL-3: Interleukin-3; IL-4: Interleukin-4; IL4-PE: Interleukin-4Pseudomonas exotoxin; Mab: Monoclonal antibody; mIL-12: Murine interleukin 12; mGM-CSF: Murine granulocyte-macrophage-colony ... modified or recombinant toxins This is achieved by deleting the DNA coding for the toxin binding region and replacing it with various complementary DNA encoding other cellbinding proteins has been ... these toxins need to be targeted to specific sites on the surface of cancer cells This process is accomplished by eliminating binding to toxin receptors by conjugating the toxins to cell-binding proteins...
Ngày tải lên: 10/08/2014, 05:21
báo cáo khoa học: "Regulation of cell cycle transition and induction of apoptosis in HL-60 leukemia cells by lipoic acid: role in cancer prevention and therapy" ppt
... following LA administration; supports the overall feasibility of using LA as a dietary supplement [3] In recent years, LA has gained considerable attention in the cancer field as an anticancer ... growth inhibition assay Human HL-60 cells were obtained from American Tissue Culture Collection (Manassas, VA) and maintained in RPMI 1640 supplemented with penicillin, streptomycin and 10% heat inactivated ... nucleus and promoting the caspase-independent induction of apoptosis chrome c in the activation caspase-independent apoptosis, as involving the nucleus accumulation of cytochrome c instead of a more...
Ngày tải lên: 10/08/2014, 22:20
báo cáo khoa học: "Recent advances of novel targeted therapy in non-small cell lung cancer" pot
... cetuximab plus cisplatin/vinorelbine compared with cisplatin/vinorelbine alone as first-line therapy in EGFRexpressing advanced non-small-cell lung cancer Ann Oncol 2008 in press Pirker R, Szczesna ... trial comparing bexarotene (L1069-49)/cisplatin/vinorelbine with cisplatin/vinorelbine in chemotherapy-naive patients with advanced or metastatic non-small-cell lung cancer: SPIRIT I J Clin Oncol ... from the National Comprehensive Cancer Network, Inc (NCCN) include cetuximab/vinorelbine/cisplatin as a first-line therapy option in patients who meet criteria for therapy with cetuximab (i.e NSCLC...
Ngày tải lên: 10/08/2014, 22:20
báo cáo khoa học: "New clinical developments in histone deacetylase inhibitors for epigenetic therapy of cancer" doc
... seen at day These findings imply that VOR may restore hormone sensitivity in hormone-refractory breast cancer patients VOR was investigated in combination with capecitabine (CAP) in a phase I/II ... was overall disappointing in early clinical trials [22,37,40,41] New HDAC inhibitors HDAC inhibitors generally consist of three parts in the chemical structure: (1) a zinc-chelating group; (2) a ... development HDAC inhibitors may have more potential in the combination therapy of a wide range of malignancies Combination of novel epigenetic agents, including hypomethylating agents and HDAC inhibitors,...
Ngày tải lên: 10/08/2014, 22:20
báo cáo khoa học: "Targeting tumorigenesis: development and use of mTOR inhibitors in cancer therapy" ppsx
... these agents The results of ongoing clinical trials with mTOR inhibitors, as single agents and in combination, will better define their activity in cancer Competing interests RY, AK, WJB, and DL ... weekly) in patients with MBC showed that continuous daily administration produced greater tumor shrinkage [55] In 2006, a phase III trial evaluating temsirolimus in combination with endocrine therapy ... patients [52,53] mTOR inhibitors have shown clinical activity in patients with advanced breast cancer [54,55] and are being actively investigated in this setting in combination with other agents...
Ngày tải lên: 10/08/2014, 22:20
báo cáo khoa học: "Complete response to FOLFOX4 therapy in a patient with advanced urothelial cancer: a case report" docx
... oxaliplatin and 5-FU/leucovorin over either therapy alone in patients with progressive colorectal cancer following irinotecan and 5-FU/leucovorin: interim results of a phase III trial J Clin Oncol ... oxaliplatin and cisplatin in non-seminomatous germ cell cancer cell lines Invest New Drugs 1997, 15:109-114 12 Rixe O, Ortuzar W, Alvarez M, Parker R, Reed E, Paull K, Fojo T: Oxaliplatin, tetraplatin, ... Oxaliplatin, tetraplatin, cisplatin, and carboplatin: spectrum of activity in drugresistant cell lines and in the cell lines of the National Cancer Institute’s Anticancer Drug Screen panel Biochem...
Ngày tải lên: 10/08/2014, 22:20
báo cáo khoa học: "Sustained complete remission of human epidermal growth factor receptor 2-positive metastatic breast cancer in the liver during long-term trastuzumab (Herceptin) maintenance therapy in a woman: a case report" docx
... as first-line metastatic therapy in February 2002 for four months The chemotherapy regimen was then changed to 40 mg/m2 vinorelbine plus 600 mg/m2 gemcitabine on days one and eight in a 21-day ... imaging in December 2003 (Figure 2) On completion of the chemotherapy regimen, the patient continued to receive maintenance trastuzumab monotherapy (6 mg/kg every three weeks), and she remains in ... define a time point beyond which trastuzumab might not offer additional benefit Furthermore, evidence in the literature supports the idea that continuing anticancer treatments as maintenance therapy...
Ngày tải lên: 11/08/2014, 02:22
Báo cáo y học: "Improving clinical research and cancer care delivery in community settings: evaluating the NCI community cancer centers program" pptx
... commitment to reconfiguring clinical research and the need to improve access to state-of-the-art cancer care in community settings Reconfiguring clinical research In 2002, the National Institutes of Health ... the cancer genome atlas) Within each site, activities are thus organized around four core components: reducing disparities in cancer care; increasing the number of patients enrolled in clinical ... National Cancer Institute's Cancer Information Service (1-800-4- CANCER) 2Number of Cancer Patients Treated: Total number of new cancer cases seen at the hospital and the cancer center combined in...
Ngày tải lên: 11/08/2014, 05:21