dags and their mode of action
Báo cáo khoa học: Assembly and molecular mode of action of the Helicobacter pylori Cag type IV secretion apparatus doc
... potential implications for the current understanding of its mode of action The cagPAI and the Cag type IV secretion apparatus Gene arrangement and variants of the cagPAI The cagPAI, which was originally ... the molecular mechanisms of effector protein secretion This minireview describes the composition of the cagPAI and the properties of both conserved and unique components of the Cag-T4SS, together ... an inversion of cagQ, a duplication of cagA and cagB associated with cagA degeneration, and a more complex rearrangement comprising all cag genes except cagA and a second inversion of several flanking...
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Báo cáo khoa học: Contribution of a central proline in model amphipathic a-helical peptides to self-association, interaction with phospholipids, and antimicrobial mode of action ppt
... determination of their concentration and peptide–lipid interactions The Pro-free peptides (PFPs) included M17, M21, and M25, and their counterpart central Pro-containing peptides (PCPs) were M17P, M21P, and ... & Hodges RS (1984) Synthesis of a model protein of defined secondary and quaternary structure Effect of chain length on the stabilization and formation of two-stranded alpha-helical coiled-coils ... Comparison of antimicrobial and hemolytic activities of the peptides The model amphipathic a-helical peptides were studied for their ability to inhibit the growth of Gram-negative and Gram-positive...
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Tài liệu Báo cáo khoa học: Characterization and mode of action of an exopolygalacturonase from the hyperthermophilic bacterium Thermotoga maritima doc
... zone of the cytoplasmic fraction (not shown) No activity on PGA was observed when the corresponding medium fraction was concentrated and similarly analysed Mode of action of PelB To examine its mode ... thaliana (AAF21195.1) The mode of action (endo or exo) and the amount of GalpA cleaved off, respectively, are annotated in parentheses A question mark indicates unknown activity mode The secondary structure ... as the rst and only product on PGA and oligoGalpA On the basis of its mode of action, PelB should be classied as an exopolygalacturonase (EC 3.2.1.67) To date, no crystal structure of an exopolygalacturonase...
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Báo cáo khoa học: Peptides that bind the HIV-1 integrase and modulate its enzymatic activity – kinetic studies and mode of action pptx
... inhibitory activity of this group of peptides is attributable to their effect on the turnover number of IN, and suggest a different mode of action from that of the rst group The third group of peptides, ... resembles that of INS [56] To convert some of these peptides into efcient antiHIV drugs, it is essential to elucidate their mode of action and their effects on the kinetic parameters of the 3Â-end ... the Vmax and Kcat values; and peptides that bind IN, but have no effect on its activity Structural analysis of their interaction sites within IN provided insights into their mechanism of action...
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Báo cáo Y học: Isolation, enzymatic properties, and mode of action of an exo-1,3-b-glucanase from Trichoderma viride doc
... from T viride AZ36 Mode of action in the hydrolysis of laminarins The mode of action of the exo-1,3-b-glucanase was studied using laminarin from L digitata with a ratio of 1,3-b- and Exo-1,3-b-glucanase ... Km and Vmax for hydrolysis of G6G are similar to those of G3G (Tables and 4) Therefore, it may be assumed that the enzyme has a mixed mode of action towards laminarins and that it is capable of ... higher and the rate of hydrolysis is < twofold lower than for laminarin from L digitata The mode of action of the exo-1,3-b-glucanase on laminarin from L digitata was studied qualitatively by TLC and...
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Báo cáo khoa học: Mode of action of the microbial metabolite GE23077, a novel potent and selective inhibitor of bacterial RNA polymerase docx
... specificity of action of GE23077 on cellular RNA synthesis and strongly suggest that its restricted antimicrobial activity is a result of its inability to cross bacterial membranes Mechanism of action of ... in the elucidation of the mechanism of action of GE23077, it is crucial to assess whether it exerts its action at the level of transcription initiation, like lipiarmycin [11] and rifampicin [16], ... potency and selectivity of GE23077, assessing its activity on different purified polymerases Second, its mode of action on whole bacteria, using permeabilized cells to confirm the specificity of RNA...
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stenersen - chemical pesticides - mode of action and toxicology (crc, 2004)
... pesticides: Mode of action and toxicology Dose and effect The law of mass action tells us that the amount of reaction products and the velocity of a chemical reaction increase with the concentrations of ... repellent, and plant activator Their mode of action is based on more new principles Most of them are listed below, together with the year of registration Chapter one: Introduction Pesticide Mode of Action ... inhibit synthesis of amino acids 81 5.2.1 The mode of action of glyphosate 81 5.2.2 Degradation of glyphosate 83 5.2.3 Selectivity 84 5.2.4 Mode of action of glufosinate...
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HERBICIDES – MECHANISMS AND MODE OF ACTION ppt
... of biochemical mode of action can be shown for the marketed herbicides Herbicides with mode of action represent around 75% of herbicide sales (Klausener et al., 2007) Understanding the mode of ... our knowledge of enzyme reaction mechanisms has improved Recent findings on the interaction of herbicides with target site enzymes and receptor proteins involved in their mode of action will be ... radicals are generated and Molecular Mechanism of Action of Herbicides 19 chlorosis develops (Ahrens and Krieger-Liszkay, 2001) Stoichiometric inhibition of D1 as an herbicide mode of action has a major...
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Chemical Pesticides: Mode of Action and Toxicology - Chapter 2 pptx
... Stenersen 2.2.2 Dose and effect The law of mass action tells us that the amount of reaction products and the velocity of a chemical reaction increase with the concentrations of the reactants This ... and resistant flies and a mixture (50:50) of susceptible and resistant flies (a) Doses and responses on linear scales (b) Doses on log scale and responses on probit scale LD50), will be large and ... between dose or concentration of the toxicant and the severity of the symptoms is fundamental in toxicology By using the law of mass action, we get the following equilibrium and mathematical expression:...
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Chemical Pesticides: Mode of Action and Toxicology - Chapter 3 pps
... butachlor, and several others) and a group of fungicides referred to as phenylamides (metalaxyl, ofurace, and oxadixyl) They have similar structure and mode of action: O C CH2R’’ N R R’ R is often ... inhibiting the formation of the microtubules Although the mode of action of the two types of compounds is different, the net result will be the same: impairment of cell division Binding of guanosine triphosphate ... fluoroglycofen-ethyl COCH3 NO2 O COCH2COCH2CH3 CF3 O OCH2CH3 NO2 Cl oxyfluorfen Bifenox, fluoroglycofen-ethyl, HC-252, lactofen, and oxyfluorfen have analogous structures and modes of action The...
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Chemical Pesticides: Mode of Action and Toxicology - Chapter 4 ppt
... proteins, and their function and versatility for insect control have yet to be elucidated 4.1 The mechanism of action of δ-endotoxins As mentioned, the δ-endotoxin (Cry protein) that makes up most of ... in cessation of feeding of Lepidoptera larvae and paralysis of the gut that retards the passage of food and allows the spores to germinate The larvae suffer a general paralysis and die Bt israelensis-treated ... from beach deserts and tundra, and may multiply in cadavers of insects and other animals Insecticidal activity does not correlate with the origin of the isolate, and many of them not seem to...
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Chemical Pesticides: Mode of Action and Toxicology - Chapter 5 docx
... describe some properties of carbaryl and carbofuran, aldicarb and oxamyl, and pirimicarb and ethiofencarb because their properties are contrasting Table 5.4 shows that their toxicities vary widely ... Despite their simplicity in structure and simple mode of action, the triesters of phosphorus or thiophosphorus acids are typical xenobiotics They are typical products of the chemical industry and ... glutamate and ammonia, and the first common enzyme in the biosynthesis of the branched-chain amino acids 5.2.1 The mode of action of glyphosate The amino acids tryptophan, phenylalanine, and tyrosine...
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Chemical Pesticides: Mode of Action and Toxicology - Chapter 6 ppsx
... axon and is then transmitted to the receiving cell at the synapse are not extremely complicated, and some knowledge about this mechanism is of importance in understanding the mode of action of ... amphibians, and others may have their modes of action by binding to one of the sites It is also important to know that cross-resistance between all the DDT analogues and the pyrethroids often occurs ... Stenersen of the synthetic analogues took off in the 1960s when M Elliott and his colleagues at Rothamstead Experimental Station, U.K., began an extensive study of the mechanisms of action and the...
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Chemical Pesticides: Mode of Action and Toxicology - Chapter 8 pptx
... A and B are constants) They measured the vapor densities of p,p-DDT on sand at 20, 30, and 40˚C and found them to be 2.9, 13.6, and 60.2 ng/l Furthermore, Spencer and Cliath found that DDE and ... an exposure of mg of dieldrin/kg of body weight/day and xenobiotics However, the enormous number of species, the high frequency of mutations per unit time in reproductive cells, and the high ... complicated and involves binding of the substrate to the enzyme, oxidation of Fe+++ to Fe++, change of the valence electrons of Fe++ from low-spin to high-spin orbital, binding of oxygen to iron, and...
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Chemical Pesticides: Mode of Action and Toxicology - Chapter 9 pdf
... to make resistant strains by breeding pairs of insects separately Some of the offspring were used for resistance testing, and the brothers and sisters of insects with low susceptibility were taken ... G.D., and Devonshire, A.L 1998 Pest Sci., 54, 319–320 The cotton bollworm, Helicoverpa armigera, in Australia is of great economic importance and is cross-resistant to parathion-methyl and profenofos, ... N NHCH(CH3)2 conjugate of atrazine and glutathione The data in Table 9.4 are extracted from data of Plaisance and Gronwald (1999) and show the difference in the activity of glutathione transferase...
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Báo cáo khoa học: "Anti-viral properties and mode of action of standardized Echinacea purpurea extract against highly pathogenic avian Influenza virus (H5N1, H7N7) and swine-origin H1N1 (S-OIV)" docx
... humans and their livestock, particularly poultry and pigs, as a consequence of antigenic drift and shift, resulting frequently and unpredictably in novel mutant and re-assortant strains, some of ... barriers and become pathogenic in their new hosts [1] Prospects for the emergence of pandemic strains of swine and avian origin have been discussed in several recent reports [2,3] Some of the highly ... activity in more detail, and to elucidate possible mechanisms of action on a variety of IV strains (human and avian), with emphasis on a human isolate of the H5N1-type HPAIV, and to evaluate the potential...
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Agents for hepatocellular carcinoma synthesis and mode of action
... bonds in 47 and guandinium side chain of Arg 97 and carbonyl O of Ser 263 Figure 4-10: H bonding between (A) sulfonyl O atoms of 3-12 and Arg 97, Ser 263 Phe 96; (B) Nitro O atoms of III and Ser ... Dose response curves of determination of (A) IC50 and (B) GI50 of 5-9 on HuH7 cells, 72 h incubation Figure 3-2: Dose response curves of determination of (A) IC50 and (B) GI50 of 3-12 on HuH7 cells, ... bonding of the lactam NH to amide carbonyl of Gln 167 and lactam CO to NH of imidazole in His 187 Figure 4-12 Overlap of best poses of compound 47, 8-7, 8-8 and 8-9 Figure 4-13: (A) 7-Cl of indolinone...
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Investigations into the chemopreventive potential of stilbenes, indolinones and isoindigos synthesis and mode of action studies
... POTENTIAL OF STILBENES, INDOLINONES AND ISOINDIGOS: SYNTHESIS AND MODE OF ACTION STUDIES ZHANG WEI (B.Sc., SOOCHOW UNIVERSITY) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF ... the ARE enhancer regions of NQO1 and other phase II genes, and stimulate their transcription (31) 1.5 Monofunctional and Bifunctional Inducers of Phase II Enzymes Inducers of phase II enzymes may ... elucidated A great deal more is known of the exogenous ligands of AhR, most of which are halogenated and polycyclic aromatic hydrocarbons One of its most potent ligands is 2,3,7,8tetrachlorodibenzo-p-dioxin...
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Antiproliferative activity of curcumin analogs on acute promyelocytic leukemia synthesis and mode of action studies
... 5.3.3 Effects of 41, 219 and 227 on ER stress markers in NB4 cells 146 5.3.4 Effects of 41, 219 and 227 on the ER stress sensors PERK and IRE2 .148 5.3.5 Effects of 41, 219 and 227 on ... IC50 determination of curcumin and 41 on trypsin-, caspaseand chymotrypsin-like active sites of 20S proteasome 181 Appendix 4-2 Determination of substrates Km Initial rate of reaction containing ... support and guidance during the ups and downs of this PhD project Words cannot fully express the gratitude and respect I have for Prof Go, who is not only my advisor, but also a pillar of support and...
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Báo cáo khoa học: Substrate specificity and transport mode of the proton-dependent amino acid transporter mPAT2 potx
... apparent Km values of glycine and alanine at pH values of pH 5.5–8.5 (Fig 4) and a broad range of membrane potentials At hyperpolarized membrane potentials Km values of glycine and alanine were ... Uptake of L-[3H]proline (100 lM) was measured at pH 6.5 for 10 in the presence of unlabeled amino acids and derivatives at a fixed concentration of 10 mM and are given as percentage inhibition of ... but also osmolytes such as sarcosine and betaine, and the D-enantiomers of serine and alanine The apparent affinities of PAT1 substrates are mainly in the range of 2–15 mM [1,2,4,6,9] As shown here,...
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