d1 and d2 antagonists increase relapse rates in animal studies and in clinical trials
Báo cáo y học: "Discontinuation rates in clinical trials in musculoskeletal pain: meta-analysis from etoricoxib clinical trial reports" ppt
Ngày tải lên :
09/08/2014, 10:23
... so in clinical practice as in clinical trials, although discontinuations have been mentioned previously in clinical trials in rheumatology, as with meloxicam in ankylosing spondylitis [37] In clinical ... coxibs and NSAIDs, both clinical trials and observational studies [11,12] concur in their conclusion that adherence is higher with coxibs than with NSAIDs Discontinuation rates in clinical trials ... in clinical trials that is paramount There are few comparisons on which to draw, although it is generally assumed that discontinuation rates are higher in clinical practice than in clinical trials...
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Using formative evaluation in an implementation project to increase vaccination rates in high-risk veterans: QUERI Series docx
Ngày tải lên :
11/08/2014, 05:21
... than one informant was interviewed for the CCR for influenza and standing orders interventions [Standing orders (for this project): a protocol or a limited general order for influenza vaccine.] ... for inpatients, outpatients, and home care patients Follow-up interviews were used to track progress in addressing barriers and for further problem-solving Standing orders for influenza vaccine ... Wallace C, Evans CT, Hammond M, Goldstein B: Interventions to increase influenza vaccination rates in veterans with spinal cord injuries and disorders J Spinal Cord Med 2007, 30:10-19 Stetler CB,...
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báo cáo khoa học: " Using formative evaluation in an implementation project to increase vaccination rates in high-risk veterans: QUERI Series" pps
Ngày tải lên :
11/08/2014, 16:21
... than one informant was interviewed for the CCR for influenza and standing orders interventions [Standing orders (for this project): a protocol or a limited general order for influenza vaccine.] ... for inpatients, outpatients, and home care patients Follow-up interviews were used to track progress in addressing barriers and for further problem-solving Standing orders for influenza vaccine ... Wallace C, Evans CT, Hammond M, Goldstein B: Interventions to increase influenza vaccination rates in veterans with spinal cord injuries and disorders J Spinal Cord Med 2007, 30:10-19 Stetler CB,...
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Báo cáo y học: "Tolerability and adverse events in clinical trials of celecoxib in osteoarthritis and rheumatoid arthritis: systematic review and meta-analysis of information from company clinical trial report" potx
Ngày tải lên :
09/08/2014, 06:22
... anti-inflammatory drug Clinical ulcers and bleeds Clinical ulcers and bleeds in the company clinical trial reports were as reported by investigators, and were not subjected to independent, blinded ... company clinical trial reports Deeks and co-workers [29] examined 15,000 patients in nine of the earlier trials of celecoxib, and Edwards and co-workers [30] examined some 5,700 patients in nine trials ... quality using a three-item, 1- to 5-point scale [12], and at least two points, one each for randomisation and double blinding, were required for inclusion Trials were scored for validity using an...
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Báo cáo y học: "because I am something special" or "I think I will be something like a guinea pig": information and assent of legal minors in clinical trials – assessment of understanding, appreciation and reasoning'''' pot
Ngày tải lên :
13/08/2014, 18:21
... criteria and the understanding of information related to clinical trials The appreciation of children and adolescents and their parents of what a clinical trial involved and their reasoning about ... practice of providing information to parents, children and adolescents in clinical trials or studies can be improved by using structured interviews This increases understanding, even that of ... assent and participation of legal minors and about the validity and conceptualisation of assent continue [6-8] As psychopharmaceutical interventions have increased in recent years and clinical trials...
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The use of hypothesis-testing statistics in clinical trials
Ngày tải lên :
01/11/2013, 11:20
... rejecting nor unthinkingly accepting them) Clinical example: maintenance studies of bipolar disorder Generalizability is a major issue in certain settings A good example is maintenance studies ... through all the hoops of randomization, and blinding, and placebo, and rating scales, and so on, one might expect that only some patients would agree to participate in research studies with all those ... hand, categorical assessments are often intuitively more understandable by clinicians Thus, it is typical for a clinical treatment study in psychiatry to be designed mainly 46 Chapter 8: Clinical...
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Báo cáo hóa học: " The Reflux Disease Questionnaire: a measure for assessment of treatment response in clinical trials" pdf
Ngày tải lên :
18/06/2014, 22:20
... viable instrument for assessing symptom severity and response to treatment in clinical trials of patients with GERD 10 11 12 Competing interests The authors declare that they have no competing interests ... status Ascertaining the minimal clinically important difference Control Clin Trials 1989, 10:407-415 Juniper EF, Guyatt GH, Willan A, Griffith LE: Determining a minimal important change in a disease-specific ... The baseline characteristics and clinical information for patients with data from both a baseline and subsequent visit are provided in Table GERD was proven in 82% of subjects while in 18% the...
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Báo cáo y học: "An analysis of correlations among four outcome scales employed in clinical trials of patients with major depressive disorder" pdf
Ngày tải lên :
08/08/2014, 23:21
... antidepressants, including tricyclic antidepressants, selective serotonin reuptake inhibitors, and serotonin-norepinephrine reuptake inhibitors [5,6] The trials in this analysis all included patients ... Montgomery-sberg Depression Rating Scale, the Hamilton Depression Rating Scale and the Clinical Global Impressions Rating Scale in antidepressant clinical trials Int Clin Psychopharmacol 2002, 17:281-285 ... Montgomery-sberg Depression Rating Scale, the Hamilton Depression Rating Scale and the Clinical Global Impressions Rating Scale in antidepressant clinical trials: a replication analysis Int Clin Psychopharmacol...
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báo cáo khoa học: "Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents" ppt
Ngày tải lên :
10/08/2014, 22:20
... with ionizing radiation and other DNA-damaging agents in pre -clinical studies [75] Recent pre -clinical data have suggested that it may act, in part, by inhibiting DNA repair resulted in a synergistic ... hematological and solid malignancies Vorinostat clinical trials have been updated lately [13,74] This review focuses on recent development in clinical trials testing newer HDAC inhibitors as ... dose and schedule was concluded to have insufficient activity for further investigation in this patient population [96] Clinical trial in lung cancer exhibited minimal clinical efficacy Nineteen...
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Can patient decision aids help people make good decisions about participating in clinical trials? A study protocol potx
Ngày tải lên :
11/08/2014, 05:21
... attained when deciding whether to participate in a clinical trial Furthermore, the related findings that DAs improve understanding, that improved understanding can increase trial participation rates ... databases contain information on all institution-specific research projects, only non-industry studies labelled as clinical trials involving adults will be eligible for inclusion Principal investigators ... presenting DAs online include easy updating compared to print media, and easy dissemination via the internet [55] For patients, advantages include accessibility and the potential for improved learning...
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báo cáo khoa học: " Can patient decision aids help people make good decisions about participating in clinical trials? A study protocol" pptx
Ngày tải lên :
11/08/2014, 16:21
... attained when deciding whether to participate in a clinical trial Furthermore, the related findings that DAs improve understanding, that improved understanding can increase trial participation rates ... databases contain information on all institution-specific research projects, only non-industry studies labelled as clinical trials involving adults will be eligible for inclusion Principal investigators ... presenting DAs online include easy updating compared to print media, and easy dissemination via the internet [55] For patients, advantages include accessibility and the potential for improved learning...
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Báo cáo y học: "The added value of ordinal analysis in clinical trials: an example in traumatic brain injury" potx
Ngày tải lên :
14/08/2014, 08:21
... effect Inefficient analysis of trials may contribute this the failure • Dichotomous analysis of an ordinal outcome scale in clinical trials results in loss of information Previous simulation studies ... simulation study evaluating approaches to the analysis of ordinal outcome data in randomized controlled trials in traumatic brain injury: results from the IMPACT Project Clin Trials 2010, 7:44-57 ... JM, Whitehead J: Glycine antagonist (gavestinel) in neuroprotection (GAIN International) in patients with acute stroke: a randomised controlled trial GAIN International Investigators Lancet 2000,...
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Báo cáo khoa học: Studies on the role of the receptor protein motifs possibly involved in electrostatic interactions on the dopamine D1 and D2 receptor oligomerization pdf
Ngày tải lên :
07/03/2014, 03:20
... dopamine D1 receptor b Measured in cell co-expressing dopamine D1 and D2 fusion proteins (D1 CFP and D2 YFP) c Measured in cell co-expressing dopamine D1 and D2 fusion proteins (D1 CFP and D2R1–YFP ... D1MUT– CFP and either D2 YFP, D2R1–YFP, D2R2–YFP, D2R3–YFP or D1MUT–YFP (green and red) Image overlays show extensive colocalization in D1 ⁄ D1, D1 ⁄ D1MUT, D1 ⁄ D2 and D1 ⁄ D2R1 assays and partial ... dopamine D2 receptor) d Measured in cell co-expressing dopamine D1 and D2 fusion protein (D1 CFP and D2R2–YFP – genetic variant of dopamine D2 receptor) e Measured in cell co-expressing dopamine D1...
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Tài liệu Central bank rates, market rates and retail bank rates in the euro area in the context of the recent crisis docx
Ngày tải lên :
15/02/2014, 05:20
... retail interest rates analysed include both lending rates (interest rates on short- and long-term loans to non-financial corporations, and loans for house purchase) and deposit rates (savings deposits) ... May 2011 In general, in keeping with the trend in market interest rates, short-term rates moved more substantially than did long-term rates, reacting more notably to both the increase in central ... determine if the relationship between market interest rates and retail interest rates was stable over the period, while also trying to determine the market interest rates most relevant for explaining...
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Tài liệu Báo cáo khoa học: Modulation of cyclin D1 and early growth response factor-1 gene expression in interleukin-1b-treated rat smooth muscle cells by n-6 and n-3 polyunsaturated fatty acids pdf
Ngày tải lên :
19/02/2014, 16:20
... role in the regulation of cell proliferation, including SMC, by inhibiting signalling molecules [45–47] Caveolin-3 is the main isoform in muscle cells, including SMC [30] Caveolin-1 and caveolin-3 ... of cyclin D1 it until it was barely detectable As the retinoblastoma protein, Rb, is a key target of cyclin D1/ cyclin-dependent kinase complexes, we investigated whether inhibiting cyclin D1 with ... studied the mechanism(s) underlying the inhibition of cyclin D1 gene expression by EPA and DHA by examining the effects of n-3 and n-6 PUFAs incorporation on cyclin D1 promoter activity Quiescent...
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Incentives of Retirement Transition for Elderly Workers: An Analysis of Actual and Simulated Replacement Rates in Ireland ppt
Ngày tải lên :
05/03/2014, 18:20
... struggling with increasing fiscal pressures This paper analyses the retirement pattern and the replacement rate observed in Ireland using the Living in Ireland panel dataset Since traditional ... becoming eligible for the state pension (Raab and Gannon, 2009) By including working individuals, bias may be introduced with regard to the real incentives behind retirement behaviour, meaning ... behind retirement and to investigate how it compares with the retirement patterns observed in Ireland The institutional features of the state pension system in Ireland are outlined briefly in...
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The financial crisis and the pricing of interest rates in the Irish mortgage market: 2003-2011 ppt
Ngày tải lên :
15/03/2014, 14:20
... break in 2008 and that changes in money market and deposit rates are an important determinant for standard variable rates In the post 2008 period, the breakdown in pass-through between lending rates ... Accordingly, this paper seeks to explain movements in variable rate mortgage interest rates and examine the factors which affect the changing relationship between market rates and bank lending rates ... outstanding by instrument, and makes the following assumptions as to the interest rates for each category: • Retail deposits - we use household share weighted deposit rates (outstanding business rates...
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WORKING PAPER SERIES NO. 518 / SEPTEMBER 2005: TERM STRUCTURE AND THE SLUGGISHNESS OF RETAIL BANK INTEREST RATES IN EURO AREA COUNTRIES docx
Ngày tải lên :
15/03/2014, 14:20
... households and firms are mainly confronted with retail bank interest rates when making investment and savings decisions Corporate financing is predominantly bank rather than market-based and euro ... (2002) and Sander and Kleimeier (2002 and 2004) confirm this finding Mojon (2000), Hofmann (2000 and 2003), Angeloni and Ehrmann (2003) and Coffinet (2005) also find short-term sluggishness in short-term ... ECM Following a time of gradual but continuing decline in money market interest rates during the years of nominal convergence, a reversal took place in the course of 1999 As our baseline estimation...
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WORKING PAPER SERIES NO. 518 / SEPTEMBER 2005: TERM STRUCTURE AND THE SLUGGISHNESS OF RETAIL BANK INTEREST RATES IN EURO AREA COUNTRIES pptx
Ngày tải lên :
22/03/2014, 23:20
... households and firms are mainly confronted with retail bank interest rates when making investment and savings decisions Corporate financing is predominantly bank rather than market-based and euro ... (2002) and Sander and Kleimeier (2002 and 2004) confirm this finding Mojon (2000), Hofmann (2000 and 2003), Angeloni and Ehrmann (2003) and Coffinet (2005) also find short-term sluggishness in short-term ... ECM Following a time of gradual but continuing decline in money market interest rates during the years of nominal convergence, a reversal took place in the course of 1999 As our baseline estimation...
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