d 2 predictors of favorable outcome in cancer

... focused on the intervals of sampling points from onset of CA Many previous studies demonstrated time-dependent changes in blood levels of these biochemical markers after CA [18 ,21 ,24 ,25 ,28 ,30, 32] In ... papers reviewed in the present study include grouping criteria for outcome (definitions of outcome) , specification of time points for blood sampling, and assay procedures for individual biochemical ... Kanz KG, Wiedemann E, Gippner-Steppert C, Jochum M: S-100b, sE-selectin, and sP-selectin for eval- 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 uation of hypoxic brain damage in patients...

Ngày tải lên: 13/08/2014, 18:22

... chronic pain A randomised, double-blind, placebo-controlled study Pain Clinic 20 03, 15:193 -20 2 Farar JT, Halpern SD: Understanding clinical trials in pain research In Cancer Pain, Assessment and Management ... participating centers during the study inception period will be screened, and if considered eligible included, registered and monitored over time After a check of the eligibility and inclusion in the ... of transdermal buprenorphine in patients with inadequately controlled chronic pain related to cancer and other disorders: a multicenter, randomized, double blind, placebo controlled trial Clin...

Ngày tải lên: 20/06/2014, 15:20

... biological feature of colorectal cancer metastasis Br J Cancer 20 09, 101: 822 - 828 22 23 24 25 26 27 28 29 Page of Dunn GP, Koebel CM, Schreiber RD: Interferons, immunity and cancer immunoediting Nat Rev ... - indeed, the majority of studies looking at T cells as predictors of outcome in this disease have been restricted to the tumour tissue [11, 12, 17,18 ,21 ,29 ] We did not identify the sentinel nodes, ... responses in tumour draining lymph nodes [27 ] Recent data also indicated that the presence of Foxp3+ T cells in tumour draining lymph nodes of colorectal cancer patients correlated with disease...

Ngày tải lên: 10/08/2014, 10:21

... findings of the studied cases, helped in the study supervision NAZ: Provided samples, and collection of data WSM: Participated in the cytokine assaying SHE-M: Participated in the practical part and drafting ... stimuli It induces the surface expression of IL -2 receptor (IL-2R) and, consequently, the production of its soluble form, sIL-2R The excess of sIL-2R is capable of binding IL -2 and causes the inhibition ... feature of CLD, regardless of the underlying etiology, and may represent a consequence of liver dysfunction instead of an inflammatory disorder [35] Cytokines imbalance between T-helper (Th1) and T-helper...

Ngày tải lên: 13/08/2014, 13:20

... fixed in buffered formalin, embedded in paraffin, and stained with hematoxylin-eosin-safran and Masson's trichrome Hepatic steatosis, stage of fibrosis and grade of disease activity were determined ... Hepatitis D virus (HDV) and Hepatitis E virus (HEV) infection, drug-induced hepatitis, alcoholic hepatitis and autoimmune hepatitis were all excluded Clinical data were obtained and recorded immediately ... and S4 (cirrhosis), and grade of disease activity was defined as G0 (no activity), G1 (mild activity), G2 (moderate activity), and G3 (severe activity) All the sections were blindly and independently...

Ngày tải lên: 25/10/2012, 11:48

... 72 72 71 5078·36 5101·17 5089· 32 5106·55 5130·65 5 125 ·61 5147·64 5 121 ·50 51 12 34 5071·30 50 92 24 5101·09 5106· 32 5106·50 5108 21 27 7 23 25 1· 12 251·96 25 6·50 25 9·59 25 4·55 27 6·58 26 5· 12 2 62 29 ... number of parameters of Model by assuming survival to be independent of age in nonbreeding animals Such an assumption held in intermediate and favourable conditions, but did not in severe conditions ... of nonbreeding untreated animals in both cohorts This is what we expected if breeding decisions depended on individual quality or condition In adults, for example aged years, a breeding cost was...

Ngày tải lên: 13/02/2014, 15:20

... volumes of the mRNA fractions were added to the reaction as indicated The amplified glyceraldehyde-3-phosphate dehydrogenase cDNA fragment was detected by staining with ethidium bromide, and the Mcm2 ... compared with the findings obtained by hematoxylin and eosin staining We examined the expression of these proteins in a cancer- free layer of squamous epithelial cells, carcinoma in situ (CIS) and invasive ... plated in dishes (30 mm in diameter) were cultured for 30 in medium depleted of methionine (Sigma) Ten microlitres of [35S]methionine (10 mCiÆmL)1) was added to the medium, and incubation was continued...

Ngày tải lên: 20/02/2014, 23:20

... carry out daily tasks such as walking, getting out of bed, climbing stairs, grooming, bathing, dressing, toileting, and feeding Items are rated “yes” or “no” in terms of dependence or independence ... and high levels of dependency tended to be more negatively affected by poor health and showed a need for social support in the form of a confidant than more autonomous and independent individuals ... examples include: “Death of a Close Friend”; “Minor Illness”; “Gain a new family member”; and “Grandchild married.” This scale was normed on 24 8 individuals 60+ years old and has shown good concurrent...

Ngày tải lên: 14/03/2014, 20:20

... Cleavage of IGF-binding proteins Shedding of membrane-anchored ligands of EGFR (HB-EGF, TGF-a and amphiregulin) Shedding of E-cadherin Activation of TGF-b Shedding of HB-EGF Proliferation Cleavage of ... overexpressed in more than one-third of all solid tumors [20 ] During cancer progression, increased shedding of the membrane-anchored ligands of EGFR, including heparin-binding EGF (HB-EGF), transforming ... increased migratory capacity [44] The communication between the cells is disrupted by the shedding of E-cadherin by ADAM10, leading to disrupted cell adhesion and induction of EMT, followed by increased...

Ngày tải lên: 15/03/2014, 00:20

... could impair host immunity against M tuberculosis through decreased production of cytokines including interferon-γ (25 ) or the reduction of CD4 and CD8 T cell numbers observed in animal models (26 ) ... patients (26 .6%) had underlying diseases including HIV infection, diabetes, chronic liver diseases, and so on; 83 patients (25 .9%) had previously diagnosed and treated TB (Table 1) Forty ( 12. 5%) of ... tuberculosis DNA in tissue (17.5%) Pathologically diagnosed (22 .5%) Clinically diagnosed 13 ( 32. 5%) Disseminated Miliary nodules in chest radiographs (22 .5%) Others� (10%) *, When a patient had more...

Ngày tải lên: 15/03/2014, 03:20

... By 20 00 a distinct third domain had appeared It had strong internal cross-links, suggesting that it had its own questions and methods But it occupied an intermediate position between basic and ... rapid advances in understanding of cancer genetics and increasing use of surface antigens to characterize cell types, yielded a hybrid of applied and basic research with clear relevance for clinical ... number of articles published) in cancer and cardiac medicine, selected with data from Journal Citation Reports (using the 20 08 edition), including the number of articles and impact factor of each...

Ngày tải lên: 18/06/2014, 19:20

... By 20 00 a distinct third domain had appeared It had strong internal cross-links, suggesting that it had its own questions and methods But it occupied an intermediate position between basic and ... rapid advances in understanding of cancer genetics and increasing use of surface antigens to characterize cell types, yielded a hybrid of applied and basic research with clear relevance for clinical ... number of articles published) in cancer and cardiac medicine, selected with data from Journal Citation Reports (using the 20 08 edition), including the number of articles and impact factor of each...

Ngày tải lên: 20/06/2014, 03:20

... enables de-intensification of therapy in pathology confirmed stage I-II disease The introduction of PET-CT imaging for assessment of cancers of the head and neck revolutionized cancer staging and is ... excluded from the study Demographic data, clinical data that included findings at physical examination, staging information, and pretreatment staging positron emission tomography-computerized tomography ... carcinoma [21 ] Furthermore, they showed PET-FDG imaging modified the management of 13.7% of patients Our findings indicate that PET-CT changed the stage in a large number of patients: upstaging...

Ngày tải lên: 09/08/2014, 03:22

... longitudinally contributed to the coordination of the study, and helped in drafting the manuscript AJF participated in the performance and the coordination of the study, and helped to draft the ... citrullinated peptidic residues in the context of adjoining amino acid residues and of peptide conformation [19 ,20 ] The short synthetic peptides used in anti-CCP ELISA were circularized and covalently ... below 2. 6 defined clinical remission [41, 42] , whereas a score above 3 .2 indicated more than mild disease Predefined outcomes Persistent arthritis was defined as the presence of at least one joint...

Ngày tải lên: 09/08/2014, 06:22

... (23 ) SDI >2 4/83 (5) 3/166 (2) SLEDAI at diagnosis 10 (1 to 25 ) (1 to 22 ) 0 .23 SLEDAI at study point (0 to 24 ) (0 to 21 ) 0.15 SLEDAI at diagnosis > 12 25/81 (31) 33/163 (20 ) 0.09 SLEDAI at study ... conceived of the study, participated in the design and coordination of the study, performed the statistical analysis and prepared the manuscript NO participated in the design of the study and in the ... significant independent effect The ORs for the significant variables did not differ between the initial model and the final model: 2. 25 and 3.90 for lung involvement, 2. 21 and 2. 50 for aPL, 1.10 and 1.11...

Ngày tải lên: 09/08/2014, 14:22

... progression in patients with 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 rheumatoid arthritis: results from a 10-year longitudinal study Ann Rheum Dis 20 08, 67 :21 2 -21 7 Hosmer D, Lemeshow S: Applied ... had received DMARD therapy, and thus had a chronic inflammatory joint condition without being diagnosed with RA None of the outcomes were seen in 23 8 patients The distribution of diagnoses during ... found to be predictive of an outcome independent of the clinician's knowledge of these factors, namely persistent joint swelling We believe that the use of this additional outcome in our study adds...

Ngày tải lên: 09/08/2014, 14:22

... associations involving gain of chromosome (Figure 2a; Figure S2a -d in Additional file 3) We repeated this test on an extended dataset of 42, 763 karyotypes, which included selected and partially ... chromosomes [22 -24 ] Our dataset included 385 MM karyotypes, 110 (29 %) of which were hyperdiploid H-MM is associated with recurrent gains of chromosomes 3, 5, 7, 9, 11, 15 and 19 [22 ] Indeed, the website’s ... MOF developed the statistical scores MOF, RS, SI and LT analyzed and interpreted the data MOF, RS and SI drafted the manuscript All authors read and approved the final manuscript Received: 20 ...

Ngày tải lên: 09/08/2014, 23:20

... known date of infection Aids 20 00, 14 (2) : 123 -131 Relucio K, Holodniy M: HIV-1 RNA and viral load Clinics in Laboratory Medicine 20 02, 22 (3):593-+ Bajaria SH, Webb G, Cloyd M, Kirschner D: Dynamics ... and

Ngày tải lên: 10/08/2014, 05:20

... complaints in older people A population-based survey of risk factors, mobility, and well-being J Am Podiatr Med Assoc 20 00, 90:397-4 02 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 Chen J, Devine ... rounding discrepancies or totals not adding based sample of people aged 18 years and over who took part in the North West Adelaide Health Study (NWAHS) The findings indicate that 9.5% of the cohort ... were last to have a birthday and aged 18 years and over were interviewed and invited to attend a clinic assessment Between 20 04 and 20 06, Stage of the study was conducted Where possible, all participants...

Ngày tải lên: 10/08/2014, 21:23

... dose dependent and that continuous daily dosing produced more profound mTOR inhibition than weekly dosing, [25 ,28 ,29 ] and everolimus had acceptable tolerability at the highest dosages studied ... for cancer therapy Nat Rev Cancer 20 04, 4:335-348 Hay N, Sonenberg N: Upstream and downstream of mTOR Genes Dev 20 04, 18:1 926 -1945 Guertin DA, Sabatini DM: Defining the role of mTOR in cancer Cancer ... of Hematology & Oncology 20 09, 2: 45 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 Faivre S, Kroemer G, Raymond E: Current development of mTOR inhibitors as anticancer agents Nat Rev Drug...

Ngày tải lên: 10/08/2014, 22:20