cytomegalovirus infection in renal transplant recipients
Báo cáo y học: " Factors affecting the long-term response to tacrolimus in renal transplant patients: Pharmacokinetic and pharmacogenetic approac"
... linear models, linear regression, tacrolimus, renal transplantation Background Tacrolimus, a calcineurin inhibitor, remains the centerpiece of the maintenance treatment scheme in renal transplant ... combination of a calcineurin inhibitor (tacrolimus) with a purine inhibitor (mycophenolate mofetil or azathioprine) and a steroid (prednizolone). Tacroli-mus was given twice a day in individually ... determine the impact of CYP3A5*1 and CYP3A5*3 on the kinetics of tacrolimus in renal transplant recipients. Material and methods: Forty kidney recipients were selected to participate. Maintenance...
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Tuberculosis in Liver Transplant Recipients: A Systematic Review and Meta-Analysis of Individual Patient Data doc
... MTB infection was defined as includinglung or mediastinal lymph node involvement. We de-fined multiorgan (ie, miliary) MTB infection as involve-ment of 2 or more organs (lymph nodes draining in- fected ... positive tubercu-lin skin test (TST) result in the absence of symptoms orclinical findings suggestive of active infection. In ana-lyzing LTBI treatment, we included studies reporting 10or more ... Tuberculosis Infection in Liver Transplant Recipients 1. Approximately 1% of liver transplant recipients develop active MTB infection. 2. Less than one-third of all liver transplant recipients...
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Báo cáo sinh học: " Cyclic cidofovir (cHPMPC) prevents congenital cytomegalovirus infection in a guinea pig model" pdf
... used for in vivo anti-viral studies. An eGFP-expressing, recombinant GPCMV was generated using gpt selection to enable detection of infection in the guinea pig model of congenital CMV infection ... cyclic cidofovir againstcongenital GPCMV infection, using an enhanced greenfluorescent protein (eGFP)-tagged virus [11], to aid in thedetection of vertically transmitted infection in pups bornto ... ofresulting in transplacental infection and conferring mater-nal and fetal disease in pregnant guinea pigs withoutdirect fetal inoculation. Characterization of the eGFP-tagged GPCMV recombinant,...
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Báo cáo hóa học: " Severe cytomegalovirus infection in apparently immunocompetent patients: a systematic review" doc
... Severe cytomeg-alovirus infection in immunocompetent patients. Clin InfectDis 1997, 24:52-6.8. Cohen JI, Corey GR: Cytomegalovirus infection in the normalhost. Medicine (Baltimore) 1985, 64:100-14.9. ... asdefined by the authors of the original reports, into infec-tions of: the gastrointestinal tract; the central nervous sys-tem; lungs; eyes; or skin. In addition, categories of CMVinfections ... determining eligibility for inclusion in thesystematic review. Any differences in the extracted databetween the three reviewers were resolved in meetings ofall authors.Definition of infection...
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báo cáo hóa học:"Cyclic cidofovir (cHPMPC) prevents congenital cytomegalovirus infection in a guinea pig model" pptx
... used for in vivo anti-viral studies. An eGFP-expressing, recombinant GPCMV was generated using gpt selection to enable detection of infection in the guinea pig model of congenital CMV infection ... cyclic cidofovir againstcongenital GPCMV infection, using an enhanced greenfluorescent protein (eGFP)-tagged virus [11], to aid in thedetection of vertically transmitted infection in pups bornto ... human cytomegalovirus infection by fetal intra-vascular administration of ganciclovir. Clin Diagn Virol 1993,1:61-7.4. Matsuda H, Kawakami Y, Furuya K, et al.: Intrauterine therapy fora cytomegalovirus- infected...
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báo cáo hóa học:" Mycophenolate pharmacokinetics and pharmacodynamics in belatacept treated renal allograft recipients – a pilot study" doc
... the find-ings. The clinical outcome, including renal function, isinvestigated in detail in the ongoing BENEFIT-EXT trial[25].Conclusion In the present pilot study, the IMPDH activity in CD4+cells ... alternative to CNIsfollowing transplantation. It binds with high affinity toCD80 and CD86, thereby resulting in T cell anergy andapoptosis [21]. A phase 2 trial in renal allograft recipients (n = 218) ... activity in CD4+ cells,intracellular MPA concentrations were restored by incu-bating the isolated cells in filtrated plasma originatingfrom the same sample. The IMPDH activity was deter-mined in...
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Chapter 126. Infections in Transplant Recipients (Part 1) pdf
... Medicine > Chapter 126. Infections in Transplant Recipients Infections in Transplant Recipients: Introduction The evaluation of infections in transplant recipients involves consideration of ... corneal transplants. eT. gondii usually causes disease in the brain. In hematopoietic stem cell Chapter 126. Infections in Transplant Recipients (Part 1) Harrison's Internal Medicine ... recipient of the transplanted organ. Infections following transplantation are complicated by the use of drugs that are necessary to enhance the likelihood of survival of the transplanted organ...
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Chapter 126. Infections in Transplant Recipients (Part 2) potx
... 126. Infections in Transplant Recipients (Part 2) In many transplantation centers, transmission of infections that may be latent or clinically inapparent in the donor organ has resulted in ... latent infections already. Nevertheless, most infections occur in a predictable time frame after transplantation (Table 126-2). Table 126-2 Common Sources of Infections after Hematopoietic ... after Hematopoietic Stem Cell Transplantation Period after Transplantation Infection Site Early (<1 Month) Middle (1–4 Months) Late (>6 Months) Disseminated Aerobic gram-negative,...
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Chapter 126. Infections in Transplant Recipients (Part 4) ppsx
... ulcerations occur in both the lower and the upper gastrointestinal tract, and it may be difficult to distinguish diarrhea due to GVHD from that due to CMV infection. The finding of CMV in the liver ... becomes available. Promising new drugs that are now being assessed in clinical trials include maribavir, a benzimidazole ribonucleoside that inhibits a viral protein kinase activity (UL97). ... abnormalities. It is interesting that the ocular and neurologic manifestations of CMV infections are uncommon in these patients. Management of CMV disease in HSCT recipients includes strategies...
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Chapter 126. Infections in Transplant Recipients (Part 5) potx
... disease. Treatment of CMV pneumonia in HSCT recipients (unlike that in other clinical settings) involves both IV immune globulin (IVIg) and ganciclovir. In patients who cannot tolerate ganciclovir, ... Chapter 126. Infections in Transplant Recipients (Part 5) Like prophylaxis, preemptive treatment, which targets patients with polymerase chain reaction (PCR) evidence of ... recipients is 0.6–1%, which contrasts with figures of ~5% for renal transplant recipients and up to 20% for cardiac transplant patients. In all cases, EBV-LPD is more likely to occur with high-dose,...
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Chapter 126. Infections in Transplant Recipients (Part 6) ppsx
... critical in an assessment of posttransplantation infections. to have activity against the different forms of latent EBV infection. Preventing lytic replication in these patients would theoretically ... the Chapter 126. Infections in Transplant Recipients (Part 6) PCR can be used to monitor EBV production after hematopoietic stem cell transplantation. High or increasing viral loads predict ... resulted in disease in HSCT recipients, although some cases of virus-associated marrow aplasia have been reported in the peritransplantation period. The relatively low seroprevalence of KSHV in the...
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