cytokines in combination with chemotherapy and biologic agents

... In vitro and In vivo study of ABT-869 in treatment acute myeloid leukemia (AML) alone or in combination with chemotherapy or HDAC inhibitors: insight into molecular mechanism and biologic ... Shock Protein 90 Indirubin Derivative Interferon gamma-inducible gene 16 Immunohistochemistry Intraperitoneally Internal Tandem Duplication c-Jun N-terminal Kinase Kinase Insert Domain Receptor ... Phosphoinositide 3-kinase Promyelocytic Leukemia Zinc Finger protein Phosphatase of Regenerating Liver Retinoblastoma Protein Red Fluorescence Protein RNA interference Receptor Tyrosine Kinase Standard...

Ngày tải lên: 11/09/2015, 09:06

... p-synephrine) Group 3: Advantra Z® with mg hesperidin and 600 mg naringin Group 4: Advantra Z® with 100 mg hesperidin and 600 mg naringin Group 5: Advantra Z® with 1,000 mg hesperidin and 600 mg naringin ... blood pressure were observed in response to p-synephrine or p-synephrine in combination with naringin and hesperidin (Table 2) p-Synephrine differs from ephedrine in that it has a hydroxyl group ... caffeine-sensitive individuals [39] The absence of changes in blood pressure, resting heart-rate and self-ratings in the four treatment groups involving p-synephrine, naringin and hesperidin relative...

Ngày tải lên: 25/10/2012, 11:04

... combining CDO with cytotoxic agents in HCT116 and GEO cells Cells were cultured with CDO (C) alone or in combination with 5-FU, SN38 or VP16 There were significant reductions in cell number in ... containing 10 lM BrdU for 30 mins before fixing with ice-cold 70% (v/v) ethanol and permeabilization in M HCl with 0.5% (v/v) Triton X-100 Samples were washed and incubated with fluorescein isothiocyanate-conjugated ... CDO in combination with chemotherapy, so we stained cells for SA-b-gal activity, and showed that CDO alone did not increase the extent of staining However, in cells that had been cocultured with...

Ngày tải lên: 07/03/2014, 15:20

... role of cytokines in epileptogenesis remains to be elucidated Cytokines may contribute initially to incite seizures in the developing brain after being induced by seizure or tissue injury, and they ... epileptogenesis in the developing brain In order to determine whether active inflammation, including HMGB1 and pro-inflammatory cytokines, occurs in children with febrile seizures and pediatric epilepsy, ... patients In addition, IL-1b levels were significantly and positively correlated with HMGB1 levels and with other pro-inflammatory cytokines (IL-6 and TNF-a), supporting the association of the cytokine...

Ngày tải lên: 19/06/2014, 22:20

... Percentage germination, including or excluding premature germination, in fully imbibed alder and birch seeds in response to chilling and priming Chilling duration (weeks) 18 Premature germination included ... during chilling on dormancy release in FI and TMC seeds of alder and birch In addition, the effect of priming at 15 ◦ C with or without PEG on the germination response of FI and TMC seeds without ... was similar in both species, with chilling and GA3 treatment having a larger effect in birch than in alder Germination was particularly low in birch seeds that received 30 days chilling without GA3...

Ngày tải lên: 07/08/2014, 16:21

... vascularity, in both psoriatic lesional skin and PsA synovial tissue, in relationship to the clinical effects In short, we found that lowdose infliximab treatment in combination with stable methotrexate ... changes in skin and synovium after infliximab treatment Skin biopsies from 11 patients were obtained at baseline and week At the same time points, synovial biopsies were obtained from nine patients ... psoriasis and PsA In comparison with previously performed clinical trials in PsA with mg/kg infliximab [33], we demonstrated that a low-dose treatment regimen with mg/kg in combination with stable...

Ngày tải lên: 09/08/2014, 01:23

... NY) containing 10% (v/v) heat-inactivated fetal bovine serum (Gibco, Grand Island, NY), penicillin (100 U/mL) and streptomycin (100 mg/mL), and they were maintained in a 37°C humidified incubator ... Apoptosis induction by isoproterenol or propranolol in combination with irradiation in BGC-823 and SGC-7901 cells There was an increasing rate of apoptosis in gastric cancer cell lines in response ... fewer and smaller colonies, suggesting that there was radiosensitization in the SGC-7901 and BGC-823 cell lines In addition, propranolol showed a synergism of growth inhibition in combination with...

Ngày tải lên: 09/08/2014, 09:20

... and oxaliplatin Both drugs were administered intraperitoneally Single doses of 5-FU (Mayne Pharma) 0-200 mg/kg and of oxaliplatin (Mayne Pharma) 0-10 mg/kg were administered alone or in combination ... 10 Gy, were given alone, or in combination with equitoxic single doses of 5-FU, oxaliplatin, or both drugs The same single doses of 5-FU and oxaliplatin were combined with split dose radiation ... Tissues were fixed immediately in 4% formalin with phosphate buffer and 10 transverse sections of jejunum from each mouse were prepared and stained with hematoxylin and eosin (H&E) These transverse...

Ngày tải lên: 09/08/2014, 10:20

... effective than single agents and is associated with increased toxicity [26] In single-agent studies, both canfosfamide and PLD have been shown to be active in patients with platinum and paclitaxel ... (ASSIST-3) with canfosfamide in combination with carboplatin versus PLD as second-line therapy in platinum resistant OC was presented [33] In this study, the primary endpoint was ORR and the secondary ... antitumor activity of TLK286 in combination with oxaliplatin, carboplatin, doxorubicin, paclitaxel and docetaxel in human colorectal, ovarian and breast cancer cell lines Proceedings of the American...

Ngày tải lên: 10/08/2014, 22:20

... replication in U1 and ACH-2 cells, and toxicity in uninfected JurPotencies Potencies of different HDACIs in terms of activation of HIV-1 replication in U1 and ACH-2 cells, and toxicity in uninfected ... HDACIs with increased selectivity and decreased toxicity Finally, we are currently searching for novel γ-glutamyl-cysteine synthetase inhibitors acting in the nanomolar range and displaying lower ... uninfected cells, and it induces cell death in infected cell cultures These results are consistent with a model in which BSO would favor the HIV-1 activating effects of HDACIs by lowering the intracellular...

Ngày tải lên: 12/08/2014, 23:21

... Hypothermia was induced by 1,000 mL saline (4°C) and maintained by a cooling device (Icy catheter and CoolGard 3000; Alsius Corp, Irvine, CA, USA) that was introduced into the femoral vein According to ... (suction rate, 200 mL/min; M-PRESTN; Datex-Ohmeda Inc., Helsinki, Finland) Total intravenous anesthesia (TIVA) was maintained by continuous infusion of to mg/kg/h propofol and 0.3 μg/kg/h sufentanil; ... increase the risk and extent of brain injury [5,24] In terms of a systemic inflammatory response, increased serum levels of different cytokines and chemokines have recently been presented in a rat model...

Ngày tải lên: 13/08/2014, 20:21

... to improving analysis speed, resolution, and automation as well as to developing and improving instrumentation, data-handling and report-generating software, while sample preparation and pretreatment ... ways in determining PCBs in soil samples were investigated Microwave-assisted extraction (MAE) with hexane-acetone (1:1) and SFE with CO2 are two recent simpler and more popular ways to determine ... very important Internal standards or standard addition are often required with heterogeneous samples, and controlling and monitoring the sampling parameters of time, temperature and operation...

Ngày tải lên: 16/09/2015, 15:54

... thereafter Imatinib was increased to a dose of 600 mg and continued for months, which caused adverse effects such as worsening of anemia and limb pain with increased CK Therefore the dose of imatinib was ... reported a clinical y trial using a combi ination of PR peptides ( R1 (peptides derived from prote einase 3) and WT1 peptide in paes tients with myeloid malignancies including AML in d comple ... suppressing the function of regulatory T cells in combination with anti-tumor immunotherapy including tumor antigen peptide vaccination The present study showed that WT1 peptide vaccination for imatinib-pretreated...

Ngày tải lên: 26/10/2012, 09:39

Ngày tải lên: 13/02/2014, 12:20

... equilibrated with buffer A containing 10 mM imidazole and 300 mM KCl After washing the column with buffer A containing 10 mM imidazole and 300 mM KCl, the enzyme was eluted with buffer A containing 50–100 ... (green) and K+ (cyan) are shown in ball-andstick models Cobalamin, pink (B) Residues hydrogen-bonded to cobalamin The residues interacting with cobalamin from distances ˚ ˚ shorter by 0.1 A and longer ... dehydratase [9] In addition, aG and bG are longer by one amino acid than aD in the N-terminal and by three than bD in the C-terminal, respectively In the final structure, all residues of the a chain (Met1–Glu555),...

Ngày tải lên: 21/02/2014, 03:20

... value in increasing level, followed by Quy Nhon and Can Tho This is quite compatible with the temperature happening in the past (increasing level declined southwards) In addition, temperatures in ... 13-24% in Quy Nhon and 18-31% in Can Tho; the months with the lowest decrease are from December to February with 2-5% of decrease in Da Nang, 10-18% in Quy Nhon and 13-23% in Can Tho In the rainy ... June to August in all three cities with 1.7 - 2.9 oC in Da Nang, 1.5-2.6 oC in Quy Nhon and 1.4-2.5 o C in Can Tho 3.2 Rainfall scenarios Rainfall scenarios show that rainfall in dry season can...

Ngày tải lên: 05/03/2014, 16:20

... unbound RepA and RepA bound to either 1IR (as a dimer with both DNA-binding domains involved in binding), or 1DR-short (as a dimer, but presumably with only one domain involved), or indeed when ... in a binding stoichiometry of : 1, i.e dimer binding The reactant concentrations were too high to obtain relevant information on the binding afnity For binding to 1DR, the best t yielded a binding ... binding stoichiometry of $ : 1, i.e monomer binding, with a Kd between 0.2 and 0.6 lm With 1DR-short, a reliable estimate for the stoichiometry of binding could not be made Assuming binding as...

Ngày tải lên: 07/03/2014, 04:20

... binding of SOX10 and Sp1 proteins to the GC1 ⁄ CA2, but were unable to detect the complexes, containing both SOX10 and Sp1 proteins (data not shown) It is conceivable that the in vitro binding ... simultaneous binding of the two proteins to the GC1 ⁄ CA2 SOX10 and Sp1 bind to the EDNRB promoter in vivo To investigate whether SOX10 and ⁄ or Sp1 bind to the EDNRB gene in vivo, chromatin immunoprecipitaion ... end-labeled with [c-32P] ATP and used as probes The SOX10-containing lysates were preincubated for 30 on ice with or without a competitor in the absence of a probe and then incubated with the probe...

Ngày tải lên: 16/03/2014, 13:20

... for binding in the product sites are conserved in C, E and F, but not in A and B isozymes Arg240 is replaced by Ser (in A) or Ala (in B), while Asp336 is replaced by Glu (in A) or Gly (in B) ... ligand are yellow Hydrogen bonds are indicated by cyan-coloured ‘bubbled’ lines Water molecules interacting with protein and ligand are small light-blue spheres above for cellobiose (Figs 3B and ... The glucosyl unit in the +1 site continues to make good stacking interactions with Trp373, although it now lies more directly against the six-membered ring of the indole O2 maintains the hydrogen...

Ngày tải lên: 23/03/2014, 13:20

... skills training; chapter considers education and coping skills training; chapter 10 discusses relapse prevention and problem solving; and chapter 11 covers graduation and termination Part III includes ... scores This list included social skills training (2nd highest rating in the 1995 review and 3rd highest rating in the 1998 review); behavioral contracting (ranked 5th and 7th in 1995 and 1998 respectively); ... reduced drinking and other nondrinking related activities Importantly, skills training also has been shown to be an effective intervention for improving functioning in SPMI clients, and behavioral...

Ngày tải lên: 29/03/2014, 00:20