cytokines growth factors and growth factor receptors

... that growth factor receptors, including EGFr, and integrin receptors are functionally associated [27,28], we explored the behaviour of EGFr to lower Triton X-100 concentrations Basically, and ... R24, goat anti-mouse IgG3 and finally with Alexa 546-conjugated donkey anti-goat Ig (pseudo-coloured green) C, G and K are merged images from A and B, E and F and I and J, respectively An enlargement ... regulation of growth factor receptors Nat Cell Biol 4, E75–E76 Wang, X.Q., Sun, P & Paller, A.S (2002) Ganglioside induces caveolin-1 redistribution and interaction with the epidermal growth factor...

Ngày tải lên: 16/03/2014, 16:20

... of the angiogenic factors VEGF and bFGF and an increase of the angiostatic factor endostatin contribute to the impaired angiogenesis in patients with SSc, and whether these factors may correlate ... of the transcription factor hypoxia inducible factor [31] In addition, a variety of cytokines (e.g interleukin-1, transforming growth factor beta and platelet-derived growth factor) known to be ... inducers and inhibitors are balanced and angiogenesis does not occur in healthy tissues In a hypoxic environment and in inflammatory states such as rheumatoid arthritis, angiogenic growth factors...

Ngày tải lên: 09/08/2014, 06:22

... PC12 cells Comparison of the effects of nerve growth factor and epidermal growth factor Biochem J 1992, 288 ( Pt 2):351-355 Publish with Bio Med Central and every scientist can read your work free ... ERK and JNK-p38 MAP kinases on apoptosis Science 1995, 270:1326-1331 Wert MM, Palfrey HC: Divergence in the anti-apoptotic signalling pathways used by nerve growth factor and basic fibroblast growth ... short-lived and relatively small effect on ERK1/2 and Akt VEGF-induced neuroprotective signaling via VEGFR-2, NRP1 and the two above-mentioned signaling cascades was shown in hypoxic and glucose-deprived...

Ngày tải lên: 11/08/2014, 08:20

... measurements of insulin-like growth factor- 1 and the growth hormone receptor Bars represent the mean expression of mRNA of insulin-like growth factor- 1 (IGF-I) and growth hormone receptor (GHR), ... Tam SP, Li H, Shen B, Lobie PE: Growth hormone as a cytokine Clin Exp Pharmacol Physiol 1999, 26:760-764 Gibson FA, Hinds CJ: Growth hormone and insulin-like growth factors in critical illness Intensive ... this regard, the effect of sepsis and the influence of nutrition on tissue protein metabolism and on the functioning of the growth hormone (GH)–insulin-like growth factor- I (IGF-I) axis is of particular...

Ngày tải lên: 13/08/2014, 08:20

... of unidentified factors to its 3Ј UTR VEGF-A gene expression is also upregulated by a variety of growth factors and cytokines, including PDGF-BB, TGF-␤, basic fibroblast growth factor (FGF-2), ... Herzog Y, Neufeld G: Neuropilin-2 and neuropilin-1 are receptors for the 165-amino acid form of vascular endothelial growth factor (VEGF) and of placenta growth factor- 2, but only neuropilin-2 ... Vascular endothelial growth factor (VEGF) and its receptors FASEB J 1999, 13:9-22 A review of VEGF receptors and intracellular signaling Zachary I: VEGF signalling: integration and multi-tasking...

Ngày tải lên: 14/08/2014, 14:21

... B & Moran P (2005) Hepsin activates pro-hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor-1B (HAI-1B) and HAI-2 FEBS Lett 579, 1945–1950 Herter S, Piper ... Morimoto Y & Kitamura N (1995) Activation of hepatocyte growth factor by two homologous proteases, blood coagulation factor XIIa and hepatocyte growth factor activator Eur J Biochem 229, 257–261 Miyazawa ... hepatocyte growth factor activator inhibitor type J Biol Chem 277, 14053–14059 Kojima K, Tsuzuki S, Fushiki T & Inouye K (2008) Roles of functional and structural domains of hepatocyte growth factor...

Ngày tải lên: 15/02/2014, 01:20

... to ERBB3 and ERBB4 NRG1 and NRG2 bind to both ERBB3 and ERBB4, whereas NRG3 and NRG4 only bind to ERBB4 [3] Although these ligands show redundancy, heparinbinding-EGF is the only ligand whose ... result of heart and lung problems, while mice lacking other EGF ligands, or even triple null mice deficient for amphiregulin, EGF and transforming growth factor- a are viable [4] These ligands are synthesized ... transmembrane proteins, and soluble ligands (growth factors) are released into the extracellular environment via proteolytic processing This shedding is mediated by ADAM (a disintegrin and metalloprotease)...

Ngày tải lên: 16/02/2014, 09:20

... gift of the Bid vectors, and P S McPherson and P A Barker for useful discussion and advice We are also extremely grateful to Michel Bouvier and Billy Breton for guidance and assistance in our BRET ... of epidermal growth factor family in the regulation of postnatal somatic growth Endocr Rev 28, 284–296 Henson ES & Gibson SB (2006) Surviving cell death through epidermal growth factor (EGF) ... MTT reagents and the recombinant human TRAIL ⁄ APO ligand were purchased from Invitrogen and Feldan Bio (St-Laurent, QC, Canada), respectively The caspase substrate (Ac-DEVD-pNA) and the inhibitor...

Ngày tải lên: 16/02/2014, 09:20

... stroke A variety of angiogenic factors such as VEGF, fibroblast growth factor (FGF) and platelet-derived growth factor are secreted from neuronal cells, astrocytes and inflammatory cells, including ... neutralizing IgG and immunotherapy against VEGFRs are undergoing clinical trials Table Activities of vascular endothelial growth factor (VEGF) family members PlGF, placenta growth factor; T.F svVEGF, ... ischemia of neurons and astrocytes around and downstream of the lesions, eventually inducing necrotic cell death Several risk factors including aging, hypertension, diabetes and atherosclerosis...

Ngày tải lên: 18/02/2014, 11:20

... Insulin-like growth factors and their binding proteins: biological actions Endocr Rev 16, 3–34 Baker J, Liu JP, Robertson EJ & Efstratiadis A (1993) A Role of insulin-like growth factors in embryonic and ... (1996) Growth hormone and the insulin-like growth factor system in myogenesis Endocrine Rev 17, 481–517 DeVol DL, Rotwein P, Sadow JL, Novakofski J & Bechtel PJ (1990) Activation of insulin-like growth ... accelerates muscle and motor neuron regeneration FASEB J 17, 53–55 Rosenthal SM & Cheng ZQ (1995) Opposing early and late effects of insulin-like growth factor I on differentiation and the cell cycle...

Ngày tải lên: 19/02/2014, 06:20

... Vascular-specific growth factors and blood vessel formation Nature 407, 242–248 Ó FEBS 2004 Neufeld, G., Cohen, T., Gengrinovitch, S & Poltorak, Z (1999) Vascular endothelial growth factor (VEGF) and its receptors ... proteins and these are called dbpB (also known as YB-1, MSY-1, chkYB-1b, EF1A, p50 and FRGY1) and dbpA (MSY4, chkYB-2 and YB2/RYBa) DbpB and dbpA CSD proteins are ubiquitously expressed and are ... single-strand RNA and DNA binding, cold shock domain (CSD) (also known as Y-box) proteins, play diverse roles in both transcriptional and post-transcriptional regulation of growth factor and stress...

Ngày tải lên: 19/02/2014, 12:20

... phosphorylation of Raf1, MEK1/2 and ERK1/2 induced by both growth factors, VEGF165 and VEGF121, was strongly decreased by PF-4 Thus, PF-4 acts directly on or upstream from Raf1 and downstream from PLCc ... cAMP-dependent protein kinase inhibits the mitogenic action of vascular endothelial growth factor and fibroblast growth factor in capillary endothelial cells by blocking Raf activation J Cell Biochem ... kinase pathways induced by VEGF121 and VEGF165 PF-4 inhibits the VEGF121- and VEGF165-induced activation of MEK1/2 and Raf1 As ERK1/2 are phosphorylated directly and activated by MEK1/2, we investigated...

Ngày tải lên: 19/02/2014, 16:20

... phosphorylates MAPK/ERK kinase (MEK) and 2, which in turn phosphorylate ERK1 and ERK2 Phosphorylated ERK (ERK-PP) has several different cytoplasmic and nuclear targets Transcription factors activated by ERK-PP ... concentration after stimulation with EGF and PMA together on the one hand, and the sum of the ERK-PP concentrations after stimulation with EGF and PMA separately on the other hand, was not constant, but increased ... Cooper, J.A & Hunter, T (1984) C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor- stimulated tyrosine protein kinase activity J Biol Chem 259,...

Ngày tải lên: 19/02/2014, 16:20

... nucleus and the cytoplasm and modulate the activity of transcription factors either via direct physical interactions or by sequestering cofactors required for their activation [29] The final understanding ... by acting as a catalytic surface and/ or protein cofactor for these transcription factors [39] The exact mechanism by which RhoA activates these transcription factors is just beginning to be elucidated ... (2000) Factor VIIa and thrombin induce the expression of Cyr61 and connective tissue growth factor, extracellular matrix signaling proteins that could act as possible downstream mediators in factor...

Ngày tải lên: 19/02/2014, 16:20

... [2,33] and are the target of this growth factor as bFGF inhibits FSH-induced estradiol synthesis ([5], and our results) HSPG and especially glypicans and syndecans have been described as coreceptors ... E.H & Cigorraga, S.B (1999) E€ects of basic ®broblast growth factor and nerve growth factor on lactate production, c-glutamyl transpeptidase and aromatase activities in cultured Sertoli cells Eur ... ®broblast growth factor- 2 binding and activity J Cell Physiol 147, 310±321 24 Steinfeld, R., Van den Berghe, H & David, G (1996) Stimulation of ®broblast growth factor receptor-1 occupancy and signaling...

Ngày tải lên: 21/02/2014, 03:20

... from the Italian Ministry of Education and Scientific Research (FIRB 2003) 12 13 14 References Jones JI & Clemmons DR (1995) Insulin-like growth factors and their binding proteins: biological ... actions of the insulin growth factor binding proteins Endocr Rev 23, 824–854 Baxter RC (2000) Insulin-like growth factor (IGF-) binding proteins: interactions with IGFs and intrinsic bioactivities ... insulin-like growth factor (IGF) binding protein-1 decreases plasma free IGF-I and muscle protein synthesis Endocrinology 144, 3922–3933 Westwood M (1999) Role of insulin-like growth factor binding...

Ngày tải lên: 07/03/2014, 00:20

... mitosis and possibly during G1 ⁄ S transition Identification of Src binding proteins has led to a better understanding of Src regulation and has provided clues about the function of Src in normal and ... locations where they bind to regulatory and ⁄ or substrate proteins and are integrated into cell signalling pathways and cell cycle events [23] The UD, Src homology and Src homology (SH2) domains in ... 2045.011 2082.033 2151.085 To determine whether epidermal growth factor (EGF) can activate Src and influences the association between MVP and Src, we treated serum starved fibroblasts Mass (m/z)...

Ngày tải lên: 07/03/2014, 12:20

... for Tissue Growth and Repair (includes Long IGF-I and Gly3IGF-I) Nerve growth factor (NGF) was acquired from Alomone (Jerusalem, Israel) BIAcore CM5 sensor chips, amine coupling kits and surfactant ... effects, and by allowing 300 s for association and 900 s for dissociation In the case of IGF-I and related analogues, the concentrations used were 12.5, 25, 50, 100, and 200 nM, and for IGF-II and ... insulin-like growth factor- I and prostate cancer risk: a prospective study Science 279, 563±566 Adams, T.E., Epa, V.C., Garrett, T.P & Ward, C.W (2000) Structure and function of the type insulin-like growth...

Ngày tải lên: 08/03/2014, 22:20

... or inhibit protein synthesis and cell growth [2] The most well defined signaling mechanism regulating mTOR activity in skeletal muscle is the insulin like growth factor- 1 (IGF-1) ⁄ insulin-dependent ... insulin-dependent pathway [5,6] Stimulation of muscle cells with growth factors such as IGF-1 leads to the activation of phosphoinositide 3-kinase (PI3K) and its downstream effector Akt, triggering multiple ... or TSC2 have higher mTOR activity, resulting in a robust cell growth and tumorigenesis [9,10,17,18] Although it is clear that growth factorinduced activation of Akt blocks TSC1 ⁄ TSC2 inhibition...

Ngày tải lên: 15/03/2014, 11:20

... epidermal growth factor (EGF)-like and Kringle (Kr) Cleavage by thrombin (T) and plasma kallikrein (K) produces the serum form (‘short form’) of HGFA, comprising the protease domain and a disulfide-linked ... (2007) Protein C inhibitor directly and potently inhibits activated hepatocyte growth factor activator J Thromb Haemost 5, 1477–1485 Suzuki K (2010) Hepatocyte growth factor activator (HGFA): its regulation ... hepatocyte growth factor activator inhibitor type J Biol Chem 277, 14053–14059 31 Kirchhofer D, Peek M, Lipari MT, Billeci K, Fan B & Moran P (2005) Hepsin activates pro-hepatocyte growth factor and...

Ngày tải lên: 15/03/2014, 11:20