cxcr4 cxcl12 in lung cancer growth and metastasis
Rapid detection of epidermal growth factor receptor mutations with multiplex PCR and primer extension in lung cancer pdf
Ngày tải lên :
10/08/2014, 05:21
... Zeng C, Franklin WA: Epidermal growth factor receptor in nonsmall-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis J Clin Oncol 2003, ... Feng Z, Roth JA, Herz J, Minna JD, Gazdar AF: Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers J Natl Cancer Inst 2005, 97(5):339-346 ... carcinomas, two squamous cell carcinomas, one adenosquamous carcinoma, and one other type of NSCLC No mutation was detected at codon 719 in exon 18 and codon 790 in codon 20 Seven tumors had in- frame...
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Báo cáo khoa học: Sp1 binds to the external promoter of the p73 gene and induces the expression of TAp73c in lung cancer doc
Ngày tải lên :
29/03/2014, 09:20
... squamous lung cancer cell lines (HTB59, HTB58, and SKMES1), in the adenocarcinoma cell lines (CALU3, CRL5935, A549, and SKLU1), and in the large cell lung cancer cell line (CORL23) In agreement ... transcription of TAp73c in lung cancer via highly conserved Sp1-binding sites on the p73 P1 promoter In addition, TAp73c and Sp1 are co-overexpressed both in vitro and in situ in lung cancer Sp1 also ... promoter in lung cancer factors that control the use of the p73 P1 promoter and, subsequently, the relative expression of p73 isoforms in lung cancer by using lung cancer cell lines and tumour...
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Báo cáo hóa học: " Multiplexed methylation profiles of tumor suppressor genes and clinical outcome in lung cancer" potx
Ngày tải lên :
18/06/2014, 16:20
... SQ participated in acquiring clinical samples and follow-up clinical information MSC participated in study design and coordination, data analysis and interpretation and final writing of the manuscript ... analysis and interpretation, and drafted the manuscript PP and LG participated in acquiring clinical and laboratory data, data analysis and data interpretation and drafted the manuscript LG, JV, and ... Methods Lung cancer cell lines Six NSCLC cell lines consisting of three adenocarcinoma cell lines (A549, H522 and H358), two large carcinoma cell lines (H460, H661), and one squamous cell carcinoma...
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báo cáo hóa học:" Curcumin induces chemo/radio-sensitization in ovarian cancer cells and curcumin nanoparticles inhibit ovarian cancer cell growth" pot
Ngày tải lên :
20/06/2014, 07:20
... chemopreventive and chemotherapeutic activity via influencing multiple signaling pathways, including those involved in survival, growth, metastasis and angiogenesis in various cancers [12-15] ... damage by increasing DNA repair proteins, such as PARP However, in curcumin pre-treated cells, cisplatin exposure resulted in a significant (p < 0.05) increase in PARP cleavage, indicating the induction ... of cisplatin treatment in cisplatin resistant cells by increasing the sensitivity of cells to apoptotic pathways and modulating nuclear β-catenin signaling Curcumin is in early phase clinical trials...
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Báo cáo khoa học: " The TGF-β1 dynamics during radiation therapy and its correlation to symptomatic radiation pneumonitis in lung cancer patients" potx
Ngày tải lên :
09/08/2014, 10:20
... the patients at six points: before treatment and at the beginning, in the middle of and at the end of RT and at and weeks after the completion of RT By using meticulous handling procedure, the blood ... volume (CTV), and normal structures (esophagus, spinal cord, heart, and lung) were defined and contoured on the multiple CT images The gross tumor volume included the tumor and clinically involved ... 4:59 Background Increasing radiation dose and combining it with chemotherapy were found to improve the local control for lung cancer and thus improve the overall survival of lung cancer patients...
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báo cáo khoa học: "Osthole induces G2/M arrest and apoptosis in lung cancer A549 cells by modulating PI3K/Akt pathway" pptx
Ngày tải lên :
10/08/2014, 10:21
... procured locally Cell line and culture conditions The human lung cancer cell line A549 was obtained from the China Center for Type Culture Collection (Wuhan, China) and maintained in RPMI-1640 supplemented ... anticancer effect of Osthole has been reported in a few papers Both in vitro and in vivo studies showed that Osthole possessed an anticancer effect by inhibiting human cancer cells growth and inducing ... Cdc2/Cyclin B1, Bcl-2 protein and up-regulated Bax in our study In summary, these results indicated that Osthole induced G2/M arrest and apoptosis possibly by down-regulating Akt signaling in human lung...
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The role of cyr61 and LASP1 in growth and metastasis of human hepatocellular carcinoma
Ngày tải lên :
13/09/2015, 19:46
... 17q21 and encodes a protein of 261 amino acids containing an Nterminal LIM domain followed by two actin binding sites and a C-terminal src homology SH3 domain (Figure 1.3) The actin binding domain ... and Marcantonio 2006) For instance, the integrin-binding proteins paxillin and talin recruit focal adhesion kinase (FAK) and vinculin to focal contacts (Sastry and Burridge 2000; Calderwood and ... 2.2.1 Growth of HCC cell lines and colon cancer cell lines…………… 41 2.2.2 Freezing HCC cell lines and colon cancer cell lines……………….42 2.2.3 Harvesting HCC cell lines and colon cancer cell lines………...
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European guidelines for quality assurance in breast cancer screening and diagnosis pot
Ngày tải lên :
15/03/2014, 00:20
... continuing advances in technical and professional knowledge Certain principles remain just as important in diagnosis as they are in screening Training, multidisciplinary teamwork, monitoring and ... screening should be established in line with the routine screening interval, taking into consideration that most programmes not succeed in keeping the routine screening interval for each individual ... screening should be established in line with the routine screening interval, taking into consideration that most programmes not succeed in keeping the routine screening interval for each individual...
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Báo cáo hóa học: "Inhibiting adenoid cystic carcinoma cells growth and metastasis by blocking the expression of ADAM 10 using RNA interference" pdf
Ngày tải lên :
18/06/2014, 16:20
... role in tumor invasion and metastasis To provide evidence supporting this supposition, we investigated the effects of ADAM 10 silencing on in vitro cell invasion as well as in vivo cancer metastasis ... verified the difference in metastasis potential of SACC-LM and SACC-83 bothin vitro and in vivo Subsequently, both ADAM 10 mRNA and protein levels were examined in adenoid cystic carcinoma cells with ... proliferation and metastasis were observed both in vitro and in vivo Materials and methods Cell lines and specimens Adenoid cystic carcinoma cells with high metastatic potential (SACC-LM) and low metastatic...
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Báo cáo sinh học: "Elevated expression of CDK4 in lung cancer" pptx
Ngày tải lên :
18/06/2014, 19:20
... nuclear staining intensity and the number of positive nuclear staining Nuclear staining intensity score was consistent with cytoplasm and positive nuclear staining scores were defined as follows: ... protein expression in lung cancer and normal lung tissues We measured the expression levels and subcellular localization of CDK4 protein in 89 archived paraffin-embedded lung cancer samples and ... Overexpression of CDK4 has been described in many tumors, including lung cancer In this investigation, we analyzed the expression of CDK4 protein in lung cancer and normal lung tissues by immunohistochemistry...
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báo cáo hóa học:" Elevated expression of CDK4 in lung cancer" ppt
Ngày tải lên :
20/06/2014, 03:20
... nuclear staining intensity and the number of positive nuclear staining Nuclear staining intensity score was consistent with cytoplasm and positive nuclear staining scores were defined as follows: ... protein expression in lung cancer and normal lung tissues We measured the expression levels and subcellular localization of CDK4 protein in 89 archived paraffin-embedded lung cancer samples and ... Overexpression of CDK4 has been described in many tumors, including lung cancer In this investigation, we analyzed the expression of CDK4 protein in lung cancer and normal lung tissues by immunohistochemistry...
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báo cáo hóa học:" Aberrant STYK1 expression in ovarian cancer tissues and cell lines" pdf
Ngày tải lên :
20/06/2014, 07:20
... (NOK) in lung cancers Lung Cancer 2007, 56:337-340 Kondoh T, Kobayashi D, Tsuji N, Kuribayashi K, Watanabe N: Overexpression of serine threonine tyrosine kinase 1/novel oncogene with kinase domain ... (GPR30-specific ligand) and estradiol were shown to synergistically induce proliferation of breast and ovarian cancer lines [15] In this study we examined STYK1 immunoreactivity in normal, benign, and malignant ... Many of the ovarian cancer tissue sections had weak STYK1 staining intensity as seen in the benign tissues, however, moderate and strong STYK1 staining intensity was seen only in the malignant ovarian...
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báo cáo hóa học:" Mucins in ovarian cancer diagnosis and therapy" ppt
Ngày tải lên :
20/06/2014, 07:20
... present, MUC1 and MUC16 are the best and only characterized mucins and monoclonal antibodies against MUC1 and MUC16 are under preclinical and clinical investigations for ovarian cancer treatment ... ovarian cancer and ovarian cancer prognosis Use of Mucins in Radioimmunodiagnosis (RID) and Radioimmunotherapy (RIT) Monoclonal antibodies against mucins may have potential applications in improving ... ovarian tumors and their potential role in ovarian cancer diagnosis and treatment Mucins Being that 90% of ovarian cancers are of epithelial origin, mucins may be attractive candidates for the...
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Báo cáo khoa học: "The Akt-inhibitor Erufosine induces apoptotic cell death in prostate cancer cells and increases the short term effects of ionizing radiation" pot
Ngày tải lên :
09/08/2014, 09:20
... ErPC3, in preclinical and clinical investigations is based on their ability to induce apoptosis in tumor cells and their ability to increase cytotoxic efficacy of chemotherapy and radiotherapy in ... inhibitors of the PI3K/Akt pathway in prostate cancer cells Combined effects of ErPC3 and ionizing radiation in prostate cancer cell lines Up to now our data revealed that ErPC3 is a potent inhibitor ... inactivated in a variety of solid human tumors, including prostate cancer Increased levels of PIP3 trigger the recruitment of phosphatidylinositide-dependent serine/threonine kinase (PDK1) and Akt...
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Báo cáo khoa học: " Radiosensitizers in cervical cancer. Cisplatin and beyond Myrna Candelaria1, Alicia Garcia-Arias1, Lucely Cetina1 " ppt
Ngày tải lên :
09/08/2014, 10:21
... cisplatin and gemcitabine in combination in which cisplatin was administered first, in this study the inverse order was chosen; thus, gemcitabine was followed by cisplatin Cisplatin was administered ... paclitaxel in this setting Three dose-finding studies have been performed combining either carboplatin or cisplatin with paclitaxel The first study was intended to determine the tolerable doses and ... biologic rationale and in view of the recent advances in heating and thermometry techniques, radiotherapy in combination with hyperthermia has been tested in cervical cancer In a small randomized study...
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Báo cáo khoa học: " Linkage disequilibrium pattern of the ATM gene in breast cancer patients and controls; association of SNPs and haplotypes to radio-sensitivity and post-lumpectomy local recurrence" doc
Ngày tải lên :
09/08/2014, 10:21
... C-terminal protein kinase domain (PI3K-domain), 2) the substrate binding domain in the N-terminal of the protein necessary for activation of p53 in response to DNA damage, 3)the FAT domain – common ... substrate binding domains, Leucine zipper, ATP-binding domains, FAT domain and PI3K domain [17] together with exonic information (The size of the exons and the distance between them are not indicative ... the domains of the protein described by [17], such http://www.ro-journal.com/content/2/1/25 as the PI3K domain, substrate binding domains and ATPbinding domains, is illustrated in Figure Single...
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báo cáo khoa học: " Rapamycin potentiates cytotoxicity by docetaxel possibly through downregulation of Survivin in lung cancer cells" ppsx
Ngày tải lên :
10/08/2014, 10:21
... twice with cold PBS, resuspended in 250 μl of binding buffer, and stained with staining solution containing Annexin V/FITC and PI After incubation in the dark for 30 min, cells were analyzed by FACSCalibur ... Results Growth inhibitory effect of rapamycin on lung cancer cells We first set out to examine whether and at what levels rapamycin inhibits the growth of four different lung cancer cell lines (NCI-H446, ... rapamycin and docetaxel-induced signaling pathways in lung cancer cell lines As a first step, we examined the expression and phosphorylation levels of some proteins known to be involved in cell...
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Báo cáo y học: " The role of IFN-γ in regulation of IFN-γ-inducible protein 10 (IP-10) expression in lung epithelial cell and peripheral blood mononuclear cell co-cultures" potx
Ngày tải lên :
12/08/2014, 15:21
... types including lung epithelial cells [5] Increased levels of both IP-10 and CXCR3 have been shown in patients with COPD, and subsequently this chemokine has been suggested to be involved in the inflammatory ... influence of stimuli including interferons, interleukins, lipopolysaccharide, tumor necrosis factor-α, platelet derived growth factor, and hypoxia [6] IL-12 is a classic IFN-γ inducing cytokine, ... amounts of leucocytes in lung tissue in COPD patients interact with several cell types including lung epithelial cells as well as endothelial cells in a similar manner increasing IP-10 secretion...
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Báo cáo y học: " Genomic approaches to research in lung cancer Edward Gabrielson" docx
Ngày tải lên :
12/08/2014, 18:20
... genes involved in cancer pathogenesis and providing new strategies for classifying cancers Developing a well-defined taxonomy for cancer is important, both for clinical management of the disease and ... number and overexpression The future of genomics in lung cancer research In the next few years, a considerable effort will be made to classify lung cancers, to discover genes involved in lung cancer ... sample [4] For lung cancer, Jen and colleagues at Johns Hopkins sequenced and analyzed over 226 000 tags from two primary lung cancers and two bronchial epithelial cell cultures, finding 175 transcripts...
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Báo cáo y học: "Clinical expert guidelines for the management of cough in lung cancer: report of a UK task group on cough" potx
Ngày tải lên :
13/08/2014, 10:20
... medicine, medical/clinical oncology with focus in lung cancer, respiratory medicine, nursing, pharmacy, and supportive care Experts had clinical, academic and research roles and three members of ... usability and clarity of the guidelines was carried out by international experts (N = 15), including consultants in palliative medicine, in medical oncology and specialist palliative care nurses (independent ... of findings Lung cancer patients, N = trials from Cochrane systematic review in cancer [12]** Brachytherapy in addition to EBRT resulted in higher improvements in cough at doses of 15 Gy in fractions;...
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