cutaneous drug reactions in the pediatric population

... complexity of these drug interactions, the key role of the rifamycins in the success of tuberculosis treatment mandates that the drug- drug interactions between the rifamycins and antiretroviral drugs ... necessitating somewhat complex dosing guidelines for rifabutin in the setting of antiretroviral therapy (see Table 3). In addition to their complexity, there is another potential problem of using ... (induce) the synthesis of several classes of drug transporting and drug metabolizing enzymes. With increased synthesis, there is increased total activity of the enzyme (or enzyme system), thereby...

Ngày tải lên: 06/03/2014, 04:20

... summer of 1778, having been established on the principles proven in the Northern Department under the guidance of Drs. Potts and Craigie. Furthermore, the turning point in the war had been reached. ... at Yellow Springs (now Chester Springs). The largest drain on medical supplies appears not to have been during the height of winter but rather in the early spring when the medicine chests of ... rather meager inventory of drugs probably was not inadequate. The siege of Boston resulted in few wounded soldiers, and there was a surprisingly small amount of sickness in the army during the...

Ngày tải lên: 31/03/2014, 18:20

... dur- ing experimental stress. Type D was also associated with a decreased activity in the amygdala in response to fear- ful expressions [10], suggesting inadequate emotion-pro- cessing in the brain. ... studies on Type D in the general population were performed by other research groups. The studies were conducted in populations from 8 different countr ies: Netherlands (n = 8), United King- dom (n ... myocar- dial infarction, and increased risk of mortality [4-7]. Given the clinical relevance of findings on Type D research in the context of cardiovascular disorders, it is also important to assess the...

Ngày tải lên: 18/06/2014, 19:20

... individual in 11 aspects of life mapped to domains and sub-domains of the ICF: mobility within the home, mobility outside the home, self-care, looking after belong- ings, looking after the home, looking ... and age for the remaining nine aspects of life. Persistence was greater in women than men for four aspects of life (looking after the home, looking after belongings, interpersonal interaction, social ... ( n=2227 ) Missing KAP data in 2005 ( n=293 ) Responders who completed the KAP in the 3yr Health Survey in 2005 and were included in the analysis (n=3709) Mailed baseline health q uestionnaire in 2002...

Ngày tải lên: 18/06/2014, 19:20

... and the BMI value in the general population [25,26]. Therefore, the aim of our research was to assess the association between the BMI value and health-related quality of life in the urban population ... smoking, physical exercise other than walking and walking (Model 3), the lower HRQL was independ- ently linked to overweight only in females. Similar results were obtained in model 4 which also included ... adequate intervention [15,16]. Accordingly, evaluation of the quality of life has become a focus of interest not only in population studies, but also in clinical medicine [17], particularly in patients...

Ngày tải lên: 18/06/2014, 19:20

... that the MHI-3 performs almost as well as the MHI-5. The best-performing single item was the one asking about "feeling downhearted and blue," which was also the case in the US [6]. The ... "depression." Like the rest of the SF-36, the MHI-5 was administered as a paper-and-pencil questionnaire. The instrument con- tains the following questions: 'How much of the time dur- ing the last ... from the MHI- 5 yields the MHI-3. We assessed the performance of the Japanese versions of the MHI-5 and MHI- 3 in detecting depressive symptoms in the general population of Japan. Methods: From the...

Ngày tải lên: 20/06/2014, 15:20

... smoking, physical exercise other than walking and walking (Model 3), the lower HRQL was independ- ently linked to overweight only in females. Similar results were obtained in model 4 which also included ... and the BMI value in the general population [25,26]. Therefore, the aim of our research was to assess the association between the BMI value and health-related quality of life in the urban population ... except in the realm of physical functioning, a finding also borne out by other authors [36,41-45]. However, assessment of quality of life in the female pop- ulation shows lower scores in the realm...

Ngày tải lên: 20/06/2014, 16:20

... Harrison's Internal Medicine > Chapter 56. Cutaneous Drug Reactions CUTANEOUS DRUG REACTIONS: INTRODUCTION Cutaneous reactions are among the most frequent adverse reactions to drugs. Every ... were the most frequent skin reactions. Severe reactions are actually too rare to be detected in such cohorts. Their incidence has been estimated to be in the range of 1 in 10,000 to 1 in 1 ... to the same dosage that induced 3–5% eruptions in non-HIV-infected populations. How HIV promotes allergy to certain medications has not yet been explained. Chapter 056. Cutaneous Drug Reactions...

Ngày tải lên: 07/07/2014, 01:20

... stimulations in vitro with the drug, their relevance to explain the original manifestations of allergy can be questioned. Regardless, these T cell clones brought definite evidence that drugs can ... In the last 10 years drug- specific T cell clones were derived from the blood lymphocytes or from skin lesions of patients with a variety of drug allergies. Since these clones had been obtained ... anaphylactic shock with hypotension and death. They occur within minutes of drug exposure. Nonsteroidal anti-inflammatory drugs (NSAIDs), including aspirin, and radiocontrast media are frequent...

Ngày tải lên: 07/07/2014, 01:20

... assume that the final pattern of drug eruptions results both from the nature of effectors—cytotoxic T cells in blistering reactions, chemokines in reactions mediated by neutrophils or eosinophils—and ... provided by the study of effector cells obtained at the site of skin lesions. Drug- specific cytotoxic T cells have been detected in the skin lesions of fixed drug eruptions and of TEN. In TEN, ... found in Taiwan have not been observed in other countries with more heterogenous populations. Therefore, widespread practical applications of these findings are not yet possible. CLINICAL...

Ngày tải lên: 07/07/2014, 01:20

... to drug dose, and the course is not altered by discontinuation of the drug after onset of the eruption. Warfarin reactions are associated with protein C deficiency. Warfarin anticoagulation in ... on the drug as well as on individual predisposition. A considerable number of drugs have been reported to induce hair loss. These include antineoplastic agents (alkylating agents, bleomycin, ... taxanes including paclitaxel and docetaxel. The risk of onycholysis in patients receiving cytotoxic drugs can be increased by exposure to sunlight. Chapter 056. Cutaneous Drug Reactions...

Ngày tải lên: 07/07/2014, 01:20

... lamivudine, indinavir, and anti-EGFR monoclonal antibodies (cetuximab, gefitinib). Nail Discoloration Some drugs, including anthracyclines, taxanes, fluorouracil, and zidovudine, may induce ... angiotensin II antagonists, and radiographic dyes, may induce urticarial reactions, angioedema, and anaphylaxis in the absence of drug- specific antibody. Although ACE inhibitors, aspirin, penicillin, ... compromise, epinephrine is the mainstay of therapy, but its effect is reduced in patients using beta blockers. Treatment with systemic glucocorticoids, sometimes administered IV, is helpful. In addition...

Ngày tải lên: 07/07/2014, 01:20

... Vasculitis may involve other organs, including the liver, kidney, brain, and joints. Drugs are an infrequent cause of vasculitis. Infection and collagen vascular disease are responsible for the majority ... vasculitis include allopurinol, thiazides, sulfonamides, other antimicrobials, and several NSAIDs. The presence of eosinophils in the perivascular infiltrate of skin biopsy may indicate a ... psoriasis is the principal differential diagnostic consideration. AGEP often begins within a few days of initiating drug treatment, most notably antibiotics. For other associated drugs, diltiazem,...

Ngày tải lên: 07/07/2014, 01:20

Ngày tải lên: 07/07/2014, 01:20

Ngày tải lên: 07/07/2014, 01:20

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Ngày tải lên: 10/08/2014, 09:22