... diabetic laboratory animals and in humans The above findings indicate that differences in the cellular availability of zinc in both insulin producing b-cells and in insulin target cells are associated ... zinc The other is MT 1A, a member of a protein family that links zinc and redox metabolism Changes in the availability of zinc ions modulate insulin signaling and redox processes Both zinc and ... replace insulin in mammalian cells cultured in serum-free media [18] The actions of zinc are intracellular because zinc increases the phosphorylation state of the insulin receptor, and hence, protein...
Ngày tải lên: 09/08/2014, 01:24
... surprising that the on-going evolution of the understanding of the non-physical aspects of pain has been applied to the areas of screening for, intervening in and predicting those at risk of developing ... a role for the cognitive-evaluative process in the modulation of pain Since the mid 1970's proponents of cognitive theory studied the influence of the meaning of pain to patients, and examined ... respondent pain may eventually evolve into operant and persisting pain if the environment offers pain contingent reinforcement Pain behaviour may also be learned by observing "pain models" i.e., individuals...
Ngày tải lên: 13/08/2014, 13:22
báo cáo hóa học:" Current status of medication adherence and infant follow up in the prevention of mother to child HIV transmission programme in Addis Ababa: a cohort study" potx
... opportunistic infections • Infant feeding counselling • First pentavalent vaccine and other routine child health services and hepatitis B) and early infant HIV testing were done The HIV testing was done in ... initiating/ingesting of the medications and bringing infants for six-week follow up Analyzing medication initiated by the mothers during pregnancy, we used abortion and death of a mother as study endpoints ... mother and infant ingesting medication and demographic variables, obstetric variables, CD4 cell count at enrolment, disclosing HIV status to partner and partner being involved in HIV counselling and...
Ngày tải lên: 20/06/2014, 08:20
báo cáo khoa học: " Expression of Ets-1, Ang-2 and maspin in ovarian cancer and their role in tumor angiogenesis" pps
... different roles in angiogenesis: Ang-1 and Ang-4 are agonist ligands for Tie2 and induce tyrosin phosphorylation of Tie2, while Ang-2 and Ang-3 are antagonist ligands They bind to Tie2 without inducing ... underlying the localization of maspin and its interaction with Ets-1 warrant further investigations In this study we employed IHC to evaluate the expression of Ets-1, Ang-2 and maspin in clinical ... expression of maspin in ovarian carcinoma Clin Cancer Res 2002, 8:2924-2932 doi:10.1186/1756-9966-30-31 Cite this article as: Lin et al.: Expression of Ets-1, Ang-2 and maspin in ovarian cancer and their...
Ngày tải lên: 10/08/2014, 10:21
Báo cáo y học: " T4 genes in the marine ecosystem: studies of the T4-like cyanophages and their role in marine ecology" doc
... manipulation of the physiology of the infected cell and are likely to be of potential importance in biotechnology as well as being intrinsically interesting However, there are three main features ... hyroxymethyl cytosine or that they glycosylate their DNA In addition all of the r genes in T4 that are known to be involved in superinfection and lysis inhibition [45] are missing in cyanophage genomes, ... in S-PM2, P-SSM4 and S-RMS4 speD encodes S-adenosylmethionine decarboxylase a key enzyme in the synthesis of the polyamines spermidine and spermine With polyamines implicated in the stabilising...
Ngày tải lên: 12/08/2014, 02:20
Bees and their role in forest livelihoods A guide to the services provided by bees and the sustainable harvesting, processing and marketing of their products
... can gain from training in how to harvest, render and market beeswax BEE–MAINTAINING Harvesting of a bee colony nesting in a tree would be described as honey hunting The piece of tree cut and, ... about sources of training, markets, research findings, and raises their awareness of the industry and available opportunities Concerning financial capital for beekeeping Access to finance is essential ... world’s remaining huntergatherers, often at the margin of the farming world The colonies of honeybees are nesting in the wild and, depending on species, may be nesting in tree cavities, in trees,...
Ngày tải lên: 03/06/2015, 08:41
Effect of muscarinic agents on sclera fibroblast and their role in myopia 1
... isoforms, which display a remarkable affinity to heparin and are also called heparin binding growth factors (HBGF) FGF-2 is an 18Kd protein consisting of 155 amino acids, and an isoelectric point ... reduced in myopic sclera and atropine subconjunctival injection reversed the expression of FGF-2 in the sclera of myopic eyes In vitro • Atropine and pirenzepine (muscarinic antagonists) inhibited ... hr incubation of the cells with up to 100 µM of atropine or pirenzepine The absence of acute toxicity shows that the effect of atropine and 43 pirenzepine in controlling cell number is due mainly...
Ngày tải lên: 17/09/2015, 17:20
Effect of muscarinic agents on sclera fibroblast and their role in myopia
... produced dark brown stain in apoptic nuclei) B Atropine 0.1 µM C Atropine µM D Atropine 10 µM E Atropine 100 µM Fig10A Immumocytochemistry of mAchR subtypes in human SF in culture Subtype selective ... control Fig10B Protein corresponding to mAchR subtypes m1,m2,m4, and m5 identified in mouse sclera by immunoblotting Subtype selective antibodies bound to specific protein bands in mouse sclera extract ... standard Diagram Mechanism of growth factor action and related events Diagram Interaction between muscarinic and EGF receptors in growth regulation Diagram Mechanism of G protein coupled m1 receptor...
Ngày tải lên: 17/09/2015, 17:20
Tài liệu Báo cáo khoa học: The small heat shock proteins and their role in human disease pptx
... metalloproteinases in vitro and eliminates production of avb3 integrin, a protein missing in normal melanocytes but often manufactured during the invasive phase [141] Hsp27 over expression in melanoma ... identified, and the role of ATP-dependent chaperones in substrate release and refolding revealed sHSPs operate in the front lines of cell defense, protecting proteins during stress and providing opportunities ... disorganized and aggresome-like inclusions develop in cultured nonmuscle cells deficient in desmin, again demonstrating inclusion body construction independent of intermediate fialments [62] Interestingly,...
Ngày tải lên: 19/02/2014, 18:20
Báo cáo Y học: Fluorescent analogs of UDP-glucose and their use in characterizing substrate binding by toxin A from Clostridium difficile pdf
... presence of saturating concentrations of the metal cofactor Together, these data are indicative of two modes of substrate binding (i.e open and closed) The closed, active form of UDP-Glc binding is ... hydrolysis of UDP-Glc in the absence of toxin Inhibition studies were performed by varying the MUG and UDP-Glc concentrations and following the kinetics of the hydrolysis reaction Synthesis of MUG, ... 7.6 and 150 mM KCl containing varying concentrations of UDP-Glc (0–145 mM) were studied The variable concentrations of UDP-Glc were obtained by starting with a stock solution containing all of...
Ngày tải lên: 08/03/2014, 22:20
Aggregate bankruptcy probabilities and their role in explaining banks’ loan losses doc
... Recycling (code 370), Manufacture of coke, refined petroleum and nuclear fuel (code 230), Mining of metal ores (code 130), Tanning and dressing of leather (code 190), Manufacture of office machinery ... component of banks’ financial strategy Lending margin reflects credit risk, goals for long-term profitability, administration costs and costs of funding The size of risk included in the lending margin ... enterprises in Mining of coal (code 100) and in Manufacture of coke, refined petroleum (code 230) There are only few of them in the database and they are registered in less than a half of the counties...
Ngày tải lên: 22/03/2014, 20:21
Báo cáo khoa học: Arthropod nuclear receptors and their role in molting pptx
... nm and Kd2 = 3.9 nm) The removal of GST had no effect on PonA binding, but altered DNA binding The presence of USP was necessary for strong ligand–EcR binding, and the presence of cofactors and ... isoforms in D melanogaster [139], and probably multiple EcR isoforms exist in several, but not all, insect species In all cases described so far, the isoforms vary in their amino-terminal domain ... residues lining the inside of the pocket The interaction between the 20-OH group of PonA and the OH group of the tyrosine amino acid residue are observed in three EcRs (Tyr408 of HvEcR, Tyr296 of BtEcR...
Ngày tải lên: 23/03/2014, 04:20
báo cáo hóa học:" RAGE (Receptor for Advanced Glycation Endproducts), RAGE Ligands, and their role in Cancer and Inflammation" pptx
... pathway, bypassing the Golgi [103] Several S100 proteins bind the tetramerization domain of p53, and some also bind the negative regulatory domain of p53 Binding of the tetramerization domain of p53 ... Vitamin D-dependent calcium-binding protein, intestinal CABP, Calbindin-3, and Calbindin-D9k [113] It is primarily a monomer in Page of 21 (page number not for citation purposes) Journal of Translational ... to consider their role in cancer and inflammation S100 proteins are a family of over 20 proteins expressed in vertebrates exclusively and characterized by two calcium binding EF-hand motifs connected...
Ngày tải lên: 18/06/2014, 15:20
Báo cáo hóa học: " Research Article New Trace Bounds for the Product of Two Matrices and Their Applications in the Algebraic Riccati Equation" potx
... Majorization and Its Applications, vol 143 of Mathematics in Science and Engineering, Academic Press, New York, NY, USA, 1979 17 C.-L Wang, “On development of inverses of the Cauchy and Holder inequalities,” ... /n 3.1 In this section, we obtain the application in the algebraic Riccati equation of our results including 3.1 Some of our results and 3.1 cannot contain each other Theorem 3.1 If 1/p and K ... 2 Journal of Inequalities and Applications where x0 ∈ Rn is the initial state of the systems 1.1 and 1.2 , K is the positive definite solution of the following algebraic Riccati equation...
Ngày tải lên: 22/06/2014, 02:20
Báo cáo khoa hoc:" A review on SNP and other types of molecular markers and their use in animal genetics" ppt
... number of families for genotyping, selecting recombination events in recurrent backcrosses, using advanced intercross lines (AIL) or performing linkage disequilibrium and haplotype-based studies in ... available, indications of high densities of SNPs in defined regions can be found A sequencing study of fragments of the leptin and amyloid precursor protein (APP) genes in 22 diverse individuals ... to in Tables I and II are still in use and the choice of one or another can be guided by the variety of parameters indicated, mainly according to the goal of the study and the importance of the...
Ngày tải lên: 09/08/2014, 18:21
Genetic polymorphisms of matrix metalloproteinases and their inhibitors in potentially malignant and malignant lesions of the head and neck potx
... domains, e.g., Hemopexin domain These additional domains are important in substrate recognition and in inhibitor binding (Fig 1) MMPs can be divided into subgroups according to their structure and ... vital role in maintaining the integrity of healthy tissues Disturbance in balance of MMPs and TIMPs is found in various pathologic conditions, including rheumatoid arthritis, periodontitis and ... similarities in their structure All MMPs have a zinc-binding motif in the catalytic domain In addition, they have an Nterminal domain called predomain, followed by the propeptide domain The majority of...
Ngày tải lên: 10/08/2014, 05:21
Báo cáo y học: "Indigenous utilization of termite mounds and their sustainability in a rice growing village of the central plain of Laos" pdf
... surface, underground and the area surrounding the mounds including standing trees in the study area in August and November in 2007, from October to December in 2008 and March in 2009 Their species were ... sustainability of their use been evaluated The objective of this study is to evaluate the possibility of sustainable use by measuring the change in volume of selected mounds and by investigating ... al.: Indigenous utilization of termite mounds and their sustainability in a rice growing village of the central plain of Laos Journal of Ethnobiology and Ethnomedicine 2011 7:24 Submit your next...
Ngày tải lên: 10/08/2014, 09:22
Báo cáo y học: " Oxygen-regulated transcription factors and their role in pulmonary disease" pptx
... arteries of rats with hypoxia-induced pulmonary hypertension J Clin Invest 1995, 96:1823–1833 23 Morrell NW, Morris KG, Stenmark KR: Role of angiotensin-converting enzyme and angiotensin II in development ... subunits in pulmonary artery smooth muscle cells J Clin Invest 1997, 100:2347–2353 Author’s affiliation: Institute of Genetic Medicine and Departments of Pediatrics and Medicine, The Johns Hopkins ... HIF-1 IGF-binding protein-2 HIF-1 IGF-binding protein-3 HIF-1 Interleukin-6 NF-IL6 Lactate dehydrogenase A HIF-1 Nitric oxide synthase-2 HIF-1 NIP3 HIF-1 Ornithine decarboxylase Not determined p21...
Ngày tải lên: 12/08/2014, 18:20
Báo cáo y học: " Bench-to-bedside review: Toll-like receptors and their role in septic shock" pps
... sections) Understanding the regulation of TLR expression will provide further insight into their tissue distribution and their role in combating infection There has been an initial report of the TLR4 ... This expanding IL-1R1-like family includes murine and human proteins, Drosophila (fruit fly) proteins, and a plant (tobacco) protein [7,8] In Drosophila, Toll is involved in the rapid and transient ... feature of being involved in host responses to injury and infection [8] Most notably, in humans these include not only the receptor and accessory protein for IL-1, but also the IL-18 receptor and...
Ngày tải lên: 12/08/2014, 18:21
Báo cáo y học: "Evolutionary history and functional implications of protein domains and their combinations in eukaryotes" pptx
... (c) Changes of domain combination networks and union networks in lineages of S cerevisiae and H sapiens during evolution Bold and dashed lines indicate γ of domain combination networks and union ... eukaryotes, in terms of the preference for generation of domain combinations Results Assignment of domains and their combinations We used the domains defined in the Pfam database [19] Of 7,459 domains ... Death domain CH 08 Euk Calponin homology (CH) domain zf-RanBP 07 Euk Zn-finger in Ran binding protein and others fn2 07 Deu Fibronectin type II domain Xlink 07 Deu Extracellular link domain F5_F8_type_C...
Ngày tải lên: 14/08/2014, 07:21