crucial role of high circulating dhea exclusively in humans
Báo cáo khoa học: "The role of high-frequency oscillatory ventilation in paediatric intensive care" pot
... noted a higher range of OI values in the DAD group, in which the mortality was higher than in the SAD group Another significant finding of the study conducted by Arnold and coworkers was that, in ... and where it is possible to maintain relatively high end-expiratory lung volumes without inducing overdistension Many of the available data regarding the use of HFOV in the paediatric population ... supporting the use of HFOV in the treatment of severe respiratory failure in children, studies in the paediatric population have not been able to demonstrate any significant improvements in clinically...
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Báo cáo y học: " The crucial role of particle surface reactivity in respirable quartz-induced reactive oxygen/nitrogen species " doc
... concerning the predominant nuclear staining pattern Discussion The data presented in this paper are part of larger ongoing in vitro and in vivo investigations on the role of surface reactivity in ... particle-cell interactions, as mainly studied using in vitro experiments, are of a minor relevance in determining neutrophilic ROS release in vivo, i.e within the lung It also suggests that surface coatings ... 8-OHdG induction would predominantly occur in proliferating tissue However, we did observe neither a clear contrast in visual staining intensities of individuals cells nor any difference in the...
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Báo cáo y học: "Unraveling the role of high mobility group box protein 1 in severe traum" doc
... capable of enhancing the clearance of HMGB1 and its bound proinflammatory co-factors or of inhibiting interactions of HMGB1 with macrophages and other cell populations that are involved in acute inflammatory ... useful in delineating the mechanisms through which HMGB1 may contribute to outcome in this clinical setting Antibodies to HMGB1 improve outcome in animal models of sepsis, clearly demonstrating a role ... to diminishing the adjuvant role of HMGB1 in potentiating inflammatory responses through enhanced presentation of bound mediators to their cellular receptors A similar situation may occur in trauma...
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Báo cáo y học: "The role of high-mobility group box-1 (HMGB-1) in the management of suspected acute appendicitis: useful diagnostic biomarker or just another blind alley?" docx
... chromosomal protein Its role as a pro-inflammatory cytokine in sepsis and rheumatoid arthritis has been described, and more recently its role in community-acquired infections and sepsis investigated ... HMGB1 as a cytokine in inflammation The mechanism of inflammation and damage is binding to toll-like receptor (TLR4), which mediates HMGB1-dependent activation of macrophage cytokine release This ... mingling molecules The diagnostic value of HMGB1 levels was investigated using ROC curve analysis in this study by Albayrak et al [5] The use of ROC analysis is an Page of appropriate method in...
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The Role of Genetically Modified Organisms (GMOs) in Beverage Production
... prevention, e.g., lycopene in tomatoes and sulfurofane in broccoli for reducing cancer risk, lutein in vegetables for reducing risk of macular degeneration, etc The advancing Þelds of human and plant ... Advantages of insect- and virus-resistant crops include improved yields and reduced use of pesticides An additional beneÞt of Bt corn is reduced contamination by fumonisin-producing fungi Fumonisin is ... consumed in place of saturated fatty acids It is possible to increase the content of vitamin E, a natural antioxidant, and to insert the capability of producing plant-based omega-3 fatty acids into...
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Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf
... promoters In G0, proteins appear to bind to the CDE ⁄ CHR, as monitored by in vivo footprinting According to these early experiments all binding is lost in G2 ⁄ M In contrast, constitutive binding ... activating E2Fs cooperate with NF-Y proteins binding to CCAAT-boxes and with Myb proteins associating with a distal Myb site in activating the Cdc2 promoter Binding of the activating E2Fs during ... repression of genes, such as cyclin A and cyclin B1, in dividing cells [92] Furthermore, depletion of Lin-9 and B-Myb in p53) ⁄ ) MEFs caused lowered expression of cyclin A, cyclin B and Cdc2 [94] In...
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Tài liệu Báo cáo Y học: Steady-state kinetics of the glutaminase reaction of CTP synthase from Lactococcus lactis The role of the allosteric activator GTP in coupling between glutamine hydrolysis and CTP synthesis potx
... presented in Fig further support a dual role for GTP activation of CTP synthesis A mechanism in which GTP only acts to increase the rate of hydrolysis of glutamine has some aws in explaining the inhibition ... titration calorimetry of the glutaminase activity of L lactis CTP synthase (A) Enthalpogram showing the recording of steady-state rates for the hydrolysis of glutamine at increasing substrate concentrations ... displacement of the baseline The peaks observed at each injection time are derived from the heat of dilution of glutamine into the reaction cell (B) The heat generated by hydrolysis of 0.15 lM of glutamine...
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Báo cáo khoa học: Role of the C-terminal extension in a bacterial tyrosinase Michael Fairhead and Linda Thony-Meyer doc
... not only in Tyr349 Tyr347 Features of the amino acid sequence of the V spinosum tyrosinase Copper binding motif Copper binding motif Cys84 Arg40 bacterial Copper binding motif Copper binding motif ... Overview of the tyrosinase gene and surrounding genes in the genome of V spinosum (A) Showing the tyrosinase gene and those in its immediate vicinity in the V spinosum genome Triangles indicate ... full-length protyrosinase (53 500 kDa) assuming the removal of the N-terminal methionine Reconstitution of recombinat V spinosum tyrosinase with copper The holo-forms of tyrosinase were obtained after...
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The Role of Small and Large Businesses in Economic Development doc
... longitudinal data from individual firms The job figures presented in Chart classify firms into size classes based on their size at the beginning of the period, which favors a finding of higher ... the beginning of the period, which favors a finding of higher growth among small firms, rather than at the end of the period Table A1 decomposes job growth from the second quarter of 2000 into ... rate in the prerecession period from 1997 to 2000 Recessions often find individuals moving out of traditional employment and into self-employment, which explains some of the discrepancy in growth...
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Báo cáo khoa học: The role of evolutionarily conserved hydrophobic contacts in the quaternary structure stability of Escherichia coli serine hydroxymethyltransferase pptx
... FEBS 139 Role of hydrophobic contacts in serine hydroxymethyltransferase to bind PLP In this intermediate, the N-terminus and an inter-domain segment remain exposed to solvent In the following, slow ... value determined from the amino acid sequence (45 320 Da) Measurement of the Kd of PLP binding equilibrium PLP binding equilibria were analyzed taking advantage of the protein intrinsic fluorescence ... located in the cores of the large and small domains, respectively, and appear to stabilize their protein scaffolds, allowing the proper positioning of the residues involved in PLP binding, substrate...
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Báo cáo khoa học: Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase pdf
... sufficient for inducing activation of GS in muscle and fat cells, and that inhibition of the kinase potentiates insulin action in muscle of insulin-resistant rats [39], and that prolonged GSK3 inhibition ... submaximal insulin dose (Fig 5) These findings are not entirely out of line with work from rodent studies showing that whilst GSK3 inhibition improves insulin responsiveness in muscle of insulin resistant ... coordinate increases in glucose uptake and glycogen synthesis allowing for more effective ÔchannellingÕ of glucose into glycogen in response to insulin However, one of the potential difficulties in...
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The Role of Gestures and Facial Cues in Second Language Listening Comprehension pptx
... people, pointing out that in such circumstances visual cues would be of little to no value This is a very specific interpretation of the meaning of lecture Having examined over 20 definitions of the ... 36, 314–331 Swain, M (1995) Three functions of output in second language learning In G Cook & B Seidlhofer (Eds.), Principle and practice in applied linguistics: Studies in honor of H G Widdowson ... minimal reference to the outline during recording The first part of the lecture covered definitions of terms and a brief history of ceramics, which tended to be done in narrative form Most of...
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Báo cáo khoa học: The role of the Fe-S cluster in the sensory domain of nitrogenase transcriptional activator VnfA from Azotobacter vinelandii potx
... absence of the N-terminal domain in this variant Because sensing is a principal function of regulatory proteins, the isolation of VnfA and AnfA with their sensor (GAF) domains is highly desirable In ... purification of an AnfA variant reported by Austin et al [22] In their study, the N-terminal domain of AnfA was truncated to prevent the intrinsic aggregation of the intact form during purification ... effect of the nucleotide binding was reported in a study of the limited trypsin digestion with NifA + MgADP, in which binding MgADP to the central AAA+ domain is ascribed to the trigger of a conformational...
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Bringing the Hidden Giants to the Footlight: the Role of Savings and Retail Banks in Increasing the Level of Access to Financial Services docx
... disbursing of loans and collecting loan repayments Another promising track for savings banks is to invest their savings deposits in microfinance institutions by specialising 18 Microfinance Information ... with microfinance institutions Linking savings to microcredits: Offering savings services requires a high level of institutional development to meet safety and soundness requirements Indeed, a large ... for lending to their micro borrowers Savings banks could refinance well-functioning microfinance institutions individually or indirectly through an apex institution A very important aspect of these...
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Báo cáo khoa học: Isothermal unfolding studies on the apo and holo forms of Plasmodium falciparum acyl carrier protein Role of the 4¢-phosphopantetheine group in the stability of the holo form of Plasmodium falciparum acyl carrier protein docx
... According to a report by Jiang et al., these atypical hydrogen bonds play an especially crucial role in stabilizing the proteinprotein interface [31] All of the interactions reported in Fig in the ... modied serine [22] PfACP is a protein of 137 residues, inclusive of signal and transit sequences, required for targeting of the protein to the apicoplast The mature protein comprises 79 amino acids ... overexpress in E coli, presumably due to inefciency of the E coli holo-ACP synthase in modifying the ACP in vivo, resulting in the production of mostly apo-ACP, which has been shown to have inhibitory...
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Báo cáo Y học: Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice usingin vivo 13 C NMR measurements of hepatic carbohydrate metabolism docx
... the increased rate of 13C label incorporation into the C6 position of glycogen in the ADM group is indicative of activated 6-phosphofructo-1-kinase, which can lead to increased 13C labeling at ... start of glucose infusion For the calculation of glycogen C6 changes, data acquired within h of the start of the glucose infusion was not included to avoid any in uence of transient changes in the ... 25 26 27 roles of insulin and glucagon in the regulation of hepatic glycogen synthesis and turnover in humans J Clin Invest 97, 642–648 Petersen, K.F., Laurent, D., Rothman, D.L., Cline, G.W...
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Báo cáo Y học: The role of hydrophobic active-site residues in substrate specificity and acyl transfer activity of penicillin acylase pdf
... may in uence the shape and volume of the acyl binding pocket and thereby alter the binding mode and affinity of the enzyme for PAA and derivatives thereof, while maintaining the hydrophobicity of ... quantities of protein utilizing the principle of protein dye binding Anal Biochem 72, 248–254 Kasche, V., Haufler, U & Zollner, R (1984) Kinetic studies on the mechanism of the penicillin amidase-catalysed ... rate-limiting step in the conversion of N-phenylacetylated substrates [9] Assuming rapid binding of the substrate, it follows that kcat represents the rate of acylation and Km equals the binding constant...
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The role of floating-rate bank loans in institutional portfolios pdf
... is not indicative of future results Russell Investments // Role of bank loans in a rising rate environment / p6 Bank loans in rising interest rate environments In the past 20 years (since 1992), ... on the chart Indexes are unmanaged and cannot be invested in directly Data is historical and is not indicative of future results Russell Investments // Role of bank loans in a rising rate environment ... Bank of St Louis, U.S Department of the Treasury Indexes are unmanaged and cannot be invested in directly Past performance is not indicative of future results Russell Investments // Role of bank...
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Báo cáo khoa học: Functional role of fumarate site Glu59 involved in allosteric regulation and subunit–subunit interaction of human mitochondrial NAD(P)+-dependent malic enzyme pptx
... Fumarate-binding site for human m-NAD-ME (A) Homotetramer of human m-NAD-ME (Proein Data Bank code: 1PJ3) (B) Fumaratebinding site of m-NAD-ME The corresponding amino acids in the fumarate-binding ... both being in dimer form in low protein concentrations and being reconstituted into tetramers in high protein concentrations In contrast to the E59Q enzyme, the E59D enzyme has a predominantly ... crystal structure of human m-NAD-ME in complex with fumarate has been determined, the binding network of fumarate in the enzyme has become clear In the fumarate-binding pocket, two arginyl residues,...
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Báo cáo khoa học: Mycobacterium tuberculosis ClpC1 Characterization and role of the N-terminal domain in its function ppt
... additional N-domain, homologous to the N-domains of ClpA or ClpB, and a linker domain homologous to, but half the size of, the linker domain of ClpB [19] The N-terminal region contains two 32-amino acid ... activity in preventing the aggregation of luciferase and reactivating heat-inactivated luciferase Deletion of the N-terminal conserved repeat I (amino acids 1–38) resulted in an alteration in the ... caused by deletion of amino acids 1–38 rendered ClpC1D1 prone to heat denaturation Deletion of N-terminal conserved repeat I along with the intervening amino acids linking it to N-terminal conserved...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25