critical factors in manufacture and delivery
Tài liệu Báo cáo khoa học: Roles of heat shock factors in gametogenesis and development pptx
... coronal section and scheme of the coronal section at E14.5 in (F) (A) At E11.5, HSF2 is expressed in forebrain, midbrain and in hindbrain except for the midbrain, hindbrain midline Surprisingly, the ... before and after birth in mouse brains [122,124] No HSF4 DNA-binding activity was reported in the developing mouse brain so far However, Hsf4b is expressed in the adult mouse brain, including cerebellum, ... seems to be intimately correlated with neurogenesis and neuronal migration in different parts of the mouse brain HSF1 and HSF2 might interact in the developing mouse brain in a stage- and tissue-specific...
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Báo cáo y học: " Interactions between genes and environmental factors in asthma and atopy: new developments" pps
... polymorphisms in candidate genes for asthma/atopy have been identified Linkage and candidate gene studies in asthma and atopy Linkage studies Results from linkage studies (genome-wide searches and candidate ... of inconsistent findings, it is intriguing that chromosomal regions linked to asthma have also shown evidence for linkage to other inflammatory and autoimmune diseases (such as psoriasis, inflammatory ... other genes involved in the allergic inflammation (e.g IL-4Rα [21], β2AR [24]) We can therefore speculate that inconsistent findings in the genetic studies of asthma and atopy summarized in this...
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Báo cáo y học: "Oxygen-sensing mechanisms and the regulation of redox-responsive transcription factors in development and pathophysiology" ppsx
... stages in the proposed pathway are indicated Genistein is an inhibitor of tyrosine protein kinase and competitive inhibitor of ATP in other protein kinase reactions; NaF is a nonspecific kinase inhibitor; ... pull NF-κB off DNA, and export NF-κB back to its resting state in the cytoplasm Thick lines indicate the activating pathway; thin lines indicate the inactivating pathway IκB-independent pathways, ... significance of maintaining reducing conditions in cells and the fight against the damaging effect of ROS intermediates [17,22,35,37–39] Oxidants, for instance, can cause carcinogenesis, sclerosis,...
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Báo cáo y học: "Genome-wide identification of novel expression signatures reveal distinct patterns and prevalence of binding motifs for p53, nuclear factor-κB and other signal transcription factors in head and neck squamous cell carcinoma" docx
... which included 17 genes with p53 binding sites in cluster A and 26 genes with NF-κB binding sites in cluster B In cluster A genes with p53 binding sites, putative models containing three and four ... transcription factors associated with NF-κB were ETSF (human and murine ETS1 factors; 8/14) and ZBPF (zinc binding protein factors; 8/14) In most cases the locations of NF-κB binding sites were ... NM_003528 h IGFBP2 Insulin-like growth factor binding protein (36 kDa) NM_000597 hmr (hr) LGALS3BP Lectin, galactoside-binding, soluble, binding protein NM_005567 hmr MATN2 Matrilin NM_002380 h (hmr)...
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Báo cáo y học: "The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease" docx
... be mediated by two distinct domains In VEGF-A, these correspond to the basic heparin-binding domain encoded by exon and the NRP1/heparin-binding domain encoded by exons and [10] The nuclear magnetic ... the heparin-binding domain; N, encodes the NRP1/heparin-binding domain; NP, encodes the amino-terminal propeptide domain; SP, signal peptide; VHD, encodes the VEGF/PDGF homology domain Information ... mammals; VEGF-A121 lacks exons and 7, and VEGF-A165 lacks exon (Table 2) Exon encodes a heparinbinding domain, while exons and encode a NRP1/heparin-binding domain; with the exception of VEGF-A121,...
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Supply on demand adapting to change in consumption and delivery models
... We are integrating subscription goods and services to our business model 40 We are integrating shared goods and services to our business model 27 We are integrating leasing/rental goods and services ... example, in some regions business models requiring live tracking of vehicles and products may find local infrastructure and mobile services to be lacking—although this is improving On the other hand, ... decisionmaking, and they have many decisions to make From defining financial oversight rules and insurance requirements to establishing data security guidelines for information exchange and collection,...
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báo cáo khoa học: " Patient- and delivery-level factors related to acceptance of HIV counseling and testing services among tuberculosis patients in South Africa: a qualitative study with " pdf
... responsible for developing and maintaining successful TB and HIV/AIDS control programs, in addition to securing financial and organizational support for continuous and uninterrupted supply of ... TBHIV interclinic referral; poor service integration and recording; logistical shortages; and high costs of services Another South African study [16] identifying constraints to integrating TB and ... starting points of the data-gathering processes: In your view, what are the major factors deterring TB patients from undergoing [HCT]?’ and In your view, what are the major factors encouraging...
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Báo cáo y học: "Prevalence of Overactive Bladder, its Under-Diagnosis, and Risk Factors in a Male Urologic Veterans Population"
... possible effective and fast screening tool Our study also examined the risk factors for OAB in men We found that OAB increased with age: 49% in men aged 40-49 years to 79% in men aged 70-79 years ... Schulz J and Corcos J A population-based study of urinary symptoms and incontinence: the Canadian Urinary Bladder Survey BJU Int 2008; 101:52 Milsom I, Abrams P, Cardozo L, Roberts RG, Throff J and ... 48:622 Irwin D, Milsom I, Hunskaar S, Reilly K, Kopp Z, Herschorn S, et al Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries:...
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Tài liệu TRADITIONAL AND NOVEL RISK FACTORS IN ATHEROTHROMBOSIS pptx
... differentiation of EPCs and their homing to sites of vascular injury are complex and involve several mediators and receptors, such as P-selectin glycoprotein ligand-1, CXC chemokine, and integrins (Chavakis ... fibrinolysis factors and promoting platelet function (Kornecki et al., 1988, Moir et al., 2002) Inhibition of interaction between p-selectin and p-selectin glycoprotein ligand reduced fibrin formation ... circulating platelets by inducing a conformational change in the glycoprotein receptors and enabling cross-linking or adhesion via fibrinogen and other adhesive ligands During this process, activated...
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Tài liệu PTSD in Women Returning From Combat: Future Directions in Research and Service Delivery doc
... diagnosing and treating PTSD These training programs include modules on military cultural competence and meeting the mental health needs of returning veterans.43 Further research is needed into ... developing appropriate screening and treatment of PTSD for service members returning from combat and reentering into the private sector Summary: Developing a Research Agenda and Improving Patient ... that counseling may have occurred in relation to the propranolol administration The authors concluded that the timing of propranolol administration and psychological counseling resulting in memory...
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Tài liệu Báo cáo khoa học: Dmrt1 genes at the crossroads: a widespread and central class of sexual development factors in fish pdf
... by a conserved DNA-binding motif known as the Doublesex- and Mab-3-related (DM) domain Being a noncanonical cysteine-rich DNAbinding motif, this domain has two highly intertwined finger structures ... chelate one zinc ion each, and binds to the minor groove of the DNA [6] Dmrts were originally described to play important roles during sex determination in flies and worms by regulating several ... pair in medaka Gonadal dmrt1 gene expression across different fish species An amazing variety of sex-determining systems is found in fish Although information is emerging about sex determination in...
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Tài liệu Pesticide Residues in Food and Cancer Risk: A Critical Analysis pdf
... HERT values as candidates for carcinogenicity testing These include solanine and chaconine, the main alkaloids in potatoes, which are cholinesterase inhibitors that can be detected in the blood ... residues in our ranking and the higher NRC risk estimates is examined in Section 38.6 812 CHAPTER 38 Pesticide Residues in Food and Cancer Risk: A Critical Analysis Cooking and Preparation of Food and ... only in the PDR for Herbal Medicines (Gruenwald et al., 1998) Poisoning epidemics by pyrrolizidine alkaloids have occurred in the developing world In the United States, poisonings, including deaths,...
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Tài liệu HEMATOPOIETIC GROWTH FACTORS IN ONCOLOGY BASIC SCIENCE AND CLINICAL THERAPEUTICS pptx
... have delineated the potential beneficial activities of HGF in current clinical use, including studies exploring dosing and scheduling parameters that inform the clinical use of these agents in the ... cytokines in vivo in murine models of leukemia and myeloproliferative disease based on BCR-ABL and several leukemogenic TEL-tyrosine kinase fusion oncoproteins (84,85); in all models, combined ... was observed during L monocytogenes infection (45) GM-CSF deficiency attenuated in ammation in a murine model of arthritis induced by BSA and IL-1 injection (56) and also in murine models of immune-mediated...
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Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
... proline-rich and glutamine-rich N-terminus, which is important for transactivation, is shown in yellow, and contains the PY-motif (green) The helix–span–helix domain at the C-terminus shown in ... AP-2e in chondrogenesis Overview of the differentiation stages during chondrogenesis and the involvement of transcription factors (henatoxylin and eosin-stained section of an embryonic cartilaginous ... transcription factors Essential transcription factors in chondrocyte differentiation are Sox9 and Runx2 Sox9 plays a key role in chondrogenesis, as an inactivating mutation in the gene encoding Sox9...
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Tài liệu Negotiations in project sales and delivery process: An application of negotiation analysis pdf
... project parties in place, even the finest engineering solutions or most innovative contracting methods for organizing project activities will remain abstract and ineffective in achieving the ultimate ... settings enable only claiming, yielding or avoidance Whereas in integrative settings creating, or synonymously - 24 - problem solving is possible, but claiming, yielding and avoidance remain available ... signing of a contract Implementation phase: delivering and supervising the project; identifying and resolving of any The parties jointly select and commit to a problems, which may arise; training...
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Tài liệu Factors Affecting Teaching and Learning in South African Public Schools pdf
... description in the preceding paragraphs indicated a major trend regarding conditions in schools and huge disparities between and within provinces It was noted that there is a significant difference in ... surroundings and sufficient resources As Klein (1993: 194) observed: ‘insufficient money results in overworked, undervalued educators working in decaying premises with inadequate resources, teaching ... of passes in matric It is critical to investigate simultaneously what individual actors in a school and what the broader social and economic system does to enhance teaching and learning It is...
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Tài liệu ‘Unheard voices’: listening to Refugees and Asylum seekers in the planning and delivery of mental health service provision in London. pptx
... befriending, and user participation in service planning and delivery Cultural sensitivity and understanding – perception, stigma, language, education and training Care provision – Talking therapies, ... about difficult things during this period User involvement User involvement was discussed both in terms of involvement in the planning and delivery of services and in terms of direct involvement or ... befriending, and user participation in service planning and delivery Cultural sensitivity and understanding – perception, stigma, language, education and training Care provision – Talking therapies,...
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Báo cáo " A web-based decision support system for the evaluation and strategic planning using ISO 9000 factors in higher education " pot
... which are standards as a single system originally designed to cover all manufacturing in service industries, and education and training [2,6] In addition, ISO 9000 is a series of generic international ... School using ISO 9000 factors because of an insufficient international standard resources For instance, lack of funding, good staffs and good instructors are significant factor to mainly affect ... better than individuals in understanding problems and catching errors Working in a group can be divided by different GDSS purposes such as top administrations, staffs and instructors 3.4 Data collection...
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Nutritional Status and Associated Factors in Institutionalized Elderly docx
... performance in the ability to perform activities of daily living and greater dependence on care, including meals and purchase of food [19] The results of the Health, Welfare and Aging in Latin America and ... polyunsaturated and monounsaturated fatty acids was shown to be inadequate in almost all individuals There was a significantly insufficient intake of potassium (100%), zinc (82.7%) and niacin (65.4%) in the ... portions of food in the dining room Immediately following the meal, the difference between what had been served and what remained was calculated in household measures, thus providing the intake This...
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Báo cáo khoa học: Binding affinities and interactions among different heat shock element types and heat shock factors in rice (Oryza sativa L.) ppt
... hetero-oligomers with HsfA4, thereby interfering in the HsfA4 DNA binding capacity and thus acting as a selective repressor [24] In addition to Hsf–Hsf interactions, a large body of information has been accumulated ... OsHsfA2c, OsHsfA9 and OsHsfB4b polypeptides formed protein–DNA complexes Binding activity was low at 12 °C and was enhanced with increasing temperature; OsHsfA2c showed maximum binding at 32 and 37 °C; ... assay, OsHsfs fused to the Gal4 DNA binding domain and activation domain were expressed in yeast cells containing a Gal4-regulated lacZ reporter construct, and the interactions were scored based on...
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