cord blood hematopoietic stem cells ppt

... induction of apoptosis and the relevant signaling pathways in hematopoietic stem cells are still poorly understood. Hematopoietic stem cells (HSCs) contain specific markers on their surface such ... erythroid cells. The cultivation of erythroid cells derived from HSCs/CD34 + cells was performed according to a procedure previously described [13] with some modifications. HSCs/CD34 + cells were ... phosphoproteins in HbE/b-thalassemic stem cells was proposed (Figure 4). Discussion Conventional methods typically have difficulty using fresh human hematopoietic stem cells for studying cell signaling...

Ngày tải lên: 20/06/2014, 04:20

... human stem cells. Stem Cells Dev 2006, 15(1):118-23. 77. Shytle RD, Ehrhart J, Tan J, Vila J, Cole M, Sanberg CD, Sanberg PR, Bickford PC: Oxidative stress of neural, hematopoietic, and stem cells: protection ... Loutit JF: Haemopoietic stem cells in the peripheral blood. Lancet 1967, 2(7526):1138-41. 43. Fried W, Johnson C: The effect of cyclophosphamide on hematopoietic stem cells. Radiat Res 1968, ... indicate statistical significance. Results Stem- Kine mobilizes CD34 and CD133 Cells Quantification of peripheral blood cells expressing the hematopoietic stem cell markers CD133 and CD34 was performed...

Ngày tải lên: 18/06/2014, 16:20

... induction of apoptosis and the relevant signaling pathways in hematopoietic stem cells are still poorly understood. Hematopoietic stem cells (HSCs) contain specific markers on their surface such ... erythroid cells. The cultivation of erythroid cells derived from HSCs/CD34 + cells was performed according to a procedure previously described [13] with some modifications. HSCs/CD34 + cells were ... phosphoproteins in HbE/b-thalassemic stem cells was proposed (Figure 4). Discussion Conventional methods typically have difficulty using fresh human hematopoietic stem cells for studying cell signaling...

Ngày tải lên: 18/06/2014, 19:20

... Chapter 68. Hematopoietic Stem Cells Hematopoietic Stem Cells: Introduction All of the cell types in the peripheral blood and some cells in every tissue of the body are derived from hematopoietic ... the clinical use of hematopoietic stem cells, tens of thousands of lives are saved each year (Chap. 108). Stem cells produce tens of billions of blood cells daily from a stem cell pool that ... much of what we know about stem cells is imprecise and based on inferences from genetically manipulated animals. Cardinal Functions of Hematopoietic Stem Cells All stem cell types have two cardinal...

Ngày tải lên: 07/07/2014, 01:20

... Chapter 068. Hematopoietic Stem Cells (Part 2) Developmental Biology of Hematopoietic Stem Cells During development, blood cells are produced at different sites. ... of nurture but imposing limits for stem cells: in effect, acting as both a nest and a cage. The niche for blood stem cells changes with each of the sites of blood production during development, ... knowledge of how stem cells get into and out of the bone marrow may improve our ability to obtain stem cells and make them more efficient at finding their way to the specific sites for blood cell...

Ngày tải lên: 07/07/2014, 01:20

... Chapter 068. Hematopoietic Stem Cells (Part 3) Excess Capacity of Hematopoietic Stem Cells In the absence of disease, one never runs out of hematopoietic stem cells. Indeed, serial ... proliferation. Hematopoietic stem cells have governing mechanisms that are distinct from the cells they generate. Hematopoietic Stem Cell Differentiation Hematopoietic stem cells sit at ... location of stem cells by indirect means, altering molecules such as CXCL12 that tether stem cells to their niche. Molecules shown to be important for altering the proliferation of stem cells, such...

Ngày tải lên: 07/07/2014, 01:20

... cross-matching obstacles. (2) Cord blood stem cells have Chapter 068. Hematopoietic Stem Cells (Part 4) Hierarchy of hematopoietic differentiation. Stem cells are multipotent cells that are the source ... Specifically, umbilical cord blood is a rich source of stem cells. However, the volume of cord blood units is extremely small, and therefore the total number of hematopoietic stem cells that can be ... capacity, stem cells have an additional feature characterizing their proliferation machinery. Stem cells in most mature adult tissues are deeply quiescent. In the hematopoietic system, stem cells...

Ngày tải lên: 07/07/2014, 01:20

... Else Can Hematopoietic Stem Cells Do? Some experimental data have suggested that hematopoietic stem cells or other cells mobilized into the circulation by the same factors that mobilize hematopoietic ... experimentally in the hematopoietic system. Taking advantage of the cell-surface markers that distinguish hematopoietic cells of varying maturity, stem cells, progenitors, precursors, and mature cells can ... hierarchical organization of cells with a base of stemlike cells capable of the signature stem- cell features, self-renewal and differentiation. These stemlike cells might be the basis for perpetuation...

Ngày tải lên: 07/07/2014, 01:20

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Ngày tải lên: 07/08/2014, 18:21

... mesenchy- mal stem cells isolated from human umbilical cord blood. Stem Cells 2004, 22(4):617-624. 25. Nunes VA, Cavaỗana N, Canovas M, Strauss BE, Zatz M: Stem cells from umbilical cord blood differentiate ... Nature 1988, 333:466-469. CD34+ stem cells transdifferentiated in muscle cells in vitroFigure 6 CD34+ stem cells transdifferentiated in muscle cells in vitro. CD34+ stem cells that transdifferentiated ... shown). Transdifferentiation of CD34+ stem cells into muscle cells During the expansion of CD34+ stem cells from umbilical cord blood, we observed the presence, in some cultures, of a small number of cells that became...

Ngày tải lên: 18/06/2014, 15:20

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Ngày tải lên: 12/08/2014, 13:22

... mesenchymal stem cells. Science 284, 143–147. 2 Porada CD, Zanjani ED & Almeida-Porad G (2006) Adult mesenchymal stem cells: a pluripotent population with multiple applications. Curr Stem Cell ... (2007) Effect of hypoxia on gene expression of bone marrow- derived mesenchymal stem cells and mononuclear cells. Stem Cells 25, 1166–1177. 7 Li L, Zhang S, Zhang Y, Yu B, Xu Y & Guan Z (2009) ... mesenchymal stem cells (MSCs) are easily obtainable and expandable, multipotent progeni- tor cells [1] that have emerged as attractive candidates for cellular therapies for heart and other organ-system disorders...

Ngày tải lên: 18/02/2014, 04:20