contemporary approaches to alzheimer s disease and frontotemporal dementia

... Psychological Disorders Alzheimer s Disease and Other Dementias Psychological Disorders Addiction Alzheimer s Disease and Other Dementias Anxiety Disorders Child Abuse and Stress Disorders Depression ... caused by infections to the brain and hereditary diseases like Wilson s disease Huntington s disease is an involuntary movement disorder that is often associated with dementia Parkinson s disease ... cardiovascular disease, also called ischemic heart disease, the blood vessels that supply the heart muscle with oxygen and nutrients narrow These diseases can cause strokes and heart disease (heart...

Ngày tải lên: 14/02/2014, 18:20

... Medical School Massachusetts Alzheimer s Disease Research Center Massachusetts General Hospital, Boston, MA USA Preface This book provides a comprehensive review of Alzheimer s disease and other dementias ... treating Alzheimer s disease In 1984, the first clinical criteria for the diagnosis of Alzheimer s disease was published, and the first five Alzheimer s Disease Research Centers were established with ... Alzheimer s Association) This private foundation spread from its base in Chicago to establish chapters across the country dedicated to raising awareness about Alzheimer s disease and raising money to support...

Ngày tải lên: 14/03/2014, 21:20

... teenagers The second factor to consider is human memory Memory loss—one of the most obvious and distressing symptoms of Alzheimer s disease is much more serious than forgetting the answers on a history ... OF FOCUS: ALZHEIMER S DISEASE AND RELATED DISORDERS A gradual loss of memory, affecting a person s skills and behavior, characterizes Alzheimer s disease In Helen s case, she slowly lost her ... disturbances or subtle changes in personality Alzheimer s is a progressive disease; this means that the condition continues to get worse with time Usually, Alzheimer s disease gets progressively worse...

Ngày tải lên: 05/03/2014, 23:20

... lost in familiar surroundings, the physician can assess visuoconstruction or the ability to copy and produce figures on demand, such as a cross, square, and cube The physician can also assess ... Psychiatric Press, 2000 66 Morris JC, Mohs RC, Rogers H, et al Consortium to establish a registry for Alzheimer s disease (CERAD) clinical and neuropsychological assessment of Alzheimer s disease ... diagnose dementia as early as possible This chapter outlines the basic elements of a clinical diagnostic evaluation for Alzheimer s disease (AD) and other dementias; and also addresses how to identify...

Ngày tải lên: 05/03/2014, 23:20

... Neurological and Communicative Diseases and Stroke /Alzheimer s Disease and Related Disorders Association CERAD = Consortium to Establish a Register for Alzheimer s Disease AIREN = Association Internationale ... diagnose is gold standard, rest conform to class 1A NINCDS–ADRDA = National Institute of Neurological and Communicative Diseases and Stroke /Alzheimer s Disease and Related Disorders Association ... diagnose is gold standard, rest conform to class 1A NINCDS–ADRDA = National Institute of Neurological and Communicative Diseases and Stroke /Alzheimer s Disease and Related Disorders Association...

Ngày tải lên: 28/03/2014, 22:21

... AD; NINCDS-ADRDA: National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer s disease and Related Disorders Association; ORs: odds ratios; PCR: polymerase chain ... results Statistical analysis Hardy-Weinberg equilibrium was assessed using the Chi-square test Genotype and allele distributions were compared using the Chi-square test Differences in allele and ... disease and Related Disorders Association (NINCDS-ADRDA) [14] All AD cases were defined as sporadic because family histories showed no mention of first-degree relatives with dementia Control subjects...

Ngày tải lên: 19/06/2014, 22:20

... antibiotic regimens against MAP In conclusion, these results might represent a good starting point to consider different drugs for treatment of the disease forms where involvement of MAP is suspected, ... months to five years [12] Moreover, considering that clarithromycin and ciprofloxacin are widely used antibiotics, strains resistant to these drugs can be very common Up to now, there is a urgent ... References 10 11 12 Sechi LA, Scanu AM, Molicotti P, Cannas S, Mura M, Dettori G, Fadda G, Zanetti S: Detection and isolation of Mycobacterium avium subspecies paratuberculosis from intestinal mucosal...

Ngày tải lên: 08/08/2014, 19:20

... http://www.jneuroinflammation.com/content/2/1/27 Findings Aberrant expression of cyclins, cyclin dependent kinases (CDKs) and their inhibitors has been observed in post mitotic neurons in Alzheimer' s disease (AD) [1,2] Proteins that normally ... neurons in the temporal cortex of AD and control cases [6] Increased neuronal COX-2 expression leads to increased expression of cell cycle mediators in post mitotic neurons, as shown using a transgenic ... Demographic characteristics of the cases used in this study Shown are differences between groups of the cases used in this study [PMI post-mortem interval, SD standard deviation] Braak score for neurofibrillary...

Ngày tải lên: 19/06/2014, 22:20

... differences, and the small sample sizes used in some studies In previous ELISA studies comparing these antibodies in AD subjects vs normal controls, only Moir et al [3], Gruden et al [14,15], and Nath ... differences with this approach Methods Serum samples Serum samples were obtained from the Rush Alzheimer s Disease Center (Chicago, IL) from individuals whose diagnosis on the basis of post-mortem clinical ... statistically significant All p-values were two-tailed Statistical analyses were performed using The SAS System for Windows version 9.2 Power and sample size analyses All calculations were based on a significance...

Ngày tải lên: 19/06/2014, 22:20

... of synthetic peptides, a bacterial expression system allows isotope labeling, which is essential for high-resolution structural analysis of Ab using NMR spectroscopy and allows use of high specific ... the small molecular mass difference between the peptides ending at Val40 and Ala42, it is not possible to resolve these peptides on standard SDS-PAGE [27]; however, this system is useful to confirm ... gels (A,C) and 1% agarose gels (B,D), and proteins were visualized by Coomassie stain Lanes HS and LS are molecular mass standards, with the molecular mass in kDa given on the left (E) 1% agarose...

Ngày tải lên: 18/02/2014, 13:20

... Subtest and the repetition of phrases from the Boston Diagnostic Aphasia Evaluation [19] Abstract reasoning was evaluated using WAIS-R Similarities subtest [66], and the non-verbal Identities ... variability is not associated with the rate of progression of Alzheimer s disease [51,59,67] The study was designed to address a specific question regarding the role of APOE-␧4 in memory As a prerequisite, ... allele is associated to dementia and loss of memory function only in the very old Neurosci Lett 222(1):29 –32 Goodglass H, Kaplan E 1983 The Assessment of Aphasia and Related Disorders, ed Lea...

Ngày tải lên: 05/03/2014, 21:20

... fluorescence We show the application of this assay to the testing of c-secretase inhibitors and PS1 mutants This assay allows for the first time the selection of cell populations and single cells ... assays based on APP or Notch c-secretase substrates can be used to specifically study modulation of c-secretase activity in parallel in various cell types Results of the inhibitor study suggest ... experiments) (Fig 4E) Discussion We have developed a novel GFP-based assay to characterize c-secretase The advantage of this assay over existing systems is that it allows the isolation of cells with stable...

Ngày tải lên: 08/03/2014, 08:20

... related diseases, and various forms of a-synuclein associated with Parkinson disease and synucleinopathies [27] Taken together with the findings that mTOR phosphorylated at the Ser2481 site has a significant ... previously measured by indirect ELISA in the same set of tissues as dot blots [6] Immunohistochemistry Immunohistochemical staining was performed on 20-lM formalin-fixed frozen sections (two AD cases, ... lane), suggesting these antibodies are specific (Fig 3) Immunohistochemistry of AD and control brains with antibodies to p-mTOR, p-4E-BP1, and p-eEF2 We used phosphospecific antibodies to p-mTOR,...

Ngày tải lên: 16/03/2014, 22:20

... powerful tools to crop scientists at a time when it is possible to study entire crop genomes As new questions arise, many crop researchers are revisiting classic evolutionary inquiries into crop ... agronomists, botanists, systematists, population biologists, archaeologists, anthropologists, economic botanists, CROP PLANTS conservation biologists, and the general public all have an interest in ... labor-intensive and costly detasseling process, and as a result much of the U .S corn crop contained this cytoplasm (male-sterile plants act as the ovule donor or female in controlled crosses and cannot...

Ngày tải lên: 03/04/2014, 12:10

... anti-influenza and anti-Ab antibodies To test that, we performed in vitro assessment using HI [29] and neurotoxicity [24,32] assays routinely used in our laboratories These analyses showed that ... disease process, pre-symptomatic if possible, is likely to be significantly more beneficial than attempting to intervene in the disease process after clinical diagnosis of the disease Davtyan ... used to generate chimeric influenza A/WSN/33 (H1N1) viruses expressing B cell epitopes Ab1-10 (WSN-Ab1-10), or Ab1-7 (WSN-Ab1-7) from Ab42 This system includes four protein expression plasmids...

Ngày tải lên: 18/06/2014, 22:20

... findings to the human disorders, distinct differences remain These models may be appropriate for studying some aspects of a disease process, while less suitable for others To determine the significance ... arthritis [122] and to be associated with autoimmune disorders including multiple sclerosis [123] and atherosclerosis [124] Some laboratories have also reported an association of this agent with ... progression of Alzheimer' s disease [abstract] Sixth International Stockholm/Springfield Symposium on Advances in Alzheimer Therapy 2000:180 Van Gool WA, Weinstein HC, Scheltens P, Walstra GJ, Scheltens...

Ngày tải lên: 19/06/2014, 22:20

... Quantitative comparisons were performed on sections processed at the same time Single ANOVA statistical analysis was used to assess the significance of the differences in plaque area, glial and C3 activation ... performed image analysis, data analysis and manuscript preparation; IH performed immunohistochemistry, image analysis, data analysis and presentation and assisted with perfusions and animal care; ... memory loss in a mouse transgenic model of Alzheimer' s disease J Neurosci 2002, 22:6331-6335 Selkoe DJ, Schenk D: Alzheimer' s disease: molecular understanding predicts amyloid-based therapeutics Annu...

Ngày tải lên: 19/06/2014, 22:20

... the earliest events occurring prior to the onset of symptoms and it has been recognised as an essential contributor to the pathogenesis and progression of the disease [1,2] In the last decade, ... clinical diagnosis of probable Alzheimer' s disease [10] All participants underwent a physical examination, blood tests and neuroimaging assessments They also underwent cognitive assessments using the ... deficit, we used the MMSE scores as proxy of status (control vs AD) and of disease progression Subjects were divided into three mutually exclusive groups ranked by increasing MMSE scores [below 20...

Ngày tải lên: 19/06/2014, 22:20

... prednisone in Alzheimer s disease Alzheimer s Disease Cooperative study Neurol 2000, 54:588-593 33 Aisen , et al: Effects of rofecoxib or naproxen versus placebo on Alzheimer Disease progression: ... processed on a RHS-1 microwave tissue processor, after which the samples were embedded in paraffin, cut on a microtome as μm thick sections and collected on glass slides Joint histopathology was ... in sections stained by Alcian blue-orange G histochemistry using a scale 0-5 previously described [23,24] Articular cloning was assessed by microscopy and counted as or more chondrocytes present...

Ngày tải lên: 19/06/2014, 22:20

... each sample was used for first-strand cDNA synthesis using the Invitrogen SuperScript III reverse transcription system cDNA was amplified using quantitative real-time PCR with Assays-onDemand ... IFN-g, as well as Ab42 oligomers and fibrils, increase levels of BACE1, APP, and bsecretase processing in cultured primary astrocytes, and that these effects can lead to increased astrocytic Ab secretion, ... reason of this discrepancy is unknown Clearly, further work is necessary to resolve this issue in the future Far less is known about APP gene regulation in astrocytes TGFb appears to increase...

Ngày tải lên: 19/06/2014, 22:20