congenital and inherited syndromes associated with bone and soft tissue tumours
PULMONARY TUBERCULOSIS AMONG HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTED PATIENTS IN THE ERA OF HIGHLY ACTIVE ANTIRETROVIRAL THERAPY (HAART) IN DAR ES SALAAM MUNICIPAL, TANZANIA pdf
... infection and TB and opportunistic infection and Sub-Saharan Africa (5 articles, review) • Tuberculosis and HAART and HIV infection and Africa (3 articles, review) • Tuberculosis and HIV infection and ... Ravera and co-workers (1999) showed that 91% of the participants (42 females, 35 males) had both oral and oesophageal candidiasis and 47% (n=40) had oesophageal symptoms and all had oesophageal candidiasis ... and mortality and Sub-Saharan Africa (4 articles) • Antiretroviral adherence and East Africa (No articles) • Antiretroviral adherence and Tanzania (2 articles) • HIV infection and TB and Tanzania...
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báo cáo hóa học:"Medication diaries do not improve outcomes with highly active antiretroviral therapy in Kenyan children: a randomized clinical trial" pot
... to standard counselling only, and followed prospectively Methods Study design and subjects This was an unblinded randomized trial with use of medication diaries as the intervention, and standardized ... for randomization and initiation of antiretroviral therapy These tests were repeated at three to six monthly intervals during follow up Randomization and diary use Computer-generated block randomization ... equation) used b Data from 20 and 24 children in diary and control respectively c Numbers for all z-scores month 25 and 28 in diary and control respectively treatment programmes with conventional counselling...
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báo cáo hóa học:" Immunological response to highly active antiretroviral therapy following treatment for prevention of mother to child transmission of HIV-1: a study in Côte d’Ivoire" pdf
... (95.1%) women, and stavudine (d4T)+3TC+NVP in seven (2.9%) women; five women started HAART with ZDV+3TC+EFV and one began with d4T+3TC +EFV The median time between exposure to sdNVP and initiation ... resistance mutations at Week 4, and 0.30 (95% CI: 0.11-0.68) in women with 3TC resistance mutation at Week In multivariate analysis (n = 247), the only factor associated with immunological failure ... routinely monitored and recorded in our study area Such data is important to fully understand the dynamics and rate of treatment failure in our population Switching treatments without using viral...
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báo cáo hóa học:" Barriers to accessing highly active antiretroviral therapy by HIV-positive women attending an antenatal clinic in a regional hospital in western Uganda" pot
... men and women in sub-Saharan Africa Factors identified and ranked high as serious obstacles to accessing HAART were transportation costs in Uganda and Tanzania [4-6] In Benin, South Africa and ... knowledge for understanding barriers to HAART among pregnant and breastfeeding women, we conducted our study in Kabarole District, western Uganda, with a sample of pregnant and post-natal women ... care and received pre-test HIV counselling and were found to be HIV positive, and were 18 years and older Each registrant was assigned a number Study participants were chosen via simple random...
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báo cáo hóa học:" Birth outcomes in South African women receiving highly active antiretroviral therapy: a retrospective observational study" pdf
... early exposure to any regimen was associated with preterm birth compared with HAART-unexposed infants, with receipt of early efavirenz and nevirapine associated with the higher odds of preterm ... efavirenzcontaining regimen, lower CD4 cell count, and maternal hypertension were associated with LBW Although rates were low, neither smoking nor alcohol use was associated with LBW In multivariate analysis, ... remained, with each 50 cells/ mm3 increase in CD4 cell count associated with a 57% reduction in the odds of LBW (95% CI 0.45-0.71, p < 0.001) There was a trend towards hypertension being associated with...
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Báo cáo y học: " Injection drug use and patterns of highly active antiretroviral therapy use: an analysis of ALIVE, WIHS, and MACS cohort" ppt
... Interagency HIV study (WIHS) [20] and the Multicenter AIDS Cohort Study (MACS) [21] We compared and contrasted the frequency of HAART modification among those with and without a history of IDU across ... abacavir- or tenofovir-containing regimen with at least NRTIs, 4) a regimen containing ritonavir and saquinavir and one NRTI, and no NNRTIs Combinations of zidovudine and stavudine were not considered ... those with a history of injection drug use Patterns and trends of HAART use The longitudinal trends in the use of HAART by class of drug are depicted in Figure Both individuals with and without...
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Báo cáo y học: "Magnitude and determinants of nonadherence and nonreadiness to highly active antiretroviral therapy among people living with HIV/AIDS in Northwest Ethiopia: a cross - sectional study" ppsx
... analysis and drafted the manuscript for publication FB, AM and AG assisted in data collection and reviewed the initial and final drafts of the manuscript FE and US interpreted the results, and reviewed ... enhance patient understanding of medication regimen, to identify potential obstacles to taking medication and trusting relationship between patients and health care providers, and ultimately to prevent ... level and determinants of nonadherence and nonreadiness to HAART among PLWHA at Gondar University Teaching Hospital and Felege Hiwot Hospital in Northwest Ethiopia Methods Study design, area, and...
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Báo cáo y học: "Outcomes of highly active antiretroviral therapy in the context of universal access to healthcare: the U.S. Military HIV Natural History Study" ppt
... higher (64% and 84%, respectively) The percentage of patients with VS at years was 59% and 85%, and at years was 65% and 82% for the EHE and LHE, respectively Analyses restricted to active duty patients ... access to care and IDU Previously, we and others have shown associations between both age at HAART initiation [41] and ethnicity [17,42,43] with treatment response Concordant with other studies, ... demographic (e.g race/ethnicity) and clinical factors (hepatitis B, prior STI, etc.) with outcomes after HAART in a U.S population with fewer confounders related to access to care and IDU Methods Study...
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Báo cáo y học: "Immune restoration disease and changes in CD4+ T-cell count in HIV- infected patients during highly active antiretroviral therapy at Zewditu" ppsx
... months of treatment in patients with and without IRD is shown in Figure After commencement of HAART, laboratory values of patients with and without IRD were compared and there were significant increases ... lamivudine, stavudine and nevirapine), 1d (combination zidovudine, lamivudine and efavirenz) and 1c (combination of zidovudine, lamivudine and nevirapine) for 34%, 23.3%, 22% and 20.6% of the patients, ... baseline characteristics of patients with and without IRD The patients with IRD at HAART initiation were younger, had low CD4+ T-cell count, low WBC count and higher proportion of extra pulmonary...
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Báo cáo y học: " Unintegrated HIV-1 provides an inducible and functional reservoir in untreated and highly active antiretroviral therapy-treated patients" potx
... culture with T20 and with our without L-731,988 Resting CD4+ T cells preincubation with T20 Resting CD4+ T cells culture with T20 Anti-CD3/ anti-CD28 polyclonal activation * ** ELISpot assay and ... viral proteins in untreated (A) and HAART-treated patients (B) The CD4+ T lymphocytes were polyclonally activated and cultured with µg/ml of enfuvirtide and with or without 40 µM of the HIV-1 integrase ... activated and cultured with or without L-731,988 Cells were cultured with T20 The HIV-1 reservoir was detected in 11/12 untreated patients (91.6%) HIV-1-Ag-SCs were not detected for patient no 10 and...
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Báo cáo y học: "Longitudinal microarray analysis of cell surface antigens on peripheral blood mononuclear cells from HIV+ individuals on highly active antiretroviral therapy" doc
... cell counts with CD9 expression and (B) CD8+ T cell counts with CD52 expression during Figure HAART5 Correlation of (A) CD4+ T cell counts with CD9 expression and (B) CD8+ T cell counts with CD52 ... with p values ranging from 0.001 to 0.048 (Table 3); results for CD11a and CD29 are shown in Figure 4A and 4B, respectively For reference, the average dot intensities of CD11a and CD29 (132 and ... for SR and TR patients, respectively, at time points (baseline), 2, and (Time points as described in Figure 3) Bars with diamond and star symbols represent the mean values for the SR and TR groups,...
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Báo cáo y học: "Survival trends in critically ill HIV-infected patients in the highly active antiretroviral therapy era" ppsx
... role of hepatitis C and B viruses and alcohol J Hepatol 2005, 42:799-805 Viale P, Baccarani U, Tavio M: Liver transplant in patients with HIV: infection risk associated with HIV and post-transplant ... decade (from 37.5 to 8.6%), with admission to the ICU in the most recent period being independently associated with increased survival • Delayed ICU admission was associated with increased ICU mortality ... JMM and BS contributed to study design and mentoring IC, PP and JP contributed to data collection, interpretation and manuscript preparation FB contributed to study design, data collection and...
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HIV INFECTION IN THE ERA OF HIGHLY ACTIVE ANTIRETROVIRAL TREATMENT AND SOME OF ITS ASSOCIATED COMPLICATIONS docx
... known and often associated with abnormal body fat distribution and glucose metabolism disturbs (Carr et al., 1998) On persons treated with HAART, TG and TC elevations are associated with the use ... morbidity and mortality and improvements in the quality of life However, the requirement for a life-long therapy with antiretroviral drugs has been associated with long-term metabolic toxicities and ... it must be used with caution when co administered with a PI, with hepatitis and myositis being potential toxicities Rosuvastatin is the most potent statin to reduce LDL-c and TG, with serum levels...
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Báo cáo y học: "Mycobacterial immune reconstitution inflammatory syndrome in HIV-1 infection after antiretroviral therapy is associated with deregulated specific T-cell responses: Beneficial effect of IL-2 and GM-CSF immunotherapy" pptx
... receiving conventional antiMAC treatment, and were given IL-2 and GM-CSF in conjunction with ART as salvage therapy as detailed in materials and methods and as previously described [9,21] Increases ... CD4 and CD8 T lymphocytes, and associated with a lack of naïve CD4 T cells possibly due to absence of thymic function Discussion Immune reconstitution after initiation of ART may be concurrent with ... manifestation and hatched bars represent T cell responses after immunotherapy with IL-2 plus GM-CSF in conjunction with ART and resolution of IRIS Data are shown as median SI values with interquartile...
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báo cáo hóa học:" Nutrition and inflammation serum biomarkers are associated with 12-week mortality among malnourished adults initiating antiretroviral therapy in Zambia" potx
... baseline serum ferritin and hsCRP levels were associated with increased mortality; compared with a ferritin value of 25 μg/L, a baseline serum level of 250 μg/L was associated with an approximate ... related to infection with HIV-1 subtype C compared with other viral subtypes [26] Elevated CRP and other inflammation biomarkers are associated with endothelial dysfunction and an increased risk ... participants with low levels [13] Relative long-term (i.e., longer than six month) declines in serum albumin are associated with increased mortality among HIV-infected women (both with and without...
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báo cáo hóa học:" Reduced renal function is associated with progression to AIDS but not with overall mortality in HIV-infected kenyan adults not initially requiring combination antiretroviral therapy" potx
... (compared with stage 2) at enrolment was associated with lower CrCl, but not with lower eGFR Lower enrolment weight was associated with lower CrCl, but in contrast, lower weight was associated with ... cells/mm3, and lower haemoglobin at enrolment were all significantly associated with both a CrCl < 60 mL/min and eGFR < 60 mL/min/ 1.73 m2 Being female was associated with lower eGFR, but not with ... those with and without a CrCl < 60 mL/min in our study cohort were similar at 28 (23-56) and 28 (23-53), respectively The median (IQR) numbers of days between visits for those with and without...
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Báo cáo khoa học: " Local tumor control and toxicity in HIV-associated anal carcinoma treated with radiotherapy in the era of antiretroviral therapy" pps
... overall and cancer-specific survival was observed (Figure and 2) The 1-year OS in the matched HIV-seropositive and -seronegative cohort was 90 % and 100 %, and the 5year OS was 70 % and 69 %, ... disease-free and overall survival is similar in HIV-positive patients under HAART compared with HIV-negative patients (iv) Standard chemo-radiation with mitomycin-C is associated with a high rate ... HIV-seropositive and HIV-seronegative patients and whether the outcome in respect of treatment toxicity and survival after standard curative 3-D conformal RT with or without chemotherapy (CT) of invasive...
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Báo cáo khoa học: Designing highly active siRNAs for therapeutic applications pdf
... Shabalina (Figs S1–S4) and Novartis (Figs S5–S8) datasets with calculations using one (Figs S1 and S5), two (Figs S2 and S6), three (Figs S3 and S7) and four (Figs S4 and S8) nearest neighbors ... guide strand and two segments of the passenger strand [61] and, when modified with selected locked nucleic acid nucleotides, were found to be more tolerant of chemical modifications than standard ... then selects one of the two strands to act as the guide strand [11–13], yielding the active RISC, which contains at a minimum the single-stranded guide strand RNA and Ago2 [14,15] (Recent work...
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Báo cáo khoa học: Mechanistic investigation of a highly active phosphite dehydrogenase mutant and its application for NADPH regeneration pptx
... efciency with both NAD(H) and NADP(H) [25,26,28,31] Thus PTDH-E175A A176R, with its relaxed cofactor specicity, is interesting from the standpoint of protein engineering and very promising with ... A176R with NAD, NADH, NADP, and NADPH with the KD values obtained displayed in Table The data shows that PTDHE175A A176R binds both NADP and NADPH very tightly with KD values of 1.9 and 1.22 ... PTDH-E175A A176R with NADP is signicantly decreased compared with the reaction of the WT or PTDH-E175A A176R enzymes with NAD Taken together with the observation that kcat is smaller with NADP as...
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