confined innovation organisational challenge and its limitations

... causes comorbidity itself [3,4], emphasising the importance of preventive arthritis care their data Although toxicity and effectiveness analyses seem to favour etanercept and adalimumab over ... Research & Therapy Vol 11 No Aletaha study by Saad and colleagues, it can serve as a very good example for that: comorbidity usually is neglected and excluded in clinical trials but is omnipresent ... more and more a mainstay of management as it has been shown that it is not the level of improvement that is decisive but rather the disease activity reached [5,6] This helps to develop and advance...

Ngày tải lên: 09/08/2014, 14:20

... Taylor-Couette flow (Coles 1965; Golubitsky and Stewart 1986; Chossat and Iooss 1994) and in differentially rotated systems (Hide and Titman 1967; Früh and Read 1999) More recently, Marques et ... lose stability and a quasiperiodic mixed mode QP is spawned In the wedgeshaped region between the curves NS1 and NS2, four states coexist: LC1 and LC2, which are both stable, and SS and QP which ... frequency ωf = 0.1 and forcing amplitude A as indicated In (b) and (d) the hot-film outputs from both channels are plotted 114 xv Fig 6.4 Phase portraits (with Wa and Ww as the horizontal and vertical...

Ngày tải lên: 14/09/2015, 14:02

... and Λ = 1.75 and its corresponding FFT analysis result, clearly showing the oscillatory state of the flow The period obtained from this method is consistent with those predicted by numerics and ... were collected, and the Reynolds number was then recalculated based on the relationship between viscosity and temperature obtained using a Haake Rheometer Since the data was sampled and acquired ... cylinder and its surroundings, there is a gradual rise in the temperature of the fluid, resulting in an increase in Re at a rate ∂Re/∂t ≈ 25 per hour For those experiments with fixed Λ and varying...

Ngày tải lên: 14/09/2015, 14:02

... independent calculations in other studies and with experimental results Table presents the values and locations of three local maxima and minima of ψ and η at H/R = 2.5 and Re = 2494 with constant rotating ... for the present study Assuming N+1 and M+1 are the number of grid points in the r and z direction, respectively, then Δr and Δz can be calculated as: Δr = so, HR and Δz = N +1 M +1 ri = i ∗ Δr , ... continuity equation and appropriate boundary and initial conditions A cylindrical container with radius R and height H is completely filled with an incompressible fluid of constant density ρ and kinematic...

Ngày tải lên: 14/09/2015, 14:02

... nominal inner radius R of 87.25 mm, and a matching rotating disk at the top and a stationary disk at the bottom of the cylinder The height H of the flow domain, and the aspect ratio Λ = H/R, can ... al (1995), Lim (2000), and Sotiropoulos et al (2002), and extra care was taken during the fabrication to ensure that various parts of the apparatus were properly matched and the dye port is located ... Generation and evolution of vortex structure with increasing Re for Λ = 4.0 Note the formation of an S-shaped structure in (c) and a spiral-type breakdown in (f) Fig 4.6 Generation and evolution...

Ngày tải lên: 14/09/2015, 14:02

... NS2), so that in between NS1 and NS2 both LC1 and LC2 are stable, between H1 and NS2 both LC1 and LC2 exist but only LC1 is stable, and between H2 and NS1 both LC1 and LC2 exist but only LC2 is ... lose stability and a quasiperiodic mixed mode QP is spawned In the wedge-shaped region between the curves NS1 and NS2, four states co-exist: LC1 and LC2, which are both stable, and SS and QP which ... 2750 and Λ = 1.72 Fig 5.4 Computed time-series of E0 for LC1 (solid curve) and LC2 (dashed curve), both at Re = 2750 and Λ = 1.72 Note that near the onset, the spatial characteristics of LC1 and...

Ngày tải lên: 14/09/2015, 14:02

... portraits in the neighborhood of the 2:1 resonance for QP at ωf /ω0 ≈ 0.1965 and A = 0.005 just outside the resonance horn and for LCL at ωf /ω0 = 2.0 and A = 0.005 inside the resonance horn; and ... recirculation zone on the axis and the formation and folding of lobes every period are clearly evident and follow the detailed description of the chaotic advection given in Lopez and Perry (1992a) for ... vortex breakdown bubble and Ww = w(r = 0.70, z = 0.75H/R) at the jet emerging from the sidewall rotating disk corner Fig 6.4 Phase portraits (with Wa and Ww as the horizontal and vertical axes, respectively)...

Ngày tải lên: 14/09/2015, 14:02

... Hopf bifurcation is at Re = 2710, and the second and third occur at Re = 3044 and 3122 Of course, the Hopf frequencies vary with parameters (Re and Λ, as well as A and ωf), but these variations are ... natural limit cycle at Re = 2800 and Λ = 2.5, and (bottom row) the synchronous state at Re = 2600, Λ = 2.5, A = 0.01 and ωf = 0.171 There are 15 positive (blue) and 15 negative (red) contour levels ... Λ = 2.5, Re = 2600, A = 0.02 and forcing frequency ωf as indicated The flow visualizations shown in Fig 7.4 at Λ = 2.5, Re = 2600, A = 0.01, and ωf = 0.171, 0.20, and 0.50 illustrate the enhanced...

Ngày tải lên: 14/09/2015, 14:02

... CONCLUSIONS AND RECOMMENDATIONS 8.2 Recommendations A confined cylindrical container driven by one rotating endwall has been used extensively to study the phenomenon of vortex breakdown and its dynamic ... the axis, and its oscillations are most pronounced near the cylinder sidewall For the mean rotation rates below the critical level for self-sustained oscillations, the experimental and numerical ... natural 153 CHAPTER CONCLUSIONS AND RECOMMENDATIONS frequency of the unforced bubble and the forcing (modulation) frequency As the amplitude is increased to between 2% and 5% (depending irregularly...

Ngày tải lên: 14/09/2015, 14:02

... advertising, and social welfare activities Benefits and costs analysis show that all costs that Canon has to pay is to satisfy customer demands by its products and services However, it gains many benefits, ... company’s image will be raised and its income will increase And the benefits that it gains come from customers, such as customer loyalty Page CANON VIETNAM CO LTD AND ITS MARKETING Figure4 Flowchart ... and high income 2.1.2 Benefits and Limitations Benefits Geographic - Customers are divided into regions - Canon resources will not be wasted Demographic - The needs of customers are focused Limitations...

Ngày tải lên: 06/09/2012, 11:05

... resistance, type diabetes, and cardiovascular disease Diabetes 2007; 5: 1198-209 Hu XB, Zhang YJ, Zhang HT, et al Cloning and expression of adiponectin and its globular domain, and measurement of the ... adiponectin and the C-terminus of GLP-1-A Compared with native GLP-1, the fusion protein has a modified site and larger molecular size, and may circumvent the rapid inactivation and renal clearance ... hampered by its very short plasma half-life [5, 6, 13] This is due to its rapid inactivation by dipeptidyl peptidase IV and by renal clearance [5, 6, 13] Many attempts have been made to increase its...

Ngày tải lên: 25/10/2012, 11:10

... injected into rabbits through the ear vein, within more than Necrotic and normal femoral heads, bone marrows, lungs and livers were harvested at 2, and w after transplantation and sectioned followed ... head necrosis, and lifetime of prosthesis, risk of surgery and high cost for surgery limit its application in a majority of patients The abovementioned strategies have limitations and thus it is ... blood examination and liver and renal functions, no manifestations of acute and chronic toxic reactions and graft versus host disease, no local swelling at injection sites, and no lower limb...

Ngày tải lên: 25/10/2012, 11:18

... Med Sci 2010, had fewer side-effects and broader indications compared with conventional anti-cancer drugs However, its anti-tumor activity was moderate, and its half maximal inhibitory concentration ... means ± standard deviations, and samples were subjected to multiple analysis of variance The Dunnett-t test was performed to compare the mean between each test group and control group, and the ... peptide, which is a ligand of several integrin receptors, has been used to modify oncolytic viral vectors, delivery vehicles, and the resulting molecules have been used as probes and radiotracers for...

Ngày tải lên: 26/10/2012, 08:57

... trade barriers Australia has joined WTO and signed free trade agreements with the United States and Thailand in 2005, with Singapore in 2003 and with New Zealand from 1993 It is now in negotiating ... countries and areas such as Japan, ASEAN, Malaysia, China, Chile and Gulf countries This research project tests the PPP between Australia and its trading partners over the period from 1984 to 2006 and ... Enders (1988) and Ardeni and Lubian (1991) reject long-run PPP However, Diebold, Husted and Rush (1991), Cheung and Lai (1993), Edison (1987), Frenkel (1981), Branson (1981), Desai (1981), and Miller...

Ngày tải lên: 29/10/2012, 16:32

... the following published and/ or accepted journal and conference papers: Anh T N and Hosoda T.: Depth-Averaged model of open channel flows over an arbitrary 3D surface and its applications to analysis ... channel, flow in meandering channel, and flow in Parshall flume with supercritical outflow was satisfactory Zhou and Goodwill (1997) presented a depth-averaged model and compared its predictions ... and Vreugdenhill, C B 1973 Calculations of two-dimensional horizontal flow Rep S163, Part 1, Delft Hydraulics Laboratory, Delft, The Netherlands Steffler M P and Jin Y C 1993 Depth averaged and...

Ngày tải lên: 06/11/2012, 10:35

... complexity and variability of the interactive environment In order for the maneuvering of investments, systematic approach should be dealt every now and then to assess its effectivity and to gauge its ... are the benefits brought by FDI: (1) Employment: While the number of jobs created are suitable for different scales of investment and production process itself and along with new jobs and income ... Build charter - Calculate fullness and synchronize - Calculate standard and integration - Righteousness, is professed and capability is realized Geographic location and infrastructure environment...

Ngày tải lên: 16/03/2013, 10:57

... trade barriers Australia has joined WTO and signed free trade agreements with the United States and Thailand in 2005, with Singapore in 2003 and with New Zealand from 1993 It is now in negotiating ... countries and areas such as Japan, ASEAN, Malaysia, China, Chile and Gulf countries This research project tests the PPP between Australia and its trading partners over the period from 1984 to 2006 and ... Enders (1988) and Ardeni and Lubian (1991) reject long-run PPP However, Diebold, Husted and Rush (1991), Cheung and Lai (1993), Edison (1987), Frenkel (1981), Branson (1981), Desai (1981), and Miller...

Ngày tải lên: 26/03/2013, 11:10

... enabling plants and animals to leave the oceans, and survive and evolve on land ♦ Between 450 million years ago and 350 million years ago, land plants and amphibian animals began to appear, and oxygen ... blocked solar uv from reaching the ground and made it possible for plants and animals to survive above the ocean surface.) Evolution of the Earth and its Atmosphere 3.0 million years ago - 200 ... ago, the industrial age, with its demand for fossil fuels, was getting underway ♦ The impact of people on the atmosphere was about to become noticeable! The Earth and its Atmosphere Today Planetary...

Ngày tải lên: 04/04/2013, 10:51

... to satisfy customer demands by its products and services However, it gains many benefits, the company’s image will be raised and its income will increase And the benefits that it gains come from ... CANON VIETNAM CO LTD AND ITS MARKETING which formal organizations establish the need for purchased products and services and identify, evaluate and choose among alternative brands and suppliers’ (BPP ... CO LTD AND ITS MARKETING the community, government and interest groups) Canon achieved the success because of understanding the interaction and behavior of these groups Firstly, employees and managers...

Ngày tải lên: 20/04/2013, 17:37