conducting an independent analysis usually in the absence of any previous analysis having been performed with the objective of reaching a particular conclu sion differs from confirm or verify as these terms imply that an analys
Analysis of p13k independent survival pathways in the prostate cancer cell line LN cap 1
Ngày tải lên :
12/09/2015, 08:18
... concentration and proper protein conformation suitable for activation of procaspase-9 Activated caspase-9 goes on to cleave and activate effector caspase like caspase-3 and caspase-7 Substrates of caspases ... conserved in all Raf isoforms Moreover, exchange of GDP for GTP triggers a conformational change in Ras allows for high affinity binding with Raf Ras binding to Raf translocates the cytoplasmic kinase ... protein in the Ras-Raf-MEK-ERK cascade, is a small GTP-binding protein anchored to the inner leaflet of the plasma membrane via a Cterminal post-translational lipid modification; and is activated...
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Analysis of p13k independent survival pathways in the prostate cancer cell line LN cap 2
Ngày tải lên :
12/09/2015, 08:18
... for both the AG1478 and AG879, and a combination of both inhibitors at a concentration ratio of 5µM:5µM (AG1478:AG879) (Figure 27c) as there was no significant cell death or caspase-3 activation ... silencing both proteins at the same time gave the same level of inhibition of caspase-3 activation as seen when Bax alone was silenced (Figure 30b and c) These data strongly argue in favor of an ... Densitometric analysis of amount of Bad and Bax in the mitochondria fraction Results are shown as the ratio of mitochondria Bad or Bax over VDAC converted to % of the ratio obtained in cells incubated with...
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an independent thesis submitted in fulfillment of the requirements for the degree of doctor of philosophy
Ngày tải lên :
20/05/2016, 21:05
... are restrictions placed on the borrower to safeguard its financial health and include both financial and general covenants Financial covenants require the borrower to maintain balance sheet or ... covenants (financial and general ones), and loan size (Ball, Bushman, and Vasvari, 2008) Collateral is the borrower’s assets pledged to secure the loan If the borrower defaults, the bank can seize ... Chomsisengphet, and Liu, 2011; Kano, Uchida, Udell, and Watanabe, 2011) Hard information is that which can be verified, such as financial statement information (Stein, 2002) It has the same meaning for different...
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Life cycle assessment (LCA) of an energy recovery plant in the olive oil industries
Ngày tải lên :
05/09/2013, 16:10
... land, as well as biomass feedstock derived by increasing yields Therefore in the case of de-oiled pomace and waste wood the effect of land use change can be ignored Finally, to complete the analysis, ... impact assessment aims to quantify the relative importance of all environmental burdens contained in an LCI and at aggregating them to a single indicator, GWP100 On the types and quantities of ... This means that the generator of the waste has to carry the full environmental impact until the point in the product´s life cycle where the waste is transported to a scrap yard or gate of a waste...
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BAMBOO AS A NEW FIBER SOURCE IN THE US PAPER INDUSTRY: A FEASIBILITY ANALYSIS FOR BOOSHOOT GARDENS, LLC docx
Ngày tải lên :
18/03/2014, 02:20
... on the need for change is even more important than the change itself • This point was easy because all of Booshoot's leadership wants to expand the company and they know they need change in order ... company grow The company's next direction was researching the use of bamboo in the paper industry Many companies in Asia have made advances in using bamboo in products such as textiles, flooring, cosmetics, ... report saying it was what just what the company was hoping for and that my report was extremely thorough Booshoot Gardens has already started to find investors to propagate full grown bamboo and...
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Báo cáo Y học: Calcium-binding by p26olf, an S100-like protein in the frog olfactory epithelium pot
Ngày tải lên :
24/03/2014, 04:21
... 7A The overall shape of the signal of a mutant was similar to that of the wild type: the signal at both 210 nm and 222 nm increased by increasing the Ca21 concentration The result indicated that ... glutamate to glutamine in the mutants induced a similar EF-hand conformational change that occurs on the binding of Ca21 in the wild-type If this is the case, Ca21-binding in the wild-type can ... through the column as a single peak with a molecular mass of < 28 kDa in the absence of Ca21, and < 16 kDa in the presence of Ca21 (data not shown) Because the calculated molecular mass of p26olf...
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Báo cáo hóa học: " An exploration of job stress and health in the Norwegian police service: a cross sectional study" docx
Ngày tải lên :
20/06/2014, 00:20
... and design, acquisition, analysis and interpretation of data and drafting of the manuscript EH was involved in design, interpretation of data, drafting of the manuscript and supervision ØE was ... was involved in conception and design, interpretation of data, drafting of the manuscript and supervision BL was involved in analysis and interpretation of data AMB is the guarantor for this paper ... work injuries was associated to somatic health complaints and the frequency of lack of support and work injuries was associated to depressive symptoms This indicates that both daily hassles and...
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Báo cáo toán học: "An inverse matrix formula in the right-quantum algebra" ppt
Ngày tải lên :
07/08/2014, 15:23
... a2 3 a3 1 a3 4 a3 3 a3 4 a3 4 a3 4 a4 2 a4 1 a4 2 a4 3 a4 1 a4 1 a4 4 into a2 2 a2 1 a1 4 a4 2 a2 3 a3 1 a1 2 a3 4 a4 1 a1 3 a3 3 a3 4 a4 2 a3 4 a4 3 a3 4 a4 1 a1 3 a4 1 a1 4 a4 4 with respect to σ = 2341 In the first five drawings, ... easy algebraic proofs of certain q-equations (implicitly based on the Gr¨bner bases of the underlying quadratic algebras) In a different direction, Hai and o Lorenz established the quantum master ... though the statement of Theorem 6.1 appears rather intricate even in the commutative case, it is very easy to find the generating function with the help of a computer A Mathematica package genmacmahon.m...
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Báo cáo y học: "A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity" doc
Ngày tải lên :
09/08/2014, 10:21
... preparation, statistical analyses and drafted the manuscript A- KL participated in the design of the study and the statistical analyses HK and LA performed the logistic regression analysis LP and ... analyses are truly independent The allele frequencies of the SNPs are affected by the LD of the region, and the stratified analyses are based on the same SNPs and samples as the initial analysis and ... all information regarding genetic factors, antibodies and matching variables was available This same sample set was used for the frequency analysis of rs729749 We used the SAS software for Windows...
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Báo cáo y học: "An artificial intelligence tool to predict fluid requirement in the intensive care unit: a proof-of-concept study" docx
Ngày tải lên :
13/08/2014, 11:23
... pre-processing, and with the help of GA, the data analysis All authors read and approved the final manuscript Acknowledgements This work has been supported in part by National Library of Medicine Training ... p values and Bayes factors are based on a Gaussian approximation In that situation, the Bayes factor is calculated with the same numbers used to calculate a p value [6] The formula is as follows: ... decided to include the following for each variable that we evaluated: mean, variance, maximum value, minimum value, number of measurements obtained and the last measurement taken during the first...
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Báo cáo y học: "A descriptive report of management strategies used by chiropractors, as reviewed by a single independent chiropractic consultant in the Australian workers compensation system" ppsx
Ngày tải lên :
13/08/2014, 14:20
... philosophical approach to management that is driven by the provision of manipulative therapy as a monotherapy rather than as a therapy that is a component part of a multimodal approach to management ... static as was the case in the majority of cases, the role of active therapy, psychosocial variables or whether change had occurred in the delivery of the passive therapies was discussed and or ... identifying information of the injured workers and practitioners was omitted from the database Data tabulated and analysed for trend included the type of management, how it had changed over time and...
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Báo cáo y học: "Research Glucose sensing in the pancreatic beta cell: a computational systems analysis" ppsx
Ngày tải lên :
13/08/2014, 16:20
... results in depolarization of the plasma membrane, influx of extracellular Ca2+ through the voltage-gated Ca2+ channels, a sharp increase in intracellular Ca2+ and activation of protein motors and kinases, ... but another factor is an increase of this rate with increased substrate concentration (NADH) (Equation 5A) Increasing the electron transport rate simultaneously with Ψm means that the enhancement ... decrease as a result of decreasing [ADP]c following a step increase in glucose As a result, ATP synthesis and respiration rate increase despite decreased [ADP]c and the ATP/ADP ratio increased with a...
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BÀI TẬP ANH 12 CÓ ĐÁP ÁN UNIT 8 LIFE IN THE FUTURE
Ngày tải lên :
08/06/2015, 18:10
... been asked to make a record C She is such a good danner that she has been asked to make a record D She is such a well dancing that she has been asked to make a record Mark the letter A, B, C, or ... for us to finish 12 She sings so well that she has been asked to make a record A She is such a well dancer that she has been asked to make a record B She is such a good dancing that she had been ... drought A B C D 30 Education and training are an important steps in getting the kind of job that you would like to have A B C D PRACTICE TEST Read the following passage and mark the letter A, B, C or...
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FUNCTION AND REGULATION OF CALCIUM INDEPENDENT PHOSPHOLIPASE a2 IN THE ATTENUATION OF PAIN IN MICE
Ngày tải lên :
09/09/2015, 08:15
... neuroinflammation and pain (Yacoubian and Serhan, 2007; Nakamoto et al., 2010; Xu et al., 2013) Pain According to the International Association for the Study of Pain (IASP), pain is defined as an ... of the neck, head, face and all of the intraoral structures (American Academy of Orofacial Pain and Okeson, 1996) The trigeminal nerve forms the primary sensory supply to the orofacial area and ... defined as “pain within the structures of the oral cavity and face, usually of a diffuse pattern” (Zwemer, 1998) Orofacial pain includes pain disorders that are linked with the hard and soft...
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Distribution and role of calcium independent phospholipase a2 in the brain
Ngày tải lên :
11/09/2015, 09:58
... stimulation of these enzymes results in a massive release of free fatty acids in brain, known as the Bazan effect (Bazan, 1970) In the early phase of ischemia, FFA accumulation was attributed to activation ... midbrain are very lightly stained with cPLA2α antibody; the hindbrain in contrast, contains many densely labeled nuclei The dorsal and ventral cochlear nuclei, the initial portions of the ascending ... functioning of the electron transport chain by maintaining the integrity of mitochondrial membrane cardiolipin and the mitochondria permeability transition pore (Gadd et al 2006) The mammalian brain...
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The winds of change an insight into ma in the renewable energy sector in 2009
Ngày tải lên :
06/12/2015, 23:15
... substantial growth in the sector over the last few years—climate change and energy security—remain as pertinent as ever The US, India and China are being targeted as key countries for investment in ... next year than have in the past year, particularly in the more established technologies of onshore wind and solar Finally, the very recession that is causing the sector so many problems may also ... figure for all of these is just 31 percent A year ago there were a lot of financial players chasing assets,” says Mr Flynn The PE guys don’t have the money any more, and the banks are being a lot...
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Methanol as an alternative transportation fuel in the US options for sustainable and or energy secure transportation
Ngày tải lên :
25/11/2016, 11:33
... Methanol can be manufactured from a wide range of feedstocks, such as renewables (biomass, including municipal wastes), coal (as in China), CO2 48 and natural gas In the US, the use of natural gas ... “methanol economy,” with methanol as a CO2 neutral energy carrier [Olah] Initial interest in methanol was not in its role as a sustainable fuel, but as an octane booster when lead in gasoline was ... blending with methanol) [Li] The adoption of methanol as a transportation fuel in China has lagged the use of methanol in some of its provinces, mainly because of the attitude of the Central Government...
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Báo cáo khoa học: "Impact of computerized physician order entry on medication prescription errors in the intensive care unit: a controlled cross-sectional trial"
Ngày tải lên :
25/10/2012, 10:39
... data, statistical analysis and drafting of the manuscript BC was responsible for data acquisition, analysis of the data, and drafting of the manuscript JD was responsible for conceiving the study, ... out of the medical and nursing file and the laboratory data Renal function was noted for every patient and renal failure was defined as calculated creatinine clearance less than 50 ml/minute The ... study, statistical analysis and critical revision of the manuscript AS, KV and HR were responsible for critical revision of the manuscript All authors read and approved the final manuscript Acknowledgements...
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Estimation of Proper Strain Rate in the CRSC Test Using a Artificial Neural Networks
Ngày tải lên :
22/03/2013, 15:01
... involved gathering the data for use in training and testing the neural network A large training data reduces the risk of under-sampling the nonlinear function, but increases the training time ... preconsolidation pressure ratio are LI and strain rate as shown in Fig In order to verify the reliance of the ANN model, the measure value, which have not been included in database, are also inferred ... to verify the applicability of MANN model, a total of 46 data of the consolidation test results are used 43 learning data are used for training the ANN model, and the others are used for the...
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Tài liệu Hyperlink from a Row in the Data Grid to a Detail Page ppt
Ngày tải lên :
21/01/2014, 12:20
... the Columns tab and set the properties as displayed in Figure 5.14 Be sure to note the name of the form you are calling in the URL Format String so that you can name it the same in step Add the ... and run the Visual Basic NET-Chapter solution From the main page, click on the hyperlink with the caption How-To 5.8: Hyperlink From a Row in the Data Grid to a Detail Page You then see all the ... grab the productID that was passed from the first form The dtProdIndiv data table is filled, and the individual column information is loaded into the text boxes Listing 5.31 wfrmHowTo5_8b.aspx.vb:...
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