conduct in market surveillance to confirm efficacy and safety

... ± 69 days, and with a mean final dose of 15.3 ± 11.2 led to a 47% discontinuation (17% due to inefficacy, 10% patient choice and 20% due to adverse events) and to 27% response including 13% remission ... Pharmacokinetics and tolerability of intramuscular, oral and intravenous aripiprazole in healthy subjects and in patients with schizophrenia Clin Pharmacokinet 2008, 47:475-485 Findling RL, Kauffman ... patients of whom 78 were randomised to intramuscular aripiprazole 9.75 mg per injection, 78 to 15 mg per injection, 70 to intramuscular lorazepam mg per injection and 75 to intramuscular placebo...

Ngày tải lên: 08/08/2014, 23:21

... in ABA-independent manner and exhibits continuous induction during dehydration and freezing treatment [21] In tobacco, a WRKY transcription factor is specifically induced during a combination ... sensitivity as indicated by significantly increase in inhibition of germination in the overexpression line relative to that of wild type (Figure 1C) Increased inhibition of germination in the WRKY60overexpressing ... proteins may form a range of protein complexes with distinct DNA-binding and transcription-activating or -repressing activities The complex pattern of DNA binding and transcription regulatory...

Ngày tải lên: 11/08/2014, 11:21

... controlling for protocol and baseline value and using the method of last observation carried forward (LOCF) Patients with a baseline and at least one post-baseline measure were included in all efficacy ... Randomized, double-blind month comparison of olanzapine and quetiapine in patients with schizophrenia and schizoaffective disorder with prominent negative symptoms and poor functioning J Clin ... fixed terms baseline weight, treatment week, protocol, investigator, race, and ethnic origin × treatment week Race P-value = 0.13 (the non-fasting studies) or “fasting and random combined”, where...

Ngày tải lên: 11/08/2014, 16:22

... (CPMP/ICH/135/95)5, and the principles of the Declaration of Helsinki, local drug law and standard operating procedures of the investigator, sponsor and CRO involved The study protocol and attached ... participants agreed to refrain from taking any other medications intended to prevent, intervene with or treat coughs/colds/flu-like symptoms, starting with study entry and continuing through day ... disturbing or irritating), = moderate (symptoms sometimes disturbing/irritating), = severe (symptoms disturbing/irritating most of the time) This scoring system was developed by Jackson in 1958 and...

Ngày tải lên: 12/08/2014, 11:22

... co-ordinating study investigator and SIR, AA, PC, HM, LF, JFD, EDB and NJG were study investigators All study investigators, CC and EGG made substantial contributions to the conception and design ... Competing interests PWJ has received fees from a number of pharmaceutical companies, including Almirall, for speaking at meetings and for consulting and participating in advisory board meetings, and ... (baseline) and at Weeks 12, 28, 44 and 52 using the St George’s Respiratory Questionnaire (SGRQ; self administered) and Baseline/Transitional Dyspnoea Index (BDI/TDI; administered by an independent...

Ngày tải lên: 12/08/2014, 13:22

... spirometers and their use, including calibration, had to meet the American Thoracic Society's criteria [16] Spirometry training was given prior to initiating the study and a repeat training session ... patients predominantly from secondary care clinics with moderate -to- severe disease according to the National Institute for Health and Clinical Excellence (NICE) guidelines [2] and severe -to- very severe ... following the intent -to- treat principle – i.e randomised patients with both baseline data and data following multiple doses of randomised treatment – for PFT and diary cards (DIARY) Missing data...

Ngày tải lên: 12/08/2014, 15:20

... patients in the studies analyzed To put this evidence of clinical efficacy into context, it is also important to take into account the costs and difficulties involved in implementing non-invasive ... first line intervention in ACPE patients is becoming mandatory • Although both techniques, CPAP and NPPV, showed similar efficacy in decreasing need for ETI and mortality, CPAP has been shown to ... preferred intervention in ACPE patients Finally, we think it is important for researchers in this field to create consensus guidelines over methods for reporting and defining population, interventions...

Ngày tải lên: 12/08/2014, 23:23

... Turin, Italy Sheep were transported to the laboratory at least two days before the experiment Anaesthesia was induced (thiopentone 10 to 15 ml/kg) and maintained (isoflurorane 0.8% to 2% and ... monitored and normothermia (38°C ± 0.5°C) was maintained throughout the experiment Saline, gelatine, and Ringer's lactate were provided for fluid replacement; low infusion rates of dopamine (2 to ... in ventilatory setting were made during the treatment A bolus of 2,000 UI of heparin was administered intravenously, followed by an infusion titrated to maintain ACT (activated clotting time)...

Ngày tải lên: 13/08/2014, 03:20

... that influence the pharmacokinetics in children and adolescents Pharmacokinetic parameter Influencing factors Absorption Gastrointestinal function (for example gastric emptying and intestinal ... rule" [18] Investigator initiated trials are rare in Europe [19] A new European Directive was implemented in summer of 2007 to increase drug safety also for minors Thus, clinical trials in minors ... additional information on the individual drug metabolizing capacity, and sometimes also information on drug efficacy, and if performed in combination with TDM, we expect further insights into the...

Ngày tải lên: 13/08/2014, 18:21

... delays occur when prices adjust only slowly to new information reaching markets due to the iliquidity and infrequent trading of stocks Since investor reactions are not immediate, serial correlation ... omitting dividends and not subsequently resuming them (subgroup 1), and the corporations omitting dividends and later resuming them (subgroup 2) is presented in Figures and 3, and in Tables and ... permission Finally, the relationship between changes in beta and changes in trading activity is analyzed The sample of dividend omissions is partitioned into quartiles according to changes in trading...

Ngày tải lên: 30/09/2015, 14:02

... Guideline on Opioid Dosing for Chronic Non-cancer Pain (CNCP) and increased monitoring is initiated (see Urine drug testing, page 8) Routinely assess function and pain status (see Tools for assessing ... their families Includes communication tools, coping skills, ten steps to managing chronic pain, and online forums and videos Information and resources about pain, online support, and information ... C: Tools for Assessing Function and Pain Pain intensity and interference In the last month, on average, how would you rate your pain? Use a scale from to 10, where is "no pain" and 10 is "pain...

Ngày tải lên: 22/03/2014, 16:21

... levels In order to define HN, in ACTHsecreting tumors, we used the dosage of ACTH serum as a parameter In GH-secreting, we evaluated the basal GH and IGF-1 and appropriate sex and age, in prolactinomas, ... acuity examinations The follow-up schedule included clinical examinations with ophthalmological and endocrinological evaluations and MRI of the brain and sellar region at 6-month intervals for ... or normalization and tumoral volume and marginal dose in our series However, Sheehan et al has found an inverse correlation between marginal dose and time to endocrine remission and a direct correlation...

Ngày tải lên: 09/08/2014, 09:20

... Cell based in vitro studies and in vivo experiments conducted in Sprague-Dawley rats suggest that 5Loxin® can inhibit proinflammatory cytokines such as tumour necrosis factor-α, interleukin-1β (unpublished ... in the clinical trial Evaluations of physical activity and pain scores, serum biochemistry, haematology, trial urine biochemistry and proinflammatory cytokines were done at baseline (day 0) and ... 5-Loxin® in OA in humans have been published Therefore, in the present double-blind and placebo-controlled clinical study, we sought to evaluate the efficacy and safety of 5-Loxin® in treatment...

Ngày tải lên: 09/08/2014, 10:23

Ngày tải lên: 16/03/2014, 03:20

... sustained remission (reaching a MADRS score of ≤8 and staying at ≤12) and response (achieving a 50% decrease in MADRS from baseline MADRS score), mean changes in the MADRS scores from baseline and ... 8 ≤8 Increase dose (20 mg to 30 mg or 30 mg to 35 mg) ... to investigate the efficacy, safety and tolerability of escitalopram in doses up to 50 mg in the treatment of MDD Methods Depression Rating Scale [9] (MADRS ≤8) or failed to tolerate the dose...

Ngày tải lên: 11/08/2014, 16:23

... desloratadine, ebastine, or fexofenadine to loratadine or cetirizine was mandated In addition, differences in efficacy and tolerability among agents can only be determined through head-tohead, ... relief of symptoms after switching to loratadine subsequent to fexofenadine failure than after switching to fexofenadine following loratadine failure [6] The Norwegian Health Agency conducted no ... experiences regarding efficacy, fatigue, and impact on work productivity and attendance after a mandatory switch from desloratadine, ebastine, or fexofenadine to cetirizine or loratadine Methods Between...

Ngày tải lên: 13/08/2014, 13:22

... it is interested in such questions as how many people are coming into the labour market, what are their education and training levels etc It is largely concerned in determining what training needs ... Due to changes in economic, political and social context in the age of globalization, there are now definitely new and growing linguistic needs and demands around the world in general and in Vietnam ... introduction Since 1986, with the open door policy, Vietnam has been integrating successfully into the world community and at the same time into the world market Due to economic, political and...

Ngày tải lên: 06/11/2012, 15:36

... critical thinking skills and inquiring attitudes • To review and summarize previous lessons • To nurture insights by exposing new relationships • To assess achievement of instructional goals and objectives ... There is no learning without teaching So as a tool in implementing teaching plans and achieving teaching goals, teacher talk plays a vital role in language learning Nunan (1991) points out that: ... literature, including: • To develop interest and motivate students to become actively involved in lessons • To evaluate students' preparation and check on homework or seatwork completion • To develop...

Ngày tải lên: 07/11/2012, 14:44

... rendering the meaning of a text into another language in the way that the author intended the text (p.5) According to him, translation seems to be simple: as one ought to be able to say something ... research With this topic, my research is conducted with the following purposes: First, researching metaphors in semantics and translation theory terms and finding the way to apply theory to practice ... metaphor, how to understand correctly its semantic implication, how to re-express it into the target language while reserving the original meaning, etc In addition, linguistic and cultural gaps...

Ngày tải lên: 26/11/2012, 09:53