concurrent chemoradiotherapy in head and neck cancer
Incidence and risk factors for acute kidney injury in head and neck cancer patients treated with concurrent chemoradiation with high-dose cisplatin
... cell head and neck cancer J Clin Oncol 2003;21:92–8 Bernier J, Cooper JS, Pajak TF, van Glabbeke M, Bourhis J, Forastiere A, et al Defining risk levels in locally advanced head and neck cancers: ... nephrotoxicity in patients with head and neck cancer receiving outpatient treatment with concurrent high-dose cisplatin and radiotherapy Am J Clin Oncol 2018;41: 432–40 23 Prasaja Y, Sutandyo N, Andrajati ... Cumulative cisplatin dose in concurrent chemoradiotherapy for head and neck cancer: A systematic review Head Neck 2016;38(Suppl 1):2151–8 Publisher’s Note Springer Nature remains neutral with
Ngày tải lên: 17/06/2020, 18:48
Progressive resistance training in head and neck cancer patients during concomitant chemoradiotherapy – design of the DAHANCA 31 randomized trial
... is integrated with extensive biological sampling and exploration into cytokines and mechanisms involved The current paper discusses decisions and methods behind exercise in head and neck cancer ... retrospectively at ClinicalTrials.gov (NCT02557529) September 11th 2015 Keywords: Head and neck cancer, Head and neck squamous cell carcinoma, Chemoradiotherapy, Progressive resistance training, Exercise, ... mitigated cisplatin-induced muscle wasting [17] Specifically, progressive resistance training (PRT) induces muscle hypertrophy in both healthy adults and cancer patients and definitely holds the
Ngày tải lên: 06/08/2020, 07:25
Nanoparticle based targeted therapeutics in head-and-neck cancer
... cigarette smoking in never drinkers, and the risk of head and neck cancer: Pooled analysis in the international head and neck cancer epidemiology consortium Journal Of the National Cancer Institute ... extracellular ligand-binding domain, a hydrophobic transmembrane segment, and an intracellular tyrosine kinase (TK) domain The extracellular domain provides a binding site for the endogenous ligand, epidermal ... Mclaughlin JK, Winn DM, et al Smoking And Drinking In Relation To Oral And Pharyngeal Cancer Cancer Research 1988; 48: 3282-7 Hashibe M, Brennan P, Benhamou S, et al Alcohol drinking in never
Ngày tải lên: 15/01/2020, 16:59
Dietary-phytochemical mediated reversion of cancer-specific splicing inhibits Warburg effect in head and neck cancer
... genes MeDIP in curcumin-PEC treated and control-PEC in H157 cells and qRT-PCR in respective genes relative to input ChIP in curcumin-PEC treated and PEC-control H157 cells using RNA Pol II and BORIS ... PKM protein expression and DNA methylation in HNC patients(a-c) PKM2 expression in HNC tumor samples extracted from (a) Cromer Head- Neck, (b) Toruner Head- Neck and (c) Ye Head- Neck cancer analyzed ... analyzed by using Oncomine database (d-e) shows the stage-wise expression of BORIS in (d) Ye Head- Neck and (e) Slebos Head- Neck cancer analyzed by using Oncomine database (f) Western blot showing the
Ngày tải lên: 17/06/2020, 18:58
Feasibility and acceptability of combining cognitive behavioural therapy techniques with swallowing therapy in head and neck cancer dysphagia
... swallowing following chemoradiotherapy Support Care Cancer 2015; Cousins N, MacAulay F, Lang H, MacGillivray S, Wells M A systematic review of interventions for eating and drinking problems following ... with head and neck cancer Palliative & Supportive Care 2016;14(1):42–51 Lin BM, Starmer HM, Gourin CG The relationship between depressive symptoms, quality of life, and swallowing function in head ... well-being Patients liked the combination of talking, visualising issues using a whiteboard and other applied techniques, and concrete goal setting ‘Maybe it should be part of the initial journey and
Ngày tải lên: 23/07/2020, 23:44
MicroRNA-363 targets myosin 1B to reduce cellular migration in head and neck cancer
... cells against virally infected squamous cell carcinoma of the head and neck Cancer Res 2005;65(23):11146–55 10 Ragin CC, Taioli E Survival of squamous cell carcinoma of the head and neck in relation ... cellular migration in head and neck cancer and reveal the biological relationship between miR-363, myosin 1b, and HPV-positive SCCHN Keywords: Squamous cell carcinoma of the head and neck, Human papillomavirus, ... squamous cell carcinoma in a prospective clinical trial J Natl Cancer Inst 2008;100(4):261–9 52 Cmelak AJ Current issues in combined modality therapy in locally advanced head and neck cancer Crit Rev
Ngày tải lên: 22/09/2020, 23:35
Noncompliance to guidelines in head and neck cancer treatment; associated factors for both patient and physician
... standards and guidelines On the other hand, cancer patients are considered partners in decision making in order to incorporate individual perspectives and needs Moreover, patients are better informed ... decisions in head and neck cancer treatment differed between the treating physician and the patient Patients who received nonstandard treatment had a lower overall 3-year survival These findings should ... survival These findings should be taken into account when counselling patients in whom nonstandard treatment is considered Keywords: Head and neck cancer, Nonstandard treatment, Patient compliance,
Ngày tải lên: 28/09/2020, 10:03
Proteoglycan-based diversification of disease outcome in head and neck cancer patients identifies NG2/CSPG4 and syndecan-2 as unique relapse and overall survival predicting factors
... PG has been proposed to influence migration and invasion of oral squamous cell carcinoma cells in vitro by interacting with the β1 integrin subunit and the laminin β1 chain [48] NG2/CSPG4 has been ... cancer cell-host microenvironment interactions and by enhancing drug resistance and protecting cells from stress-induced programmed cell death [49,50] In an increasing number of tumours, prognostic ... extraction and qPCR Total RNA from healthy specimens and 119 neoplastic specimens were extracted using Trizol® according to the manufacturer’s instructions and in combination with Qiagen RNAeasy Mini
Ngày tải lên: 29/09/2020, 16:16
Diagnostic value of retrospective PET-MRI fusion in head-and-neck cancer
... imaging, PET-MRI fusion, Retrospective image fusion, Side-by-side analysis, Head- and- neck cancer, Staging Background Clinical examination and imaging is routinely performed for the staging of head- and- neck ... data; drafting and revising the manuscript LMR: analysis and interpretation of data; drafting and revising the manuscript TM: analysis and interpretation of data; drafting and revising the manuscript ... primary) (n = 4) in the head- and- neck region were included in the study All patients underwent clinically indicated preoperative contrast-enhanced MR imaging and 18F-FDG PET/CT imaging within 14 days
Ngày tải lên: 30/09/2020, 15:04
Tumor cells with low proteasome subunit expression predict overall survival in head and neck cancer patients
... F: In vivo imaging, tracking, and targeting of cancer stem cells J Natl Cancer Inst 2009, 101:350–359 22 Prince ME: Identification of a subpopulation of cells with cancer stem cell properties in ... of the developmental Notch signaling pathway links the CSC phenotype with the proteasome Musashi, a RNA binding protein crucial for maintaining Notch signaling, binds to the 3’-UTR of NF-YA mRNA, ... [33] and pancreatic cancer [34] Interestingly, in prostate cancer [35], breast cancer [16,36], and glioma [21,25] cells with low proteasome activity are radioresistant and patients with breast cancers
Ngày tải lên: 05/11/2020, 01:29
MicroRNA expression profile in head and neck cancer: HOX-cluster embedded microRNA-196a and microRNA-10b dysregulation implicated in cell proliferation
... targets: Moesin contributes to cancer cell proliferation and invasion in head and neck squamous cell carcinoma Biochem Biophys Res Commun 2012, 418(2):378–383 Lund AH: miR-10 in development and cancer ... predictive of head and neck squamous cell carcinoma Clin Cancer Res 2009, 15(8):2850–2855 Fletcher AM, Heaford AC, Trask DK: Detection of metastatic head and neck squamous cell carcinoma using the ... expression in head and neck squamous cell carcinoma promotes tumor growth and tumor angiogenesis PLoS One 2012, 7(5):e37601 Corney DC, Flesken-Nikitin A, Godwin AK, Wang W, Nikitin AY: MicroRNA34b and
Ngày tải lên: 05/11/2020, 05:32
focal overexpression of ceacam6 contributes to enhanced tumourigenesis in head and neck cancer via suppression of apoptosis
... contributes to cancer formation and its role in head and neck squamous cell carcinoma (HNSCC) remains unclear Therefore, we examined the role of CEACAM6 in head and neck squamous cell carcinoma (HNSCC) ... Saunders NA: Cisplatin treatment induces a transient increase in tumorigenic potential associated with high interleukin-6 expression in head and neck squamous cell carcinoma Mol Cancer Ther 2010, ... University of Queensland Diamantina Institute, Epithelial Pathobiology Group, Princess Alexandra Hospital, Queensland, Australia University of Queensland Diamantina Institute, Princess Alexandra Hospital,
Ngày tải lên: 02/11/2022, 10:46
Risk factors for aspiration pneumonia during concurrent chemoradiotherapy or bio-radiotherapy for head and neck cancer
... mass index (BMI), TNM staging defined by the American joint Committee on Cancer/ Union for International Cancer control staging classification (7th edition), tumor histology, the Brinkman index ... undergoing CRT or BRT Keywords: Head and neck cancer, Aspiration pneumonia, Chemoradiotherapy, Radiotherapy, Risk factors Background Radiotherapy (RT) plays a central role in the treatment of head and ... important side effects of chemoradiotherapy (CRT) and bioradiotherapy (BRT) in patients with head and neck cancer (HNC) Aspiration pneumonia can lead to cancer- related mortality in HNC patients However,
Ngày tải lên: 17/06/2020, 03:31
HSP90 inhibition sensitizes head and neck cancer to platin-based chemoradiotherapy by modulation of the DNA damage response resulting in chromosomal fragmentation
... Park HB, Park JY The Hsp90 inhibitor 17-(allylamino)-17demethoxygeldanamycin increases cisplatin antitumor activity by inducing p53-mediated apoptosis in head and neck cancer Cell Death Dis 2013;4: ... efficacy in conjunction with existing CCRT being the most likely route to clinical development [1, 2] HSP90 is a molecular chaperone involved in the initial folding and continued conformational maintenance ... standard-ofcare and support further preclinical and clinical studies in HNSCC Abbreviations CCRT: Concurrent- cisplatin radiation; CI: Confidence interval; DDR: DNA damage response; HNSCC: Head and neck
Ngày tải lên: 20/09/2020, 01:18
Gene-expression signature regulated by the KEAP1-NRF2-CUL3 axis is associated with a poor prognosis in head and neck squamous cell cancer
... alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk Int J Epidemiol 2010;39(1):182–96 Leemans CR, Braakhuis BJ, Brakenhoff RH The molecular biology of head and neck cancer ... altering tumor growth and drug resistance in HNSCC Page of 11 A very interesting recent study on the inhibition of NRF2, glutathione (GSH), and thioredoxin (Trx) in head and neck cancer (HNC) strongly ... alterations in the KEAP1 (Kelch-like ECH-associated protein 1)-NRF2 (nuclear factor erythroid like 2)-CUL3 (cullin 3) axis leads to tumorigenesis and drug resistance in many cancers including head and neck
Ngày tải lên: 23/07/2020, 23:49
New paste for severe stomatitis in patients undergoing head-and-neck cancer radiotherapy and/or chemotherapy with oral appliance
... stomatitis in patients undergoing head- and- neck cancer CRT and using oral appliances (dentures and PAP) Short-term use of the admixture paste for head and neck cancer with severe stomatitis resulted in ... and/ or chemotherapy (hereinafter referred to as “CRT”) for cancer in the head and neck region with severe oral stomatitis Radiotherapy for head and neck cancer has a nearly 100% risk of causing ... denture-wearing patients In patients with head and neck cancer, severe stomatitis may occur in both the oral cavity and in the pharynx The latter often causes contact/swallowing pain and thereby
Ngày tải lên: 24/07/2020, 01:55
Guidance on Cancer Services - Improving Outcomes in Head and Neck Cancers pot
... NHS National Institute for Clinical Excellence Guidance on Cancer Services Improving Outcomes in Head and Neck Cancers The Manual Improving Outcomes in Head and Neck Cancers Cancer service ... from head and neck cancers, are discussed in Improving Outcomes in Haematological Cancers.4 There are marked regional variations in the incidence of head and neck cancers, with rates ranging from ... “UAT cancer refers to the majority of cancers in this group; head and neck cancer will be used when all, including thyroid cancer, are being discussed Table 1a Registrations, incidence, and...
Ngày tải lên: 22/03/2014, 16:21
Báo cáo khoa học: "Early clinical experience with volumetric modulated arc therapy in head and neck cancer patients" ppsx
... radiathion therapy in head and neck cancers: an update Head and Neck 2007, 29:387-400 Popovtzer A, Eisbruch A: Advances in radiation therapy of head and neck cancer Expert Rev Anticancer Ther 2008, ... Marsh LH, Ship JA: Dose, volume and function relationships in parotid salivary glands following conformal and intensity-modulated irradiation of head and neck cancer Int J Radiat Oncol Biol Phys ... contoured by the planner and included as follow: spinal cord, brain stem, left and right parotids; larynx and uninvolved oral cavity were outlined whenever not heavily included in the target Whenever...
Ngày tải lên: 09/08/2014, 09:20
Báo cáo khoa học: " IMRT using simultaneously integrated boost (SIB) in head and neck cancer patients" pps
... Urba S, Lin A, Schipper MJ, Wolf GT: Recurrences near base of skull after IMRT for head- and- neck cancer: implications for target delineation in high neck and for parotid gland sparing Int J Radiat ... failure in patients receiving definitive and postoperative IMRT for head- and- neck cancer Int J Radiat Oncol Biol Phys 2003, 55:312-321 Puri DR, Chou W, Lee N: Intensity-modulated radiation therapy in ... neck cancer: preliminary results Head Neck 1997, 19:567-575 Buntzel J, Schuth J, Kuttner K, Glatzel M: Radiochemotherapy with amifostine cytoprotection for head and neck cancer Support Care Cancer...
Ngày tải lên: 09/08/2014, 10:20
Báo cáo khoa học: " Clinical-dosimetric analysis of measures of dysphagia including gastrostomy-tube dependence among head and neck cancer patients treated definitively by intensity-modulated radiotherapy with concurrent chemotherapy" pdf
... with head and neck cancer treated with radiotherapy J Clin Oncol 3776, 26:3770-2008 Rosenthal DI, Trotti A: Strategies for managing radiationinduced mucositis in head and neck cancer Semin Radiat ... regarding chemotherapy regimens and participated in manuscript writing DGF and QL performed dysphagia data collection including TNE and FEES, and delineation of swallowing structures KN and JC ... AA: An Intergroup phase III comparision of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer J Clin Oncol...
Ngày tải lên: 09/08/2014, 10:20