computational views of host and pathogen

... Limitations of current host- pathogen interaction verification approaches Due to the limitation of current known gold-standard host- pathogen PPI data and limited understanding of the host- pathogen ... a pathogen and its host This Chapter consists of the following parts: (i) host- pathogen PPI prediction; (ii) basic principles derived from analysis of known host- pathogen PPIs; (iii) host- pathogen ... depends on the performance of Dali in determining structurally similar pathogen and host proteins The availability of pathogen and host protein structures and the quality of host intra-species PPI...

Ngày tải lên: 10/09/2015, 09:08

... range of microbes, and which are not found in the host The chemical structures of PAMPs are conserved within a particular group of microbes, and the detection of PAMPs can thus indicate the type of ... Construction of bacterial and saccharide structures ……………… 2.1.4 Protein-protein and protein-ligand docking ……………………… 2.1.5 Identification of LPS-binding motifs ……………………………… 2.1.6 Design and synthesis of ... the assembly of PRRs to prompt the innate immune response 1.7 Structures of hCRP, TtCRP and LpCRP 10 1.8 The structure of TL-1 11 1.9 Oligomers of TPL-1 and GBP 11 1.10 An example of a beta-propeller...

Ngày tải lên: 14/09/2015, 08:38

... Higgins of the National Institute of Standards and Technology Office of Law Enforcement Standards; Jim Gass of the Oklahoma City Memorial Institute for the Prevention of Terrorism; and Andy Levinson ... Location and Type of Participating Organizations 2.1 Number and Average Size of Fire Departments and Number of Firefighters in 2000 13 2.2 Number and Average Size of Local Police Departments and ... qualitative nature of the input Because of the broad scope of the discussion protocol, the wide range of types of agencies and organizations included in the study, and the individual nature of the discussions,...

Ngày tải lên: 15/03/2014, 15:20

... knowledge of coral pigmentation is a prerequisite for these studies, and therefore we have analyzed in detail the origin of red fluorescent coloration of Faviina and Meandriina corals Results and Discussion ... coloration of M cavernosa and L hemprichii is due to GFP-like proteins and not caused by a fluorescent phycoerythrin The contribution of mcavRFP, EosFP and lhemOFP to the total content of soluble ... (cjarRFP), and L hemprichii (lhemOFP, EosFP) Fig S2 Contribution of zooxanthellae pigments to the visual appearance of M cavernosa Fig S3 Western blot analysis of purified cjarRFP, lhemOFP, mcavRFP and...

Ngày tải lên: 16/03/2014, 11:20

... (1) evidence and patterns of drought-disease interactions, (2) current understanding of processes and mechanisms, and (3) three well documented cases studies EVIDENCE AND PATTERNS OF DROUGHT-DISEASE ... Zealand, Chile and Australia [56], and in the Northern Hemisphere, e.g Northeast of the USA [158], East of China [178] and Europe [71, 97, 160] In most of these regions, an increasing number of ... latent endophytes of living trees and 606 M.-L Desprez-Loustau et al water stress is often only a revealer of their presence, by triggering host susceptibility and/ or releasing pathogen quiescence...

Ngày tải lên: 07/08/2014, 16:20

... Monatsberichte aus dem Messnetz Weidensaul T.C & of ozone and Darling S.L (1979) Effects sulphur dioxide on the host- pathogen relationships of Scots pine and Scirria acicola Phytopathology 69, 939-941 ... than that of uninfected control needles (Fig C and ozone D) Discussion Air pollutants, especially S-compounds are known to alter the structure of epicuticular waxes of conifers (Cape and Fowler, ... (Huttunen and Laine, 1983; Gunthardt-Goerg, 1986) Erosion of the epicuticular wax, both natural and that caused by air pollution, probably increases cuticular transpiration (Cape and Fowler, 1981) and...

Ngày tải lên: 09/08/2014, 04:20

... 36:1175-1183 Ingerslev HC, Cunningham C, Wergeland HI: Cloning and expression of TNF-alpha, IL-1beta and COX-2 in an anadromous and landlocked strain of Atlantic salmon (Salmo salar L.) during the ... 7:509-510 Takle H, Andersen O: Caspases and apoptosis in fish 2007, 71:326-349 Takle H, McLeod A, Andersen O: Cloning and characterization of the executioner caspases 3, 6, and Hsp70 in hyperthermic ... of the apoptosis machinery, cells undergo distinct morphological and biochemical changes, which include DNA fragmentation and condensation [19], blebbing of the plasma membrane and exposure of...

Ngày tải lên: 12/08/2014, 04:21

... perceptions of their disability and the social stigma attached to it A small body of literature was found using an electronic search of Medline and PsycINFO, a hand-search of key journals and by examination ... School pupils' views of schooling and awareness of needs 66 2.6.4.3 Methods and concluding comments 71 2.6.4.4 Young people with Down syndrome's awareness of disability and developmental ... consequence of being a member of a stigmatised group As a result of this review, Crocker and Major (1989) proposed that the symbolic interactionist account of Goffman (1963) was simplistic and did...

Ngày tải lên: 22/12/2014, 21:32

... include the increase of the thickness of the structure and of the stiffness of a spring attached to the structure (see Fig 9), respectively, and the reduction of the rise of the undeformed structure ... properties of asphalt 2.4 Rubber Materials and Products The treatment of rubber materials and products is characterized by a synthesis of experimental and numerical investigations and the consideration ... University of Technology The aim of this report is to demonstrate that Computational Mechanics of Materials and Structures is indeed a scientific field with many characteristics of an e-golem Computational...

Ngày tải lên: 02/06/2015, 17:15

... in various MOFs (IRMOF-1, IRMOF-3, IRMOF-1-4NH2, IRMOF-6, IRMOF-8, IRMOF-12, IRMOF-14, IRMOF-18 and IRMOF-993) and found that the larger linkers bind more H2 molecules and addition of NH2 or CH3 ... (left) and volumetric (right) isotherms of CO2 116 adsorption in IRMOF1, Mg-IRMOF1, Be-IRMOF1, IRMOF1 (NH2)4, IRMOF10, IRMOF13, IRMOF14, UMCM-1, F-MOF1 and COF102 Figure 5.9 Gravimetric (left) and ... and volumetric (right) isotherms of CO2 120 adsorption in COF-102, COF-103, COF-105, COF-108, COF6, COF-8, COF-10 and COF_NT at 300 K Symbols are from simulation and the lines are to guide the...

Ngày tải lên: 14/09/2015, 08:49

... occurs after the host cadaver decomposes and environmental spores are released Infection follows ingestion of spores by the filter feeding host The parasite reduces host survival and fecundity Its ... evidence of contamination The length of contigs averaged 320 bp (100 bp to a maximum of kb) The small size of most contigs resulted in the incompleteness of most ORFs identified in this study and, ... microsporidian phylogeny based on available - and -tubulin amino acid sequences and gains of ATP and ABC transporters Known genome sizes and number of transporters are shown Ent bieneusi tubulins...

Ngày tải lên: 09/08/2014, 20:20

... that modulate the host environment to the advantage of the virus while inhibiting host activities One of the most important interactions between virus and host is the modulation of host cell environment, ... Virus -host interactions In a coronavirus infection, the virus replicates in the host cytosol, amid a myriad of host signaling pathways and systems, interaction between the virus and the host systems ... 3.2: Band densities of MADP1 (normalized with band densities of actin for each cell line) in 16 cell lines classified by tissue of origin 163   ix List of Figures Figure 1.1: Schematic diagram of...

Ngày tải lên: 09/09/2015, 18:54

... perceptions and interprofessional relationships (5) Best practices and standardization of care Participants reported that standardizing care within professions may facilitate opportunities for interprofessional ... multidisciplinary focus group composed of both chiropractic and medical professionals The goals of the focus group were to explore the attitudes and experiences of medical and chiropractic clinicians regarding ... Treatment and prognosis; (3) Chest pain as a chronic, multifactorial, or comorbid condition; (4) Interprofessional coordination of care; (5) Best practices and standardization of care; and (6)...

Ngày tải lên: 25/10/2012, 10:06

... worked as a Professor and Head of department in the Department of Mechanical Engineering, Vidya Vikas Institute of Technology, Andhra Pradesh, India He has 14 years of teaching and research experience ... are larger than that of 400°CA and the eddy formed in right half of bowl is larger than that of left half of bowl At 400°CA, the shape of high temperature regions for baseline and adiabatic with ... Because of shortage of oxygen in the charge of cylinder in the EGR case, amount of burnt fuel and consequently accumulated heat release are less than the others Figure 10 shows the effect of insulation...

Ngày tải lên: 05/09/2013, 16:11

... apoptosis and induces the synthesis of antioxidants [22] Alterations in mitochondrial proteins, on the other hand, are specifically linked to one of the major pathogenetic mechanisms of PD [5] Worthy of ... spots were manually excised and destained (1 · 10 50 lL of K3[Fe(CN)6] 30 mm and Na2S2O3 100 mm; · 10 100 lL of deionized water; · 20 100 lL of NH4HCO3 200 mm; · 20 100 lL of deionized water), dehydrated ... each sample and data were processed using CellQuest software (Becton-Dickinson) Fluorescent emission of propidium iodide and Annexin V-FITC were collected through a 575 and a 530 ⁄ 30 bandpass filter,...

Ngày tải lên: 15/02/2014, 01:20

... details about pathogenesis of latent tuberculosis infection (LTBI) and TB disease are described in Figure 2.3 Figure 2.3 Pathogenesis of LTBI and TB Disease Area of detail for boxes 2, 4, and Droplet ... Chapter 2: Transmission and Pathogenesis of Tuberculosis 42 References American Thoracic Society and CDC Diagnostic standards and classification of tuberculosis in adults and children Am J Respir ... affect the concentration of M tuberculosis organisms (Table 2.3) Exposure Proximity, frequency, and duration of exposure (Table 2.4) Chapter 2: Transmission and Pathogenesis of Tuberculosis 22 Table...

Ngày tải lên: 15/02/2014, 12:20

... moves into the ÔupÕ position and interacts with the substrate and Glu144 This rotation of Asp142 is accompanied by removal of a water molecule and adjustments of Tyr10 and Ser93 that seem to compensate ... kinetic parameters of Y10F could not be measured at pH 9.0 due to enzyme instability At pH 8.0 Y10F showed a kcat of 0.55 and Km of 47.2 (compared to a kcat of 3.5 and a Km of 24.9 in the wildtype ... formed, and covalent bonds being formed and broken) Thus, the calculated effect of rotation of Asp142 on the pKa of Glu144 only gives an indication of what may happen to the acidity of Glu144...

Ngày tải lên: 07/03/2014, 14:20

... terms of durativity, and not of atomicity 498 John drank a glass of beer In (9), the development of the drinking event can be measured along the subparts of the glass of beer Each subpart of the ... formal, computational treatment of incremental non-atomic events A formal and computational treatment of incremental non-atomic events will be formulated here, relying on model-theoretic logics and ... University of Michigan, Ann Arbor, MI, April Caudal, P (1999b) Result Stages and the Lexicon : The Proper Treatment of Event Structure Proceedings of the 9th Conference of the European Chapter of the...

Ngày tải lên: 08/03/2014, 06:20

... a third of known species of this genus Regarding the effect of taxa sampling on the reconstruction of ancestral host use, most of our species are European, reflecting the most detailed host data, ... conservation of host use) using Permutation Tail Probability tests (PTP utility in PAUP*) These compare the number of host change steps in the actual tree with the number of steps observed in 10 000 randomized ... Fig Lines connect host plants with their specific parasitoids Fig Comparison of parasitoid and host (moth) phylogenies The host phylogeny is from Lopez-Vaamonde et al (2003) and the parasitoid...

Ngày tải lên: 14/03/2014, 16:20