compounds in the clinic
fragment based drug discovery and x-ray crystallography
... cysteine is introduced into a protein and used to capture fragments that bind in the vicinity, thus providing some information on the binding site It is also possible to measure fragments binding ... Pyridine Cyclohexane Pyrimidine N N 1,3,5-triazine H N Piperidine H N H N N N N Indole 1H-indazole N N Benzimidazole N Purine N N N Napthalene Fig (continued) Quinoline Isoquinoline N Quinazoline ... unstrained state Finally, the linker must not make any unfavorable interactions with the protein Given these difficulties, it is understandable that fragment linking has resulted in fewer clinical...
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Credit Growth and the Effectiveness of Reserve Requirements and Other Macroprudential Instruments in Latin America pdf
... deposit and lending interest rates These findings, more generally support the use of RRs as a policy instrument in an inflation-targeting regime in terms of their effectiveness in reinforcing monetary ... “lean against the wind”: (i) raising RRs during the upswing phase of the cycle to contain excessive credit growth and the associated build up of vulnerabilities and (ii) lowering them during the downswing ... borrowers in the economy, thus acting as a speed limit (see discussion below) In the downswing, they can ease liquidity constraints in the financial system, thus operating as a liquidity buffer.7 In...
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Assessing and Managing Rapid Credit Growth and the Role of Supervisory and Prudential Policies docx
... Lending booms coincide with a decline in inflation in most of the countries Inflation at the start of the lending boom is much higher in the crisis countries and declines sharply during the credit ... while the spreads remained wide in the crisis countries, they have contracted in the CEE countries during the build-up phase • For most of the countries in the sample, loans are also being financed ... values decline This reverses the financial accelerator, increasing the indebtedness of the borrowers, decreasing both their capacity to service their loans and their access to new loans These factors...
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Tài liệu Finance and the Sources of Growth pptx
... conditioning information A The conditioning information set The set of conditioning information is determined by the different theories of consumption The permanent income hypothesis focuses on an infinitely ... serial correlation at the 5% level when using the simple conditioning information set and at the 10% level when using the policy information set By including the private saving rate or lagged values ... In the case of the cross-section estimator, we reject the LM-test of overidentifying restrictions when using the simple conditioning information set However, when we expand the conditioning information...
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Tài liệu Ghost Wave - The Discovery of Cortes Bank and the Biggest Wave on Earth pptx
... immediately in its wake, and another “All the things you’re used to doing: taking in a lineup from the beach, measuring how far you’ve paddled according to the beach, duck diving, sitting on the outside ... leapt over the side and immediately started paddling across the two-hundred-yard gap between the boat and the wave The freezing water seeped through the seams in their wetsuits, inducing an involuntary ... lifted up right in front of you And everything was in motion the boat and the buoys—everything I remember just sitting out there after the set passed and thinking, We’re in another world.” As...
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Tài liệu The Economic Promise of Investing in High-Quality Preschool: Using Early Education to Improve Economic Growth and the Fiscal Sustainability of States and the Nation pptx
... of including the savings from reducing the victim cost of crime When only including the direct cost savings from reductions in criminal activity, the returns from Perry Preschool are more in line ... Other countries are also gaining ground in higher education The United States has slipped to ninth in the share of students enrolling in college.‡39 In short, the new global economy increasingly ... CED’s previous work in early education by providing the economic evidence that justifies increasing investments in preschool In the 40 years since CED first recommended investing in preschool, it...
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aggarwal and conroy-price discovery in initial public offerings and the role of the lead underwriter
... during the preopening because learning takes place If the indicative price ~Price t ! is the conditional expectation of the value of the stock ~pure learning!, then innovations in the preopening ... starts the process by entering the first quote in the five-minute preopening window These preopening quotes are not binding We find that this first quote is very informative and can explain a large ... with the identity of the market maker to examine the quoting behavior of the lead underwriter during the preopening period; the behavior of other market makers; the importance of the preopening...
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Three essays on the credit growth and banking structure of Central and Eastern European countries
... increases as the shift in the supply curve decreases the cost of borrowing The increase in financial The number of banks operating in the CEE countries and the share of foreign owned assets increased ... during the second half of the dataset The decline in the spread between the bank lending and borrowing rate, and the spread between the domestic and Euro area interest rate, is influential in the ... lending and borrowing rate and increases equilibrium borrowing in the country Greater competition in the banking system is helpful in improving financial intermediation and efficiency Financial intermediation...
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Flow and the Psychology of Discovery and Invention
... of the spectral analysis of the same galaxy obtained a year apart By comparing the faint spectral lines indicating the positions of stars in the two pictures, Rubin noted that some had moved in ... them the rising and setting of the sun, the wheeling stars, the alternating seasons Awe suffused their groping for a foothold in this mysterious world Then, slowly at first, and with increasing ... creativity is the field, which includes all the individuals who act as gatekeepers to the domain It is their job to decide whether a new idea or product should be included in the domain In the visual...
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Dissertation for doctor of philosophy in agriculture study on the growth and development ability of some imported soybean varieties and cultivation techniques for prospect variety in thai nguyen
... was the highest (2.75 tons/ha in module in winter and 2.83 tons/ha in spring) In Vo Nhai district, the yield module were 2.55 tons/ha in winter and 2.67 tons/ha in spring, the lowest yield in ... plants/m2 in winter At these densities, the EY was 2.78 tons/ha in spring crop and 2.47 tons/ha in winter; the AY was 2.50 tons/ha in spring and 1.90 tons/ha in winter, significantly higher than other ... 99084 - A28 in spring and winter crops in Thai Nguyen The table 3.22 showed that, in all spring and winter crops, the different densities resulted in different AY and EY In spring, the EY ranged...
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Báo cáo sinh học: "Of mice and men: phylogenetic footprinting aids the discovery of regulatory elements." doc
... http://jbiol.com/content/2/2/11 and the technique itself in this context has become known as ‘phylogenetic footprinting’ [15,16], a term inspired by the wet-lab technique of DNAse footprinting The reasoning behind the approach ... ConSite can either provide an existing alignment of two orthologous sequences or input just the sequences alone and the program will generate the alignment The program then scans the individual ... within a whole genome [29] It can be imagined that, with the emergence of more mammalian genome sequences in the near future, we can finally identify all the gene regulatory elements in the human...
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Báo cáo lâm nghiệp: "Evaluation of the growth and health status of selected clone mixtures in comparison with ordinary planting stock" docx
... alization started in the eighties, at the time of the culmination of air-pollution disaster In that period, within the programme of the gene conservation of indigenous forest tree species in the Krkonoše ... rooted cuttings of the 2nd generation The selection of individuals for further growing was performed on the basis of the complex evaluation of parent trees (the health status was the main criterion, ... both the individuals with intensive growth dynamics and the slow-growing individuals were selected for a subsequent mixture of clones) After their growing in a nursery they were outplanted in exposed...
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Báo cáo lâm nghiệp: " Effects of ectomycorrhizal inoculation and the type of substrate on mycorrhization, growth and nutrition of containerised Pinus pinea L. seedlings produced in a commercial nursery" docx
... only the growth of the seedling but also their physiological status by enhancing the photosynthetic capacity [11] and by increasing the uptake of water and nutrients, and their accumulation in the ... and on the fungus-tree combination used [4, 34] The spore inoculum of P tinctorius has been successfully used in previous experiments to produce containerised Pinus species, including P pinea [15, ... seedlings inoculated with R roseolus showed the highest levels of Mn in their needles (Fig 2f) For all inoculation treatments, the levels of Mn in needles were significantly lower in seedlings...
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Báo cáo lâm nghiệp: "Effects of light intensity on the growth and energy balance of photosystem II electron transport in Quercus alba " potx
... quenching with increasing actinic light The slope of this relationship gives a relative value of the ‘quenching shift rate’ [44] As growth irradiance declined, the ‘quenching shift rate’ increased ... RCD increased (p < 0.001) under all light levels At the beginning of the experiment, there was no difference in either RCD (p = 0.811) or HT (p = 0.310) Difference in RCD was first detected at the ... dividing ETR by 1-qP to obtain an approximate estimate of the conductance of the photosynthetic apparatus [44] The large drop in the ratio seen at low PPFD in FL plants and slightly evident in...
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Báo cáo lâm nghiệp:"Growth and biomass partitioning of Fagus sylvatica L. and Quercus robur L. seedlings in response to shading and small changes in the R/FR-ratio of radiation" pot
... respectively)) and the dry mass of the main stem (DMshoot) at the end of the experiment, the dry mass of the main stem at the start of the experiment and after 50 days was estimated using the following equations: ... where V2 is the value of the regarding variable at the end of the observed period and V1 at the beginning respectively In the present study the relative growth rates were calculated for the first ... RGDS in the second part of the growing period as well as in the total period indicates that the difference between the control and the shade treatments in height growth and stem dry mass increment...
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Báo cáo khoa học: "Effects of irrigation and nitrogen fertiliser on the growth and nutrient relations of Prunus avium L and ’Colt’ (Prunus avium x Prunus pseudocerasus) in the nursery and after transplantation" doc
... INTRODUCTION This report investigates the interaction nitrogen fertiliser and irrigation on the growth and nutrient relations of cherry seedlings and cuttings in the liner nursery and the ... Thus, differences in the total aerial dry matter weights of the types of cherry at the final harvest were mainly due to the initial differences in size at planting Irrigation increased dry matter ... transplantation in 1990 fertiliser applied in 1989 had no residual effect on the growth of the trees in 1990 Irrigation in 1989 caused an increase Nitrogen The irrigation of the transplanted trees in 1990...
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Báo cáo lâm nghiệp: "Response of shoot growth and gas exchange of Picea abies clones to rain acidity and the addition of ions" ppt
... also very similar as can be deduced from the slopes of = = = = = the curves in Fig 2a Relative growth rates (RGR) are plotted in Fig 2b The lines connecting the RGR values for different time periods ... one another, there were no clear differences between the treatments Similar results (not shown here) were obtained for top shoot growth of clones 1011 and 1019, the latter showing lower final lengths ... 4.8-5.7) and inflexion points on d 35-38 The growth of lateral shoots also did not show clear differences between the pH treatments = = acidity and the addition of the ionic mix- ture The effect...
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Báo cáo lâm nghiệp: "Effect of soil temperature upon the root growth and mycorrhizal formation of white spruce (Picea glauca (Moench) Voss) seedlings grown in controlled environments" doc
... for more of the variability in final caliper than did temperature The data suggest that caliper growth was greatest when seedlings were colonized by other species (P = = 0.09) The inoculation ... were measured prior to and after the treatment period The number of actively growing roots greater than cm in length was recorded when the seedlings were harvested These data were analyzed by Duncan’s ... doubtless had different physiologies interactions between inoculation and tem- maintained out-of-doors before the first trials; were stored at 2°C in darkness for the period Dec 87-May 88, a common...
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Báo cáo y học: "The discovery of potential acetylcholinesterase inhibitors: A combination of pharmacophore modeling, virtual screening, and molecular docking studies" pptx
... making hydrogen interactions with the active site containing Y72, Y124, Y203 and Y337 amino acids In the PAS, the benzyl ring forms another π-π interaction with the indole ring of W286 Despite the ... peripherical anionic sites Blocking the daul-binding sites has the advantages of both preventing the degradation of acetylcholine in the brain and inhibiting the pro-aggregating effect of AChE, thus, ... program The binding modes for the 252 compounds identified by virtual screening were ranked according to the information obtained by different scoring constraints The 154 highest scoring compounds...
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Báo cáo y học: "The discovery of the first human retrovirus: HTLV-1 and HTLV-2" doc
... cell leukemia depending upon clinical nuances Though IL-2 was supplied by us for them to use in their initial culturing of these cells, the cells rapidly immortalized An outstanding post-doctoral ... showing human sera with complement lysed animal retroviruses many investigators utilizing the co-culture system that involved cell lines, including one by me The usual problem was a cross contamination ... was succeeding in growing cells from human bone marrow, and was intensely nursing them daily for months But they were lymphocytes, not myeloid cells It was neither unique nor interesting to grow...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008