components of the neuronal snare complex and their function

... variants H1.1–H1.5 and Structure and function of the linker histone variants Location and structure of the linker histones Historically, the location of the globular domain of the linker histone ... overall number of these modifications is low, the density of modifications is much the same as in the rest of the linker histones It is the shortness of the N-terminal tails Table Alignment of chicken, ... referred to by their actual genomic position, as given in Swiss-Prot and similar databases PTMs of linker histones the entry and exit of the DNA Similarly, the geometry of one nucleosome in the fibre...

Ngày tải lên: 18/02/2014, 08:20

... few, often overlapping, essential cell functions and ⁄ or protein complexes (Fig 3A) In the following paragraphs we select a few examples from these clusters and describe their functions and the ... analysis of the contribution of key residues and their context to the global binding energy of all known eukaryotic linear motifs including the LC8 recognition motif also highlighted the importance of ... interaction What are the functions of the LC8 binding partners and what could they tell us about the cellular role of LC8? Apparently, LC8 is involved in a wide variety of functions Nevertheless, its...

Ngày tải lên: 14/03/2014, 22:20

... mice from the acute phase and two from the chronic phase) As was seen in the QD and B10.Q mice, more macrophages were observed in the acute than in the chronic stage aScore tion, and their heterozygous ... from to 5; see Materials and methods All control mice (n = 4) were scored at the same time, and mean values of their weight are presented R487 Inflammation and erosion of the cartilage were observed ... correlation between the titer of anti-matrilin-1 antibodies and clinical symptoms, in both the IL-10-deficient and the heterozygous mice Surprisingly, several of the IL-10 knockout mice, all of which were...

Ngày tải lên: 09/08/2014, 01:24

... alter the photosynthetic capability of their hosts The most well studied of the photosynthetic phage genes are psbA and psbD, which encode for the proteins D1 and D2 respectively The D1 and D2 ... they are homologues of host genes The most obvious of these is the collection of genes that are involved in altering or maintaining photosynthetic function of the host The most well studied and ... assess the contribution the genes make to the infection process There is also the related topic of evaluating the role of these phages as agents of horizontal gene transfer and assessing their...

Ngày tải lên: 12/08/2014, 02:20

... A ROLE FOR THE ENDOSOMAL SNARE COMPLEX AND TETHERS IN AUTOPHAGY A thesis submitted to the INSTITUTE OF MOLECULAR, CELL AND SYSTEMS BIOLOGY For the degree of DOCTOR OF PHILOSOPHY by Marianne ... Structure and function of SNARE proteins 32 1.2.2 Expression and localisation of SNARE proteins 34 1.2.3 The endosomal SNARE complex 34 1.2.4 Syntaxin 16 is the mammalian orthologue of ... investigated binding of the COG complex subunits to Tlg1, Vti1 and Snc2, the partner SNARE proteins of Tlg2 Direct interaction of Tlg1, the yeast orthologue of Syntaxin 6, with Cog1, Cog2 and Cog4 were...

Ngày tải lên: 22/12/2014, 21:44

... Vietnamese Design of the study The thesis is composed of three main parts as follows: Part I: Introduction (Background of the research) Rationale of the study Aims and objectives of the study Research ... progress From the above review on the studies of But, I suggested on the complementation of the dissertation tiltled “ A study on the linguistic features of the discourse marker BUT and their Vietnamese ... our express The part of grammar that concerns the structure of phrases and sentences is called syntax Part of the meaning of a sentence meaning is more than the sum of the meanings of words 1.2.1.1...

Ngày tải lên: 17/07/2015, 11:04

... results of the PhD thesis and their application in practice An overview and classification of the process of risk management of consumers and the factors influencing it (creating a logical model and ... directions, and on the basis of this, to create logical models and comprehensive tables On the other hand, the practical aim is to formulate recommendations based on the outcomes of the thesis for the ... of subjective risks is different from that of objective risks First of off, it is because they undervalue their own potential and responsibility n preserving their health - On the one hand, they...

Ngày tải lên: 19/12/2016, 12:14

... that the basic amino-terminal domain of TRF2 is important for binding of the ds/ssDNA junction and for the supercoiling of telomeric DNA, and may regulate the formation and stabilization of the ... within the telomere interactome The TRFH domains of TRF1 and TRF2 display distinct specificities and affinities for their targets, suggesting a new avenue of research for probing the function of ... members of the telosome and with a diverse array of proteins and protein complexes that are involved in the cell cycle and in DNA repair and recombination, to maintain telomere structure and length...

Ngày tải lên: 14/08/2014, 20:22

... spectroscopy of the interaction of PSBD and E3int Plots of the (A) 15N and (B) 1HN chemical shift changes between the [15N,1H]-HSQC spectra of free PSBD and the PSBD–E3int dimer (10 : 1) mixture as a function ... 2-oxoglutarate dehydrogenase complex of E coli [12] and of the dihydroacetyltransferase chain of the PDH complex of B stearothermophilus [13] The domain consists of two a-helices comprising residues ... was subsequently determined and compared with that of the PSBD in the crystal structure of the PSBD–E3 complex [28], thereby allowing a better estimate of the extent of molecular rearrangement...

Ngày tải lên: 16/03/2014, 18:20

... region and periphery of the Seto Inland Sea The location of the research area and the distribution of the citrus groves in Matsuyama region are shown in Fig Matsuyama is situated in Shikoku Island ... fruits is popular The ratio of the citrus groves to the total land use is more than 10% in Ehime alone Furthermore, it is reported that the pH of the grove soils is less than 4, and the soil contains ... kind of citrus called Iyokan is mainly cultivated There are two small streams on the upper part of the hill and the streams flow together from 47 m above sea level The water in the stream is the...

Ngày tải lên: 05/09/2013, 10:17

... requirements, requestives and advisories In fact, the complication and the diversity of the structures and the meaning nuances of SVs are clear Table 4.52 A Summary of Structures of ESVs and Their Vietnamese ... features of SVs in English and their Vietnamese equivalents It is hoped that the results of the study can help to raise the awareness of Vietnamese learners of English in terms of this kind of verbs ... linguists and researchers indicate the pragmatic features of SVs and their position in the sentence However, none of the above studies focus on the syntactic and semantic features of SVs in detail...

Ngày tải lên: 26/11/2013, 13:17

... only the reporter gene situated on the same side, relative to the boundary, of the construct However, when the combination of the PTS and the boundary is placed 3¢ to one of the reporter genes, the ... locate and physically approach their proper target promoter in the viscous environment of the nucleus Somatic pairing of chromosomes and the regulation of Abd-B A peculiarity of Drosophila is the ... later than in the case of the histone gene cluster [10] This difference in the timing of somatic pairing perhaps reflects the difference between the complexities of the regulation of the two systems:...

Ngày tải lên: 20/02/2014, 01:20

... steric clashes, the distance between the C-terminus of the RNase A in the first complex and the N-terminus of the RNase A in the second 334 ˚ complex is about A, i.e less than the distance that ... within the RATEs are catalytically active and that the activity decrease [16] is a result of the tandemization Accessibility of the linker of SGRSGRSG-RATE in the presence of RI The accessibility of ... ratio of : of RI and SGRSGRSG-RATE in the complex Analysis of the RI-binding stoichiometry by gel electrophoresis For verification of the : stoichiometry in the RI– RATE complex, RNase A and SGRSGRSG-RATE...

Ngày tải lên: 22/03/2014, 16:21

... residues of the LH1 a polypeptide in the organization of the LH1–RC complex [12] In the present work, we have investigated the possible involvement of the N-terminus and of the C-terminus of PufX ... PufXD2)7 neither affects the photosynthetic capability of the bacteria nor the efficiency of exchange of the ubiquinol molecules between the RC and the bc1, as judged from the reduction kinetics of cytochrome ... could influence the shortening processes of the assembled PufX protein The exchange of ubiquinone between the RC and the cyt bc1 in the presence of mutated PufX protein The role of the PufX protein...

Ngày tải lên: 31/03/2014, 09:20

... distances between the centroids of the digitized attachment areas on talus, calcaneus and fibula Once the position of the AJC was reproduced in the modeling software, the length of the ATFL and CFL was ... position of AJC motion There was no bony interference with the path of the ATFL and CFL The position of the AJC during MR scanning was defined as the neutral reference position The length of the ATFL ... However, the in-vivo behavior of these two ligaments is still not well studied To the best of our knowledge, no data has been reported on the elongation of the ATFL and CFL in-vivo The objective of the...

Ngày tải lên: 20/06/2014, 01:20

... sequence and PG2 (x) = PH2 (x), PG3 (x) = PH3 (x) Moreover, the characteristic polynomials of the pairs G7 , H7 , G11 , H12 and G12 , H11 differ only in their respective coefficients of x The list of the ... subgraph and its complement This is crucial to the proof of Theorem 3.1 Finally, the referee noted that the result from the title can be reformulated as follows: The eigenvalues and main angles of ... -1 -1 0 0 0 0 0 0 Table 1: Coefficients of the characteristic polynomials of the graphs of Figure and their vertex-deleted subgraphs 7 the electronic journal of combinatorics (2000), #R12 G • HH...

Ngày tải lên: 07/08/2014, 06:20

... the S character This last fact allows us to reject the hypothesis of a fundamental role of these pathogenic microorganisms in the control and transmission of the S character B of fitness of the ... bristles of S mothers This fact is further support for the maternal inheritance of this character of development The rate of development of the offspring of the measured during the same experiment ... for the pathogenic microorganisms in the SimES strain, and secondly, the results of the measures of some fitness parameters of the SimES strain free of these pathogenic microorganisms Finally, these...

Ngày tải lên: 09/08/2014, 22:22

... contributions SL and GF collected the data and reviewed the literature and case notes and was involved in followup appointments Furthermore, SL was involved in the active followup and workup of the patient ... either SNB or axillary node clearance (ANC) [2,3,6] Despite the lack of firm evidence about the safety of SNB, increasingly there is an acceptance of the technique and its use [2,6] Radiation therapy ... patient SL wrote the paper with the assistance of GF RAM reviewed and edited the initial manuscript DJH performed the initial operation, and organised the primary management plan of the patient He...

Ngày tải lên: 11/08/2014, 23:21

... cancer and 46 children of these women, were recruited for this study The demographic profile of the women and their children is given in Table and Table respectively More than two-third of the women ... designed the research project and drafted the manuscript TPK collected and processed the samples from the women with cervical cancer SBR collected and processed the samples from the children of the ... Thus, the positivity could be, in part, due to the sexual activities rather than transmission from the mother Similar to our results, Koch et al tested the presence of HPV in the anal region and the...

Ngày tải lên: 12/08/2014, 04:20