complexity uncertainty and their role in shaping management decisions

Tài liệu Báo cáo khoa học: The small heat shock proteins and their role in human disease pptx

Ngày tải lên : 19/02/2014, 18:20

... opaque with age and contain many inclusion bodies reactive with antibody to aB-crystallin, but not to b- and c-crystallin, suggesting an important role for aA-crystallin in maintaining lens transparency ... formation of huntingtin-containing inclusion bodies in Huntington’s disease encourages cell survival, whereas monomers and small inclusion bodies of huntingtin, a protein possessing abnormal polyQ ... aAcrystallin requires this domain [66] Attachment of R116C aA-crystallin to Hsp27 and aB-crystallin increases in comparison to wild type, while binding to cC-crystallin and bB2-crystallin decreases...

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Aggregate bankruptcy probabilities and their role in explaining banks’ loan losses doc

Ngày tải lên : 22/03/2014, 20:21

... and 20 and in Recycling (code 370) over 1996-2000 in county 19 For the corresponding years, there are no enterprises registered in the corresponding industries and counties, and submitting financial ... are found in the following industries: Agriculture and forestry (code 111) in 1990-1992, Raising of fish (code 051) in 1988-1993, Fishery (code 052) in 1988-1993, Publishing, printing and reproduction ... enterprises with debt in financial institutions in industry Transport via pipelines (code 603) in 1997 and in industry Private households with employed persons (code 950) in 1996, 1998 and 2000 Enterprises...

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Báo cáo khoa học: Arthropod nuclear receptors and their role in molting pptx

Ngày tải lên : 23/03/2014, 04:20

... also contain a carboxy-terminal extension containing T-box and A-box motifs [124] In each zinc finger, four invariant cysteine residues coordinate tetrahedrically to a zinc ion, and both zinc fingers ... overlapping ligand-binding pockets The difference of the binding pocket is easy to understand by looking at the superimposition between PonA and BYI06830 shown in Fig Ligand-binding affinity Typically, ... for retaining the ligand-binding activity They found two high-affinity binding sites (Kd1 = 0.24 nm and Kd2 = 3.9 nm) The removal of GST had no effect on PonA binding, but altered DNA binding The...

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báo cáo hóa học:" RAGE (Receptor for Advanced Glycation Endproducts), RAGE Ligands, and their role in Cancer and Inflammation" pptx

Ngày tải lên : 18/06/2014, 15:20

... but has role in shuttling HIPK2 (homeodomaininteracting protein kinase 2) to the cytosol Abundantly expressed in undifferentiated and proliferating embryonic cells but usually undetectable in adult ... that have distinct and often unapparent RAGEactivating properties S100 Proteins as RAGE ligands and their role in Inflammation A recent review on S100 proteins has been published, and provides ... to consider their role in cancer and inflammation S100 proteins are a family of over 20 proteins expressed in vertebrates exclusively and characterized by two calcium binding EF-hand motifs connected...

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báo cáo khoa học: "A Review of Metallothionein Isoforms and their Role in Pathophysiology" ppsx

Ngày tải lên : 09/08/2014, 01:24

... diabetic laboratory animals and in humans The above findings indicate that differences in the cellular availability of zinc in both insulin producing b-cells and in insulin target cells are associated ... on insulin signaling and coronary heart disease Insulin and zinc ions have potent stimulatory effects on lipogenesis and glucose uptake Zinc-deficient animals are less sensitive to insulin Zinc ... zinc The other is MT 1A, a member of a protein family that links zinc and redox metabolism Changes in the availability of zinc ions modulate insulin signaling and redox processes Both zinc and...

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báo cáo khoa học: " Expression of Ets-1, Ang-2 and maspin in ovarian cancer and their role in tumor angiogenesis" pps

Ngày tải lên : 10/08/2014, 10:21

... different roles in angiogenesis: Ang-1 and Ang-4 are agonist ligands for Tie2 and induce tyrosin phosphorylation of Tie2, while Ang-2 and Ang-3 are antagonist ligands They bind to Tie2 without inducing ... been fully investigated in ovarian cancer In the present study, we examined the relationship between the expression of Ets-1 and its targets Ang-2 and maspin in ovarian cancer and their clinical ... papillary cystadenocarcinoma; D: Ang-2 expression in ovarian borderline mucinous cystadenoma; E: Maspin expression in mucinous cystadenocarcinoma; F: Maspin expression in mucinous cystadenoma The...

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Báo cáo y học: " T4 genes in the marine ecosystem: studies of the T4-like cyanophages and their role in marine ecology" doc

Ngày tải lên : 12/08/2014, 02:20

... hyroxymethyl cytosine or that they glycosylate their DNA In addition all of the r genes in T4 that are known to be involved in superinfection and lysis inhibition [45] are missing in cyanophage genomes, ... in S-PM2, P-SSM4 and S-RMS4 speD encodes S-adenosylmethionine decarboxylase a key enzyme in the synthesis of the polyamines spermidine and spermine With polyamines implicated in the stabilising ... factor in T4 and is involved in the transcription of structural proteins [45] Homologues of the T4-genes g33 and g45 which are also involved in late transcription in T4 are all found in Clokie...

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Báo cáo y học: " Oxygen-regulated transcription factors and their role in pulmonary disease" pptx

Ngày tải lên : 12/08/2014, 18:20

... HIF-1 Hexokinase-1 HIF-1 Hexokinase-2 HIF-1 Insulin-like growth factor-2 (IGF-2) HIF-1 IGF-binding protein-1 HIF-1 IGF-binding protein-2 HIF-1 IGF-binding protein-3 HIF-1 Interleukin-6 NF-IL6 ... rats with hypoxia-induced pulmonary hypertension J Clin Invest 1995, 96:1823–1833 23 Morrell NW, Morris KG, Stenmark KR: Role of angiotensin-converting enzyme and angiotensin II in development of ... subunits in pulmonary artery smooth muscle cells J Clin Invest 1997, 100:2347–2353 Author’s affiliation: Institute of Genetic Medicine and Departments of Pediatrics and Medicine, The Johns Hopkins...

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Báo cáo y học: " Bench-to-bedside review: Toll-like receptors and their role in septic shock" pps

Ngày tải lên : 12/08/2014, 18:21

... This expanding IL-1R1-like family includes murine and human proteins, Drosophila (fruit fly) proteins, and a plant (tobacco) protein [7,8] In Drosophila, Toll is involved in the rapid and transient ... sections) Understanding the regulation of TLR expression will provide further insight into their tissue distribution and their role in combating infection There has been an initial report of ... (see Fig 3) Further evidence for the role of TRAF6 and NF-κB-inducing kinase in TLR4 signaling came from the study of TRAF6 and NF-κB-inducing kinase dominant-negative (DN) variants, which could...

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Báo cáo y học: "Psychosocial factors and their role in chronic pain: A brief review of development and current stat" ppsx

Ngày tải lên : 13/08/2014, 13:22

... respondent pain may eventually evolve into operant and persisting pain if the environment offers pain contingent reinforcement Pain behaviour may also be learned by observing "pain models" i.e., individuals ... the on-going evolution of the understanding of the non-physical aspects of pain has been applied to the areas of screening for, intervening in and predicting those at risk of developing into a ... central and dominant influencing psychological factors in the assessment for identification and intervention strategies Competing interests The author(s) declare that they have no competing interests...

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Bees and their role in forest livelihoods A guide to the services provided by bees and the sustainable harvesting, processing and marketing of their products

Ngày tải lên : 03/06/2015, 08:41

... Nectar-producing species in highland forests 10 Nectar-producing species in wooded grassland (savannah) 11 Nectar-producing species in arid and semi-arid land 12 Nectar-producing species in coastal plains ... trees In spite of this, the bees perhaps play a minor role as pollinators in the rain forest compared to their role in temperate forests, monsoon forests and savannah woodland In tropical rain forests, ... national and international networks, to find out about sources of training, markets, research findings, and raises their awareness of the industry and available opportunities Concerning financial...

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HCV functional genomic protein interactions with NS3 and their role in viral replication

Ngày tải lên : 16/09/2015, 17:12

... protein containing the RNA-binding motif reduces the strength of the interaction The NS3-NS3 interaction was also confirmed by co-expressing myc-tagged and flag-tagged NS3 in COS-7 cells and showing ... implicating its involvement in oncogenesis Taken together, most of the viral proteins interact and may affect the activities of host proteins in the long-term The understanding of the interplay ... activity (Levin and Patel, 1999), helicase mutants defective in self-interaction may be inactive for their unwinding activity because of their inability to from dimers or oligomers To investigate...

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Effect of muscarinic agents on sclera fibroblast and their role in myopia 1

Ngày tải lên : 17/09/2015, 17:20

... display a remarkable affinity to heparin and are also called heparin binding growth factors (HBGF) FGF-2 is an 18Kd protein consisting of 155 amino acids, and an isoelectric point of 9.6, without ... that growth factors, cytokines, integrins, antigens and G protein coupled receptors also utilise tyrosine kinase pathways to transduce intracellular signals (Zachary and Rozengurt 1992, Aoki et ... specific ligands and activate second transduction pathways Intracellular signals are transmitted by coupling of receptors to cytoplasmic guanine nucleotide-binding regulatory 15 proteins (G proteins)...

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Effect of muscarinic agents on sclera fibroblast and their role in myopia

Ngày tải lên : 17/09/2015, 17:20

... produced dark brown stain in apoptic nuclei) B Atropine 0.1 µM C Atropine µM D Atropine 10 µM E Atropine 100 µM Fig10A Immumocytochemistry of mAchR subtypes in human SF in culture Subtype selective ... corresponding to mAchR subtypes m1,m2,m4, and m5 identified in mouse sclera by immunoblotting Subtype selective antibodies bound to specific protein bands in mouse sclera extract Sepcific bands did ... Fig 8A Effect of atropine inhibiting SF cell proliferation in culture Chick SF were incubated with atropine Phase contrast photomicrographs were taken after 24...

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PHYTOCHEMICALS – A GLOBAL PERSPECTIVE OF THEIR ROLE IN NUTRITION AND HEALTH potx

Ngày tải lên : 28/06/2014, 11:20

... important alkaloids of plant origin include the addictive stimulants caffeine, nicotine, codeine, atropine, morphine, ergotamine, cocaine, nicotine and ephedrine (Fig 1) Amino acids act as precursors ... of saponins and these include: steroid saponins and triterpene saponins Saponins are soluble in water and insoluble in ether, and like glycosides on hydrolysis, they give aglycones Saponins are ... DNA-degradation in cancer Isothiocyanates and the indole-3-carbinols interfere categorically in the metabolism of carcinogens thus causing inhibition of procarcinogen activation, and thereby inducing the...

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Báo cáo y học: "Dynamic activation of bone morphogenetic protein signaling in collagen-induced arthritis supports their role in joint homeostasis and disease" ppsx

Ngày tải lên : 09/08/2014, 13:22

... staining pattern in mouse knee joint was influenced by disease severity Mild inflammation (Figure 5a) was associated with discrete BMP7 staining in the lining layer of synovium (Figure 5b) and in ... shown Severity scoring was done on sections stained with hematoxylin and eosin Boxes indicate areas that are magnified in BMP2 stainings Arrows indicate BMP2-positive cells in synovium Bars = ... BMP7 stainings Arrows indicate BMP7-positive cells in synovium, and arrowheads indicate BMP7-positive cells in articular cartilage Asterisk indicates gradual clearing of the synovial lining layer...

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báo cáo khoa học: " Functional analysis of B and C class floral organ genes in spinach demonstrates their role in sexual dimorphism" pdf

Ngày tải lên : 12/08/2014, 03:21

... recombination of the masculinizing and feminizing factors by chromosomal linkage and inversion The result is the establishment of sex determining superloci that allow for segregation of male and ... position -30 in the 5'UTR, (ACAAAAAAGG) position 1083 in the second intron, and (TCAAAAAAGG) position 3052 in intron We detected a single potential LEAFY binding site (CCATTGT) in the second intron ... genes in their native context SpAGAMOUS retains floral organ identity and meristem determinacy functions in spinach A single C class gene has been previously described in Spinacia oleracea and...

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Báo cáo y học: "Comparative analysis of transposed element insertion within human and mouse genomes reveals Alu''''s unique role in shaping the human transcriptom" pptx

Ngày tải lên : 14/08/2014, 07:21

... containing transposed elements tions are located within intronic sequences Alu in humans and B4 in mice have the highest ratio of insertions within introns (66%), whereas L1 and LTR both in human ... human and mouse have the lowest percentage of copies within introns (58% in human and 56% in mouse for L1, 44% in human and 52% in mouse for LTR) L1 and LTR exhibit a biased insertion in the ... TEs: 3.5% and 7.6% of the first and last exons in human coding genes contain TE insertions, as compared with 0.4% and 1.7% of first and last exons in mouse coding genes that contain TE insertions...

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Khóa luận tiếng anh PESTICIDE USE AND MANAGEMENT IN THE MEKONG DELTA AND THEIR RESIDUES IN SURFACE AND DRINKING WATER

Ngày tải lên : 26/11/2014, 14:31

... plants and animals, including human beings Humans may be exposed to pesticides directly by breathing in the chemicals while spraying or indirectly by drinking contaminated water or consuming foods ... waters are also monitored In this chapter, drinking water sources and the situation of drinking water supply in the Delta is presented Water using practice for drinking and selected pesticide residues ... Organochlorine insecticides comprising DDT and its metabolites and lindane were monitored in soil and sediment in representative agricultural areas in the north of Vietnam DDT was detected and its...

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The role of matrix metalloproteinases (MMP) and their inhibitor in influenza a virus induced host lung injury

Ngày tải lên : 13/10/2015, 16:41

... (SP), pro-domain (Pro), which contains a zinc ligating thiol (–SH) group, and catalytic domain, which contains a zinc ion (Zn2+) Hemopexin-like domains are essential in binding to tissue inhibitors ... injury in mice infected with the mouse-adapted Influenza A/Aichi/2/68 P10 (H3N2) virus 97-98 Increase in MMPs expression and activity and their role in influenza virus-induced host lung injury ... homogenates, expressed in pfu/µg protein 73 Immunostaining for detection of virus in lung sections counterstained with DAPI nuclear dye 74 Figure 4.5: Hematoxylin and Eosin staining of formalin-fixed mice...

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