complexes physiological role mechanism of action and regulation
Mechanism of action and binding mode revealed by the crystal structures of key enzymes in plants sugar metalbolic pathway
Ngày tải lên :
11/09/2015, 09:08
... docked-UDP ligand and the actual UDP ligand Superimposition of one docked-ADP ligand and the actual ADP ligand Superimposition of the catalytic regions of the open SPS-F6P complex (cyan) and the closed ... filtration profile of FRK Crystal of SeMet FRK 3.4 Sample diffraction pattern of SeMet FRK crystal 81 3.5 Crystal structure of HoFRK 85 3.6 Structure based sequence alignment of HoFRK 90 3.7 Stereo ... (magenta) Schematic diagram of the reaction between F6P and UDP-Glc in the binding cleft of SPS A schematic diagram of the reaction involving FRK and Fructose Top a) SDS-GEL image of purified FRK Bottom...
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Báo cáo y học: "Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action"
Ngày tải lên :
26/10/2012, 09:39
... mellitus High levels of free radicals and the decline of antioxidant defense mechanisms lead to damage of cellular organelles and enzymes, increased lipid peroxidation, and development of insulin resistance ... stroke, and diabetes, and plays a fundamental role in endothelial dysfunction associated with these diseases (1-6) Further, oxidative stress plays a major role in the pathogenesis of both types of ... effects on diabetes, hypertension and wound healing Presumably, one of mechanisms of action is its antioxidant activity The action of EPRT is to produce electrical pressure rather than an electrical...
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Tài liệu Báo cáo khoa học: Antifungal effects and mechanism of action of viscotoxin A3 docx
Ngày tải lên :
19/02/2014, 07:20
... generation of H2O2 in spores [9,15–18] In this work we have gained more information on the cellular targets and the mechanism of action of vis- cotoxins, by examining the interaction of VtA3 with ... monochromator, and Glan-Thompson polarizers using quartz cuvettes with continuous stirring of the suspension, bandwidths of nm for excitation and nm for emission, and excitation and emission wavelengths of ... 79 Analysis of the fungicidal effect of viscotoxin A3 M Giudici et al excitation and emission wavelengths were 360 ⁄ 425 and 362 ⁄ 450 nm for observation of the fluorescence of DPH and TMA-DPH,...
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Báo cáo y học: "Anti-inflammatory effects and possible mechanism of action of lupeol acetate isolated from Himatanthus drasticus (Mart.) Plumel." ppt
Ngày tải lên :
11/08/2014, 03:20
... neutrophils, and is a biomarker for inflammation Furthermore, to clarify the LA mechanism of action, we studied the participation of pentoxifylline, a PDE5 and TNF-alpha inhibitor, and morphine, a mu and ... pre-treatment of mice with LA (12.5 and 25 mg/kg, i.p) significantly reduced the volume (μL) of the edema in the 2nd (31 and 41%), rd (30 and 50%) and 4th (23 and 27%) hours after administration of dextran, ... light/dark cycle and food and water supplied ad libitum The experiments were carried out according to the Guide for the Care and Use of Laboratory Animals of the U.S Department of Health and Human Services...
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Báo cáo y học: "The triple combination of tenofovir, emtricitabine and efavirenz shows synergistic anti-HIV-1 activity in vitro: a mechanism of action study" pdf
Ngày tải lên :
12/08/2014, 23:21
... and by FTC-MP-terminated DNA and HIV-1 RT in the presence of EFV This study furthers our understanding of the mechanism of action for anti-HIV drug interactions and the efficacy observed for ... in the presence of EFV, which could play an important role in the mechanism of action for the synergistic effects of TFV+EFV and FTC+EFV combinations observed in cell culture and in HIV-1 RT ... Where and represent the individual action of drug or drug 2, while 1,2 represents the combined action of the drug combination The CI values of < 1, = 1, and > indicate synergy, additive effect, and...
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Discovery and mechanism of action study of anti viral compounds for dengue virus
Ngày tải lên :
10/09/2015, 15:51
... need to determine its mode of mechanism During the studies to determine the mode of mechanism of NITD770, host lipid rafts (as suggested by chemogenomic profiling data) and cholesterol were confirmed ... 68 3.2.4 Anti-viral activity of compound NITD448 73 3.3 DISCUSSION 75 A STUDY OF THE MODE OF ACTION OF NITD770, A SMALL MOLECULE INHIBITOR OF DENGUE VIRUS 79 4.1 INTRODUCTION ... activity profile of NITD770 in several assays 81 Table 4-2: Sequencing results of the genome of the NITD770 resistant viruses 91 Table 5-1: Effect of sterol inhibitors on DENV and HCV replicon...
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Characterisation of the effects and mechanism of action of rapamycin and genistein on acute myeloid leukemia using high throughput techniques
Ngày tải lên :
11/09/2015, 09:18
... comparison of transcriptome profiles of MV411 and THP-1 75 Figure 4.3 Hierarchical clustering of transcriptomic profiles of microarray data 78 Figure 4.4 Linear regression analysis of fold-changes of ... understanding the mechanism of action of drugs (Li, et al., 2007; Frolov, et al., 2003) (Nunoda, et al., 2007) Transcriptomic techniques can survey the expression levels of thousands of genes and ... transcriptomic and proteomic modulations caused by the drug Such a study would go a long way in illustrating the mechanism of action of rapa in AML in its totality and in expanding our cognizance of the...
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The mechanism of action of sprouty2 characterization of the interaction between sprouty2 and PKCdelta
Ngày tải lên :
14/09/2015, 14:06
... Inhibition of the Ras-ERK signaling pathway by Spry 29 1.6.6 Points of action of Spry 30 1.6.6.1 Upstream of Ras 30 1.6.6.2 Upstream of Raf 32 1.6.7 Regulation of receptor ubiquitination and endocytosis ... the point of receptor-ligand binding, upstream of Ras, upstream of Raf, and at the level of or downstream of Raf (Guy et al., 2003; Kim and Bar-sagi, 2004) The study conducted by Casci and colleagues ... representation of the Ras-ERK pathway induced by RTKs 1.3.1.3 The primary structure of Ras isoforms 12 1.3.1.4 Schematic representation of the primary structure of Raf 15 1.6.2 The structure and isoforms of...
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Tài liệu BIOCHEMICAL TARGETS OF PLANT BIOACTIVE COMPOUNDS A pharmacological reference guide to sites of action and biological effects doc
Ngày tải lên :
17/02/2014, 05:20
... tens of thousands of individual primary scientific papers and reviews describing the isolation, structural characterization, pharmacological effects and biochemical targets of thousands of plant-derived ... I DHpyrrole I THpyrrole), eserine (physostigmine) (Phe I DHpyrrole I THpyrrole) and eseridine (Phe I DHpyrrole I C4NO) Indican (3-(P-g1ucoside)indole)from Indigofera species (Fabaceae) and Po~ygonumtinctorunz ... chemistry of living things) This biochemical review provides a detailed background for understanding the nature and function of the targets of plant defensive metabolites and proteins The remainder of...
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Tài liệu Báo cáo khoa học: On the mechanism of action of the antifungal agent propionate Propionyl-CoA inhibits glucose metabolism in Aspergillus nidulans doc
Ngày tải lên :
19/02/2014, 16:20
... by the action of cycloheximide Cycloheximide binds to the 80S-subunit of eukaryotic ribosomes and prevents the initiation and elongation reaction of protein biosynthesis The mycelium of pregrown ... cell-free extract and water to a final volume of 980 lL The reaction was started by the addition of 20 lL of a 100 mM ATP solution (final concentration mM) and the reduction of NAD was monitored ... propionyl- Ó FEBS 2004 CoA and acetyl-CoA In the presence of both thioesters one might expect an accumulation of succinyl-CoA in the cell and a deadlock of further reactions of the citric acid cycle...
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Tài liệu Báo cáo khoa học: Unraveling the catalytic mechanism of lactoperoxidase and myeloperoxidase A reflection on some controversial features Elena Ghibaudi and Enzo Laurenti docx
Ngày tải lên :
20/02/2014, 02:21
... survey of the absorption features of MPO, LPO and their intermediates The absorption spectrum of MPO is characterized by an intense Soret peak at kmax ¼ 430 nm and weaker bands at 570, 620 and 690 ... enzymatic pathway, now abandoned O’Brien suggests its role is in the oxidation of physiologically relevant substrates, drugs and in the etiology of some pathologies [57] In the light of the work by De ... cycles of both LPO and MPO have unusual features with respect to the classical peroxidase mechanism and interactions with H2O2 In the light of the experimental data presented above, we offer the...
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Tài liệu Báo cáo Y học: Tissue factor pathway inhibitor A possible mechanism of action doc
Ngày tải lên :
22/02/2014, 04:20
... Scheme shows the reactions of the two-step mechanism of action of TFPI It is shown in the Appendix that Scheme is equivalent to Scheme I of [8] within the area of the applicability of the latter In ... values d and found the values of the hypothetical reactions separately The model of the inhibitory action of the Xa–TFPI complex on the enzyme–substrate complex (model 3) The reaction of X–VIIa–TF ... significant amount of the Xa–VIIa–TF complex The mathematical model has shown that the analysis of the inhibition curves of the Scheme A development of Scheme by addition of the reaction of the enzyme–substrate...
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Báo cáo khoa học: Branched chain mechanism of polymerization and ultrastructure of prion protein amyloid fibrils ppt
Ngày tải lên :
07/03/2014, 10:20
... Branched chain mechanism of polymerization consistent with the mechanism of branched-chain reactions Employing the theory of branched-chain reactions will greatly benefit our understanding of the prion ... strong dependence of the reaction rate on the volume or the shape of reaction vessel, the presence of a lag-phase, threshold effects and a strong dependence of the reaction rate on microimpurities ... used for extraction and purification of PrPSc involved sonication, treatment with detergents and, sometimes, freezing and thawing [49–51] All of these steps cause severe fragmentation of fibrils In...
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STANDARD ON INTERNAL AUDIT (SIA) 17 CONSIDERATION OF LAWS AND REGULATIONS IN AN INTERNAL AUDIT ppt
Ngày tải lên :
23/03/2014, 02:20
... provisions of the laws and regulations The Internal Auditor’s Consideration of Compliance with Laws and Regulations Obtaining an Understanding of the Legal and Regulatory Framework 22 As part of obtaining ... activities of the entity) by those charged with governance, management or employees of the entity Effect of Laws and Regulations The effect on the functioning of an entity of laws and regulations ... management and internal control system.” Compliance with laws and regulations is an inherent part of the functioning of an entity Since the role of an internal auditor is to carry out a continuous and...
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stenersen - chemical pesticides - mode of action and toxicology (crc, 2004)
Ngày tải lên :
03/04/2014, 12:11
... and toxicology Dose and effect The law of mass action tells us that the amount of reaction products and the velocity of a chemical reaction increase with the concentrations of the reactants This ... the law of mass action, and our knowledge of the nature of the chemical processes in organisms, we can condense biochemical toxicology to three sentences, and about seven types of reactions: ... inhibit synthesis of amino acids 81 5.2.1 The mode of action of glyphosate 81 5.2.2 Degradation of glyphosate 83 5.2.3 Selectivity 84 5.2.4 Mode of action of glufosinate...
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báo cáo khoa học: "Mechanism of action of lenalidomide in hematological malignancies" pptx
Ngày tải lên :
10/08/2014, 22:20
... before treatment showed decreased expression of the set of the genes Figure Mechanism of action of lenalidomide Mechanism of action of lenalidomide Various mechanisms by which lenalidomide achieves ... inhibition of apoptosis protein-2, increased sensitivity to Fas mediated cell death, and up regulation of caspase-8 activation, down regulation of caspase-8 inhibitors (FLIP, cIAP2), down regulation of ... transduction or a combination of all of these Figure summarizes the mechanism of action of lenalidomide as we know so far Future studies will assess these mechanisms as well as direct actions on the malignant...
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Chemical Pesticides: Mode of Action and Toxicology - Chapter 2 pptx
Ngày tải lên :
11/08/2014, 12:21
... 2.2.2 Dose and effect The law of mass action tells us that the amount of reaction products and the velocity of a chemical reaction increase with the concentrations of the reactants This means that ... and resistant flies and a mixture (50:50) of susceptible and resistant flies (a) Doses and responses on linear scales (b) Doses on log scale and responses on probit scale LD50), will be large and ... between dose or concentration of the toxicant and the severity of the symptoms is fundamental in toxicology By using the law of mass action, we get the following equilibrium and mathematical expression:...
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Chemical Pesticides: Mode of Action and Toxicology - Chapter 3 pps
Ngày tải lên :
11/08/2014, 12:21
... butachlor, and several others) and a group of fungicides referred to as phenylamides (metalaxyl, ofurace, and oxadixyl) They have similar structure and mode of action: O C CH2R’’ N R R’ R is often ... diafenthiuron, and dinocap 3.1.2 Synthesis of acetyl coenzyme A and the toxic mechanism of arsenic Acetyl coenzyme A (Ac-CoA) plays a central role in the production of useful chemical energy, and about ... may be derivatives of urea, s-triazines, anilides, ©2004 by Jorgen Stenersen Table 3.2 Site of Action of Some Mitochondrial Poisons Site of Action Compounds Toxic for Inhibition of acetyl-CoA synthesis...
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Chemical Pesticides: Mode of Action and Toxicology - Chapter 4 ppt
Ngày tải lên :
11/08/2014, 12:21
... proteins, and their function and versatility for insect control have yet to be elucidated 4.1 The mechanism of action of δ-endotoxins As mentioned, the δ-endotoxin (Cry protein) that makes up most of ... in cessation of feeding of Lepidoptera larvae and paralysis of the gut that retards the passage of food and allows the spores to germinate The larvae suffer a general paralysis and die Bt israelensis-treated ... from beach deserts and tundra, and may multiply in cadavers of insects and other animals Insecticidal activity does not correlate with the origin of the isolate, and many of them not seem to...
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