comparison of treatment effects between animal experiments and clinical trials

... of the effects of rough and smooth LPSs of E coli, both in the presence and absence of EDTA (Fig 1) The rate of oxidation was increased in the presence of the LPSs of both the smooth and rough ... fast phase of the reaction, but decreased the rate of the slow phase of oxidation in the presence of EDTA A comparison of rough and smooth LPSs of E coli and S minnesota in the presence of EDTA ... initial rate (Fig 5) A comparison of the effects of the rough and smooth LPSs of E coli and S minnesota on the oxidation of Hb A0 in the presence of EDTA revealed that the oxidation of Hb A0 was somewhat...

Ngày tải lên: 08/03/2014, 10:20

... position and relative intensity is very similar On the other hand, the intensity distribution of the diffraction peaks in the range of 32–35◦ can provide a clue to distinguish between triclinic and ... of (A) nitrogen and (B) oxygen They were observed with an Ar-ion laser excitation at 514 nm close to the wavenumbers of the strongest modes of monoclinic tungsten oxide The two bands at 270 and ... corner-sharing and two edge-sharing octahedral neighbors Each component consists of W 4f7/2 and W 4f5/2 doublet peaks with the spin-orbit splitting energy of 2.1 eV Fig 6A and B shows W 4f XPS spectra of...

Ngày tải lên: 20/03/2014, 13:11

... 2) A comparison of the keratome biopsies before and after transplantation showed that the number of CD3 seemed to increase and the expression of CD4 and CD8 Table 1: Immunohistochemical and histopathological ... both treatments compared to vehicle treated skin After three weeks of treatment the TCS was reduced by 84% and 61% by Daivobet® and calcipotriol ointment, respectively These clinical effects of ... excellent method for obtaining early clinical "proof -of- concept" for comparing several treatments and for exploring the mechanism of action of topical anti-psoriatic treatments in the relevant patient...

Ngày tải lên: 18/06/2014, 15:20

... dynamic screw and plate for intertrochanteric fractures of the femur J Orthop Trauma 2001, 15:394-400 Bess RJ, Jolly SA: Comparison of compression hip screw and gamma nail for treatment of peritrochanteric ... plus 5° of valgus of the femoral shaft axis Exaggerated walking kinematics of the left limb was simulated by ± 75° rotation of the actuator, which resulted in a 45° arc of flexionextension and a ... SH, Patel AD, Bircher M, Calvert PT: Fixation of intertrochanteric fractures of the femur: a randomised prospective comparison of the gamma nail and the dynamic hip screw J Bone Joint Surg Br...

Ngày tải lên: 20/06/2014, 01:20

... sulphur and amine-groups of the organoclay and of chain opening reaction of epoxy group in ENR 50 that participated in the vulcanisation reaction This leads to a lowering of the scorch time and cure ... (phr) Filter loading (phr) Figure 5: The effect of organoclay loading on tensile modulus M100 of NR and ENR nanocomposites Comparison of the Effects of Organoclay Loading 46 1.7 SMR L ENR 50 Modulus ... compared to NR, which resulted in more intercalation of rubber in between the intergalleries of the organoclay Comparison of the Effects of Organoclay Loading 3.4 48 Scanning Electron Microscopy...

Ngày tải lên: 07/08/2014, 14:20

... research center of GATA MMA of the Faculty of Medicine All animals received humane care in compliance with the European Convention on Animal Care and the study protocol was approved by the Animal Ethics ... conceived of the study, and participated in its design and coordination and helped to draft and performed the statistical analysis AFÇ carried out the macroscopic and microscopic studies HÇ, OY and ... restlessness), and when necessary, they received buprenorphine 1.3 mL, subcutaneously The animals were maintained in adequate cages and fed according to the protocol of the animal Page of quarters...

Ngày tải lên: 10/08/2014, 09:23

... groups and number of observation years for suicide victims and controls A majority of the suicide attempts were made in close connection to admission (often a cause of admission), 89% of the ... than controls and women repeat attempts more often than men and also more often make severe attempts Repetition and severity not appear to discriminate between suicide victims and controls for ... Committee, 1985 and 2003 Statistics A Poisson regression was used for comparisons between the age groups for 5-year intervals for suicide victims and controls by gender and between suicides and controls...

Ngày tải lên: 11/08/2014, 17:20

... fell between and on the scale would have low discretion managerial discretion Industries that fell between and on the scale would have medium managerial discretion, and those that fell between and ... grants and exercise prices, CEO age and tenure and CEO shareholdings were used as measures of CEO compensation while ROE was adapted as a measure of firm performance The results of the analysis of ... plans and policies established by the board of directors As the leader of the firm, the CEO has an astounding impact on the performance of the firm and many believe this to be the result of the...

Ngày tải lên: 11/09/2013, 11:44

... magnitude of traction forces and stability of FAs both depend on the flexibility of the underlying substrate [22,23], and thus, in recent years, researchers have focused on exploring the effects of substrate ... for understanding the processes of vasculogenesis (formation of new blood vessels) and angiogenesis (formation of vascular trees), especially as one of the current hurdles in the field of tissue ... kinase cascade, and proteolysis leading to apoptosis Activation of the NF-jB pathway leads to recruitment and activation of IjB kinase kinase; the phosphorylation and activation of IjB kinase by...

Ngày tải lên: 22/03/2014, 21:20

... superimposition of the 3D structures of kistrin [32] and cardosin A (Fig 8) The importance of both motifs and in particular their basic residues was further emphasized by the complete lack of interaction between ... terms of charge and is positioned at the tip of a loop and is therefore reminiscent of RGD sequences present in integrin-binding molecules because of its exposed location On the basis of these structural ... cells, the fundamental role of the RGD-mediated interaction between integrins and their ligands for the activation of essential signalling pathways in cell proliferation and growth has been well...

Ngày tải lên: 30/03/2014, 11:20

... distinguish between lemma identity, where only the word-stems of the constituents have to be identical, and wordform identity, which requires not only identity of the stems but also of their morphological ... subject and direct object are elided from the right-hand conjunct If modifiers that are neither lemma- nor wordform-identical, are placed in between subject and object—as in (16)—, then elision of ... hunter and [the hunter]s shot a hare In the theoretical framework by Kempen (2009) and its implementation for German and Dutch in ELLEIPO, the elision process is guided by constraints on lemma- and...

Ngày tải lên: 31/03/2014, 20:20

... Reproduced with permission of the copyright owner Further reproduction prohibited without permission Reproduced with permission of the copyright owner Further reproduction prohibited ... without permission Reproduced with permission of the copyright owner Further reproduction prohibited without permission Reproduced with permission of the copyright owner Further reproduction prohibited ... without permission Reproduced with permission of the copyright owner Further reproduction prohibited without permission Reproduced with permission of the copyright owner Further reproduction prohibited...

Ngày tải lên: 01/06/2014, 13:57

... BHRF1 of EBV and E1B19k of Adenovirus [19,20] On the other hand, viruses also developed proapoptotic mechanisms in the late stage of infection to break host cell and promote the spread of viral ... consist of both suppressors and promoters of apoptosis Four conserved domains within the Bcl-2 family of proteins have been identified through sequence comparisons and named as Bcl2-homology (BH) ... effect by HBV genome A, B, and C Flow cytometry analysis of apoptotic effect by HBV genome A, B, and C HepG2 cells were transiently transfected with HBV genome A, B, and C and incubated for 24 h...

Ngày tải lên: 18/06/2014, 18:20

... Health and Quality of Life Outcomes 2008, 6:89 areas of research insofar as they support a state (i.e., environmental) and trait (i.e., genetic) conceptualization of quality of life and to start ... revisions of the Hedonic Treadmill model create a more flexible and nuanced representation of what is changeable and what is fixed between and within people Refocusing may change chronic levels of happiness ... of the relationship between genes and quality of life, both genetic and quality -of- life research is hindered by a mono-disciplinary approach Few genetic researchers are working with quality -of- life...

Ngày tải lên: 18/06/2014, 19:20

... environment [6,7] The advantage of using VR in community, clinical and laboratory settings is that by virtue of its programmability, environments and the amount and type of feedback can be modified ... shoulder, cm above and cm to the left of the subject's hand The target was placed 31 cm in front of the shoulder, 12.5 cm above and 14 cm to the right of the initial position of the ball (Figure ... world activities of daily living [10] One of the factors that may decrease the real world relevancy of practice in the clinical setting is the lack of attention to the retraining of varied goal-directed,...

Ngày tải lên: 19/06/2014, 10:20

... BHRF1 of EBV and E1B19k of Adenovirus [19,20] On the other hand, viruses also developed proapoptotic mechanisms in the late stage of infection to break host cell and promote the spread of viral ... consist of both suppressors and promoters of apoptosis Four conserved domains within the Bcl-2 family of proteins have been identified through sequence comparisons and named as Bcl2-homology (BH) ... effect by HBV genome A, B, and C Flow cytometry analysis of apoptotic effect by HBV genome A, B, and C HepG2 cells were transiently transfected with HBV genome A, B, and C and incubated for 24 h...

Ngày tải lên: 20/06/2014, 01:20

... difference between the mini-posterior approach and the standard posterior approach weeks after implantation of hip endoprostheses [11,36] A weakness of this study is clearly the lack of any randomization ... conceived of the study, participated in its design and coordination and drafted the manuscript AM participated in the study and analyses of the study MSS participated in the design of the study and ... 20 hips and J.S 30 hips) who are both experienced surgeons and perform the operations in the same way, differing only in the length of the skin incision and the extent of the detachment of the...

Ngày tải lên: 20/06/2014, 04:20

... devastating conflict between unregulated possession of this kind of property and all the higher welfare of the community If we add to the railway the common city monopolies of lighting and transportation; ... political fact is the corruption of officials and legislators Think of a product so vital to the future as the forests; and then picture, if you can, the waste and despoiling of this strictly common wealth ... overwhelming part of the main and primary sources of wealth—mines, forests, water-power, oil deposits, and ground areas in large towns These are the sure nesting-places of monopoly, and therefore, of all...

Ngày tải lên: 28/06/2014, 17:20

... http://digitalcommons.ilr.cornell.edu/articles/404 Positive and negative information exposures and recruitment A comparison of the effects of positive and negative information on job seekers’ organizational attraction and attribute recall ... impact of positive and negative information (Hypotheses and 2), and the effects of a source and topic combinations, on job seekers’ organizational attraction (Hypotheses 3) was not a result of differences ... A Comparison of the Effects of Positive and Negative Information on Job Seekers’ Organizational Attraction and Attribute Recall Abstract To date there have been no direct studies of how...

Ngày tải lên: 07/07/2014, 10:38

... 154 C Hoff and S Rambal fall and leaf quantity [33, 43] Important then are the timing of rainfall and drought events, the quantity of rainfall, the storage capacity of the soil and quantity and ... relations between the LAI and both climatic and soil factors; (2) understand how the water and carbon balances behave as a function of water availability and LAI; and (3) define how the balance between ... function of the climate via precipitation and evapotranspiration requirements, but also as a function of the retention properties of the soil and of the rooting depth of the vegetation The range of...

Ngày tải lên: 08/08/2014, 01:21