common vehicles for nonclinical evaluation of therapeutic agents

... 1.4.1 In Vitro Evaluation of PLGA Nanoparticles for Paclitaxel Delivery Across 13 the Blood Brain Barrier 1.4.2 Gd-DTPA Loaded Nanoparticles of Biodegradable Polymers for MRI of 15 the Brain ... Nanoparticles of Biodegradable Polymers for MRI of 41 the Brain 3.2.2.1 Fabrication of nanoparticles 41 3.2.2.2 Encapsulation efficiency of Gd-DTPA 42 3.2.2.3 In vitro release of gadolinium 42 ... using nanoparticles to deliver across the BBB therapeutic agents for chemotherapy and contrast materials for medical imaging of the brain However, most of them were focused on using poly(butylcyanoacrylate)...

Ngày tải lên: 26/11/2015, 22:48

... Roukos, T Ward, and W Zhu 2001 Bleu: a method for automatic evaluation of machine translation In Proceedings of the 40th Annual Meeting of the Association for Computational Linguistics (ACL), pages ... quality of the models as a reference A direct formulation can be: KM,A (X) = P (QUEEN(m) > QUEEN(a)) According to this formula, the quality of a metric set X is the probability that the quality of ... rightmost part of the figure, peers are distributed around the set of models, closely surrounding them, receiving a high JACK value A Case of Study In order to test the behaviour of our evaluation...

Ngày tải lên: 17/03/2014, 05:20

... choice of the biased sampling method affects the performance of our procedure and its relations to uniform sampling 3.1 Corpora as unigram distributions A compact way of representing a collection of ... pairs is a value between and h, the length of the diagonal of the rectangle which is the union of A and B Instead of drawing pairs we can draw triples of points, one point from A, one from B, and ... be between and g, for approximately half of the points (those laying in the B region), while the distance is between and h for the other half of the points (those in A) Therefore, if m is large...

Ngày tải lên: 17/03/2014, 22:20

Ngày tải lên: 19/03/2014, 00:20

... Evaluation We had two groups of human judges The first group, called the monolingual group, consisted of 10 native speakers of English The second group, called the bilingual group, consisted of ... Human Evaluation Figure shows a linear regression of the monolingual group scores as a function of the BLEU score over two reference translations for the systems The high correlation coefficient of ... output of ChineseEnglish MT systems References E.H Hovy 1999 Toward finely differentiated evaluation metrics for machine translation In Proceedings of the Eagles Workshop on Standards and Evaluation, ...

Ngày tải lên: 23/03/2014, 20:20

... (Summary of the evaluation of existing reliability evaluation methods and Summary of the reliability evaluation of the non-standard test data sections) Hypothesis and endpoint Usefulness of proposed ... not reported by any of the four evaluation methods: date of start of the test; method of preparation of stock solutions; the recovery efficiency of the method; the limit of quantification in ... criteria/questions concerning endpoints and a summary of the evaluation results Evaluation method Evaluation criteria/question Type of criteria/mark Summary of evaluation results Klimisch et al Data on the...

Ngày tải lên: 21/06/2014, 03:20

... of “very good normal speech.” For the four raters of the OC patients there was no need to alter the Likert scale For both databases the mean score of all perceptual evaluations was computed for ... standardized perceptual evaluation of the individual handicap ASR will enable precise evaluations of speech and voice as a precondition for scientific purposes, for example, for outcome measurements ... computed for each of the raters using the respective other raters as reference, that is, the mean of the four other raters for the LE group and the three other raters for the OC group For the...

Ngày tải lên: 21/06/2014, 20:20

... restriction on the values of m, it is now possible to very easily obtain performance results for odd integer as well as noninteger values of m For convenience, we note here some of the key expressions ... perfect agreement between both expressions It is now of interest to inspect the accuracy of the PA for noninteger values of m For the sake of comparison, we revert to obtaining the MGF via Monte ... a new set of results for the cases of odd and noninteger values of the Weibull fading parameter The PA technique indeed proves to be an invaluable tool in the performance analysis of communications...

Ngày tải lên: 22/06/2014, 22:20

... complex (IDMC) to the fed pattern of the phase contractions after consumption of a meal The physical and chemical composition of the food determines the length of time before the IDMC pattern returns ... ultrasound for small intestinal motility evaluation in dogs mazine administered group, respectively The number of peristaltic waves in the xylazine HCl treated group was lower than those of the control ... control and fed group (p

Ngày tải lên: 07/08/2014, 14:23

... report the usefulness of D ultrasonography for measuring volume of cervical lymph nodes They found that a cut off volume of 0.7 cm3 had a 80% sensitivity and 90% specificity for differentiating ... Usefulness of ultrasonography for the evaluation of cervical lymphadenopathy World Journal of Surgical Oncology 2011 9:29 Conclusion We conclude that ultrasonographic examination of cervical ... any of the reactive lymph nodes Fusion tendency was found in 81% of tubercular, 66% of metastatic and 14% of lymphomatous nodes (p > 0.01) Significant differentiating feature among the types of...

Ngày tải lên: 09/08/2014, 01:24

... findings of the present study show the reliability of ST analysis using a DIA system for the evaluation of serial synovial biopsy samples before and after treatment This approach may be used for efficient ... methods for studying the ST are pivotal The use of computerized or digital image analysis (DIA) has greatly facilitated the evaluation of ST The major advantage of DIA is standardization of image ... exceeding the SDC), for CD3+ lymphocytes four of the 10 patients in the prednisolone group responded versus none of the nine patients in the placebo group; for CD38+ plasma cells four of the 10 patients...

Ngày tải lên: 09/08/2014, 06:23

... This means that each of the profiles was combined with its 'foldover' profile A foldover profile includes the exact opposite attribute levels of the original profile and, therefore, ensures a completely ... elsewhere [8] Therefore, we will now present the DCE method to the extent that the information is relevant for understanding of the present paper For more theoretical background information about ... users of the results and responsible for getting the research findings into practice Therefore, we asked respondents for their opinions about the feasibility of DCE In particular, we asked for...

Ngày tải lên: 11/08/2014, 05:21

... external evaluation of the initiative as a whole (which included support for the selfevaluations of each project) This paper describes the development of the protocol for the external evaluation ... arrangements for ownership and disclosure of data and results • strength of proposed strategies for quality improvement interventions and their evaluation • strength of proposed evaluation plan for quality ... in all aspects of the external evaluation Page of 12 (page number not for citation purposes) Implementation Science 2008, 3:46 The invitation to tender for the external evaluation of the EwQI The...

Ngày tải lên: 11/08/2014, 16:21

... This means that each of the profiles was combined with its 'foldover' profile A foldover profile includes the exact opposite attribute levels of the original profile and, therefore, ensures a completely ... elsewhere [8] Therefore, we will now present the DCE method to the extent that the information is relevant for understanding of the present paper For more theoretical background information about ... users of the results and responsible for getting the research findings into practice Therefore, we asked respondents for their opinions about the feasibility of DCE In particular, we asked for...

Ngày tải lên: 11/08/2014, 16:21

... particular, laboratory data for the use of TH in stroke, spinal cord injury and asphyxial cardiac arrest is very supportive of benefit of TH in animal models of these injuries [10,11] Fortunately, there ... support Task Force of the International Liaison committee on Resuscitation: Therapeutic hypothermia after cardiac arrest An advisory statement by the Advancement Life Support Task Force of the International ... Therefore, given that there is a sound scientific basis and likelihood of benefit, a proven low incidence of adverse events and a high morbidity or mortality rate with the injury, the use of TH...

Ngày tải lên: 12/08/2014, 20:20

... However, the role of biomarkers in the evaluation of patients in the ICU setting remains largely unexplored Because hemodynamic monitoring is a frequent theme in the evaluation of patients in the ... end-organ dysfunction or need for vasopressor or Page of (page number not for citation purposes) For each patient, ml blood was collected into a tube containing EDTA at the time of PAC placement Samples ... analyses for death as a function of NT-proBNP concentration were performed, using Analyze-it software (Analyze-it, Leeds, UK) Patients were categorized into quartiles using log-transformed NTproBNP...

Ngày tải lên: 12/08/2014, 23:21

... with other BG signals require the fulfilment of three conditions The first of these is consensus concerning the desired target BG range (and definitions of hypoglycaemia/hyperglycemia) The two landmark ... Second, the use of future reliable near-continuous glucose sensors will permit appropriate consideration of the time dimension in the indicator Accordingly, duration and magnitude of hypoglycaemic/hyperglycemic ... 2008 [6], was not evaluated by Eslami and coworkers [1]) are indispensable for adequate assessment of the overall level of BG control and are less complex than is sometimes claimed Indeed, the...

Ngày tải lên: 13/08/2014, 11:23

... model for animal i is y i = X i b + Z ia + Wih + i (1) where y i = (y i,1 y i, m )’ is a vector of phenotypic values of animal i for m traits, b is a vector of fixed effects, a is a vector of ... generated for each of the three true models Phenotypes of 50 progeny from each of 50 unrelated sires for two traits, yi = (yi, yi, 2)’ were simulated using equation (1) The vector of fixed effects ... http://(http://www.gsejournal.org/content/42/1/26) Page of 13 Heritabilities of simulated traits were h1 = 0.43 and = 0.53 , respectively For each animal i, li was for BN-∞ or generated from Gamma(ν/2, ν/2) for BSt - ν with ν = 4, 12 Offspring...

Ngày tải lên: 14/08/2014, 13:21

... can establish the uniformity of the shotcrete in a member Its’ major disadvantages are the need for access to two sides of the member and lack of information of the location of an apparent anomaly ... the use of such procedures has become common 1.3-Procedures for in-place evaluation of shotcrete have not been well developed or widely used This may be due to the lack of understanding of the ... Practice for Examination and Sampling of Hardened Concrete in Constructions C 900 Standard Test Method for Pullout Strength of Hardened Concrete C1117 Standard Test Method for Tiie of Setting of Shotcrete...

Ngày tải lên: 24/10/2014, 22:11

... improve their performance in the future Fifth, Coaching is aim to look for indications of good aspects of performance and to offer suggestions for improvement Therefore, the important information is ... performance scale 78 Figure 3.12 Overall performance scale of construction department 79 Master Degree Thesis in Management Implementation of Balanced Scorecard for Performance Evaluation of ... Management Implementation of Balanced Scorecard for Performance Evaluation of Construction Department – Phu Tho Tourist Co., Ltd xi LIST OF APPENDICES Appendix A: Validation of KPIs of Construction Department...

Ngày tải lên: 24/11/2014, 00:35