common inflammatory skin diseases

... Latvia Although skin diseases are officially recognised occupational diseases in Macedonia, currently none has been registered as such Skin diseases are the most frequent occupational diseases in ... Occupational skin diseases The data on occupational skin diseases was particularly defective For this reason, it was not possible to consider any effect of EU membership on the development of skin diseases ... occupational skin diseases was decreasing in half the countries (4 of 8) A similar experience was made in another study on occupational skin diseases in the European Union "The statistical data on skin diseases...

Ngày tải lên: 20/06/2014, 00:20

... produce extensive denudation of the skin (Fig 55-1) PV typically involves the mouth, scalp, face, neck, axilla, groin, and trunk PV may be associated with severe skin pain; some patients experience ... lesional or intact patient skin shows deposits of IgG on the surface of keratinocytes; deposits of complement components are typically found in lesional but not uninvolved skin Deposits of IgG on ... basement membrane, hence blister formation is within the suprabasal portion of the epidermis Lesional skin may contain focal collections of intraepidermal eosinophils within blister cavities; dermal...

Ngày tải lên: 07/07/2014, 01:20

... Tunisia Patients with PF have immunopathologic features in common with PV Specifically, direct immunofluorescence microscopy of perilesional skin demonstrates IgG on the surface of keratinocytes Similarly, ... lesional skin from these patients show varying combinations of acantholysis, keratinocyte necrosis, and vacuolar-interface dermatitis Direct immunofluorescence microscopy of patient skin shows ... macroglobulinemia, and Castleman's disease; the latter is particularly common among children with PNP In addition to severe skin lesions, many patients with PNP develop life-threatening bronchiolitis...

Ngày tải lên: 07/07/2014, 01:20

... lesional skin demonstrate subepidermal blisters and histologic features that roughly correlate with the clinical character of the particular lesion under study Lesions on normal-appearing skin generally ... BP from other subepidermal blistering diseases by routine histologic techniques alone Direct immunofluorescence microscopy of normal-appearing perilesional skin from patients with BP shows linear ... membrane of normal human skin in indirect immunofluorescence microscopy IgG from an even higher percentage of patients shows reactivity to the epidermal side of M NaCl split skin [an alternative...

Ngày tải lên: 07/07/2014, 01:20

... contraceptives Occasionally, infants of affected mothers demonstrate transient skin lesions Biopsies of early lesional skin show teardrop-shaped subepidermal vesicles forming in dermal papillae in ... Differentiation of PG from other subepidermal bullous diseases by light microscopy is difficult However, direct immunofluorescence microscopy of perilesional skin from PG patients reveals the immunopathologic ... including childhood; onset in the second to fourth decades is most common The disease is typically chronic Biopsy of early lesional skin reveals neutrophil-rich infiltrates within dermal papillae...

Ngày tải lên: 07/07/2014, 01:20

... Other patients with EBA have widespread inflammatory, scarring, and bullous lesions that resemble severe BP Inflammatory EBA may evolve into the classic, noninflammatory form of this disease Rare ... often associated with inflammatory bowel disease (especially Crohn's disease) The histology of lesional skin varies depending on the character of the lesion being studied Noninflammatory bullae ... (The inherited form is discussed in Chap 357.) Patients with classic or noninflammatory EBA have blisters on noninflamed skin, atrophic scars, milia, nail dystrophy, and oral lesions Because lesions...

Ngày tải lên: 07/07/2014, 01:20

... dermatomyositis from these two diseases Cutaneous changes may be similar in scleroderma and dermatomyositis and may include thickening and binding down of the skin of the hands (sclerodactyly) ... distribution may resemble the malar eruption of SLE Erythematous or violaceous scaling patches are common on the upper anterior chest, posterior neck, scalp, and the extensor surfaces of the arms, ... the erythema and scaling on the dorsum of the fingers in some patients with SLE, which spares the skin over the interphalangeal joints Periungual telangiectasia may be prominent Lacy or reticulated...

Ngày tải lên: 07/07/2014, 01:20

... hydropic degeneration of basal cells of the epidermis Direct immunofluorescence microscopy of lesional skin frequently reveals deposits of immunoglobulin(s) and complement in the epidermal basement membrane ... erythematosus showing prominent, scaly, malar erythema Involvement of other sun-exposed sites is also common B Acute cutaneous LE on the upper chest demonstrating brightly erythematous and slightly ... back, chest, shoulders, extensor surfaces of the arms, and the dorsum of the hands; lesions are uncommon on the face, flexor surfaces of the arms, and below the waist These slightly scaling papules...

Ngày tải lên: 07/07/2014, 01:20

... Scleroderma and Morphea The skin changes of scleroderma (Chap 316) usually begin on the hands, feet, and face, with episodes of recurrent nonpitting edema Sclerosis of the skin begins distally on ... taut skin over the nose, shrinkage of tissue around the mouth, and perioral radial furrowing (Fig 55-8) Matlike telangiectases are often present, particularly on the face and hands Involved skin ... of patients with scleroderma Skin biopsy reveals thickening of the dermis and homogenization of collagen bundles Direct immunofluorescence microscopy of lesional skin is usually negative Figure...

Ngày tải lên: 07/07/2014, 01:20

... 14870982] Braverman IM: Connective tissue diseases, in Skin Signs of Systemic Disease, 3d ed Philadelphia, Saunders, 1998 Mutasim DF et al: Immunobullous diseases J Am Acad Dermatol 52:1029, 2005 ... develop localized sclerodermatous skin changes, weight loss, and/or neuropathy (Chap 316) The precise cause of this syndrome, which may resemble other sclerotic skin conditions, is unknown However, ... depressed These skin findings are accompanied by peripheral blood eosinophilia, increased erythrocyte sedimentation rate, and sometimes hypergammaglobulinemia Deep biopsy of affected areas of skin reveals...

Ngày tải lên: 07/07/2014, 01:20

... other chronic inflammatory diseases including sarcoidosis, chronic hepatitis C and ulcerative colitis Furthermore, there was an abnormality of the IL-15–IL-15Rα system defined in diseases caused ... Abnormalities of IL-15 expression in inflammatory autoimmune diseases Opportunities for therapeutic strategies directed against IL-15 or its receptor IL-15 is a dangerous inflammatory cytokine that inhibits ... develop autoimmune diseases [16] In contrast, mice genetically deficient in IL-15 or IL-15Rα not manifest lymphoid enlargement, high concentrations of immunoglobulins, or autoimmune diseases; rather,...

Ngày tải lên: 09/08/2014, 01:23

... infiltrates and inflammatory lesions in patients with SLE after irradiation and in LE skin lesions To study the inflammatory response induced by a single dose of UVB irradiation, skin biopsies ... standard deviation (SD)]; four males, 11 females) were included Skin types were determined based on the Fitzpatrick skin typing chart [20] Skin type distribution (apart from two type or higher scores ... before and after irradiation and biopsies of LE skin lesions were assessed for the presence of inflammatory lesions and colocalisation with SBCs Inflammatory lesions were defined as the presence...

Ngày tải lên: 09/08/2014, 08:22

... supported by grant R01 AR45347 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases 20 References 21 10 11 12 13 14 15 Firestein GS: Invasive fibroblast-like synoviocytes...

Ngày tải lên: 09/08/2014, 08:22

... we directly compared the HRQoL of patients with three inflammatory rheumatic diseases The distribution of baseline PCS scores for all three diseases were shifted to the left of the distribution ... Although all rheumatic diseases evaluated were immune-mediated inflammatory disorders that share some pathophysiological characteristics, comparisons of patients with different diseases should always ... begin in adolescence Daily pain, stiffness, fatigue, and physical disability are common features of all three rheumatic diseases Persistent active disease without effective treatment may lead to permanent...

Ngày tải lên: 09/08/2014, 10:21

... TNFα-independent IL-7-driven inflammatory and bone-destructive activity [6,7] IL-7 is also able to regulate joint pathology by T cell-driven immune activation in the absence of a clear inflammatory response ... respect, the IL-7/IL-7R-stimulated pathology is a target of interest for the treatment of rheumatic diseases such as rheumatoid arthritis, osteoporosis and OA Competing interests The authors declare ... Exp Hematol 1996, 24:1521-1529 10 Weitzmann MN, Pacifici R: Estrogen deficiency and bone loss: an inflammatory tale J Clin Invest 2006, 116:1186-1194 ...

Ngày tải lên: 09/08/2014, 10:23

... daily practice Conclusions Inflammatory rheumatic diseases are generally diseases with variable presentation and, therefore, multiple outcomes are measured in most of these diseases Because of the ... developments in outcome measurement of rheumatic diseases started in RA and have been applied to other rheumatic diseases However, in rheumatic diseases in which multiple organ systems are involved, ... other rheumatic diseases, notably psoriatic arthritis and ankylosing spondylitis (Table 2) [20-23] In contrast to RA, where the target organ system may be defined as the joints, these diseases have...

Ngày tải lên: 09/08/2014, 14:22

... here are indicative of the importance of histone acetylation in the expression of inflammatory genes in inflammatory diseases, such as IBD Whether this is causal or downstream to activation of inflammation ... function and that pro -inflammatory cytokines are key factors in the pathogenesis of Crohn’s disease (CD) Activation of nuclear factor kappa B (NF-B), which is involved in pro -inflammatory cytokine ... butyrate decreases pro -inflammatory cytokine expression via inhibition of NF-B activation and IBa degradation [14,18,42] while it has also been demonstrated that NF-B induction of inflammatory gene...

Ngày tải lên: 11/08/2014, 03:20

... here are indicative of the importance of histone acetylation in the expression of inflammatory genes in inflammatory diseases, such as IBD Whether this is causal or downstream to activation of inflammation ... function and that pro -inflammatory cytokines are key factors in the pathogenesis of Crohn’s disease (CD) Activation of nuclear factor kappa B (NF-B), which is involved in pro -inflammatory cytokine ... butyrate decreases pro -inflammatory cytokine expression via inhibition of NF-B activation and IBa degradation [14,18,42] while it has also been demonstrated that NF-B induction of inflammatory gene...

Ngày tải lên: 11/08/2014, 06:22

... promising marker and therapeutic target in respiratory diseases The expression, regulation and clinical significance of sCD14 and mCD14 in pediatric lung diseases has not been defined Therefore, we quantified ... (exercise challenge) and ≥20% intraday peak flow variability, positive skin prick testing (wheal diameter of ≥3 mm to at least one common allergen), elevated total serum IgE (>150 kU/ml; IgE-Elecsys, ... localization and clinical significance of soluble and membrane CD14 receptors in pediatric inflammatory lung diseases sCD14 serum levels were specifically increased in serum of children with pneumonia...

Ngày tải lên: 12/08/2014, 11:21

... for immune-mediated diseases, the immune response to stress was different in patients and controls, and also differed between the various types of inflammatory rheumatic diseases Differences ... question whether inflammatory rheumatic diseases are related to a specific physiological stress responses profile Future studies of stress responses in patients with rheumatic diseases should ... with inflammatory rheumatic diseases compared with healthy subjects In contrast, there is evidence that immune function is altered by stress in a manner specific to different rheumatic diseases, ...

Ngày tải lên: 12/08/2014, 12:20