combining targeted agents and immunotherapies

... pain and/ or diarrhea Nausea and vomiting Fatigue Other side effects: Skin discoloration Hyperpigmentation of soles of feet and /or palms of hands may occur In most cases this has been mild and ... in significant and potentially life-threatening adverse effects Coadministration with anticonvulsants and antimycobacterial agents Certain anticonvulsants and antimycobacterial agents are not ... antibiotics (e.g., ciprofloxacin) and certain antifungals, such as ketoconazole and 44 Antiviral Agents itraconazole, require an acidic environment for absorption, and will be affected if administered...

Ngày tải lên: 10/08/2014, 00:21

... 1999 and is indicated for use in combination regimens with other 78 Antiviral Agents Fig 2.18 Trade names, structure, and uses of Amprenavir antiretroviral agents The chemical structure, brand ... M.N., and D.H Shepp 1997 Antiretroviral agents: Current usage Dermatol Clin 15:319–329 49 Sales, S.D., P.G Hoggard, D Sunderland, S Khoo, C.A Hart, and D.J Back 2001 Zidovudine phosphorylation and ... T Lengauer, J Selbig, A-M Vandamme, K Korn, and R Schmidt 2003 Tenofovir resistance and resensitization Antimicrob Agents Chemother 47:3478–3484 169 Gallant, J.E., and S Deresinski 2003 Tenofovir...

Ngày tải lên: 10/08/2014, 00:21

... transcription, and replication in viruses and a reason for the broad-spectrum attributes of ribavirin (208) Ribavirin significantly increases the mutation rate of RNA in poliovirus and 180 Antiviral Agents ... influenza and chronic hepatitis A and B (206,209,210) (Table 3.17) Treatment Ribavirin is usually prescribed as an inhalant for infants and small children Elderly patients, teenagers, and adults ... more severe liver disease and is more commonly found in Asian and Mediterranean countries The wild type also responds favorably to adefovir Brand name, chemical structure, and antiviral uses of adefovir...

Ngày tải lên: 10/08/2014, 00:21

... Brand, D S Barnes, W D Carey, A C McCullough, K Easley, N Boparai, and T Gramlich 2001 A randomized, double-blind controlled trial of interferon alpha-2b and ribavirin vs interferon alpha-2b and ... Wood, M J., R W Johnson, M W McKendrick, J Taylor, B K Mandal, and J Crooks 1994 A randomized trial of acyclovir for days or 21 days with and without prednisolone for treatment of acute herpes ... Collins, M Trowbridge, and G Darby 1998 Survey of resistance of herpes simplex virus to acyclovir in northwest England Antimicrob Agents Chemother 42:868–872 98 Patel, R., and S E Barton 1995 Antiviral...

Ngày tải lên: 10/08/2014, 00:21

... children and adolescents is selected states and regions and for certain high-risk groups; consult your local public health authority Children and adolescents in these states, regions, and high-risk ... causes other than Vaccines and Immunotherapies 325 hepatitis B, prisoners, users of illicit injectable drugs, and police and fire department personnel who render first aid) and all children aged 0–18 ... dog in Ghana Bats had been in house and landing on him as he slept Woke to find bat on hand and was bitten while killing it Removed bats from house with bare hands Exposure October 14 October 14...

Ngày tải lên: 10/08/2014, 00:21

... Hildebrand, K L Isganitis, H Matthews, W J Miller, P J Provost, R W Ellis, R J Gerety, and G B Calandra 1991 Varicella vaccine (VARIVAX) in Vaccines and Immunotherapies 377 healthy children and ... cytotoxicity, and cytolytic T cells (321) IgA and IgG are present in high concentrations and contribute to intracellular neutralization and cell lysis The antibodies can move through interstitial fluid and ... Cochi, and W W Williams 1990 Measles, mumps, and rubella vaccines Infect Dis Clin North Am 4:47–73 27 Centers for Disease Control and Prevention 1998 Measles, mumps, and rubella—vaccine use and...

Ngày tải lên: 10/08/2014, 00:21

... Giannakopoulos and Karkaletsis (2011), Conroy et al (2011), and de Oliveira (2011) Giannakopoulos and Karkaletsis (2011) created two character-based n-gram graph representations for both the model and candidate ... summary, X, and the BNG of the candidate summary, Y The ith entry in X is xi and has weight xW (analogously i W for yi and yi ) A similarity score s(xi , yj ) between all ngrams xi and yj w=0.1 ... derstanding Conference (DUC) and Text Analysis Conference (TAC) DUC and TAC also manually evaluated machine generated summaries by adopting the Pyramid method Besides evaluating with ROUGE/BE and...

Ngày tải lên: 07/03/2014, 18:20

... Abney and Light, 1999; Ciaramita and Johnson, 2000; Clark and Weir, 2002) Brockmann and Lapata (2003) compared some of the models against human judgements on the acceptability of sentences, and ... pairs into classes of verbs and nouns On the one hand, their model is asymmetric, thus not giving the same interpretation power to verbs and arguments; on the other hand, the model provides a more ... itself is the sum of the model length and the data length, with the model length defined as the number of bits needed to encode the model and its parameters, and the data length defined as the number...

Ngày tải lên: 08/03/2014, 01:20

... conjugated with fluorescin 5-isothiocyanate and PI Fluorescence emission of fluorescin 5-isothiocyanate and PI from single cells were separated and measured using the standard optics of the FACSort The CELLQUEST ... calculated by: SCA ¼ ðAr À AvÞ=ðFr À FvÞ where Ar and Av are the cAMP (or IP) of cells transfected with the mutant constructs and vector, respectively, and Fr and Fv are the corresponding mean fluorescence ... Gs-alpha and Gq-alpha and its binding characteristics and responsiveness to bTSH When two strong activating mutations of the TSHr gene (both possessing constitutive activity for both cAMP and IP...

Ngày tải lên: 08/03/2014, 08:20

... the ontology This mapping between words and ontology is generally to be built by hand Most of the time in transporting the lexicon is spent in identifying and building FLs Efficiently building ... ones; moreover we can also inspect its coordinated terms and assign the same label to of the 33 coordinate terms (and then to their direct and indirect hyponyms) Marking is equivalent to assigning ... current application and those associated to the possible synsets • integrate the Core Lexicon by adding, for each term: synonyms in the synsets, hyponyms and (maybe) hypernyms and some coordinated...

Ngày tải lên: 08/03/2014, 21:20

... 42 CDC agents and toxins to its current 82 CDC and USDA agents and toxins The current list includes 40 HHS-only agents, 10 overlap agents, and 32 USDA-only agents (24 animal pathogens and plant ... those biological agents and toxins that might be used as biothreat agents Policies and practices for work with biological select agents and toxins should promote both science and security Not ... those biological agents and toxins that might be used as biothreat agents Policies and practices for work with biological select agents and toxins should promote both science and security Not...

Ngày tải lên: 15/03/2014, 15:20

... (Ravi and Knight, 2011) The best performing methods in (Ravi and Knight, 2011) use the full 411 × 579 lexicon model and apply standard EM training Using a 2-gram LM they obtain 15.3 B LEU and with ... active set of translation candidates Based on the assumption that some of the active candidates and their respective probabilities are already correct, we induce new active candidates In the context ... assignment of translation candidates The optimal assignment would contain (time,Zeit) and (work,Arbeit) Training Algorithm and Implementation Given the model presented in Section and the methods illustrated...

Ngày tải lên: 16/03/2014, 19:20

... Romano L and Kouylekov M O and Szpektor I and Dagan I and Lavelli A 2006 Investigating a Generic Paraphrase-Based Approach for Relation Extraction Proceedings of EACL 2006 pp 409-416 Wyner A and van ... Web Corpus Proceedings of ECAI pp.581-585 Dagan I and Dolan B and Magnini B and Roth D 2009 Recognizing textual entailment: Rational, evaluation and approaches Natural Language Engineering (JNLE), ... to evaluate our task3 , we randomly selected a set of topics (reported in column Topics, Table 1) of Debatepedia debates, and for each topic we coupled all the pros and cons arguments both with...

Ngày tải lên: 16/03/2014, 20:20

... adjectives, and 81.9% of the adverbs directly exploited the use of SemCor augmented examples Combining SemCor and ExpandL seems to have a positive impact on the verbs and adverbs, but not on the nouns and ... scorer2 software to report finegrained (P)recision and (R)ecall and (F)-measure 5.3 Baselines We consider here several baselines A random baseline (RAND) is the most appropriate baseline for an unsupervised ... impact Combining SemCor with ExpandL yields the best results Observing the results yielded per POS in Table 1, ExpandL seems to have the biggest impact on the Nouns only This is understandable...

Ngày tải lên: 17/03/2014, 00:20

... Hansjorg Hauser and Didier ¨ ´ ´ ´ Trono (Ecole polytechnique federale de Lausanne EPFL, Lab of virology and genetics, Switzerland) for 4752 the supplied reagents We thank Sandra Manthey and Maria ... kinases JAK1 and tyrosine kinase (TYK2) are activated in response to ligand binding to the receptor, and these kinases phosphorylate signal transducers and activators of transcription STAT1 and STAT2 ... for pJAK1, JAK1, pTYK2 and TYK2, calnexin for pSTAT1, STAT1, pSTAT2, STAT2 and IRF9, in the cytoplasm and poly [ADP-ribose] polymerase for pSTAT1, STAT1, pSTAT2, STAT2 and IRF9 in the nucleus...

Ngày tải lên: 23/03/2014, 03:20

... MK–EN, and Pr(b|e) and Pr(e|b) for EN–BG, where m, e, and b stand for a Macedonian, an English, and a Bulgarian word Then, following (Callison-Burch et al., 2006; Wu and Wang, 2007; Utiyama and ... (Och and Ney, 2003) with standard settings and the growdiagonal-final -and heuristics to symmetrize the final IBM-model-4-based Viterbi alignments (Brown et al., 1993) The phrases were extracted and ... words, and we further appended special start and end characters We split the resulting list into training, development and testing parts and we trained and tuned a character-level MacedonianBulgarian...

Ngày tải lên: 23/03/2014, 14:20

... tn, and P(ti]tl-2ti-1) is the prob ability of seeing a part-of-speech tag tl given the two preceding part-of-speech tags ti-2 and ti-1 Equations and will also be used to tag sentences W and W ... handle multiple confusion sets by applying the same technique to each confusion set independently Each method involves a training phase and a test phase We trained each m e t h o d on 80% (randomly ... from Equations and 2: when comparing P(W) and P(WI), the dominant term corresponds to the most likely tagging; and in this term, if the target word wk and its substitute w~ have the same tag t,...

Ngày tải lên: 23/03/2014, 20:21

... into separate training and development sets The training set contained around 300K words, and 9752 instances of relations and the development set contained around 46K words, and 1679 instances of ... 24.9 23.6 Table 4: The F-measure and ACE Value for the test sets with true (T) and system output (S) mentions and entities high precision Adding the parse tree and dependency tree based features ... produces no output and 100% value for a system that extracts all the relations and produces no false alarms We count the misses; the true relations not extracted by the system, and the false alarms;...

Ngày tải lên: 31/03/2014, 03:20

... candidates at rank k and C + (k) denotes the correct ones When k increases, the number of candidates also increases whereas the number of entries B is independent of k Clearly, precision(k) and ... correct candidates by the number of entries Each correct candidate is inversely EURASIP Journal on Bioinformatics and Systems Biology weighted by its rank The contribution of a correct candidate ... matching result is used as a boosting factor Finally, the candidates scores are reordered by considering the overlap between the candidates and the noun phrases extracted from the text The noun phrases...

Ngày tải lên: 21/06/2014, 22:20

... substrates into water and lifted off a second layer Then, the as-prepared monolayer of PS spheres with diameters of 465 and 1,000 nm were put into an airtight oven and preheated for and min, respectively ... preheating, and oxygen reactive ion etching techniques The long-range ordered network pattern of PS particle arrays with tunable neck width and length were obtained The hexagonal- and the rectangular-shaped ... preheating These structures and patterns differ noticeably from the known elliptical-shaped PS particles and triangular nanoholes produced without preheating Such unique colloidals and their ordered arrays...

Ngày tải lên: 22/06/2014, 00:20