... adequate organ function, and life expectancy of months or more Written informed consent was obtained from all patients prior to enrollment in the study according to institutional guidelines Treatment ... better for patients with good performance status, tumor response and second-line chemotherapy In the Cox proportional hazard model, the only independent prognostic factor for OS was the tumor response ... - 1.2 Grading according to CTCAE (version 3.0) The main rationales for combination treatment with docetaxel and S-1 were synergistic antitumor activity in vivo and lack of overlapping toxicities...
Ngày tải lên: 09/08/2014, 03:21
... Perseverative Errors; Trail Making Test part B; and Color-Word Interference Trial of the Stroop Color and Word Test) 2) Short-term Memory (Digit Span Forward Test) 3) Working Memory (backward part ... APD administered Patients' performance on tasks of executive functions, verbal working memory, short-term memory, verbal memory, visual memory, speed of processing, verbal fluency, and motor speed ... and took 90 minutes approximately in one experimental session 1) Executive Functions/Reasoning and Problem Solving (Wisconsin Card Sorting Test [WCST] measuring Categories, Total errors and Perseverative...
Ngày tải lên: 11/08/2014, 16:22
Báo cáo khoa học: "Drotrecogin alfa (activated) in patients with severe sepsis presenting with purpura fulminans, meningitis, or meningococcal disease: a retrospective analysis of patients enrolled in recent clinical studies" ppt
... risk for developing ICH These findings should be borne in mind when considering DrotAA in the management of patients with severe sepsis with evidence of PF, MEN, or MD DrotAA is approved only for ... patients with severe sepsis and used the following inclusion criteria: proven or suspected infection; two or more signs of SIRS within 24 hours of study entry; and evidence of one or more sepsisinduced ... was reported Because DrotAA has been approved for the treatment of adults with severe sepsis with two or more organ dysfunctions (for example in the European Union) or at high risk of death in the...
Ngày tải lên: 12/08/2014, 22:21
Báo cáo khoa học: "Skeletal muscle oxygen saturation does not estimate mixed venous oxygen saturation in patients with severe left heart failure and additional severe sepsis or septic shock" docx
... standard treatment for localized infection, severe sepsis and septic or cardiogenic shock, including source control, fluid infusion, catecholamine infusion, replacement and /or support therapy for organ ... forearm vein that drained the exercising muscle StO2 was minimally affected by skin blood flow Changes in limb perfusion affect StO2; skeletal muscle StO2 decreases during norepinephrine and increases ... oxygenation in severe left heart failure with or without additional severe sepsis/septic shock and to compare with with SvO2 The hypothesis was that StO2 may estimate SvO2 in patients severe left...
Ngày tải lên: 13/08/2014, 03:20
Báo cáo y học: " Increased blood flow by insulin infusion targeting normoglycemia in patients with severe sepsis: friend or foe" ppt
... 2010, 14:122 http://ccforum.com/content/14/1/122 The clinical relevance of a reduction in forearm flow in patients with severe sepsis with intensified insulin therapy remains unclear, as recognized ... vasopressors or inotropes; and neither did they reveal any difference in organ function Secondly, it remains obscure whether a change in forearm flow is giving any information on the vital organ perfusion ... den Berghe G: Survival benefits of intensive insulin therapy in critical illness: impact of maintaining normoglycemia versus glycemia-independent actions of insulin Diabetes 2006, 55:1096-1105 Su...
Ngày tải lên: 13/08/2014, 20:21
Báo cáo y học: " Treatment effects of recombinant human soluble thrombomodulin in patients with severe sepsis: a historical control study" docx
... brain imaging, gastrointestinal or respiratory tract bleeding uncontrollable by conservative treatments, and bleeding at a critical location such as retinal hemorrhage, major hemarthrosis or spinal ... activated protein C (APC), which, in the presence of protein S, inactivates factors VIIIa and Va, thereby inhibiting further thrombin formation Moreover, the N-terminal lectin-like domain of rhTM ... anti-inflammatory effect by inhibiting the production of inflammatory cytokines (tumor necrosis factor a, interleukin (IL) and IL-6) by monocytes, suppressing the production of NF-B and limiting...
Ngày tải lên: 14/08/2014, 08:21
In vitro and in vivo study of ABT 869 in treatment acute myeloid leukemia (AML) alone or in combination with chemotherapy or HDAC inhibitors insight into molecular mechanism and biologic characterization
... In vitro and In vivo study of ABT-869 in treatment acute myeloid leukemia (AML) alone or in combination with chemotherapy or HDAC inhibitors: insight into molecular mechanism ... Cyclin-Dependent Kinase CCAAT/enhancer-binding protein α Chromatin Immunoprecipitation Combination Index Chronic Myelogenous Leukemia Colorectal Carcinomas C-terminal Src Kinase 4'-6-Diamidino-2-phenylindole ... Protein 90 Indirubin Derivative Interferon gamma-inducible gene 16 Immunohistochemistry Intraperitoneally Internal Tandem Duplication c-Jun N-terminal Kinase Kinase Insert Domain Receptor Low...
Ngày tải lên: 11/09/2015, 09:06
Báo cáo y học: "Pre-hospital intubation by anaesthesiologists in patients with severe trauma: an audit of a Norwegian helicopter emergency medical service"
... The minimum requirement for HEMS physicians in Norway is years of anaesthesiology as stated in a governmental report [9] In addition flight operators require a flight operative initial training ... Hence, the combination of short transport and a less severe injury may be put forward as a partial explanation for the finding Although we based our interpretation of the results on internationally ... system, and the validity of our findings in other systems is, therefore, uncertain However, our finding that a large proportion of patients with an indication for pre-hospital ETI did not receive...
Ngày tải lên: 25/10/2012, 09:56
báo cáo hóa học:" Short term effects of milrinone on biomarkers of necrosis, apoptosis, and inflammation in patients with severe heart failure" pot
... attending physician, including inotrope administration and dosing It is well recognized that heart failure leads to increased circulating levels of pro-inflammatory cytokines, such as tumor necrosis ... cardiac index
Ngày tải lên: 18/06/2014, 15:20
Báo cáo hóa học: " EQ-5D visual analog scale and utility index values in individuals with diabetes and at risk for diabetes: Findings from the Study to Help Improve Early evaluation and management of risk factors Leading to Diabetes (SHIELD)" potx
... (3.18 for VAS score and 0.009 for index score; p = 0.008) reported higher EQ-5D scores The model F statistic was 94.0 for VAS score and 83.6 for index score, and the model r-square was 0.16 for VAS ... population, and not include military or institutionalized individuals In addition, SHIELD relied only on self-reported data to identify samples of respondents, without clinical or laboratory confirmation ... for VAS score and 0.15 for index score Other sociodemographic characteristics were significantly associated with EQ-5D scores upon adjusting for diabetes risk status, including age, income, obesity,...
Ngày tải lên: 18/06/2014, 22:20
Báo cáo hóa học: " Effects of attention on the control of locomotion in individuals with chronic low back pain" pdf
... Stroop words (Dutch original in parentheses) walking jumping climbing waving kicking bending lifting clambering skating playing football jogging leaning skiing exercising dancing hopping juggling ... demanding task This finding, in combination with overall poorer performance on the cognitive task, suggests that abnormal gait is partly due to subtle disturbances in information processing that have ... Competing interests The authors declare that they have no competing interests Authors' contributions CJCL was the main investigator of the study, analyzed the gait data and was involved in revising...
Ngày tải lên: 19/06/2014, 08:20
Báo cáo hóa học: " Motor unit potential morphology differences in individuals with non-specific arm pain and lateral epicondylitis" pptx
... were no more sensitive to pressure and no more disabled than individuals with LE The DASH questionnaire is scored out of 100, with a higher score indicating a greater disability The DASH scores measured ... actually showed increases in MUP size relative to the control subjects, suggesting that the neuromuscular changes seen in individuals with NSAP are not the same as those seen in individuals with LE The ... Bonde JP, Fallentin N, Borg V, Mikkelsen S: Physical, psychosocial, and individual risk factors for neck/shoulder pain with pressure tenderness in the muscles among workers performing monotonous,...
Ngày tải lên: 19/06/2014, 08:20
báo cáo hóa học: "Infrared thermography as an access pathway for individuals with severe motor impairments" docx
... participants and two individuals with quadriplegia (one with a C1-C2 incomplete spinal cord injury and the other with severe spastic quadriplegic cerebral palsy) participated in this study All participants ... compensate for changes in these contextual factors A final limitation of thermal imaging is the relatively low resolution of infrared cameras and the inherent difficulty in discriminating between fine ... Blain S, Chau T: A review of emerging access technologies for individuals with severe motor impairments Assistive Technology 2008, 20:204-219 Sellers EW, Kubler A, Donchin E: Brain-computer interface...
Ngày tải lên: 19/06/2014, 08:20
báo cáo hóa học: " Gait quality is improved by locomotor training in individuals with SCI regardless of training approach" ppt
... form of locomotor training has been shown to increase walking speed [15,16] Despite the many studies that have explored the benefits of different forms of locomotor training in individuals with ... approach for improving gait quality in individuals with chronic SCI However, this training approach could be more effective for subjects with more severely impaired locomotor function Furthermore, ... of training parameters for walking with robotic assistance [40] For all training approaches, locomotor training did not lead to a more consistent coordination between limbs and the timing of...
Ngày tải lên: 19/06/2014, 08:20
báo cáo hóa học: " The effects of powered ankle-foot orthoses on joint kinematics and muscle activation during walking in individuals with incomplete spinal cord injury" pptx
... training in individuals following motor incomplete spinal cord injury Physical Therapy 2005, 85:52-66 Reinkensmeyer D: Robotic gait training: toward more natural movements and optimal training ... therapist-controlled orthoses by speed Mean ± standard error and statistical results for kinematics of subjects with incomplete spinal cord injury who walked without-orthoses (WO), wearing orthoses unpowered or ... spinal cord injury Topics in Spinal Cord Injury Rehabilitation 2005, 11:1-17 Colombo G, Wirz M, Dietz V: Driven gait orthosis for improvement of locomotor training in paraplegic patients Spinal Cord...
Ngày tải lên: 19/06/2014, 10:20
báo cáo hóa học:" A cross-sectional study of health-related quality of life deficits in individuals with comorbid diabetes and cancer" potx
... assess the HRQL burden in the following groups: 1) Individuals with comorbid diabetes and cancer compared to individuals with either condition alone, and 2) Individuals with comorbid diabetes and ... criteria for a major depressive disorder [36] Depression is an important comorbidity to include in the analyses, as it has been linked to a reduced HRQL in patients with diabetes and in patients with ... The HUI3 is a useful measure for capturing HRQL in patients with comorbid diabetes and cancer There is increasing evidence of the use of the HUI3 in individuals with type diabetes [25-27] There...
Ngày tải lên: 20/06/2014, 15:20
báo cáo hóa học:" Health-related quality of life in patients with severe COPD hospitalized for exacerbations - comparing EQ-5D, SF-12 and SGRQ" potx
... patients with available and missing scores In all instruments, missing items were more frequent in women than in men (11% vs 6% for EQ-5D, 38% vs 27% for SF-12, 12% vs 4% for SGRQ), as well as in patients ... (10% vs 6% for EQ-5D, 41% vs 21% for SF-12, 13% vs 2% for SGRQ) Proportion with best or worst health state Table (col 5-8) summarizes the proportion of patients reporting best or worst health ... mixed linear regression adjusted for age, sex, smoking status and time of assessment MCS: mental component score; PCS: physical component score scores in individuals with full health in EQ-5D...
Ngày tải lên: 20/06/2014, 16:20
Báo cáo y học: "Impact of concomitant aortic regurgitation on long-term outcome after surgical aortic valve replacement in patients with severe aortic stenosis" potx
... main coronary artery or ≥ 70% lumen diameter narrowing of at least one of the major epicardial vessels Multivessel coronary artery disease was defined as either left main or two or three major ... Bangdiwala SI, for the SOLVD Investigators: Prediction of mortality and morbidity with minute walk test in patients with left ventricular dysfunction JAMA 1993, 270:1702-1707 Bittner V, Weiner DH, Ghali ... moderate (2+), severe (3+) or very severe (4+) AR Their medical records were reviewed for demographic, clinical, and ECG data Preoperative echocardiographic findings Preoperative transthoracic echocardiographic...
Ngày tải lên: 10/08/2014, 09:21
Báo cáo y học: "Free functional gracilis muscle transfer in children with severe sequelae from obstetric brachial plexus palsy" potx
... deep finger flexors bundled together by side-to-side sutures in an harmonic finger adjustment, like in a natural fist (with slightly increasing finger flexion from the index to the little finger) ... 4) Finally, wound closure is performed and the monitor skin island fixed with running intracutaneous sutures (figure 5) The flexed fingers and the wrist in neutral position are immobilized in ... postoperatively and increased without specific training (table 2) Figure Intraoperative situation – muscle sutured in the forerarm Intraoperative situation – muscle sutured in the forerarm out of...
Ngày tải lên: 10/08/2014, 10:20
Báo cáo y học: "Augmented low-Dye tape alters foot mobility and neuromotor control of gait in individuals with and without exercise related leg pain" docx
... also recruited These individuals did not have a lower limb injury in the twelve months prior to the study that interfered with work/leisure activities or required treatment Individuals were excluded ... if a history of surgery to the lower limb, blood clotting or bleeding abnormalities, a neurological or cardiac condition, or allergy to tape was reported All individuals provided informed written ... reduction in MG activation, and a small increase in PL activation with application of ALD tape This supports preliminary findings of tape-induced reductions in TP and TA activation in a small cohort...
Ngày tải lên: 10/08/2014, 21:24