cocoa chocolate and endothelial function in humans in health and disease
Báo cáo y học: " Interrelated modulation of endothelial function in Behcet''''s disease by clinical activity and corticosteroid treatmen" ppt
Ngày tải lên :
09/08/2014, 10:21
... corticosteroid treatment on endothelial function in patients with chronic inflammatory diseases Interestingly, administration of corticosteroids improves endothelial function in patients with giant ... prednisolone (according to standard clinical practice for disease relapse), in addition to concomitant treatment, which remained unchanged during the following days Clinical assessment and vascular ... Regarding NMD, no differences were found between active and inactive BD or between corticosteroid receiving and nonreceiving patients, and no interaction between corticosteroids and BD disease...
- 6
- 386
- 0
Báo cáo y học: "The association between microvascular and macrovascular endothelial function in patients with rheumatoid arthritis: a cross-sectional study" pdf
Ngày tải lên :
12/08/2014, 17:21
... endothelial- dependent function in healthy individuals have reported mixed findings, with some reporting an association between microvascular and macrovascular endothelial- dependent function [22,23] and others ... macrovascular endothelial function using FMD and glyceryl trinitrate-mediated dilation (GTN) Microvascular endothelial function Endothelial function of the microvasculature was assessed noninvasively using ... microvascular and macrovascular endothelial function requires further investigation using newer and more accurate assessments of endothelial function Accordingly, the aim of the present study was to examine...
- 5
- 295
- 0
Báo cáo y học: "Carotid intima-media thickness and endothelial function: useful surrogate markers for establishing cardiovascular risk in patients with inflammatory rheumatic disease" pdf
Ngày tải lên :
09/08/2014, 10:23
... al Taking all of these considerations into account, we support the use of surrogate markers to determine the cardiovascular risk of patients with inflammatory rheumatic diseases Competing interests ... declare that they have no competing interests References Veldhuijzen van Zanten JJCS, Kitas GD: Inflammation, carotid intima-media thickness and atherosclerosis in rheumatoid arthritis Arthritis ... Martin J, Gonzalez-Gay MA: Carotid intima-media thickness predicts the development of cardiovascular events in patients with rheumatoid arthritis Semin Arthritis Rheum 2008 [Epub ahead of print]...
- 2
- 249
- 0
Báo cáo y học: " High blood pressure, antihypertensive medication and lung function in a general adult population"
Ngày tải lên :
25/10/2012, 10:45
... Conclusions Our findings are in line with previous observations showing an inverse association between blood pressure and lung function Furthermore, our analysis indicates that BBL medication and not ... Asklepios Hospital Gauting and Helmholtz Zentrum München, Munich, Germany 6Department of Internal Medicine B - Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases, University ... Relationship between lung function and blood pressure in Chinese men and women of Beijing and Guangzhou PRC-USA Cardiovascular and Cardiopulmonary Epidemiology Research Group Int J Epidemiol 1998,...
- 8
- 579
- 1
Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx
Ngày tải lên :
14/02/2014, 18:20
... involved in ligand binding, presumably abolishing the interaction with signaling partners The remaining mutations alter amino acids located outside the ligand-binding pocket and reduce protein ... lymphoproliferative disease Arginine 335 is found in the ‘BG loop’ not involved in phosphotyrosine binding and mutation to tryptophan most probably causes instability of the SH2 domain Thus, these ... mutation in the BTK PH domain; arginine 28 is in dark blue, encircled in red Bottom left: SH2 domain Right: kinase domain The mutated residues are indicated in yellow, a-helices are in cyan,...
- 10
- 926
- 0
Tài liệu Báo cáo khoa học: Verprolin function in endocytosis and actin organization Roles of the Las17p (yeast WASP)-binding domain and a novel C-terminal actin-binding domain doc
Ngày tải lên :
18/02/2014, 16:20
... previously showed does contain an actinbinding domain (this actin-binding domain has not yet been mapped) [23] We name the actin-binding domain that we have identified VH2-C and VH2-N because it is ... domain structure Schematic of Vrp1p showing the Vrp1p truncations and mutant proteins used in this study and their various known domains: actin-binding domains, Hof one trap (HOT) domain, and ... only expressing Gal4-AD (AD-vect) Plasmids were introduced into the tester strain PJ69-4A and interaction was assessed by growth on medium lacking histidine and containing mM 3-amino 1,2,4-triazole...
- 23
- 679
- 0
Báo cáo khoa học: Amino acids Thr56 and Thr58 are not essential for elongation factor 2 function in yeast potx
Ngày tải lên :
07/03/2014, 05:20
... cystein, methionine and serine (Fig 2) Mutants containing asparagine, aspartic acid, glycine, lysine or valine were nonfunctional (Fig 2) Clones expressing eEF2 in which the adjacent threonine ... by recombination using LR clonase The destination vector was transformed into strain YOR133w for confirming gene expression, and into strain GB1 for functional analysis by plasmid shuffling A copy ... protein (MAP) kinase and mTOR-signalling pathways [17] These signalling pathways activate the eEF2 kinase in response to mitogens and other stimuli that increase the cellular energy demand [18–...
- 13
- 424
- 0
Reproductive System Structure, Development and Function in Cephalopods with a New General Scale for Maturity Stages pot
Ngày tải lên :
14/03/2014, 16:20
... rigid capsules, capsule glands and albumin glands are present in a complex of pallial glands These differ in their origin and function (Chukchin, 1984) Oviductal glands in octopus secrete an adhesive ... oocytes in the coelom, and usually a single spawning, occur in octopus of the suborder Incirrata Octopus zonatus, in which repeated spawning has been observed (Rodaniche, 1984), is an exception In ... complicated than in females, especially because of the greater number of accessory glands involved in spermatophore formation ARKHIPKIN: Reproductive System Structure, Development and Function in Cephalopods...
- 12
- 623
- 0
Báo cáo khoa học: Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis pptx
Ngày tải lên :
15/03/2014, 23:20
... Accumulating evidences indicate that HSPGs act to inhibit cellular invasion by promoting tight cell–cell and cell–ECM interactions, and by maintaining the structural integrity and self-assembly of ... heparanase in human cancer by focusing on head and neck carcinoma and multiple myeloma as examples of solid and hematological malignancies Heparanase in head and neck carcinoma: signaling in motion ... seemingly distinct protein domains observed in the 3D model, namely the TIM-barrel and C-domain regions, mediate enzymatic and nonenzymatic functions of heparanase, respectively Interestingly,...
- 14
- 397
- 0
Báo cáo khoa học: An a-proteobacterial type malate dehydrogenase may complement LDH function in Plasmodium falciparum Cloning and biochemical characterization of the enzyme potx
Ngày tải lên :
16/03/2014, 18:20
... highest in late rings and early trophozoites which declined further in schizonts and was very low in early rings Western blotting analysis, with anti-Pf MDH IgG, detected only a single protein band ... substrate and the cofactor in addition to hydrophobic interactions Important residues lining the cofactor binding pocket indicates that Gln11, Asp32, Thr76, Ala77, Val117 and M142 are involved in hydrogen ... containing the enzyme and the inhibitors were preincubated for 10 before initiating the reaction by addition of NADH Bovine heart LDH (j/solid line); Pf LDH (d/broken line); Pf MDH (h/solid line);...
- 15
- 508
- 0
Báo cáo khoa học: Protective effect of active oxygen scavengers on protein degradation and photochemical function in photosystem I submembrane fractions during light stress pdf
Ngày tải lên :
16/03/2014, 18:20
... antenna proteins indicating mainly 1O2 was involved [28] In spinach thylakoids, illumination at low light intensity resulted in the degradation of PsaB gene product into two fragments of 51 and 45 ... photoinactivation of PSI was retarded by glycinebetaine and sucrose [18] In intact leaves, PSI was also found to be inactivated by light In Cucumis sativus leaves, weak light induced the photoinactivation ... better insight into the photo-induced changes in PSI The submembrane particles used contain all the components of PSI, including the cytochrome b6 ⁄ f complex and plastocyanin [31,32] In the...
- 11
- 405
- 0
Báo cáo khoa học: LRRK2 in Parkinson’s disease: function in cells and neurodegeneration doc
Ngày tải lên :
23/03/2014, 04:20
... but in concert with a number of conserved domains, including a GTPase domain Multidomain proteins that encode functional kinase domains often utilize intrinsic protein kinase activity distinct ... original US government works 6437 Function in cells and neurodegeneration kinase domain encodes a tyrosine kinase-like family member of the larger nonreceptor protein-serine ⁄ threonine kinase ... receptor-associated kinase family Many of these kinases have clear roles in the MAPK pathway, and MLK proteins serve as critical mitogen-activated protein kinase kinase kinase (MAPKKK) proteins in signaling cell...
- 9
- 478
- 0
Báo cáo hóa học: " Adipose-derived mesenchymal stem cells markedly attenuate brain infarct size and improve neurological function in rats" pptx
Ngày tải lên :
18/06/2014, 16:20
... 15 μm in diameter) in BIA was substantially lower in group than in groups and on IHC staining (Figure 9A-D) All of these findings indicate an ADMSC-induced enhancement in neurogenesis and vasculogenesis ... by saline injection alone Accordingly, rather than supporting a crucial role of direct cellular participation in limiting brain infarct size and improving neurological function, our findings suggest ... surface makers, including nestin and microtubule-associated protein (MAP-2), on flow cytometric analysis following 14 days of culturing, both pathological finding (TTC staining) and corner test...
- 16
- 488
- 0
Báo cáo hóa học: "Early combined treatment with sildenafil and adipose-derived mesenchymal stem cells preserves heart function in rat dilated cardiomyopathy" doc
Ngày tải lên :
18/06/2014, 16:20
... lower in group than in groups 3, 4, and 5, significantly lower in group than in groups and 5, and also notably lower in group than in Page 10 of 16 group This finding indicates that early combined ... groups and These findings indicate that the expression of cytochrome C, an index of energy supply and storage in mitochondria, was notably lower in group than in groups and The increase in cytosolic ... laboratory assay and troubleshooting FYL and HKY participated in refinement of experiment protocol and coordination and helped in drafting the manuscript 15 16 17 Competing interests The authors...
- 16
- 495
- 0
Báo cáo hóa học: "IL-2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease" doc
Ngày tải lên :
18/06/2014, 16:20
... diseases including T1D [6] T1 D is a chronic autoimmune disease that results in the destruction of the insulin-producing beta (b) cells of pancreatic islets of Langerhans, resulting in insulin ... be examined Page of 12 In humans, exposing CD4+ T cells to both IL-2 and rapamycin in vitro leads to an increase in the cellular frequency of FOXP3+ T cells, originating from nTreg cells and de ... targets the cytosolic protein FK-binding protein 12 (FKBP12) and downstream mTOR pathway, and in turn inhibits IL-2 responsiveness in activated T cells [86] Investigations into its mechanism of action...
- 12
- 573
- 0
Báo cáo hóa học: " Effects of pegylated G-CSF on immune cell number and function in patients with gynecological malignancies" doc
Ngày tải lên :
18/06/2014, 16:20
... implicated in inflammation, immunity and angiogenesis [2] Initial studies in mice supported a role for G-CSF in immune deviation towards T helper type (Th2) cytokine production [3] In humans, G-CSF increases ... stimulating factor treatment of Crohn’s disease is associated with the appearance of circulating interleukin-10-producing T cells and increased lamina propria plasmacytoid dendritic cells Clin Exp ... G-CSF In vitro DC phenotype and function It has been previously shown that filgrastim indirectly affects DC number and function, skewing in vitro DC Bonanno et al Journal of Translational Medicine...
- 15
- 796
- 0
Báo cáo sinh học: "Combination of cyclosporine and erythropoietin improves brain infarct size and neurological function in rats after ischemic stroke" potx
Ngày tải lên :
18/06/2014, 22:20
... Oxidative index and protein expression levels of cytochrome (Cyt) C in brain infarct area A) Oxidative index determination by Western blotting of brain infarct area (BIA) (n = 6), showing notably increased ... substantially increased in group than in other groups, remarkably higher in groups and than in groups and 5, and significantly higher in group than in group On day 21 following acute IS induction, ... Discussion Combined Therapy with Cyclosporine and EPO Provided Additional Benefits of Limiting Brain Infarct Size and Improving Recovery of Neurological Function The most important finding in the current...
- 14
- 475
- 0
Báo cáo hóa học: " Dipolar cortico-muscular electrical stimulation: a novel method that enhances motor function in both - normal and spinal cord injured mice" pdf
Ngày tải lên :
19/06/2014, 08:20
... (4°C) in 4% paraformaldehyde in 0.1 m PBS and cryoprotected in 20% sucrose in PBS at 4°C for 24 h The spinal column was freeze mounted and cut into 30 μm sections and placed on poly-L-lysine-coated ... 0.50) and right (18.83 ± 1.16) hindlimb Collectively, these results indicate that spinal cord injury procedure used in the current study was reliable in inducing behavioral signs of the injury ... calculating the fidelity index, which is the ratio of spinal response to muscle twitch force The dCMS-induced changes in the fidelity index were opposed in control and injured animals While this index...
- 15
- 639
- 0
báo cáo hóa học: " Gliovascular and cytokine interactions modulate brain endothelial barrier in vitro" docx
Ngày tải lên :
19/06/2014, 22:20
... human brain endothelial lines (HBMEC-3 and HCMEC-D3) and ECV-304 (an endothelial- like bladder carcinoma cell line) were studied in monoculture, as well as in co-culture with human astrocytes and barrier ... support and interaction with astrocytes and neurons [70,71] We attempted to identify specific responses involving interactions between astrocytes, individual cytokines, individually and in combination, ... IL-1b and IFNg) on brain endothelium and astrocytes (individually or in synergy) on barrier during metabolic stresses using a Page of 16 3-D in vitro BBB model with human, mouse brain endothelial...
- 16
- 257
- 0