clinical trials and oral cancer
Tài liệu Clinical trials in gynecological cancer ppt
... comprehensive database for open clinical cancer trials The 2007 IGCS and ESGO, International Journal of Gynecological Cancer 17, 547–556 Clinical trials in gynecological cancer largest database is ... Italian Trials in Ovarian Cancer www.mito-group.it/ MRC—Medical Research Council www.mrc.ac.uk NCI—National Cancer Institute—ctep .cancer. gov NCIC-CTG—National Cancer Institute of Canada Clinical Trials ... management, and quality assurance Recently, the All-Ireland Cancer Consortium and the UK National Cancer Research Institute have established national infrastructures for the support of clinical trials...
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Báo cáo y học: " Molecular therapies for systemic lupus erythematosus: clinical trials and future prospects" pptx
... hopefully some of them represent interesting candidates for future clinical trials Two peptides and one peptide construct have reached advanced clinical trials in lupus patients The efficacy of the ... phase I and phase II clinical trials conducted by ImmuPharma (Mulhouse, France) Peptide P140 was found to be safe and well tolerated by subjects, and significantly improved the SLEDAI score and biological ... activity and patients deteriorated [18] DHEA or prasterone Androgen Review: analysis of randomized controlled trials (7) comparing DHEA with a placebo in SLE patients (842 participants) Little clinical...
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báo cáo khoa học: "Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents" ppt
... carcinoma, human cancer, chronic lymphocytic leukemia, prostate cancer, bladder cancer, head and neck squamous carcinomas and ovarian cancer cells in preclinical studies [118-126] In a phase I clinical ... including both hematological and solid malignancies Vorinostat clinical trials have been updated lately [13,74] This review focuses on recent development in clinical trials testing newer HDAC inhibitors ... colorectal(11), renal (12) Day1 and of a 21-day and other neoplasms(14) cycle Colorectal(8), breast(4), sarcoma(3) and other (15) Day1, 8, and 15 of 28day cycle CLL/AML(20) Day1, 8, and 15 of 28day cycle...
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Tài liệu ACCELERATING PROGRESS AGAINST CANCER: ASCO’s Blueprint for Transforming Clinical and Translational Cancer Research doc
... ctac/1210/presentations/GHWG.pdf 15 National Cancer Institute National Cancer Institute’s Clinical Trials Cooperative Group Program Available at http://www .cancer. gov/cancertopics/factsheet/NCI/clinicaltrials-cooperative-group ... 30,000 physicians and other professionals who treat people with cancer and conduct clinical research — provides a high-level blueprint for transforming the translational and clinical cancer research ... that surround the cancer as it arises Development and spreads — the cancer environment” — so that Our expanded knowledge of cancer- and patient- researchers can better understand the entire spec-...
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Oral Cancer and Precancerous Lesions pot
... for Oral Precancerous Lesions Definition of leukoplakia and related lesions: An aid to studies on oral precancer Oral Surg Oral Med Oral Pathol 1978;46:518-539 54 Shafer WB, Waldron CA A clinical ... of the literature Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996;82:57-68 28 Sugerman PB, Shillitoe EJ The high risk human papillomaviruses and oral cancer: Evidence for and against a causal ... patients with oral lichen planus Oral Surg Oral Med Oral Pathol 1991;72:665-670 35 Barnard NA, Scully C, Eveson JW, et al Oral cancer development in patients with oral lichen planus J Oral Pathol...
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Oral Cancer and Precancerous Lesions doc
... radiotherapy and watchful waiting/ active monitoring (20) Current debate and the involved stakeholders Prostate cancer screening is controversial On the one hand health technology assessment and public ... screening for prostate cancer does more good than harm Two large screening trials are underway and may provide this evidence Further treatment trials are also underway and will help policy makers ... early prostate cancer New England journal of medicine, 2002, 347, 11:781-789 11 Chodak GW et al Results of conservative management of clinically localized prostate cancer New England journal of...
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Classification of colorectal cancer based on correlation of clinical, morphological and molecular features doc
... island methylator phenotype (CIMP),62–66 and diploid status or chromosomal stability.67–70 It is notable that MSS CRCs with high-level CIMP and ⁄ or BRAF mutation also share certain clinical and ... immunohistochemistry for MLH1] The glands to the left are normal and show nuclear expression of both MGMT and MLH1 The gland with features of serrated adenoma and the poorly differentiated adenocarcinoma ... process of trial and error This correlative process incorporates clinical, morphological and biological components Furthermore, since genetic instability and CIMP are acquired at the precancerous stage,...
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ORAL CANCER AND ITS DETECTION - HISTORY-TAKING AND THE DIAGNOSTIC PHASE OF MANAGEMENT pdf
... an independent risk factor for oral cancer Int J Cancer 2000;86(1): 128-31 Zain RB Cultural and dietary risk factors of oral cancer and precancer: a brief overview Oral Oncol 2001;37(3):205-10 ... carcinogen and may be produced both systemically and by the oral microflora.10-12 Diet Recently, attention has been directed toward diet and its influence on the development of precancer and cancer ... the detection of oral precancerous and malignant lesions Oral Surg Oral Med Oral Pathol 1984;57:379-82 31 Lonky NM, Edwards G Comparison of chemoluminescent light versus incandescent light in...
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Cancer Clinical Trials: Participation by Underrepresented Populations doc
... 2000 10(8 Suppl):S8591 17 National Cancer Institute Facts and Figures About Clinical Trials Accessed March 2008, from http://www .cancer. gov/clinicaltrials/facts-andfigures#patients 18 Newburger ... http://www .cancer. gov/clinicaltrials/resources/basicworkbook/ , Baquet CR, Commiskey P Mullins CD, Mishra SI Recruitment and participation in clinical trials: sociodemographic, rural/urban, and health ... investigation of nonsurgical NCI cancer trials demonstrated that women were less likely than men to be enrolled in colorectal and lung cancer trials. 6 Patient Barriers to Cancer Clinical Trial Participation...
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Preventing and Controlling Oral and Pharyngeal Cancer pot
... of oral cancer, its epidemiology, ongoing and needed research, and clinical experience with five other cancers (i.e., leukemia and breast, cervical, lung, and prostate cancers) A survivor of oral ... for oral cancer; standardize techniques for oral cancer examination and implement them consistently; create a national speakers bureau with standardized educational materials; place an oral cancer ... asymptomatic oral and oropharyngeal squamous cancers CA Cancer J Clin 1195;45:328–51 Blot WJ, McLaughlin JK, Winn DM, et al Smoking and drinking in relation to oral and pharyngeal cancer Cancer Res...
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From Cancer Patient to Cancer Survivor - Lost in Transition: An American Society of Clinical Oncology and Institute of Medicine Symposium pot
... Committee on Cancer Survivorship: Improving Care and Quality of Life; and President and CEO, National Coalition for Cancer Survivorship Good morning My name is Ellen Stovall, and I am a 34-year cancer ... outpatient, and then could go ahead and prepare herself for the fact that she had cancer and needed to have a mastectomy There was mounting clinical evidence by two large trials, one done in Europe and ... high on the agenda of cancer research And I say that as a customer of cancer research and cancer care I have not recently examined the figures, although I did at one point, and the amount we spent...
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Genetics and Testicular Cancer: Division of Cancer Epidemiology and Genetics Clinical Genetics Branch doc
... Feb;24(2):197-200 Sporadic and Familial Testicular Cancer Sporadic Testicular Cancer Familial Testicular Cancer Familial Testicular Cancer Linked To Xq27 (20%) Familial Testicular Cancer For Which No ... testicular cancer to: Develop gene mutation tests for testicular cancer Determine who is at higher risk of testicular cancer Determine the risk of developing testicular and/ or other cancers based ... ASCO, modified 12/02 The Genetics of Testicular Cancer The Human Genome and Cancer The Human Genome Project is helping us to discover new cancer genes and to develop: Predictive tests to identify...
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báo cáo hóa học:" Comparative study on the immunogenicity between an HLA-A24-restricted cytotoxic T-cell epitope derived from survivin and that from its splice variant survivin-2B in oral cancer patients" pot
... normal tissues, and oral cancer cell lines and primary oral cancer tisExpression of survivin mRNA as assessed by RT-PCR in normal tissues, and oral cancer cell lines and primary oral cancer tissues ... findings in vitro, clinical trials of survivin-2B80-88 peptide immunotherapy have been conducted for advanced cancers such as colorectal cancer, breast cancer, lung cancer, and oral cancer [24,26], ... one healthy volunteer and 12 cancer patients (one breast cancer and eleven oral cancer) by standard density gradient centrifugation on Lymphoprep (Nycomed, Oslo, Norway) and cultured in AIM-V...
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Báo cáo hóa học: " Multiplexed methylation profiles of tumor suppressor genes and clinical outcome in lung cancer" potx
... acquiring clinical and laboratory data, data analysis and interpretation, and drafted the manuscript PP and LG participated in acquiring clinical and laboratory data, data analysis and data interpretation ... interpretation and drafted the manuscript LG, JV, and SQ participated in acquiring clinical samples and follow-up clinical information MSC participated in study design and coordination, data analysis and ... the cancer specificity of the methylated candidates), and also with previous reports describing methylation for some of the candidates under study, such as PRDM2 [32], RUNX3 [35,36], SFRP4 and...
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Báo cáo sinh học: "Shipping blood to a central laboratory in multicenter clinical trials: effect of ambient temperature on specimen temperature, and effects of temperature on mononuclear cell yield, viability and immunologic function" potx
... and cryopreservation of PBMC at off-site locations is expensive and requires oversight and quality control of the processing lab at each center Thus, for many multicenter clinical trials of cancer ... approval (IRB-HSR# 10598, 10524, and1 1491) and review by the FDA (BB-IND# 9847 and 12191) Patients’ blood specimens from clinical trials (HSR# 1524(HSR# 10524 and 11491) were monitored during ... and Bill Goodwin Additional philanthropic support was provided by Frank and Jane Batten, the James and Rebecca Craig Foundation, George S Suddock, Richard and Sherry Sharp, and the Patients and...
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Báo cáo khoa học: "Clinical pharmacokinetics of norfloxacin-glycine acetate after intravenous and oral administration in pigs" doc
... turkeys and geese after a single oral administration J Vet Pharmacol Ther 1998, 21, 161-164 13 Lavy E, Ziv G, Glickman A Intravenous disposition kinetics, oral and intramuscular bioavailability and ... [17], and also longer than that found in the previous studies of norfloxacin in pigs (3.65 ± 0.16 h) [2] and dogs (3.56 h) [4], and that of norfloxacin nicotinate in swine (2.1 h) [21] and donkeys ... (40%) [18], and in broiler chickens (57.0%) [3], but is significantly higher than the oral bioavailability of norfloxacin nicotinate in donkeys with F values of 9.6% and 6.4% for the 10 and 20 mg/kg...
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Báo cáo y học: "Tolerability and adverse events in clinical trials of celecoxib in osteoarthritis and rheumatoid arthritis: systematic review and meta-analysis of information from company clinical trial report" potx
... Clinical ulcers and bleeds Clinical ulcers and bleeds in the company clinical trial reports were as reported by investigators, and were not subjected to independent, blinded adjudication in trials ... authors independently read each clinical trial report and scored the reports for reporting quality and validity Disagreements were discussed and consensus achieved Trials were scored for quality ... Arthritis Research & Therapy Vol No Moore et al Results Trials Clinical reports of 31 randomised trials – 21 in osteoarthritis, in rheumatoid arthritis, and in mixed osteoarthritis or rheumatoid arthritis...
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Báo cáo khoa học: "Clinical efficacy and problems with CT lymphography in identifying the sentinel node in breast cancer" docx
... identifying SN in breast cancer patients by CTLG and a dye-guided method since February 2003 as a clinical trial [5] Here, we report our findings to date regarding the clinical efficacy and problems associated ... vessels leading to Sentinel nodes and the number of Sentinel nodes Single rout and Single node Multi routs and single node Single rout and multi nodes Multi routs and multi nodes 151(68%) 8(4%) ... initiated and co-wrote the paper with MT and CH, YB examined surgical specimen, MS, SH, MT and TH took part in the care of patients and helped in preparation of the manuscript All authors read and...
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