clinical trial results with replication competent adenoviruses in cancer patients

... actual trial in order not to disrupt clinical routine [7] Completion time was now on average 7.5 minutes, which we found acceptable since it did no longer interfere with clinical routine Patients' ... HRQoL information again in the future, especially for patients awaiting liver transplantation, patients with HCV, and non-native speakers (mostly patients with HBV) They suggested embedding the information ... physicians in the experimental group requested the information in 92% of the consultations, discussing it with their patients in 58% of the consultations They indicated finding the HRQoL information...

Ngày tải lên: 18/06/2014, 19:20

... actual trial in order not to disrupt clinical routine [7] Completion time was now on average 7.5 minutes, which we found acceptable since it did no longer interfere with clinical routine Patients' ... HRQoL information again in the future, especially for patients awaiting liver transplantation, patients with HCV, and non-native speakers (mostly patients with HBV) They suggested embedding the information ... physicians in the experimental group requested the information in 92% of the consultations, discussing it with their patients in 58% of the consultations They indicated finding the HRQoL information...

Ngày tải lên: 20/06/2014, 16:20

... bank’s” business The gains in efficiency achieved in Morocco and Lebanon and the encouraging perforLatin America Remains a Strong mance at our grinding stations and Group Region import terminal in West ... will again invest more to offset the resultant declines in sales heavily in plant expansion In our view, by midyear HISALBA again presented a sustained improvement in earnings is an outstanding performance, ... Ce- ating profit matched the previous ment in the Philippines suffered a loss year’s figure The increase in sales due to market factors The increase in investment activity by continuing financial...

Ngày tải lên: 27/07/2014, 16:05

... double-blind, multicenter, and controlled phase II clinical trial involving 236 patients with severe active RA, a decrease in the number of swollen joints and tender joints occurred in subjects ... disease in several animal models, including arthritis CII is the most abundant structural protein of human cartilage The cartilage within the joint caused mainly damage of autoimmunity in patients with ... Registration Clinical trial registration number: ChiCTRTRC-00000093 Introduction Investigators in our laboratory found that collagen-induced arthritis (CIA) could be established in Wistar rats, Kunming...

Ngày tải lên: 12/08/2014, 11:22

... ASSOCIATED WITH DAIRY PRODUCTS 12 TABLE 1-2 SUMMARY OF CLINICAL TRIALS EVALUATING EFFECTS OF PROBIOTICS ON ORAL VACCINATION 19 TABLE 1-3 SUMMARY OF CLINICAL TRIALS EVALUATING EFFECTS ... This double-blind, placebo-controlled randomized clinical trial involved 253 infants with a family history of allergic disease Infants received at least 60ml of milk formula with or without probiotic ... Paraguay in the 13-14 years old children, and from 4.2% in the Indian Sub-Continent to 12.7% in Latin America in the 6-7 year olds Co-morbidity with asthma and eczema varied from 1.6% in the Indian...

Ngày tải lên: 11/09/2015, 21:39

... Changes in Type I IFN responses from day to day 29 in clinical responders and non-responders We further investigated within the HDI-responding and non-responding patients on day and day 29 and examined ... and clinical details are shown in Table These patients participated in a clinical trial for neoadjuvant therapy with HDI and their treatment has been thoroughly described [12] Briefly, the HDI induction ... Type I IFN signaling responses through IFN-a induced phosphorylation of STAT1-Y701 in patients undergoing HDI therapy with known shortterm clinical responses and long-term clinical outcome This...

Ngày tải lên: 18/06/2014, 19:20

... Changes in Type I IFN responses from day to day 29 in clinical responders and non-responders We further investigated within the HDI-responding and non-responding patients on day and day 29 and examined ... and clinical details are shown in Table These patients participated in a clinical trial for neoadjuvant therapy with HDI and their treatment has been thoroughly described [12] Briefly, the HDI induction ... Type I IFN signaling responses through IFN-a induced phosphorylation of STAT1-Y701 in patients undergoing HDI therapy with known shortterm clinical responses and long-term clinical outcome This...

Ngày tải lên: 20/06/2014, 03:20

... staging was based on the pathology findings, according to the American Joint Committee on Cancer Staging System, 6th edition In addition, the following variables were recorded: size and invasion ... factors for recurrence in oral tongue cancer include an infiltrating pattern of tumor growth, diffuse histological invasion, and a tumor within mm of the resection margin [15] This study has ... et al reported that histological grading was related, as an independent factor, in predicting survival in patients with oral squamous cell carcinoma [17] In this study, tumor grades were shown...

Ngày tải lên: 09/08/2014, 08:23

... data Results PLA2R1 gene polymorphisms in IMN patients and in controls Two SNPs within PLA2R1 were genotyped in 129 patients with IMN and in 106 healthy controls Analysis of IMN patients in comparison ... associated with the development of IMN These findings suggest that PLA2R1 may play a pathogenic role in inducing or maintaining glomerular barrier dysfunction in humans The role of PLA2R1 in the ... pressure, serum albumin level, haematuia or proteinuria The initial laboratory test reveals no difference in baseline serum Cr level, daily urinary protein excretion (DUP), or creatinine clearance (CCr)...

Ngày tải lên: 10/08/2014, 05:21

... correlated with EGFR protein expression and clinical response in NSCLC patients treated with EGFR tyrosine kinase inhibitor[18] To find markers that could predict gemcitabine sensitivity, we analyzed ... 10-3) Patients were divided into two groups, those with expression equal to or higher than the median and those with expression below the median No differences in clinical characteristics, including ... included in the toxicity analysis Hematological toxicity grade ≥ was observed in 22 patients, and grade 3/4 was seen in 12 patients Hepatotoxicity grade ≥ was observed in two patients; vomiting...

Ngày tải lên: 10/08/2014, 22:20

... Alternatively, an increased susceptibility of myeloid precursors to the inhibitor in older patients might play a role in the genesis of hypoplasia [8] However, the cause of hypoplasia in children needs ... however, dispersed blasts were positive for antiMPO stain In view of the abovementioned findings, a diagnosis of hypocellular AML was established along with a focal area of necrosis The patient was referred ... Peripheral blood smear examination revealed 40% blasts with low platelets These blasts were of intermediate size, had moderate cytoplasm, opened-up nuclear chromatin and to prominent nucleoli Bone marrow...

Ngày tải lên: 11/08/2014, 19:21

... Darmon et al reported with many anti -cancer agents, including gemcitabine, bleomycin, cisplatin, CCNU, cytosine arabinoside, daunorubicin, deoxycoformycin, 5-FU, azathioprine and interferon α [25] ... develops in 20% to 40% of BMT recipients [47] Amphotericin during conditioning Acyclovir during conditioning Vancomycin during conditioning The main site of liver damage in this setting is the ... Intern Med 1990, 150:1693-1695 Available online http://ccforum.com/content/10/2/211 20 Ying WZ, Sanders PW: Mapping the binding domain of immunoglobulin light chains for Tamm-Horsfall protein...

Ngày tải lên: 12/08/2014, 23:23

... These findings suggest that PCR-positive patients had been infected recently in our study, most of them within the two weeks before admission According to previous studies focusing on patients ... Baseline characteristics of patients with or without a virus-positive respiratory sample are presented in Table The main reason for admission was respiratory dis- tress alone (77/187), including ... virus influenza A (7/45) Rhinovirus detected in the lower respiratory tract was associated with clinical signs of acute COPD exacerbation, of pneumonia or of pulmonary edema in all cases except in...

Ngày tải lên: 13/08/2014, 03:20

... been chosen correctly If, in addition, v(x) is inde- will be uniquely defined for any partitioning, meaning that finding u* is reduced to finding an optimal partitioning of I which can be performed ... renal cell carcinoma Cancer Res 2005, 65:5628-5637 Frigola J, Song J, Stirzaker C, Hinshelwood R, Peinado M, Clark S: Epigenetic remodeling in colorectal cancer results in coordinate gene suppression ... state-of-the-art method to compare our results with Interestingly, this finding signifies that the TV-based scheme, to a great extent, manages to avoid reporting false breakpoints inside relevant regions This...

Ngày tải lên: 14/08/2014, 08:20

... 348(10):891-899 Allin KH, Bojesen SE, Nordestgaard BG: Baseline C-reactive protein is associated with incident cancer and survival in patients with cancer J Clin Oncol 2009, 27(13):2217-24 Ghiringhelli ... hypothesis further by examining the timing of chemotherapy doses with respect to the LCRP immune oscillatory cycle, in patients with advanced melanoma, while examining the clinical responses The current ... Timing of Vaccinations with the CRP cycle in a patient with advanced melanoma Timing of Vaccinations with the CRP cycle in a patient with advanced melanoma Multiple fortnightly doses of vaccine...

Ngày tải lên: 18/06/2014, 15:20

... examining the prognostic value of quality of life data for survival time in cancer patients The review contained 104 studies and with only a few exceptions, the results in most instances indicated ... quality-of-life data in predicting survival in glioblastoma cancer patients: results from an international randomised phase III EORTC Brain Tumour and Radiation Oncology Groups, and NCIC Clinical Trials Group ... that pain and appetite loss are independent determinants of overall survival One found that a 40-point increase in the pain subscale of the EORTC QLQ-C30 was associated with a 27% increase in the...

Ngày tải lên: 18/06/2014, 19:20

... available in medical literature any large parallel randomized controlled trial conducted in advanced cancer patients suffering from severe pain (step in the WHO's pain ladder), comparing any alternative ... aimed at making available to treating physicians, patients and families valid information about pain management in cancer Two main lines of activities were identified as necessary: information ... history including past cancer history, b) physical examination, c) recording of medications and recent therapies, including analgesic consumption, d) pain assessment using the Brief Pian Inventory...

Ngày tải lên: 20/06/2014, 15:20

... complications indicates that US guidance should be mandatory for CVC insertion in patients with cancer Background Central venous access is essential in patients with cancer, and the need for intravenous ... administration of cancer therapy has increased proportionally with the increasing number of patients diagnosed with cancer The percutaneous approach to the subclavian or internal jugular vein ... catheter in the internal jugular vein [19] In addition, a report in the United States also showed that

Ngày tải lên: 09/08/2014, 03:22

... adding an equal volume of 4% formaldehyde fixative After washing and incubating with PBS/BSA/saponin for 10 min, cells were incubated with for 30 min, respectively Results were analyzed using ... hepatic resection groups, the mean being 5.2 ± 3.6 in patients with gastric cancer, 7.2 ± 3.1 in those with colorectal cancer and 6.6 ± 4.0 in those with hepatic cancer (Fig 2) Preoperatively, malignancy ... suggesting that the elevation of IL-4 production during an ongoing immune response to tumor can down-regulate Th1 cytokine production Therefore, in gastrointestinal cancer patients, the initial...

Ngày tải lên: 09/08/2014, 04:21

... 0.002), without increasing the rate of major bleeding (6% vs 4%) or any bleeding (14% vs 19%) [63] Similar findings were reported in a study comparing long-term treatment with the LMWH tinzaparin with ... Furthermore, as patients with advanced cancer, renal or hepatic impairment, or with a short-term prognosis are frequently excluded from clinical trials, the patients included in clinical trials are ... LMWH in cancer patients (Table 1) [39-45] The Enoxaparin and Cancer (ENOXACAN) study compared the LMWH enoxaparin and UFH in 1,115 patients undergoing abdominal or pelvic cancer surgery Enoxaparin...

Ngày tải lên: 10/08/2014, 22:20