clinical studies of a human photosensitivity disease
Báo cáo y học: "Moving towards high density clinical signature studies with a human proteome catalogue developing multiplexing mass spectrometry assay panels" doc
Ngày tải lên :
10/08/2014, 09:22
... instrumentation and diagnostic validation capability that also are in demand for improving health care area These limitations already extend from early indicators of disease, through disease severity, ... caption (Figure 4B) typically had a
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Báo cáo khoa học: "Lack of evidence for qualitative treatment by disease severity interactions in clinical studies of severe sepsis" docx
Ngày tải lên :
12/08/2014, 22:22
... Opal et al (2004) [28] Platelet activating factor hydrolase Parallel groups 28-Day all-cause mortality Abraham et al (2003) [29] Tissue factor pathway inhibitor Parallel Groups 28-Day all-cause ... all-cause mortality Abraham et al (1995) [31] Anti-TNF antibody (BAYx1351) Parallel groups 28-Day all-cause mortality Abraham et al (1998) [36] Anti-TNF antibody (BAYx1351) Parallel groups 28-Day ... 28-Day all-cause mortality Bernard et al (2001) [26] Activated protein C Parallel groups 28-Day all-cause mortality Dhainaut et al (1998) [48] Platelet activating factor receptor antagonist Parallel...
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Tài liệu Báo cáo khoa học: Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1 docx
Ngày tải lên :
15/02/2014, 01:20
... I, Pimkhaokham A, Nakagawa T, Kamata N, Kozaki KI, Amagasa T & Inazawa J (2007) PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter ... Canyuk B, Focia PJ & Eakin AE (2001) The role for an invariant aspartic acid in hypoxanthine phosphoribosyltransferases is examined using saturation mutagenesis, functional analysis, and X-ray ... complexes of the human HPRT and several bacterial and protozoan HPRTs have been undertaken [13–17] The structure of human HPRT can be divided into two domains: a core domain and a hood domain [14,18]...
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Tài liệu Báo cáo khoa học: Structural and biochemical characterization of a human adenovirus 2/12 penton base chimera pptx
Ngày tải lên :
19/02/2014, 06:20
... 5¢-CTTTATTTTCAGGGCGCCATGAAGCGCG CAAGACCGTCTGAA-3¢ and a reverse oligomer 5¢-AGCT CGAATTCG GATCCGGTACCTCAGAAGGTAGACAG CAGAACC-3¢ For derivitization with TMR, a Gly-Gly-Cys sequence was introduced at the ... chain and hides a large amount of the hydrophobic surface area Surface area calculations for the pentamer give a total surface ˚ ˚ area of $ 81 000 A2 with 30% ($ 24 000 A2 ) as contact area Thus, ... 5¢-CTGCTGTCTACCTTTGGAGGTTGCTGATCCGAA TTCGAG-3¢ (forward) and 5¢-GCTCGAATTCGGATCAG CAACCTCCAAAGGTAGACAGCA-3¢ (reverse) BL21 cells were transformed with the pETM11 construct and grown until a D of 0.8...
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Báo cáo khoa học: Conformational studies of a hyperthermostable enzyme potx
Ngày tải lên :
07/03/2014, 21:20
... beam Extreme care was taken to avoid artefacts from depolarization effects At the front of the sample housing a Glan-laser polarizer was mounted, optimizing the already vertical polarization of ... single-domain protein with a molar mass of 30 085 Da Experimental data from mass spectroscopy (MALDI TOF) and size exclusion chromatography showed that LamA in solution is a monomer LamA contains ... spectroscopic analysis will enable us to characterize the thermally and chemically denatured states of LamA Using a combination of circular dichroism, steady-state and time-resolved spectroscopy and anisotropy...
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Báo cáo Y học: Crystal structure of the catalytic domain of a human thioredoxin-like protein pdf
Ngày tải lên :
08/03/2014, 22:20
... Murakawa, M., Takahashi, S., Tsubuki, S., Kawashima, S., Sakamaki, K & Yonehara, S (1998) Purification, molecular cloning, and characterization of TRP32, a novel thioredoxin-related mammalian ... in length and contains an 867-bp ORF, which encodes for a protein with 289 amino acids and a calculated molecular mass of 32 kDa A search of the nonredundant protein sequence database was performed ... smoothly in alternating steps of automatic adjustment with CNS and manual adjustment with the program O [34] The final model has a final R-factor of 0.222 with a free R-factor of 0.253 Molecular graphics...
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Báo cáo khoa học: Ligand binding and antigenic properties of a human neonatal Fc receptor with mutation of two unpaired cysteine residues docx
Ngày tải lên :
16/03/2014, 06:20
... I-related receptor consisting of a heavy chain (HC) with three ectodomains (a1 , a2 and a3 ), a transmembrane part and a short intracellular signaling tail Like MHC class I HC, the FcRn counterpart ... Sundaresan G, Subbarayan M, Carter NH, Ikle DN, Yazaki PJ, Chatziioannou AF, Gambhir SS et al (2005) Tailoring the pharmacokinetics and positron emission tomography imaging properties of anti-carcinoembryonic ... human HC variants Table S3 Numbers of cysteine residues of FcRn HCs across speciesa Table S4 Numbers of cysteine residues of nonclassical MHC class I HCa This material is available as part of the...
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NUTRITIONAL ASPECTS and CLINICAL MANAGEMENT of CHRONIC DISORDERS and DISEASES doc
Ngày tải lên :
28/03/2014, 22:20
... elucidation of active and passive calcium absorption in human and experimental animals, a definition of renal calcium movement, and quantitative analysis of plasma calcium homeostasis Author of more ... Takala J, Karveranta H, and Valimaki I Water, sodium, and acidbase balance in premature infants: therapeutic aspects Acta Pediatr Scand 76:47–53, 1987 32 Fitzgerald KA and Mackay MW Calcium and ... Standard growth charts can be used to plot weight and classify infants as appropriate for gestational age (AGA), small for gestational age (SGA), or large for gestational age (LGA) Appropriate...
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Báo cáo khoa học: Crystal structure determination and inhibition studies of a novel xylanase and a-amylase inhibitor protein (XAIP) from Scadoxus multiflorus pot
Ngày tải lên :
29/03/2014, 09:20
... observations indicate that XAIP associates with GH11 xylanase and GH13 a- amylase, as well as with both xylanase and a- amylase simultaneously Tissue distribution of XAIP The output of SDS–PAGE for ... activity of a- amylase in a : 1.2 molar ratio The inhibition of a- amylase by XAIP was also observed in the presence of GH11 xylanase Thus, the inhibition of a- amylase by XAIP is unaffected by the addition ... cleft of a- amylase There are at least 12 hydrogen bonds and ˚ several van der Waals’ contacts (£ 4.0 A) between the two molecules There are at least six common residues of a- amylase that participate...
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báo cáo hóa học:" Lentivirus-mediated RNAi silencing targeting ABCC2 increasing the sensitivity of a human nasopharyngeal carcinoma cell line against cisplatin" docx
Ngày tải lên :
18/06/2014, 15:20
... were as follow: ABCC2 forward: 5'-CTC ACTTCAGCGAGACCG-3'; ABCC2 reverse: 5'-CCAGCCAGTTCAGGGTTT-3'; ACTB forward: 5'-CACCCAGCACAATGAAGAT-3'; ACTB reverse: 5'-CA AATAAAGCCATGCCAAT-3' Cycling conditions ... siRNA increased the intracellular accumulation of cisplatin ABCC2 ABCC2 siRNA increased the intracellular accumulation of cisplatin (A) A typical chromatogram for total analysis of cisplatin ... Wada M, Kohno K, Nakamura T, Kawabe T, Kawakami M, Kagotani K, Okumura K, Akiyama S, Kuwano M: A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant...
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Báo cáo hóa học: " Higher polymerase activity of a human influenza virus enhances activation of the hemagglutinin-induced Raf/MEK/ERK signal cascade" pot
Ngày tải lên :
20/06/2014, 01:20
... appearance of H3N2 in 1968 and the reappearance of H1N1 in 1977, IVAs have continued to circulate in humans Although infection with either of these strains appears to have similar clinical manifestations ... was constant These data clearly demonstrate that a greater amount of the H3N2-HA accumulates on the cell membrane compared with that of the H1N1-HA and suggest that the amount of the H3N2-HA ... kinase (MAPK) signaling cascades [11,14] The Raf/MEK/ ERK pathway represents one of the best-characterized MAPK signaling pathways MAPK cascades are key regulators of cellular responses such as...
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báo cáo hóa học:" The OnyCOE-t™ questionnaire: responsiveness and clinical meaningfulness of a patient-reported outcomes questionnaire for toenail onychomycosis" potx
Ngày tải lên :
20/06/2014, 15:20
... which was funded solely by Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA In addition, Amir Tavakkol and Farid Kianifard (Novartis Pharmaceuticals Corporation) and Monika Raut (employed ... Pharmaceuticals Corp The analysis for this study was conducted by Ovation Research Group Amir Tavakkol and Farid Kianifard are employees of Novartis Pharmaceuticals Corporation Monika Raut is an ... questionnaire at baseline and at the end of the study and who had measures of clinical efficacy (clinical assessment of target nail clearing and re-growth) Change scores were computed for each scale...
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báo cáo hóa học: " In vitro and in vivo pre-clinical analysis of a F(ab’)2 fragment of panitumumab for molecular imaging and therapy of HER1-positive cancers" pot
Ngày tải lên :
21/06/2014, 02:20
... panitumumab F(ab’) fragment with an emphasis on its evaluation towards both imaging and therapeutic applications Materials and methods Preparation of F(ab’)2 fragments Panitumumab (Amgen) was ... M, et al: Cetuximab: Preclinical Evaluation of a Monoclonal Antibody Targeting EGFR for Radioimmunodiagnostic and Radioimmunotherapeutic Applications Cancer Biotherapy and Radiopharmaceuticals ... intact panitumumab Trastuzumab F(ab’)2 was used as a negative control All values were corrected for on a nanomolar basis The immunoreactivity of the 111 In-panitumumab F(ab’)2 was assessed in a...
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Báo cáo y học: "Clinical use of a modified release methylphenidate in the treatment of childhood attention deficit hyperactivity disorder" pps
Ngày tải lên :
09/08/2014, 01:21
... in managing the child’s behaviour and psychoeducational materials are made available When pharmacological therapy is recommended, the various types of medication available and their risks and ... medication effect wears off and children eat normally Children are usually advised to eat a substantial breakfast before taking their medication and most are able to eat a healthy portion of food in the ... delivery, and had a history of delay in all areas of her development; she walked late, talked late (age 3) and found mainstream schooling very challenging Patient 4’s parents separated when she was...
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Báo cáo y học: "Identification of a human peripheral blood monocyte subset that differentiates into osteoclasts" doc
Ngày tải lên :
09/08/2014, 08:22
... GTC ATC CCT 3'-AGA CAC ATT GAC CAC AGA GGC ACT β-Actin 5'-GTC CTC TCC CAA GTC CAC ACA 3'-CTG GTC TCA AGT CAG TGT ACA GGT AA GAPDH 5'-TGA TGA CAT CAA GAA GGT GGT GAA G 3'-TCC TTG GAG GCC ATG TGG ... 3'-TCC AGG GCT ATG AAT CAC AAC AGG c-Fos 5'-CAG GAG ACA GAC CAA CTA GA 3'-TTC ACG GAC AGA TAA GGT CC DNAX-activation protein 12 5'-ATG GGG GGA CTT GAA CCC Fc receptor γ chain 5'-TGA TTC CAG CAG TGG ... CTC AGA 3'-CAG AGC GCT GAT TGG TCC ATC TTA 3'-TCC CGT TGC AGA CGT AGA AAC TGA Integrin αv 5'-TCC CAT CAG TGG TTT GGA GCA TCT 3'-TCC GAC AGC CAC AGA ATA ACC CAA Integrin β3 5'-TGC CTC AAC AAT GAG...
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Báo cáo y học: "SOX9 transduction of a human chondrocytic cell line identifies novel genes regulated in primary human chondrocytes and in osteoarthritis" docx
Ngày tải lên :
09/08/2014, 10:21
... GACAAAGACGTGCACTCAACCTT ACTGTCTAAATTGCCCAGAAATGG SRPX TGGCTGGTTGATTTTGTAGAGAAA TAGAAAAGAGTTAGGTGTCACATTGAATAA SPINT1 CGAGTTGTTTCCTCGCTGATC GCAATGGAATTCAACATAAGCAAA CRTL1 TTCCACAAGCACAAACTTTACACAT GTGAAACTGAGTTTTGTATAACCTCTCAGT ... GTGAAACTGAGTTTTGTATAACCTCTCAGT CRLF1 AACGGCCATAACAGCTCTGACT ACTCAACCAACCCTCACACACA MYBPH AGGCCTACAGTCAAACTCCAGAGA GAAGGGAGGCCAGCAGGTA Page of 10 (page number not for citation purposes) Arthritis Research & ... GATACATGACAAGGTGCGGCT COMP CTGGGCCAACCTGCGTTA CGCAGCTGATGGGTCTCATAG APOD ACGCCCTCGTGTACTCCTGTA TTCCACAAGCACAAACTTTACACAT S10 0A1 CCAGGAGTATGTGGTGCTTGTG ATGTGGCTGTCTGCTCAACTGT RGC32 GACAAAGACGTGCACTCAACCTT...
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Báo cáo y học: " Postresectional lung injury in thoracic surgery pre and intraoperative risk factors: a retrospective clinical study of a hundred forty-three cases" pptx
Ngày tải lên :
10/08/2014, 09:22
... risk) [ASA-I: Normally healthy patient, ASA-II: Patient with mild systemic disease, ASA-III: Patient with severe systemic disease that is not incapacitating, ASA-IV: Patient with an incapacitating ... Nishimura M, Hashimoto S, Takanashi M, Okazaki H, Satake M, Nakajima K: Role of anti -human leucocyte antigen class II alloantibody and monocytes in development of transfusion-related ARDS Transfus ... strategy) Statistical Analysis Data are presented as median (range), absolute numbers, or percentages Each of the preoperative and perioperative variables was examined using Fisher exact test for categorical...
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báo cáo khoa học: " 3-D reconstruction of a human fetus with combined holoprosencephaly and cyclopia" pptx
Ngày tải lên :
11/08/2014, 20:20
... with a Leitz DMRB microscope (Leica, Wetzlar, Figure Photographs of the macroscopic appearance of the head Photographs of the macroscopic appearance of the head a) Frontal view of the investigated ... 2) Both maxillae were hypoplastic, with three tooth anlagen on each side Between the maxillae the anlage of a single midaxial incisor was found (Fig 3a) No nasal septum or nasal cavity was present; ... a spontaneously aborted human fetus of undetermined sex and an estimated age of 20 – 22 weeks The maternal history was not available Due to formalin fixation prior to receipt of the fetus, karyotyping...
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Báo cáo y học: "Atypical clinical presentation of a subset of patients with anti-RNA polymerase III - nonscleroderma cases associated with dominant RNA polymerase I reactivity and nucleolar staining" potx
Ngày tải lên :
12/08/2014, 17:22
... Satoh T, Ishikawa O, Ihn H, Endo H, Kawaguchi Y, Sasaki T, Goto D, Takahashi K, Takahashi H, Misaki Y, Mimori T, Muro Y, Yazawa N, Sato S, Takehara K, Kuwana M: Clinical usefulness of anti-RNA ... ACR: American College of Rheumatology; ANA: antinuclear antibodies; GAVE: gastric antral vascular ectasia; ILD: interstitial lung disease; IP: immunoprecipitation; IRB: Institutional Review Board; ... Autoantibodies to RNA polymerase I/III were found in 21 patients (1.1% of 1,966); 18 Caucasians, African Americans, and of mixed ethnic background Sixteen of 21 cases had a diagnosis of SSc at...
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