... Folpe et al [12] report a local recurrence rate of 9%, metastasis rate of 6%, and 1% of cases dying of LGFMS at a mean of 38 months and median of 24 months follow-up Guillou et al [13] report ... location of tumour (4.3%) was not specified The history of symptom duration was available in 14 patients, with a mean of 33.3 months (range 3-300 months) All referred cases were resection specimens Of ... presence or absence of the FUS-CREB3L2 translocation by both methods was noted Histopathological analysis and clinical outcomes for all identified cases of LGFMS were compared to results of FUS-CREB3L2...
Ngày tải lên: 20/06/2014, 04:20
... Folpe et al [12] report a local recurrence rate of 9%, metastasis rate of 6%, and 1% of cases dying of LGFMS at a mean of 38 months and median of 24 months follow-up Guillou et al [13] report ... location of tumour (4.3%) was not specified The history of symptom duration was available in 14 patients, with a mean of 33.3 months (range 3-300 months) All referred cases were resection specimens Of ... presence or absence of the FUS-CREB3L2 translocation by both methods was noted Histopathological analysis and clinical outcomes for all identified cases of LGFMS were compared to results of FUS-CREB3L2...
Ngày tải lên: 20/06/2014, 07:20
Báo cáo hóa học: " Clinical significance of elevated B-type natriuretic peptide in patients with acute lung injury with or without right ventricular dilatation: an observational cohort study" potx
... consent Clinical data collection The primary etiology of ALI was determined based on a detailed review of clinical history Sepsis was defined as suspected infection and presence of at least two of ... partial pressure of mixed expired CO2, which is then used in the Enghoff modification of the Bohr equation [20] Page of Table Baseline demographics and clinical characteristics of the 42 patients ... measurements was collected at the time of enrollment in tubes containing potassium EDTA and was measured by clinical laboratory personnel blinded to the clinical status of the patients The measurement...
Ngày tải lên: 21/06/2014, 03:20
báo cáo khoa học: "Clinical significance of preoperative serum interleukin-6 and C-reactive protein level in breast cancer patients" pot
... patients were divided into two groups on the basis of an IL-6 cutoff value of 20.3 pg/ml by the ROC curve with a sensitivity of 88.6% and a specificity of 54.1% We noted significant differences in ... between the serum level of IL-6 and LN metastasis (P < 0.001, r = 0.844) The median level of IL-6 increased proportionally with the stage of the cancer (the median level of IL-6 in stage 2a 5.6 ... mg/dl was taken as the cutoff value of CRP by ROC curve, after which the patients were divided into two groups The sensitivity and specificity of 15.5 mg/dl as the cutoff value were 62.1% and...
Ngày tải lên: 09/08/2014, 01:24
Báo cáo khoa học: "Clinical significance of 4 patients with chronic hepatitis B achieving HBsAg clearance by treated with pegylated interferon alpha-2a for less than 1 year: a short report" pot
... during the total course of anti-viral therapy Discussion The aims of treatment for CHB are to achieve sustained suppression of HBV replication, thereby inducing remission of liver diseases and ... respectively All of them are kept under observation until now The Variations of sera HBV DNA, ALT and HBV markers in the four patients are outlined in Table Adverse events During the course of pegasys ... monotherapy (the longest period of treatment was 40 weeks, the shortest period of treatment was 20 weeks) or sequential therapy with pegasys and baraclude (the longest period of treatment with pegasys...
Ngày tải lên: 12/08/2014, 04:21
Báo cáo y học: " Expression, regulation and clinical significance of soluble and membrane CD14 receptors in pediatric inflammatory lung diseases" pptx
... small number of patients, CRP levels of >60 mg/l were present in 20 of all 32 (= 63%) children with bacterial pneumonia and had a high diagnostic accuracy of 93.6% for diagnosis of pneumonia ... Long-Term Study of 105 Patients with Cystic Fibrosis Ama Journal of Diseases of Children 1958, 96(1):6-15 14 [Anon]: Standardization of Spirometry - 1994 Update American Journal of Respiratory ... regulation and clinical significance of sCD14 and mCD14 in pediatric lung diseases has not been defined Therefore, we quantified sCD14 and mCD14 levels in peripheral blood and BALF of children with...
Ngày tải lên: 12/08/2014, 11:21
Báo cáo y học: " The clinical significance of 5% change in vital capacity in patients with idiopathic pulmonary fibrosis: extended analysis of the pirfenidone trial" potx
... examine the characteristics of the improvement ratings and PFS based on 5% change in VC in the comparison of efficacy among treatment groups, and the clinical significance of the 5% decline in VC ... Analysis of the H-J classification was performed with Welch’s T-test Analyses of the mortality ratio and incidence of acute exacerbation were with Fisher’s exact test Page of • Comparison of PFS ... progression of disease was defined by a ≥ 5% decline in absolute VC from baseline or death K-M plots of PFS times based on the definition and the results of comparison of the distributions of PFS...
Ngày tải lên: 12/08/2014, 13:22
Báo cáo y học: "Natural history and clinical significance of MRI-detected bone marrow lesions at the knee: a prospective study in community dwelling older adults" pot
... unknown whether BMLs in a Page of 12 community-based sample also predict knee joint replacement The conflicting data on the natural history and clinical significance of BMLs may be due to studies ... and an average of the two was taken The repeatability estimate was 0.91 (Cronbach’s a) The Assessment of Quality of Life (AQoL) instrument was used to measure health-related quality of life The ... sites and the majority of participants who had a BML present had it at only one of the four sites To our knowledge there is no commercially available software to deal with data of this sort in longitudinal...
Ngày tải lên: 12/08/2014, 15:22
Báo cáo khoa học: "Hypertrophic cardiomyopathy in young Maine Coon cats caused by the p.A31P cMyBP-C mutation - the clinical significance of having the mutation" ppsx
... the recommendations of the Echocardiography Committee of the Specialty of Page of 11 Cardiology, American College of Veterinary Internal Medicine and the American Society of Echocardiography, ... early stages of disease, a high percentage of false negative results may be the consequence of too high a cut-off point The group of equivocal MC cats may contain a high number of both “false ... the mutation A small cohort consisting of all cats over years of age (with a median age of 4.9 years, 95% range 4; 8.1) was used to examine the significance of being affected by the p.A31P cMyBP-C...
Ngày tải lên: 12/08/2014, 18:22
Clinical significance of cancer stem cell markers and other related proteins in colorectal carcinomas biological and methodological considerations
... wife, Lyn i TABLE OF CONTENTS ACKNOWLEDGMENTS i SUMMARY v LIST OF PUBLICATIONS viii LIST OF TABLES vi LIST OF FIGURES x CHAPTER 1: INTRODUCTION 1.1 Incidence and Survival Rates of Colorectal Cancer ... 58 Extent of disagreement in reproducibility of results between human visual and computer-assisted scoring methods 58 Frequency of positive expression of protein markers using cut-off scores ... survival rate of colorectal cancer patients vary accordingly to the stage of the disease determined at the time of diagnosis (Table 1) As it is with any type of cancer, prognosis of the patient...
Ngày tải lên: 03/10/2015, 20:57
Báo cáo hóa học: " Strategy Escalation: An emerging paradigm for safe clinical development of T cell gene therapies Richard Paul Junghan" pdf
... features of the modified cells and the method of their proposed administration This Commentary presents an example of such a discussion from the current state of the art for designer T cell therapies, ... infusion may allow "tuning" of the activity against tumor versus normal tissue by judicious dose exposures and a gradation of suppressive therapies (as needed) in the manner of DLI [15], where a Strategy ... independent of antigen stimulation As such, low doses of infused T cells could expand 100-fold in vivo to become a stable, "engrafted" component of the lymphoid compartment, in some instances >50% of...
Ngày tải lên: 18/06/2014, 16:20
Báo cáo hóa học: " Co-evolution of cancer microenvironment reveals distinctive patterns of gastric cancer invasion: laboratory evidence and clinical significance" pptx
... itself A major drawback of such study, however, is the lack of appreciation of the “temporal and spatial coevolution of cancer and its environment”, which is the real context of tumor progression ... Excellent Talents Supporting Program of the Ministry of Education of China (No NCET-04-0669), Foundation for he Author of National Excellent Doctoral Dissertation of PR China (FANEDD-200464) and The ... Peng et al.: Co-evolution of cancer microenvironment reveals distinctive patterns of gastric cancer invasion: laboratory evidence and clinical significance Journal of Translational Medicine 2010...
Ngày tải lên: 18/06/2014, 16:20
Báo cáo sinh học: "The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance" doc
... School of Medicine, Cardiff, CF14 4XN, UK 2Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Thoracic Surgery, Peking University School of Oncology ... division of the patients based on the expression levels of MTSS1 yield a significant correlation with overall survival; (F) A three-way division of the patients based on the expression levels of MTSS1 ... adhesive nature of KYSE510 was observed through the knockdown of MTSS1 expression (C) In vitro motility assay (Left panel) Over-expression of MTSS1 significantly inhibited the motile nature of oesophageal...
Ngày tải lên: 18/06/2014, 19:20
o cáo hóa học:" The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance" docx
... School of Medicine, Cardiff, CF14 4XN, UK 2Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Thoracic Surgery, Peking University School of Oncology ... division of the patients based on the expression levels of MTSS1 yield a significant correlation with overall survival; (F) A three-way division of the patients based on the expression levels of MTSS1 ... adhesive nature of KYSE510 was observed through the knockdown of MTSS1 expression (C) In vitro motility assay (Left panel) Over-expression of MTSS1 significantly inhibited the motile nature of oesophageal...
Ngày tải lên: 20/06/2014, 04:20
Báo cáo khoa học: "Incidence of synchronous appendiceal neoplasm in patients with colorectal cancer and its clinical significance" docx
... metachronous tumours of colon cancer A review of years of experience (1999–2004) Ann Ital Chir 2006, 77:233-239 Wolff M, Ahmed N: Epithelial neoplasms of the vermiform appendix (exclusive of carcinoid) ... know the incidence and the biological significance of synchronous appendiceal tumors in CRC patients The aims of this study were to evaluate the incidence of synchronous appendiceal neoplasm in ... university hospital, and to determine the clinical significance of these findings Methods Pathological reports and medical records were retrospectively reviewed of patients with colorectal adenocarcinoma...
Ngày tải lên: 09/08/2014, 04:21
Báo cáo y học: "Clinical significance in the number of involved lymph nodes in patients that underwent surgery for pathological stage III-N2 non-small cell lung cancer" pot
... heterogeneous subsets of stage III patients have been observed in a wide variety of clinical trials incorporating various combinations of chemotherapy, radiotherapy, and surgery The evidence of whether ... subpleural lymphatic spread to the mediastinum The incidence of skip N2 metastases is 20% to 40% of all N2 diseases, but the nature and clinical significance remain unclear [16] Some investigators report ... Project: validation of the proposals for revision of the T, N, and M descriptors and consequent stage groupings in the forthcoming (seventh) edition of the TNM classification of malignant tumours...
Ngày tải lên: 10/08/2014, 09:22
Báo cáo y học: "Pain as a symptom of peripheral nerve sheath tumors: clinical significance and future therapeutic directions" potx
... neurofibromas [1] In contrast, 94/99 of patients with benign tumors had a positive Tinel's test [1] Thus, further clarification of the character and timing of the pain increases the PPV of the ... symptom of malignancy) suggests that these types of pain might result from distinct pathophysiologic mechanisms It follows from this hypothesis that development of optimal therapies for each of these ... transducer of these mechanical pain impulses is unknown Figure esis in the representation sheath tumors Schematic setting of nerveof possible mechanisms of algogenSchematic representation of possible...
Ngày tải lên: 10/08/2014, 10:20
Báo cáo khoa hoc:" Expression of estrogen and progesterone receptors in vestibular schwannomas and their clinical significance" docx
... evidence of cutane- Figure Magnetic Resonance (MR) image of vestibular schwannoma Magnetic Resonance (MR) image of vestibular schwannoma Table summarizes the statistical analysis of 100 cases of vestibular ... cases of vestibular schwannomas operated from January 2006 to June 2009 in the Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India The clinical ... objective of the present study was to retrospectively determine the expression of estrogen and progesterone receptors by means of immunohistochemical methods using monoclonal antibodies in 100 cases of...
Ngày tải lên: 11/08/2014, 07:21
Báo cáo khoa học: "The clinical value of daily routine chest radiographs in a mixed medical–surgical intensive care unit is low"
... performance of a bronchoalveolar lavage for culture, or start of or a change in antimicrobial therapy in case of unexpected infiltrates on the CXR; repositioning of tubes in case of malposition of orotracheal ... ultrasound of the thorax in case of pleural effusion on the CXR, start or change in medication (diuretics); insertion of a pleural drain; and repositioning of devices in the case of malposition of medical ... removal of intravenous lines) The observers were not involved in the daily care of the patients, and ICU physicians were not aware of this part of the observation As a consequence, the clinical...
Ngày tải lên: 25/10/2012, 10:39
Báo cáo y học: "Hepatitis C Virus Serologic and Virologic Tests and Clinical Diagnosis of HCVRelated Liver Disease"
... of Hepatology, the official journal of the American Association for the Study of Liver Diseases (AASLD), and of Current Hepatitis Reports, and a member of the Editorial Board of the Journal of ... University of Paris and Pasteur Institute, France Jean-Michel Pawlotsky, MD, PhD, is Professor of Medicine at the University of Paris XII and the Director of the Department of Virology, of INSERM ... lower limit of detection of 50 IU/ml or less [1] Four marker profiles can be observed according to the presence or absence of either marker The presence of HCV RNA in the absence of anti-HCV...
Ngày tải lên: 02/11/2012, 09:56