... Page i Toxicology and Clinical Pharmacology of Herbal Products Page ii Forensic Science and Medicine Steven B Karch, MD, SERIES EDITOR TOXICOLOGY AND CLINICAL PHARMACOLOGY OF HERBAL PRODUCTS, edited ... toxicological analysis of biofluids, or the pharmacologic or toxicologic effects of the herb, further investigation might prove difficult or impossible Toxicology and Clinical Pharmacology of Herbal Products ... effects of herbs can be found Toxicology and Clinical Pharmacology of Herbal Products is designed to provide medical examiners, toxicologists, and health care providers with an objective review of...
Ngày tải lên: 06/03/2014, 14:20
Clinical Pharmacology of Sleep doc
... and clinicians of various disciplines who want to get an overall grasp of the clinical pharmacology of sleep This volume includes contributions from a wide range of authors, many of whom are world-recognized ... tendency to pick and choose their clinical subject matter as it relates to their interest in specific conditions and their clinical pharmacology Clinical Pharmacology of Sleep is an important and timely ... either of difficulty falling asleep or maintaining sleep, or of poor quality of sleep However, the presence of the complaint of unsatisfactory sleep is not sufficient for the diagnosis of insomnia...
Ngày tải lên: 22/03/2014, 23:20
... effect of mannitol Lüllmann, Color Atlas of Pharmacology © 2000 Thieme All rights reserved Usage subject to terms and conditions of license 162 Diuretics Diuretics of the Sulfonamide Type These drugs ... a reduced incidence of coronary heart disease Lüllmann, Color Atlas of Pharmacology © 2000 Thieme All rights reserved Usage subject to terms and conditions of license 157 Drugs used in Hyperlipoproteinemias ... cholesterol-lowering drugs Lüllmann, Color Atlas of Pharmacology © 2000 Thieme All rights reserved Usage subject to terms and conditions of license 156 Drugs used in Hyperlipoproteinemias liver meets...
Ngày tải lên: 18/10/2013, 00:15
Color Atlas of Pharmacology (Part 17): Drugs Acting on Motor Systems
... Lüllmann, Color Atlas of Pharmacology © 2000 Thieme All rights reserved Usage subject to terms and conditions of license 191 Drugs Acting on Motor Systems Drugs used in the treatment of status epilepticus: ... Lüllmann, Color Atlas of Pharmacology © 2000 Thieme All rights reserved Usage subject to terms and conditions of license Drugs Acting on Motor Systems 185 Arrow poison of indigenous South Americans ... y and is followed by gradual loss of symptom control, on-off fluctuations, and development of orobuccofacial and limb dyskinesias These long-term drawbacks of levodopa therapy may be delayed...
Ngày tải lên: 24/10/2013, 19:15
Color Atlas of Pharmacology (Part 18): Drugs for the Suppression of Pain
... Bronchoconstriction Irritation of gastrointestinal mucosa Impaired hemostasis with risk of bleeding Risk of anaphylactoid shock Agranulocytosis A Antipyretic analgesics Lüllmann, Color Atlas of Pharmacology © ... cannot be confined to the intended site of action Lüllmann, Color Atlas of Pharmacology © 2000 Thieme All rights reserved Usage subject to terms and conditions of license Antipyretic Analgesics Phospholipase ... Pain stimulus A Origin and effects of prostaglandins Lüllmann, Color Atlas of Pharmacology © 2000 Thieme All rights reserved Usage subject to terms and conditions of license 197 198 Antipyretic Analgesics...
Ngày tải lên: 24/10/2013, 19:15
CRC Desk Reference of Clinical Pharmacology SECOND EDITION doc
... Library of Congress Cataloging-in-Publication Data Ebadi, Manuchair S Desk reference of clinical pharmacology / author, Manuchair Ebadi 2nd ed p ; cm Rev ed of: CRC desk reference of clinical pharmacology ... Dr Ebadi served as chairman of the Department of Pharmacology at the University of Nebraska College of Medicine from 1970 until 1988, and subsequently as professor of pharmacology, neurology, and ... July of 1999, he was appointed professor and chairman of the Department of Pharmacology and Toxicology at the University of North Dakota School of Medicine and Health Sciences In September of 1999,...
Ngày tải lên: 06/03/2014, 14:20
PRINCIPLES OF CLINICAL PHARMACOLOGY Second Edition potx
... principles of clinical pharmacology currently are being applied in the process of drug development Journals Clinical Pharmacology and Therapeutics British Journal of Clinical Pharmacology Journal of ... Protein Binding of Acidic Drugs 55 Plasma Protein Binding of Basic and Neutral Drugs 56 Tissue Binding of Drugs 56 Effects of Renal Disease on Drug Absorption 56 Hepatic Elimination of Drugs 73 Restrictively ... year of age: Children 1–13 years of age: Females 13–20 years of age: Males 13–20 years of age: k = 0.45 k = 0.55 k = 0.57 k = 0.70 From the standpoint of clinical pharmacology, the utility of using...
Ngày tải lên: 22/03/2014, 23:20
báo cáo hóa học: " Relationship between the EQ-5D index and measures of clinical outcomes in selected studies of cardiovascular interventions" pot
... cross-sectional study in a cohort of patients implanted with an ICD at one of two centres between 1991 and the end of 2001 Sixtynine percent of the patients that had an ICD implant - all of those still alive ... developed, they are often tested in clinical trials against current treatment options Clinical trial-based evaluations of treatments in many fields, including cardiology, often include cost-effectiveness, ... analysis of the literature has shown that EQ-5D index scores are variable in examples of patients with cardiovascular disease (Dyer M, Goldsmith, K, Sharples, L, Buxton, M: A review of health...
Ngày tải lên: 18/06/2014, 19:20
Chapter 005. Principles of Clinical Pharmacology (Part 1) pps
... interaction occurs to achieve drug effects Two important goals of the discipline of clinical pharmacology are (1) to provide a description of conditions under which drug actions vary among human subjects; ... Drugs interact with specific target molecules to produce their beneficial and adverse effects The chain of events between administration of a drug and production of these effects ... may be related to specific drugs, or combinations of drugs, that their patients receive Beneficial and adverse reactions to drug therapy can be described by a series of dose-response relations...
Ngày tải lên: 06/07/2014, 08:20
Chapter 005. Principles of Clinical Pharmacology (Part 2) ppt
... from the site of administration (Fig 52) The extent of absorption may be reduced because a drug is incompletely released from its dosage form, undergoes destruction at its site of administration, ... P-glycoprotein, the product of the normal expression of the MDR1 gene P-glycoprotein is expressed on the apical aspect of the enterocyte and on the canalicular aspect of the hepatocyte (Fig 5-3); in both locations, ... and each drug may be a substrate for one or more of these enzymes "Phase II" metabolism involves conjugation of specific endogenous compounds to drugs or their metabolites The enzymes that accomplish...
Ngày tải lên: 06/07/2014, 08:20
Chapter 005. Principles of Clinical Pharmacology (Part 3) docx
... processes are first-order; i.e., the rate of the process depends on the amount of drug present Clinically important exceptions are discussed below (see "Principles of Dose Selection") In the simplest ... half-life As a consequence of this relationship, a plot of the logarithm of concentration vs time is a straight line (Fig 5-2A , inset) Half-life is the time required for 50% of a first-order process ... ~42 L The volume of distribution of drugs extensively bound to plasma proteins but not to tissue components approaches plasma volume; warfarin is an example By contrast, for drugs highly bound...
Ngày tải lên: 06/07/2014, 08:20
Chapter 005. Principles of Clinical Pharmacology (Part 4) ppsx
... rapid (t1/2 of seconds) uptake into erythrocytes and endothelial cells before the drug can reach its clinical site of action, the atrioventricular node Plasma Protein Binding Many drugs circulate ... to sites of pharmacologic action, drug response is related to the free rather than the total circulating plasma drug concentration Clinical Implications of Altered Protein Binding For drugs that ... concentrations of total drug Conversely, conditions such as hypoalbuminemia, liver disease, and renal disease can decrease the extent of drug binding, particularly of acidic and neutral drugs, such...
Ngày tải lên: 06/07/2014, 08:20
Chapter 005. Principles of Clinical Pharmacology (Part 5) doc
... site of action, it alters the function of that molecular target, with the ultimate result of a drug effect that the patient or physician can perceive For drugs used in the urgent treatment of acute ... the risk of concentration-related drug toxicity For example, administration of drugs that inhibit P-glycoprotein reduces digoxin clearance, since P-glycoprotein is the major mediator of digoxin ... or accumulation of active metabolites Commonly, the clinical effect develops as a downstream consequence of the initial molecular effect the drug produces Thus, administration of a proton-pump...
Ngày tải lên: 06/07/2014, 08:20
Chapter 005. Principles of Clinical Pharmacology (Part 6) pdf
... onset of efficacy can be delayed for weeks or months; drugs used in the treatment of cancer and psychiatric disease are examples Sometimes a ... toxicity is absent and the likelihood of serious toxicity is small For example, a small percentage of patients with strong seizure foci require plasma levels of phenytoin >20 g/mL to control seizures ... an understanding of the relationships between plasma concentration and anticipated effects For example, measurement of QT interval is used during treatment with sotalol or dofetilide to avoid...
Ngày tải lên: 06/07/2014, 08:20
Chapter 005. Principles of Clinical Pharmacology (Part 7) pptx
... clearance of lidocaine is reduced by about 50% in heart failure, and therapeutic plasma levels are achieved at infusion rates of 50% or less than those usually required The volume of distribution of ... clotting parameters are well controlled Exaggerated responses to cardiovascular drugs are also common because of the impaired responsiveness of normal homeostatic mechanisms Conversely, the elderly display ... linked to the occurrence of hip fractures in elderly patients, perhaps reflecting both a risk of falls from these drugs (due to increased sedation) and the increased incidence of osteoporosis in elderly...
Ngày tải lên: 06/07/2014, 08:20
Chapter 005. Principles of Clinical Pharmacology (Part 8) pot
... the concept of genotyping to identify optimal drugs (or dosages) in individual patients prior to prescribing can be considered for widespread clinical practice Nevertheless, the appeal of using ... advanced at the end of the nineteenth century, and the first examples of familial clustering of unusual drug responses due to this mechanism were noted in the mid-twentieth century Clinically important ... pathways of drug disposition (Table 5-1) A distinct multimodal distribution of drug disposition (as shown in Fig 5-6) argues for a predominant effect of variants in a single gene in the metabolism of...
Ngày tải lên: 06/07/2014, 08:20
Chapter 005. Principles of Clinical Pharmacology (Part 9) pps
... of glucose-6phosphate dehydrogenase (G6PD), most often in individuals of African or Mediterranean descent, increases risk of hemolytic anemia in response to primaquine and a number of other drugs ... benefit Drugs may also interact with genetic pathways of disease, to elicit or exacerbate symptoms of the underlying conditions In the porphyrias, CYP inducers are thought to increase the activity of ... incidence of the drug-induced lupus syndrome during procainamide and hydralazine therapy and of hepatitis with isoniazid Induction of CYPs (e.g., by rifampin) also increases the risk of isoniazid-related...
Ngày tải lên: 06/07/2014, 08:20
Chapter 005. Principles of Clinical Pharmacology (Part 10) doc
... Indeed, one major result of understanding of the role of genetics in drug action has been improved screening of drugs during the development process to reduce the likelihood of highly variable metabolism ... diagnosis of any unusual response occurring during drug therapy Prescribers should recognize that patients often come to them with a legacy of drugs acquired during previous medical experiences, often ... applicable to the problem of identifying genomic predictors of variable drug effects Prospects for Incorporating Genetic Information into Clinical Practice The examples of associations between...
Ngày tải lên: 06/07/2014, 08:20
Chapter 005. Principles of Clinical Pharmacology (Part 11) pps
... concentrations of grapefruit juice (Table 5-2) The consequences of such interactions will depend on the drug whose elimination is being inhibited; high-risk drugs are those for which alternate pathways of ... increases the risk of serious toxicity (see "The Concept of High-Risk Pharmacokinetics," above) Examples include CYP3A inhibitors increasing the risk of cyclosporine toxicity or of rhabdomyolysis ... markedly inhibited by quinidine, a number of neuroleptic drugs (chlorpromazine and haloperidol), and the SSRIs fluoxetine and paroxetine Clinical consequences of fluoxetine's interaction with CYP2D6...
Ngày tải lên: 06/07/2014, 08:20
Chapter 005. Principles of Clinical Pharmacology (Part 12) doc
... Adverse Reactions to Drugs The beneficial effects of drugs are coupled with the inescapable risk of untoward effects The morbidity and mortality from these untoward effects often present diagnostic ... latter effects are often unanticipated (especially with new drugs) and frequently severe and result from recognized as well as undiscovered mechanisms Drugs may increase the frequency of an event that ... the prescription of new drugs and alert for the appearance of previously unrecognized adverse events Elucidating mechanisms underlying adverse drug effects can assist development of safer compounds...
Ngày tải lên: 06/07/2014, 08:20