clinical pharmacology and pharmacogenetics of chemotherapy in prostate cancer

... (11.9%), in ascending colon of 14 patients (15.2%), in transverse colon of subjects (8.7%), in hepatic flexure of patients (8.7%), in splenic flexure of patients (7.6%), in descending colon of 10 ... resection and type of operation are important prognostic factors In a recent Table 2: Results of multivariate analysis of clinical and laboratory data of patients with colon cancer Source Main effects ... of increase of CEA and CA 19-9 levels to predict the prognosis of the patients remains a problem for debate; in our experience CEA and CA 19-9 levels were found indicators neither of pT staging...

Ngày tải lên: 09/08/2014, 07:21

... preclinical study in prostate cancer xenografts, and suggest that the combination of functional MRI parameters, in addition to standard clinical parameters, increases the power of predicting therapeutic ... training, testing and validating the network showed curve flattening after a few training epochs, this indicated that no overtraining occurred However, if such a model is to be applied on clinical ... from a preclinical study in prostate cancer xenografts, indicate that the combination of several functional MRI parameters obtained pre-treatment and early in the course of treatment, into an artificial...

Ngày tải lên: 09/08/2014, 09:20

... comparison of the use of bony anatomy and internal markers for offline verification and an evaluation of http://www.ro-journal.com/content/4/1/13 41 42 43 44 the potential benefit of online and offline ... systematic error inherent to the use of a reference image obtained by use of the planning-CT The random component of the setup error is mainly caused by uncertainties from utilisation of skin markers, ... the standard deviation of the random error (σ) to ensure a minimum dose of 95% to the clinical target volume for 90% of the fractions, i.e allowing significant dose discrepancies in = 10% of sessions...

Ngày tải lên: 09/08/2014, 09:22

... Days post infection Figure Longitudinal changes in serum BUN, creatinine and phosphorus following SIV infection and ART treatment Longitudinal changes in Blood Urea Nitrogen, creatinine, and phosphorus ... examined at different stages of disease and treatment and revealed an initial increase in BUN and creatinine and decrease in phosphorus, which coincided with ART initiation (Figure 2) These values ... evidence of acute renal failure that developed 26 and 31 days, respectively, following initiation of ART Abnormalities included marked and abrupt increases in serum BUN, creatinine and calcium...

Ngày tải lên: 10/08/2014, 05:21

... [22] There is a growing interest in the possible role of exercise in enhancing QOL, reducing recurrence and other diseases, and extending survival in cancer survivors Preliminary research suggests ... easier In our study only 10.7% of participants withdrew from the study: this surprisingly positive finding may be explained in terms of perceived quality of care related to the offering of custom-made ... impact of exercise training on QOL in breast cancer survivors The aim of this study was to assess the association between physical exercise and quality of life in a population of female breast cancer...

Ngày tải lên: 08/08/2014, 16:23

... retroelements (IAPs) Together with our data, these findings highlight the difficulty of avoiding DNA contamination in clinical samples and the risk of testing contaminated samples as XMRV-positive by sensitive ... XMRV infection and PCa, PCa grades and RNASEL R462Q polymorphism by testing prostate tissues for the presence of XMRV In addition, to determine the correlation between PCa and seroprevalence of ... sequences In order to establish consistency and to minimize the risk of contamination during the procedure, three individuals independently performed the nested PCR experiments using independently...

Ngày tải lên: 13/08/2014, 01:20

... observed to be more sensitive than staining in 69% of total aspirates, including cases that were found negative with gram staining Cultures are more specific in diagnosing early stage tuberculosis (21) ... sensitive and specific tests Considering the serious impact of missed or delayed diagnoses and the risk of transmission to health care professionals, clinicians must maintain a high level of suspicion ... number of patients The clinical diagnosis that was the primary contributing factor to mortality was community-acquired pneumonia, seen in 54% of cases This is a predominant condition in developing...

Ngày tải lên: 15/02/2014, 12:20

... of Engineering was established in 1964, under the charter of the National Academy of Sciences, as a parallel organization of outstanding engineers It is autonomous in its administration and in ... principal operating agency of both the National Academy of Sciences and the National Academy of Engineering in providing services to the government, the public, and the scientific and engineering ... implementing the cancer survivorship care plan and coordinating care; (3) developing guidelines, instituting quality improvement, and strengthening professional education programs; and (4) addressing...

Ngày tải lên: 22/03/2014, 20:21

... risk and individualised intervention aimed at promoting independence and improving physical and psychological function [A] 1.4 Strength and balance training 1.4.1 Strength and balance training ... methods of assessment and identification of older people at risk of falling ✦ The evidence for factors that increase the risk of falling ✦ The most clinically and cost effective interventions and ... appropriate training and who know how to initiate and maintain correct and suitable preventative ✦ measures Staffing levels and skill mix should reflect the needs of patients Principles of practice...

Ngày tải lên: 28/03/2014, 16:20

... Immunostaining of prostate cancer tissue with antibodies against AMACR and PSA Immunostaining of prostate cancer tissue with antibodies against AMACR and PSA Surgically resected prostate cancer tissue ... overexpressed in a variety of tumor tissues, including prostate cancer AMACR was identified as a tissue biomarker for prostate cancer by gene expression profiling of primary human prostate cancer and benign ... liver and pancreas by immunohistochemical staining In contrast, PSA was stained in both prostate cancer tissue and non-cancerous tissue (Figure 2C) These data indicated that AMACR had a mostly cancer- specific...

Ngày tải lên: 18/06/2014, 15:20

... up, drafting and reviewing of the manuscript AR participated in conception of the study, drafting and writing of the manuscript EK was involved in the conception of the study and drafting of the ... manuscript writing MW was involved in the conception of the study, data analysis and drafting of the manuscript BHP participated in the drafting and reviewing of the manuscript MAS participated in study ... participated in the data analysis, drafting and reviewing of the manuscript JM participated in the data analysis, reviewing and writing of the manuscript RC participated in the study conduct, reviewing and...

Ngày tải lên: 20/06/2014, 08:20

... (age and CD4+ cell count) Table Number and incidence rates of opportunistic infections in the initial 24 months after ART initiation, and percent underreporting of OI events in routine clinic ... database (n = 559) Type of OI Routine clinic database (n = 559) Routine clinic database (n = 1233) % underreporting of OI % events in 559 patients in underreporting routine clinic vs of OI research cohort ... (comprising missing and incorrect items) of 67% for OIs, 52% for ART-related toxicities, and 83% and 58% for ART discontinuation Page of and modification, respectively Nineteen of the 559 patients in...

Ngày tải lên: 20/06/2014, 08:20

... further examine causality by following clinical changes in the patients Further studies of the importance of changes in QOL in subjects with clinical depression are also needed Competing interests ... useful in clinical situations [33,34] Implications for clinicians, QOL research, and choosing study instruments These findings have implications for clinicians, for QOL researchers, and for investigators ... quality of life over a 6-week period [10] Here, we expand on these earlier findings by examining a wider range of health status and quality of life measures as well as examining synchrony of change...

Ngày tải lên: 20/06/2014, 15:20

... contribution of the thesis: - Described the situation demands, access to and use of clinical services (CL) of EL in Binh Duong province Also, evaluated the ability of health station (HS) to meet the demand ... (HPr) and the work of preventive medicine, clinical ordinary activities for the people 1.3 Elderly health care models 1.3.1 Policy on Ageing Being aware of the meaning and importance in EL health ... them 69.1% of households in group Q1; 37.4% households in group Q2; 14.5% of households in Q3 group; 19.9% of households in group Q4 and 57.2% in Q5 group However, the purpose of debt in each group...

Ngày tải lên: 25/07/2014, 14:07

... factors of the study method, interpretation of data and final formulation of the manuscript, GK and CI contributed to the study design and interpretation of data and final formulation of the manuscript ... performed a clinical interview of each control subject, in order to determine the current medical and psychiatric status Only subjects normal beyond doubt according to the clinical interview were included ... in addition to the finding that DST non-suppressors were likely to be born during autumn and winter are difficult to interpret and could not be explained on the basis of the virus infection in...

Ngày tải lên: 08/08/2014, 23:20

... individuals tested Intracellular staining for perforin and IFN-γ was performed in activated cells to determine the number of cytokine producing cells Production of perforin was more frequent in CD4+CD28– ... levels of CD3+CD4+CD28– T cells and grade of clinical restriction in ankylosing spondylitis patients Patients were grouped into those with minor restrictions (cervical rotation in sitting and lying ... model of CD4+CD28– NK T cells initiating and sustaining immune responses, and providing a link between the adaptive and the innate immune systems, may hold true for AS disease Competing interests...

Ngày tải lên: 09/08/2014, 01:23

... Page of 12 effects on the genome [9] The use of two clinically relevant derivatives, the oral drug perifosine and the prototypic intravenously applicable ErPC3, in preclinical and clinical investigations ... to induce apoptosis in tumor cells and their ability to increase cytotoxic efficacy of chemotherapy and radiotherapy in preclinical investigations [10-12] Induction of apoptosis by ErPC3 and ... inactivated in a variety of solid human tumors, including prostate cancer Increased levels of PIP3 trigger the recruitment of phosphatidylinositide-dependent serine/threonine kinase (PDK1) and Akt...

Ngày tải lên: 09/08/2014, 09:20

... diminution of late GI and GU toxicity to grades 0-1 in a majority of acute toxicities of patients suffering grades 1-3 The relevance of our study lies in the complex evaluation of clinical and ... for matching with portal images Planning target volume (PTV) of the prostate (PTV3) was the entire organ (clinical target volume of prostate- CTV3), and PTV2 was the entire prostate and seminal vesicles ... Background Quality of life is becoming one of the most significant issues in treatment decision-making, in general, and more so in prostate cancer [1] Thus late rectal and urinary damage became...

Ngày tải lên: 09/08/2014, 09:20

... use of FCS-containing media during genistein incubation and the incubation with higher genistein doses Mechanisms of interaction To search for mechanisms of interaction we investigated protein ... radiosensitivity in the androgen independent PC cell line PC-3 has been demonstrated in vitro and in vivo [26,27] Our study analyzes the interactions of irradiation and genistein or estradiol incubation in androgen ... several protein tyrosine- and histidine kinases [810], and inhibits topoisomerase I and II [11] These effects result in alterations of several intracellular and extracellular pathways including cell...

Ngày tải lên: 09/08/2014, 09:22

... cystic carcinomas of the head and neck are a unique kind of tumour deriving from cells of the major and minor salivary glands, they account for 25% of all malignant salivary gland tumours in different ... clinical examination and MRI scans Depending on clinical and radiological findings the period between individual follow-ups was increased after the second year The measurement of follow-up was initiated ... target point of the IMRT treatment was defined stereotactically and treatment was performed on a step -and- shoot approach using a linear accelerator with photon energies of MV and 15 MV and integrated...

Ngày tải lên: 09/08/2014, 10:21