chorea tics and other movement disorders
Tài liệu Molecular Neurobiology of Alzheimer Disease and Related Disorders doc
... when both S1P and S2P are involved in RIP, the transmembrane domain of the substrates seems to share type II topology On the other hand, when a disintegrin and metallo-protease (ADAM)- and PS-dependent ... regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and ... Target for Alzheimer Disease and Related Disorders Grundke-Iqbal, I (Staten Island, N.Y.); Tatebayashi, Y (Saitama); Lee, M.H.; Li, L (Beijing); Iqbal, K (Staten Island, N.Y.) 183 Learning Deficits...
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Báo cáo khoa học: "Upregulated but insufficient generation of activated protein C is associated with development of multiorgan failure in severe acute pancreatitis" pot
... and LK executed the study and drafted the manuscript LK, JAF, JHG, PP, HR, and JP participated in the original design and coordination of the study, and in writing the original protocol JAF and ... between HLA-DR expression and the PC and APC levels may therefore support the concept of interaction between inflammation and the PC pathway In severe AP, levels of PC and APC were moderately associated ... JHG carried out the PC and APC assays LK, PM, HR, and JP analysed the data PM, EK, PP, HR, and JP assisted in drafting the manuscript RH assisted in the original design and drafting of the final...
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Báo cáo khoa học: In vitro gamma-secretase cleavage of the Alzheimer’s amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc potx
... similar to Ab and an e-CTF when transformed with MC99-3FLAG (A) Schematic of proteins (B) Lysate from MC99-3FLAGexpressing E coli, c and e standards were separated by SDS ⁄ PAGE and western blotted ... slightly faster mobility than the c-3FLAG standard (Fig 3C, lane 1) Using C101-3FLAG, c-3FLAG and e-3FLAG standards as molecular mass markers, the FLAG-reactive band migrating below C101-3FLAG is calculated ... PS2 and mature and immature Nct could be found in low molecular mass fractions Thus 0.5% CHAPSO during chromatography abolishes c-secretase activity and causes a subset of both Nct isoforms and...
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The effect of s1p lyase deficiency on the metabolism of the alzheimer’s related amyloid precursor protein
... of S1Plyase impairs the β- and γ-secretase dependent processing of APP on one hand, but also decreased the lysosomal degradation of APP and its CTFs on the other hand The increase of lysosomal ... al, 2013), neurological disorders/ neuro-inflammation (Davies et al, 2013; Gomez-Munoz et al, 2013) and other metabolic disorders (Hla & Dannenberg, 2012) 1.2.1 Topology and metabolism of sphingolipids ... or B (NPA, NPB), Sandhoff disease, Tay Sachs disease and many others In Gaucher’s disease, GluCer is the primarily stored lipid and causes malfunction of the liver, skeletal disorders, anemia...
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Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx
... leading to hemorrhage and perivascular microgliosis and astrocytosis The Dutch and Iowa mutations both reduce the negative charge of Ab and stimulate the formation of amyloid fibrils and attachment to ... cerebrospinal fluid (CSF) and plasma of young transgenic mice and healthy human Measures in PDAPP refer to Ab 1–x, in Tg2576, APP23 and humans to the sum of Ab1–40 and Ab1–42, and in tgArcSwe they ... that metal ions like Zn2+ and Cu2+ play a role in Ab biology, and possibly in AD pathogenesis Both ions bind APP and Ab with high affinity, and stimulate Ab aggregation and oxidizing effects of...
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Tài liệu Báo cáo khoa học: A facile method for expression and purification of the Alzheimer’s disease-associated amyloid b-peptide pdf
... supplied with the enzyme, and contained Aba, Abb and Abc at 40 nm each, and the start and stop primers Abstart and Abstop at 600 nm each, and 200 lm each of dATP, dCTP, dGTP and dTTP The product was ... Ab(1–40) and Ab(M1–40) are at least 97% pure In the lanes containing Ab(1–42) and Ab(M1– 42), there were prominent bands at approximately kDa and faint bands at approximately 14 kDa The band at ... loaded per lane, and only a single band was detected in the lanes containing Ab(1–40) and Ab(M1–40) (Fig 5E) In other experiments, 400 ng of peptide were loaded in each well, and very darkly stained...
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Báo cáo khoa học: Selecting cells with different Alzheimer’s disease c-secretase activity using FACS Differential effect of presenilin exon 9 deletion on c- and e-cleavage doc
... substrate-activator and reporter genes yielded fluorescent cells Double-transfected COS-7 cells were fixed and observed by phase (panels and 3) and fluorescence microscopy (panels and 4) Phase microscopy ... Reinhard and A Weidemann for providing DNA-constructs and advice, and Ms F Katsis for protein sequencing We thank Dr M Shearman and Dr M Bogyo for providing inhibitors We thank Drs S Mok, A Hill and ... (5Gal-E1b-EGFP) DNA constructs into COS-7 and CHO cells resulted in the expression of GFP positive cells Figure 1B shows phase (panels and 3) and fluorescence microscopy (panels and 4) of COS-7 cells transfected...
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Báo cáo khoa học: Amyloid-b protofibril levels correlate with spatial learning in Arctic Alzheimer’s disease transgenic mice docx
... PSAPP mice exhibit robust and progressive deficits in learning and memory tests [31,32], and some data imply a correlation of deposited Ab and memory dysfunction [33], whereas other data obtained in ... committees and performed in compliance with national and local animal care and use guidelines (protocols #C258 ⁄ and #C242 ⁄ at Uppsala University and #M2804 and #M2814 at the University of South Florida) ... al In spite of similarities and obvious differences between animal models and human disease, it is still interesting and important to reflect upon these observations and to try to provide explanations...
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Báo cáo khoa học: Amyloid–cholinesterase interactions Implications for Alzheimer’s disease pot
... more and larger plaques than control animals, and some behavioral deterioration, as shown by the working memory test [17] By contrast, when two acetylcholinesterase inhibitors: physostigmine and ... presented Km and Vmax values higher than those observed by the free enzyme and was more resistant to: (b) incubation under low pH conditions, (c) inhibition by anti-cholinesterase agents and (d) inhibition ... aggregates In some Alzheimer’s disease patients the Ab and prion pathology coexist and the both kind of amyloid plaques formed have similar characteristics [42] In 2006, the effect of acetylcholinesterase...
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Báo cáo khoa học: High-resolution NMR studies of the zinc-binding site of the Alzheimer’s amyloid b-peptide pdf
... conditions, zinc binding occurs with His6, His13, His14 and Asp1 as ligands The binding seems to be specific and affects mainly the ligands and the neighboring residues The detected residue-specific ... experiments were performed at 286 K and pH 7.0–7.3, unless stated otherwise The 1H–15N HSQC and 1H–13C HSQC experiments were performed using 2048 · 128 increments and 32 scans, and with the carrier placed ... 10 mM phosphate buffer at pH 7.4 and 286 K without (black) and with (red) 30 lM zinc as chloride (red) The d and e resonances of the histidines shown in (A) and (B), respectively, show significant...
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Báo cáo khoa học: Shedding of the amyloid precursor protein-like protein APLP2 by disintegrin-metalloproteinases Retinoic acid-induced upregulation of substrate and proteinase ADAM10 during neuronal cell differentiation ppt
... matrixmetalloproteinases (MMPs) and ADAMs, decreased basal APPsa and APLP2s secretion to 60 and 75%, respectively, of untreated cells (Fig 2A,B, lanes and 3) and reduced the PMA-stimulated amount ... apparent molecular mass between 130 and 170 kDa (Fig 1) Two minor sharp bands between 95 and 120 kDa probably represent, according to earlier studies, APLP2s and truncated APLP2s without CS-GAG-modification ... mammalian APP-related protein APLP2 by the disintegrin and metalloproteinases ADAM10 and TACE (ADAM17), and a common upregulation of ADAM10 and its substrate by RA The main criteria for the involvement...
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báo cáo hóa học: " Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer''''s disease" potx
... total Aβ as compared to TgAPPsw mice at the same age, and levels of insoluble and soluble Aβ (both 1–40 and 1– 42) correlated well with each other (Table 1) Analysis of the ratio of soluble:insoluble ... patient brain and show an increased production of inflammatory markers such as COX-2, PGE2 and also increased levels of the pro-inflammatory cytokines IFN-γ and IL-12, TNF-α, IL-1α, IL-1β and IL-6 ... 15 fold more Aβ1–40, and 20 fold more 1– 42) but there was considerable slice-to-slice variation in soluble and insoluble Aβ levels within and between genotypes The TgAPPsw and PS1/APPsw mice express...
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báo cáo hóa học: " Toll-like receptor 2 -196 to -174 del polymorphism influences the susceptibility of Han Chinese people to Alzheimer’s disease" potx
... according to the criteria of National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer’s disease and Related Disorders Association (NINCDS-ADRDA) [14] All AD cases were ... late-onset AD; NINCDS-ADRDA: National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer’s disease and Related Disorders Association; ORs: odds ratios; PCR: polymerase ... calculating the D’ and r2 statistics These were found to be in weak linkage disequilibrium (D’ = 0.376 and r = 0.009) Hence, haplotype frequencies were not estimated, and both the GT repeat and the -196...
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Báo cáo y học: " Research In silico modeling of the specific inhibitory potential of thiophene-2,3-dihydro-1,5-benzothiazepine against BChE in the formation of β-amyloid plaques associated with Alzheimer''''s disease" doc
... performed in vitro testing and studied inhibition kinetics and pharmacological profiles combined with in silico tools, such as molecular docking and 3D-QSAR (CoMFA and CoMSIA) studies [15-24] ... (each), Max T = 23.03 for Trp84 and 32.22 for Trp279, and Mean T = 16.962 for Trp84 and 19.214 for Trp279) Maximum 2000 minimization cycles (for flexible residues and ligand) along with the maximum ... repositioning of the selected side chains and minimization of ligand were performed using the standard non-softened potentials Default potentials for Trp84 and Trp279 side chains were maintained...
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Tài liệu Alzheimer’s Disease and Other Dementias doc
... Psychological Disorders Alzheimer’s Disease and Other Dementias Psychological Disorders Addiction Alzheimer’s Disease and Other Dementias Anxiety Disorders Child Abuse and Stress Disorders Depression and ... related to involuntary movement disorders like Parkinson’s disease and Huntington’s disease have symptoms of chorea (involuntary movements that look like dancing), tremor, and other physical symptoms ... Professor of Psychology Vanderbilt University Foreword by Pat Levitt, Ph.D Vanderbilt Kennedy Center for Research on Human Development Psychological Disorders: Alzheimer’s Disease and Other Dementias...
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Memory performance in healthy elderly without Alzheimer’s disease: effects of time and apolipoprotein-E pptx
... visuospatial and tests of reasoning were the main contributors These included the Rosen Drawing Test [45], matching and recognition components of the Benton Visual Retention Test [4] and the Identities and ... Marder K, Bell K, Gurland B, Lantigua R, Andrews H, Feng L, Tycko B, Mayeux R 1998 The APOE-epsilon4 allele and the risk of Alzheimer disease among African Americans, whites, and Hispanics [see ... Apolipoprotein E epsilon 4, other risk factors, and course of Alzheimer’s disease Biol Psychiatry 45(5): 633– [68] Yaffe K, Cauley J, Sands L, Browner W 1997 Apolipoprotein E phenotype and cognitive decline...
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LifeOut of Focus Alzheimer’s Disease and Related Disorders ppt
... disorders, including mental and emotional disorders, problems related to alcohol and drug abuse, and some diseases that cause both emotional and physical symptoms Psychological disorders often begin ... successful, and well respected in her community At home, she and her husband especially enjoyed spending time with their six grandchildren There, Helen could put numbers and finances and tax forms ... Disease and Related Disorders Dan Harmon CHELSEA HOUSE PUBLISHERS Philadelphia The ENCYCLOPEDIA OF PSYCHOLOGICAL DISORDERS provides up-to-date information on the history of, causes and effects of, and...
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PET in the Evaluation of Alzheimer’s Disease and Related Disorders docx
... neurosurgeons, psychiatrists (and others examining disorders of the brain) order and read brain PET scans, demand is greatest for those pertaining to dementia and related disorders This demand is driven by ... patients and asking questions to gather information about a patient’s behavior and appearance, ambulation and movement, mood and affect, speech, thought processes and content, insight and judgment, and ... respectively; and my family—my wife Wei, our kids, our parents Donna and Robert and Pei and Robert, and my sibs Anne, Beth, and Mikhael, whose contributions of friendship, love, understanding of...
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Báo cáo khoa học: The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer’s disease pptx
... and that the mechanisms of toxicity precede Ab aggregation and accumulation Curtain et al [49,65] demonstrated that the capacity for Ab to bind Zn and Cu determined its ability to penetrate and ... stress (described above), and several lines of evidence indicate that intracellular Cu deficiency in AD may involve Ab and APP Ab and its precursor APP both bind Cu, and over-expression of a C-terminal ... tight control of metals within the cell [5,6] The toxic effects of Fe and Cu and their role in numerous neurodegenerative and age-related diseases have been reviewed recently [7] Equally detrimental...
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Báo cáo khoa học: Therapeutic approaches for prion and Alzheimer’s diseases pot
... degradation and toxic to neurons Neurological symptoms in AD and prion disease are directly related to loss of neurons and synaptic connections Oligomeric and fibrillar Ab can be directly neurotoxic and ... in Great Britain, 21 in France, four in Ireland, three in the USA, two in the Netherlands and one each in Italy, Canada, Japan, Saudi Arabia, Portugal and Spain Most of the patients from these ... chain), compared to approximately 5600 BSE cases in other European countries (with the highest numbers being 1590, 1030 and 986 in Ireland, Portugal and Frances, respectively) This suggests a significantly...
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