... operations... International Covenant on Civil and Political Rights, and the International Covenant on Economic, Social and Cultural Rights, the Convention against Torture, the Convention on ... Convention on the Elimination of All Forms of Racial Discrimination, the Convention on the Elimination of All Forms of Discrimination against Women and the Convention on the Rights of the ... regard to consumer protec- tion G Obligations with regard to environmental protection H General provisions of implementation The full content of the Matrix and explanatory notes on the Draft
Ngày tải lên: 29/03/2014, 19:20
... Evaluation 51 Thomas A. Shannon 4 A Traditional Christian Refl ection on Reengineering Human Nature 73 H. Tristram Engelhardt, Jr. 5 Germline Gene Modifi cation and the Human Condition before ... Question of Human Germline Modification 23 of traditional Christianity, he identifies specific limitations or conditions that must be met by germline modification With these in place, he concludes ... based on the hope that religious voices might deepen the public conversation about human germline modification, taking it to new dimensions of reflection on the meaning of our humanity
Ngày tải lên: 11/06/2014, 12:51
báo cáo hóa học:" Bioactivity-guided identification and cell signaling technology to delineate the immunomodulatory effects of Panax ginseng on human promonocytic U937 cells" potx
... University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, PR China and 2 Molecular Chinese Medicine Laboratory, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, ... and ELISA. Consistently, PGSE showed inhibition on TNF-α-induced CXCL-10 expres- sion (Figures 1A and 2A) but augmentation of TNF-α- induced IL-8 expression (Figures 1B and 2B). By contrast, there ... of Translational Medicine 2009, 7:34 http://www.translational-medicine.com/content/7/1/34 Page 3 of 10 (page number not for citation purposes) before the next injection. The injection volume was
Ngày tải lên: 18/06/2014, 15:20
báo cáo hóa học:" Regulatory activity of azabisphosphonate-capped dendrimers on human CD4+ T cell proliferation enhances ex-vivo expansion of NK cells from PBMCs for immunotherapy" potx
... driven proliferation of CD4+ T cell among human PBMCs We have previously reported that addition of azabisphosphonate capped dendrimers (3a-G1) on human PBMCs together with human recombinant IL-2 ... competition for IL-2 by performing the same assay at various concentrations of the cytokine Irrespective of IL-2 concentration, 3a-G1 locks CD4+ T cell proliferation In contrast, NK cell proliferation ... dissociation constant and k the coefficient of the non-specific fixation component Interestingly, competition experiments revealed that the parental 3a-G1 was able to shift the apparent dissociation constant
Ngày tải lên: 18/06/2014, 15:20
Báo cáo sinh học: " Ozone acting on human blood yields a hormetic dose-response relationship" pdf
... ozone concentrations of either 0.84 μmol/ml or 1.68 μmol/ml per ml of plasma, respec- tively. On the other hand, in blood taken from the same donors, after being treated with the same ozone concen- ... of electron donation continuously supplied by NADPH-reducing equivalents to GSH-Rd and thiore- doxin reductase [42] (Figure 1). These data, by showing that the therapeutic ozonation only temporarily ... 2, 53100, Siena, Italy. Authors’ contributions VAB and VT conceived, outlined the direction of, provided information to shape the manuscript content and discussion, gathered references, and drafted
Ngày tải lên: 18/06/2014, 19:20
báo cáo hóa học:" Ozone acting on human blood yields a hormetic dose-response relationship" pot
... ozone concentrations of either 0.84 μmol/ml or 1.68 μmol/ml per ml of plasma, respec- tively. On the other hand, in blood taken from the same donors, after being treated with the same ozone concen- ... of electron donation continuously supplied by NADPH-reducing equivalents to GSH-Rd and thiore- doxin reductase [42] (Figure 1). These data, by showing that the therapeutic ozonation only temporarily ... 2, 53100, Siena, Italy. Authors’ contributions VAB and VT conceived, outlined the direction of, provided information to shape the manuscript content and discussion, gathered references, and drafted
Ngày tải lên: 20/06/2014, 03:20
Báo cáo hóa học: " Cytotoxic effects and the mechanism of three types of magnetic nanoparticles on human hepatoma BEL-7402 cells" ppt
... ultrasonication. The stock suspensions were sonicated for 20 min to distribute the particles, and then dilutions were made in complete media to achieve desired testing concentrations. The test suspensions ... PBS,andpost-fixedin1%osmiumtetroxideat4°Cfor 1 h. After dehydration in series concentrations of ethanol and infiltration in acetone, cells were em bedded in Epon 812, and ultra-thin sections cut with glass knives were stained ... the low concentration, while without signifi- cant differences (P >0.05).Athighconcentration,the cytochrome C protein expression of all treated groups decreased dramatically, which is consistent
Ngày tải lên: 21/06/2014, 01:20
Báo cáo y học: " Non-imprinted allele-specific DNA methylation on human autosomes" pptx
... Correlation of DNA methylation with age in amplicon 262 Correlation of DNA methylation with age in amplicon 262 (a) Methylation of amplicon 262 in old and young individuals analyzed without considering ... Allele-specific methylation and expression of the first exon of the C21orf81 gene We observed strong ASM on the first exon of the C21orf81 gene where we studied the methylation pattern of amplicon 23_2 and ... 262_L DNA methylation [%] 80 Amplicons Figure Inter-individual variation of DNA methylation Inter-individual variation of DNA methylation (a) DNA methylation levels of all amplicons studied in blood
Ngày tải lên: 09/08/2014, 20:21
Báo cáo y học: "A new approach to understanding the impact of circadian disruption on human health'''' pps
... disruption on human health or how laboratory studies using animal models relate to the human condition Second, with an understanding of circadian light, it is now possible to measure the synchrony ... JC, Knauer RS: Human sleep: its duration and organization depend on its circadian phase Science 1980, 210(4475):1264-1267 Conroy RTWL Mills, J N.: Human Circadian Rhythms London , Churchill; ... DJ: An action spectrum for melatonin suppression: evidence for a novel non-rod, non-cone photoreceptor system in humans J Physiol 2001, 535(Pt 1):261-267 Figueiro MG, Bullough JD, Parsons RH, Rea
Ngày tải lên: 10/08/2014, 09:20
báo cáo khoa học: "The effects of β-glucan on human immune and cancer cells" pptx
... Faculty of Medicine, The University of Hong Kong, Hong Kong and 2 Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong Email: Godfrey Chi-Fung Chan* - ... and solution conformation were shown to have an impact on the elimination half-life, volume of distribu- tion and clearance [27]. The low systemic blood level of β-glucans after ingestion does ... circulating granulocytes, monocytes or macro- phages via the complement receptor (CR)-3. The immune response will then be turned on, one of the actions is the phagocytosis of the monoclonal antibody tagged
Ngày tải lên: 10/08/2014, 22:20
Báo cáo y học: "Effect of the Cannabinoid Receptor-1 antagonist SR141716A on human adipocyte inflammatory profile and differentiation" ppt
... Provisional PDF corresponds to the article as it appeared upon acceptance. Fully formatted PDF and full text (HTML) versions will be made available soon. Effect of the Cannabinoid Receptor-1 antagonist ... restored adiponectin secretion to normal levels after LPS treatment. Lastly, no effect of SR141716A was detected on human pre-adipocyte differentiation, although the compound enhanced adiponectin ... inhibition of pre -adipocyte cellular proliferation [24] With this in mind we decided to study the effect of SR141716A on adipocyte differentiation The evaluation of proliferation
Ngày tải lên: 11/08/2014, 03:20
Báo cáo khoa hoc:" Generation of a panel of antibodies against proteins encoded on human chromosome 21" pps
... 24263) No human specific region USP25 Basal expression in all human tissues but high expression only in fetal N/A brain and adult testis [19,20] NCAM2 Expression in adult human brain [21] No human ... mouse and human brain [29,30] No human specific region TIAM1 Expression in adult mouse and human brain [18] No human specific region SOD1 Expressed in human and mouse brain [31,32] region used ... human specific region S100Beta Expression in adult mouse and human brain (particularly astrocytes and spinal, medullar, pontine and deep cerebellar neurons) [18,21,85] No human specific region
Ngày tải lên: 11/08/2014, 07:21
Báo cáo y học: "Early Effects of anti-inflammatory [1, 2, 4]triazolo[4, 3-a] [1, 8]naphthyridine derivatives on human stimulated PMN and endothelial cells: an in vitro study" doc
... responsible for the production of large amounts of pro-inflammatory PGs at sites of inflammation For this reason we measured PG produc- Effect on O2- production induced by FMLP on PMNs Considering ... FMLP-induced adhesion was 283 ± 28% vs control: it has been shown that the tested concentration produces near-maximal activation of PMNs [35,36,20] Concentrations of the other stimuli were chosen on the ... inhibitory actions of gliclazide on neutrophils-endothelial cells adhesion and surface expression of endothelial adhesion molecules mediated by a high glucose concentration J Diabetes Complication 2003,
Ngày tải lên: 11/08/2014, 08:21
Báo cáo y học: " The effect of the pro-inflammatory cytokine tumor necrosis factor-alpha on human joint capsule myofibroblasts" ppsx
... prevention and treatment of post-traumatic joint contracture Here, we describe the effect of TNF-α and its specific inhibitor infliximab (IFX) on human MFs under controlled in vitro conditions We ... DMEM containing 1% FCS The expression of α-SMA and COX2 in MFs was determined by immunofluorescence double-staining using a primary monoclonal mouse anti -human- α-SMA antibody (dilution 1:50, clone ... Germany) Collagen gel contraction assay A three-dimensional (3D) collagen gel contraction model, which is a well-accepted method for the estimation of the cell-mediated contracture of the ECM
Ngày tải lên: 12/08/2014, 11:22
Báo cáo y học: " Differential expression of Toll-like receptors on human alveolar macrophages and autologous peripheral monocytes" pdf
... 187.3* 3.6 ± 0.9 Constitutive surface expression of TLR2, TLR4 and TLR9 on human monocytes and alveolar macrophages and monocyte-derived macrophages.TLR levels were determined on monocytes (MN, n ... expression. Basal TLR expres- sion levels on alveolar macrophages were determined on freshly isolated bronchoalveolar cells within 2-4 hours of the bronchoalveolar lavage procedure. Preparation of ... peripheral blood mononuclear cells and purification of monocytes Peripheral blood mononuclear cells were obtained from heparinized venous whole blood by gradient centrifuga- tion over Ficoll (Axis-Shield
Ngày tải lên: 12/08/2014, 14:20
Báo cáo y học: "Pharmacoproteomic study of the effects of chondroitin and glucosamine sulfate on human articular chondrocyte" pot
... two-dimensional electrophoresis (2-DE) map of human articular chondrocyte proteins obtained in this work. Pro- teins were resolved in the 3 to 11 (non linear) pH range on the first dimension, and on ... creased by GS alone and in combination with CS. A. Underexpres- sion values of SOD2 determined by real-time polymerase chain reaction (PCR) analysis on cultured human articular chondrocytes treated ... influ- ence of GS and CS on oxidative stress is a possible mech- anism of action for its protective effect on chondrocytes [55]. Conclusions Taking into account the limitations of an in vitro study,
Ngày tải lên: 12/08/2014, 14:22
Báo cáo y học: " Effect of hypoxia and Beraprost sodium on human pulmonary arterial smooth muscle cell proliferation: the role of p27kip1" ppsx
... ANOVA with Bonferroni correction for multiple comparisons Comparisons were considered statistically significant at p < 0.05 Figure HPASMC Effects of hypoxia and BPS on BrdU incorporation in cultured ... expression, which was not affected by the oxygen concentration These results indicated that the BPScAMP pathway functioned even under hypoxic conditions and that p27kip1 elevation might be a consequence ... pathway Oncogene 1997, 15(6):629-37 Dong Y, Aronsson M, Gustafsson JA, Okret S: The mechanism of cAMP-induced glucocorticoid receptor expression Correlation to cellular glucocorticoid response J
Ngày tải lên: 12/08/2014, 15:21
Báo cáo y học: " Biphasic effect of extracellular ATP on human and rat airways is due to multiple P2 purinoceptor activation" ppsx
... alone did not produce any contrac- tion but rather induced relaxation on strips precontracted with acetylcholine, a mechanical response due to P2 receptor activation. A relaxant effect on precontracted ... amplitude depended on the con- centration of agonist and the location along the airway tree. Original trace obtained in IPB is presented in figure 1A. Non-cumulative concentration-response curves, ... variation in ring size, con- traction was normalised to a reference functional response (see below). When needed, the epithelium was mechani- cally removed. Preparation of human bronchial rings Human
Ngày tải lên: 12/08/2014, 18:20
Cambridge.University.Press.The.Works.of.Archimedes.Volume.1.The.Two.Books.On.the.Sphere.and.the.Cylinder.Translation.and.Commentary.May.2004.pdf
... Propositions 17–20, measuring conical volumes. Interlude Propositions 21–2, finding proportions holding with a circle and an inscribed polygon. Section 2: Main treatise Chapter 5 Propositions 23–34, ... stretched to the limits and beyond: the mini-treatise at the end of the work relies essentially upon conic sections; the notion of the exponent is ad- umbrated in Proposition 8. Both treat geometrical ... definite article alone. Thus the Greek may contain expressions such as “The by the AB, B” goal of the translation 3 translations of On Floating Bodies, the Method and the Stomachion will be published...
Ngày tải lên: 21/09/2012, 11:00
A comparative study of discourse structures and some major linguistic features of international declarations and international conventions on human rights part 3
... against Women, 1993. * Conventions: 4. European Convention on Human Rights, 1950. 5. Convention on the Rights of the Child, 1989. 6. Convention against Discrimination in Education, 1960. Source: ... Declaration of Human Rights and European Charter on Human Rights. (European Convention on Human Rights). Charter of the United Nations; Universal Declaration of Human Rights; International Covenants ... Conflict (Convention on the Rights of the Child). Universal Declaration of Human Rights (Convention against Discrimination in Education). * Differentiating from the Preamble of a Declaration,...
Ngày tải lên: 07/11/2012, 14:17
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