chicken chorioallantoic membrane angiogenesis model

Ngày tải lên: 07/08/2014, 18:21

... ABBREVIATIONS CAM Chorioallantoic membrane CAMVA Chorioallantoic membrane vascular assay CV Coefficient of variance EA Embryo age GTN Glyceryl trinitrate HET-CAM Hen’s egg test – Chorioallantoic membrane ... chorioallantoic membrane (CAM) is potentially a good candidate for an in vivo drug absorption model D The fertilized chicken egg and its chorioallantoic membrane D.1 An Overview Chicken eggs (Figure ... sac is the inner egg membrane, followed by the chick chorioallantoic membrane (CAM) The CAM, which is found in fertilized egg, is derived from the fusion of extraembryonic membranes: chorion and...

Ngày tải lên: 11/09/2015, 10:00

... optimization, Agrotech Publishing Academy, Udaipur, pp 131-133 Haghighi K., Segerlind L.J, (1988), Modeling Simultaneous Heat and Mass Transfer in Isotropic Sphere, Trans ASEA, pp 31 Husain A., Chen...

Ngày tải lên: 28/08/2013, 08:31

... monogalactosyldiacylglycerol) may form reversed hexagonal phase in model lipid membranes and it has been reported that such structures exist in biological membranes [26–28] 31P-NMR spectra shown in Fig clearly ... binding to thylakoid membrane, and also it usually increases leaf temperature, which results in the increase of the membrane dynamics A temperature-induced increase of thylakoid membranes dynamics ... lipid fatty acyl chains in liposome membranes were recorded by EPR spin label measurements using a spin label 5-doxylstearic acid reporting on dynamics of membrane regions close to the headgroup...

Ngày tải lên: 08/03/2014, 10:20

... released from the membrane by proteolysis is unknown If cleavage occurs on 72 the endosomal membrane, the domain could be rapidly degraded in lysosomes If cleavage occurs on the plasma membrane or ... differentiation, angiogenesis and apoptosis through the ability of its isoforms to initiate key signaling cascades at the plasma membrane (PM) [41] Upon stimulation, PKCa and PKCbII and plasma membrane ... (2008) The single-subunit transmembrane E3 ligase gene related to anergy in lymphocytes (GRAIL) captures and then ubiquitinates transmembrane proteins across the cell membrane J Biol Chem 283, 28497–28505...

Ngày tải lên: 15/03/2014, 00:20

... been the use of unreliable methods to isolate membrane rafts The conventional protocol, irrespective of the type of membrane, has been to recover a membrane fraction that survives dissolution by ... molecular species of sphingolipids Membrane raft structure and phospholipids creates a matrix that is coupled across the raft membrane According to such a model, glycosphingolipids based on molecular ... activity-associated remodelling of lipid anchors is a recognized process in raft function [40,41] suggests that the configuration of the raft anchors is a likely candidate The lipid matrix model of the membrane...

Ngày tải lên: 15/03/2014, 23:20

... towards membrane lipid synthesis by a systems biological approach [6] Our theoretical model is based on the well-established concept of flux-balance analysis (FBA) [7], a structural network model ... introduced virtual membrane particles (MP), which contain glycerophospholipids and membrane sterols in a single entity that reflects the typical lipid composition of cellular membranes The chemical ... subdivision of membrane material between the organelles remained constant, the rate of membrane production should be proportional to the change in the surface area of the cell As membranes are...

Ngày tải lên: 16/03/2014, 04:20

... Ó FEBS 2002 High pressure e€ects on biological membrane (Eur J Biochem 269) 111 the cell membrane consisting of lipid bilayer and transmembrane proteins EXPERIMENTAL PROCEDURES Materials ... incorporation into membrane- bound Na+/K+-ATPase Membrane- bound Na+/K+-ATPase was mixed with tritiated water at various pressures and at 37 °C for 15 and ®ltered by Millipore ®lter membranes After ... Millipore ®lter membranes After washing the ®lter membrane by tritium-free bu€er, radioactivity of the ®lter membrane was determined (d) The membrane- bound ATPase trapping tritium by pressurization...

Ngày tải lên: 24/03/2014, 00:21

... for the angiogenesis process and has not previously been studied in the choroid of alcoholic rats Although there have been numerous studies using laser-induced CNV as a model of choroidal angiogenesis ... pharmaceuticals Although there is no perfect animal model to study CNV that resembles humans, the laser-induced model may be the best available animal model to study CNV CNV can be induced by laser ... of antiangiogenic factors may help to enhance angiogenesis In a mouse tumor model, Brakenhielm et al [35] showed that APN was a direct inhibitor of angiogenesis Xu et al [36] showed that circulating...

Ngày tải lên: 30/03/2014, 11:20

... be studied with this model Conclusion In this report, we used inflammation as a model to illustrate the efficacy of in vitro hippocampal slice culture as an intermediate model between single ... by applying this model it is possible to avoid the potential bias emerging from interactions between slices when a number of slices are placed in proximity on the same culture membranes The possibility ... transferred on to porous membrane inserts (one slice per insert) of 12-well culture plates (Transwell TR 3462; Costar, Corning, NY, USA) To reach the level of insert membrane, some 600 µL culture...

Ngày tải lên: 19/06/2014, 22:20

... 34 Membrane Proteins 35 Separation and Identification of Membrane Proteins 35 Membrane Proteins and Membrane Structure 36 Membrane Proteins in the Red Cell Surface 37 Membrane Proteins and Membrane ... and Nature of Membrane Lipids 28 Asymmetry of the Membrane Lipid Bilayer 31 Membrane Fluidity 32 Renewal of Membrane Lipids 33 Interactions Between Membrane Lipids and Proteins 34 Membrane Lipids ... Dawn of Red Cell Membrane Research abnormalities in the red cell membrane constituents It is well known that red cell membranes are composed mainly of membrane proteins and membrane lipids Although...

Ngày tải lên: 29/06/2014, 11:20

... migration/invasion, proliferation, cytoskeletal remodeling and capillary differentiation (angiogenesis section) are up-regulated in SSc-MVECs However, the angiogenesis inhibitor pent(r)axinrelated gene ... function In this process, an endothelial cell modifies the interaction with its basement membrane, remodels and migrates through ECM, proliferates, and differentiates The final effect is the ... or negatively involved in the regulation of angiogenesis Therefore, we included the biological processes obtained by GO into the following families: angiogenesis, apoptosis, haemostasis, inflammation...

Ngày tải lên: 09/08/2014, 08:22

... response in both tumor models with an AGD of 14 and 30.4 days in the allograft and the spontaneous tumor model, respectively (Figure 1, Table 1) More important Allograft tumor model 800 control 700 ... spontaneous tumor models is highly laborious and cost-effective Our comparative study furthermore demonstrates that an allograft tumor model is adequate and represents a valid tumor model to investigate ... littering To generate the corresponding allograft tumor model, mammary carcinoma cells (NF9006), which were established from the spontaneous tumor model, were subcutaneously injected (4 × 106 cells)...

Ngày tải lên: 09/08/2014, 09:20

... example, chicken chromosome corresponds to human chromosomes 11, 12, 15 and 17 [40], and some genes of the chicken chromosome 7q are conserved on human chromosome 2q [31, 33] Two cases involving chicken ... More recently, electron microscopic analyses on chicken synaptonemal complexes enabled confirmation that microchromosomes account for 30 % of the chicken genome and determination of the position ... microchromosomes were thus found to be acrocentric (37] The physical size of the chicken genome is 200 Mb: the mean size for chicken macrochromosomes is around 130 Mbases, and only 12.5 Mbases for microchromosomes,...

Ngày tải lên: 09/08/2014, 18:21

... roles that VEGF, sVEGFR-1 and Ado can play in angiogenesis using an algorithmic exploratory model We introduce here a computational model of sprouting angiogenesis in which the ECs divide and move ... computational model specification) Page of 20 Azuaje et al Theoretical Biology and Medical Modelling 2011, 8:7 http://www.tbiomed.com/content/8/1/7 Figure is a cartoon diagram of our angiogenesis model ... algorithmic models the reader may refer to [31,32] Figure summarizes the different phases of our investigation In the first phase, model verification, we implemented a foundation angiogenesis model...

Ngày tải lên: 13/08/2014, 16:20

... and skin injury model 74 3.1.1 Angiogenesis in the corneal injury model 74 3.1.2 Sexual dimorphism in angiogenesis in the corneal injury model 74 3.2 Key roles of neutrophil in angiogenesis in ... corneal injury model 79 3.2.1 Lymphocytes have little impacts on angiogenesis in the corneal injury model 79 3.2.2 Key roles of neutrophils in angiogenesis in the corneal injury model 81 I Efficacy ... Introduction of animal models used in the current study 129 4.1.1 To study angiogenesis in the corneal and skin injury model 129 4.1.2 Sexual dimorphism in angiogenesis in the corneal injury model 130 4.2...

Ngày tải lên: 11/09/2015, 10:03

... Unregulated angiogenesis can be divided into insufficient angiogenesis and excessive angiogenesis Insufficient angiogenesis may result in tissue ischemia and delayed wound healing; excessive angiogenesis ... induced endothelial cell chemotaxis in vitro as well as angiogenesis in the chick chorioallantoic membrane assay in vivo MCP-1 induced angiogenesis was associated with the expression of CCR2 ... promotes angiogenesis by degrading ECM Secondly, neutrophils are associated with angiogenesis in a Matrigel sponge model in vivo induced by laminin peptides (Kibbey et al 1994) The induction of angiogenesis...

Ngày tải lên: 11/09/2015, 10:03

... experiments to establish the corneal and skin injury models 75 Fig 3.1 Angiogenesis response in the corneal injury model The time course of angiogenesis response in the cornea of BALB/c mouse ... 6) 78 3.2 Key roles of neutrophils in angiogenesis in the corneal injury model 3.2.1 Lymphocytes have little impacts on angiogenesis in the corneal injury model Although lymphocytes has been indicated ... their roles in angiogenesis induced by injury are still unclear We established the corneal injury model in Rag1KO mice and control mice to study the roles of lymphocytes in inflammatory angiogenesis...

Ngày tải lên: 11/09/2015, 10:03

... this model, the authors optimized 3.2 Two-dimensional models 29 the membrane thickness requirements by investigating di¤erent types of membranes, i.e Na…on 112, Na…on 115, Na…on 117 This model ... single-phase mathematical model for later veri…cation of the reduced models This model will also provide a benchmark for comparison of the e¢ ciency of the reduced models; Apply the volume averaging ... the aid of step (3), the 2D model in step (2) will be parabolized to a ‘spacemarching model , or named as a reduced model in this thesis; Extend the reduced single cell models to PEMFC stacks comprising...

Ngày tải lên: 30/09/2015, 06:29

... simplest form of membrane model It reduces the complexities of biological membranes, hence allows the investigation of the specific aspects of any biological phenomenon occurring in the membranes [15] ... drug -membrane interaction: Table 2.4 Events leading from Drug -Membrane Interaction (Source: Reference 47,48) Drug ↔ Interaction I Action of Membrane on Drug Molecules • Diffusion through membrane ... • Drug may change membrane potential and hydration of head groups • Drug may change membrane fusion 2.3.2 Nanoparticle -membrane interaction The major factor that nanoparticle -membrane interaction...

Ngày tải lên: 08/11/2015, 16:31