chemotherapy of bacterial infections

... Prophylaxis of Bacterial Infections (Part 1) Harrison's Internal Medicine > Chapter 127. Treatment and Prophylaxis of Bacterial Infections Treatment and Prophylaxis of Bacterial Infections: ... recycling of membrane lipid carrier Not defined of Antibacterial Agents Let ter for Fig. 127-1 Antibacterial Agent a Maj or Cellular Target Mechani sm of Action Major Mechanisms of ... development of vaccines and drugs that prevent and cure bacterial infections was one of the twentieth century's major contributions to human longevity and quality of life. Antibacterial...

Ngày tải lên: 08/07/2014, 02:20

... because of a marginally broader spectrum. Chapter 127. Treatment and Prophylaxis of Bacterial Infections (Part 2) Inhibition of Cell-Wall Synthesis One major difference between bacterial ... any stage of the synthesis, export, assembly, or cross-linking of peptidoglycan lead to inhibition of bacterial cell growth and, in most cases, to cell death. Peptidoglycan is composed of (1) ... enzymes (autolysins) that cleave peptidoglycan bonds in the normal course of cell growth. In the presence of antibacterial agents that inhibit cell-wall growth, autolysis proceeds without...

Ngày tải lên: 08/07/2014, 02:20

... Inhibition of Protein Synthesis Most of the antibacterial agents that inhibit protein synthesis interact with the bacterial ribosome. The difference between the composition of bacterial and ... several amino acids. Inhibition of folate synthesis leads to cessation of bacterial cell growth and, in some cases, to bacterial cell death. The principal antibacterial antimetabolites are sulfonamides ... synthetase by competing with bacterial isoleucine for its binding site on the enzyme and depleting cellular stores of isoleucine-charged tRNA. Inhibition of Bacterial Metabolism The antimetabolites...

Ngày tải lên: 08/07/2014, 02:20

... of Bacterial Infections (Part 4) Trimethoprim Trimethoprim is a diaminopyrimidine, a structural analogue of the pteridine moiety of folic acid. Trimethoprim is a competitive inhibitor of ... antimicrobial agents are inactivation of the compound, alteration or overproduction of the antibacterial target through mutation of the target protein's gene, acquisition of a new gene that encodes ... and its fluorinated derivatives (ciprofloxacin, levofloxacin, and moxifloxacin), are synthetic compounds that inhibit the activity of the A subunit of the bacterial enzyme DNA gyrase as well...

Ngày tải lên: 08/07/2014, 02:20

Ngày tải lên: 08/07/2014, 02:20

Ngày tải lên: 08/07/2014, 02:20

Ngày tải lên: 08/07/2014, 02:20

Ngày tải lên: 08/07/2014, 02:20

Ngày tải lên: 08/07/2014, 02:20

Ngày tải lên: 08/07/2014, 02:20

Ngày tải lên: 08/07/2014, 02:20

Ngày tải lên: 08/07/2014, 02:20

Ngày tải lên: 08/07/2014, 02:20

Ngày tải lên: 08/07/2014, 02:20

... follows: 5 μlof10×PCR buffer, 4 μlof10mmol/ldNTPmix;1μlof10μmol/l 16s-a, 1 μlof10μmol/l 16s-b, 1 μlof10μmol/l 16s-c, 0.5 μl of Tap polymerase, 1 μl of template and 36.5 μl of dd H 2 O. PCR was carried ... 9:85 http://www.translational-medicine.com/content/9/1/85 Page 5 of 9 Preparation of bacterial DNA Bacteria suspension was prepared at a density of 1 × 10 8 cfu/ml with 0.9% sterile normal saline. Then, 1 ml of bacterial suspension was ... Germany), 400 μl of the eluent were obtained and stored at -20°C for use. Amplification of single-stranded DNA and sequencing of four bacterial genes The mixture for PCR was as follows: 5 μlof10×PCR buffer,...

Ngày tải lên: 18/06/2014, 19:20

... follows: 5 μlof10×PCR buffer, 4 μlof10mmol/ldNTPmix;1μlof10μmol/l 16s-a, 1 μlof10μmol/l 16s-b, 1 μlof10μmol/l 16s-c, 0.5 μl of Tap polymerase, 1 μl of template and 36.5 μl of dd H 2 O. PCR was carried ... 9:85 http://www.translational-medicine.com/content/9/1/85 Page 6 of 9 Preparation of bacterial DNA Bacteria suspension was prepared at a density of 1 × 10 8 cfu/ml with 0.9% sterile normal saline. Then, 1 ml of bacterial suspension was ... Germany), 400 μl of the eluent were obtained and stored at -20°C for use. Amplification of single-stranded DNA and sequencing of four bacterial genes The mixture for PCR was as follows: 5 μlof10×PCR buffer,...

Ngày tải lên: 20/06/2014, 03:20

... HIV-Infected Children and Adolescents 7 Bacterial Infections 8 Bacterial Infections, Serious and Recurrent 8 Bartonellosis 13 Syphilis 16 Mycobacterial Infections 19 Mycobacterium tuberculosis ... absence of a laboratory isolate, differentiating viral from bacterial pneu- monia using clinical criteria can be difficult (85). In a study of intravenous immune globulin (IVIG) prophylaxis of bacterial ... the Caribbean, 60% of 462 unin- fected infants of HIV-infected mothers experienced infectious disease morbidity during the first 6 months of life, with the rate of neonatal infections (particularly...

Ngày tải lên: 12/02/2014, 12:20

... spectra of CyaY titrations. Superimpo- sitions of a reference [ 1 H, 15 N] HSQC spectrum of CyaY (blue) with a spectrum (red) of a 1 : 1 mixture of CyaY ⁄ Gd 3+ (A), a 1 : 1 mix- ture of CyaY ... Fe 3+ Addition of Fe 2+ induced the displacement of several resonances in the [ 1 H, 15 N]-HSQC NMR spectrum of CyaY, but the most striking consequence of the addi- tion was the total disappearance of specific ... concomitant appearance of other signals in other parts of the spectrum. This result could be a consequence of the paramagnetic properties of Fe(II), or it might arise from the presence of an intermediate equilibrium...

Ngày tải lên: 18/02/2014, 16:20

... y PUZZLE .Thelatter method w i th the Ô+GÕ option f or rates of heterogeneity Fig. 4. Structural comparison of four representatives of class I of the superfamily of bacterial, fungal, and plant peroxidases. (A) ... introduction of new Ó FEBS 2004 Molecular evolution of heme peroxidases (Eur. J. Biochem. 271) 3307 Fig. 2. Multiple sequence alignment of 50 selected representatives of t he superfamily of bacterial, ... based on the analysis of three archaeal and 16 bacterial KatGs [42]. Later it was postulated that this phenomenon often occurs in all lineages of hydroperoxidases capable of catalytic reaction...

Ngày tải lên: 19/02/2014, 16:20

... FTIR (micro)spectroscopy as a technique of choice also in the study of the influence of the physiology of expres- sion (i.e. temperature, induction, formation of disulfide bonds) on the kinetics of aggregation and ... b-sheets. The use of this spectroscopic technique for the study of IB aggregates is often limited by the intrinsic insolubility of the samples, responsible for a high level of light scattering ... native a-helices of the N-terminal 185 residues of the functional domain of the HA2 subunit of the influenza virus hemagglutinin protein and to detect conformational heterogeneity of the protein...

Ngày tải lên: 06/03/2014, 00:20