chemotherapy of bacterial infections ppt

Ngày tải lên: 08/07/2014, 02:20

... hemo- lymph of DCV infected flies. (A) MALDI-TOF mass spectrometry analysis of the hemolymph of single flies 3 days after injection of buffer (Tris) or a DCV suspension. The position of the 12 820 ... Histology of the fat body of flies 2 (C) or 4 (B,D) days after injection of Tris (B) or DCV (C,D). The scale bar represents 20 lm (E,F). Accumulation of viral particles in the cytoplasm of cells ... hemolymph of a cocktail of potent antimicrobial peptides active against bacteria and/or fungi. Transcriptional induction of the genes encoding these peptides involves two pathways: infections...

Ngày tải lên: 08/03/2014, 08:20

... Objectives At the end of this presentation, the participant should be able to: ã Cite 3 opportunistic infections where ARV therapy is part of the treatment ã Cite 5 opportunistic infections where ... has a CD4 count < 200. ã Give the dose of EFV that should be used when treating TB in Vietnam. ã Cite the recommendation of the MOH of the use of NVP with a RIF containing TB therapy ã Cite ... the induction period of TB treatment is over to start NVP containing ARV. Weerawat M et al. CID 2006;43:253-5. Guidelines for Diagnosis and Treatment of HIV/AIDS, Ministry of Health, Vietnam....

Ngày tải lên: 01/04/2014, 12:20

... Prophylaxis of Bacterial Infections (Part 1) Harrison's Internal Medicine > Chapter 127. Treatment and Prophylaxis of Bacterial Infections Treatment and Prophylaxis of Bacterial Infections: ... of membrane lipid carrier Not defined of Antibacterial Agents Let ter for Fig. 127-1 Antibacterial Agent a Maj or Cellular Target Mechani sm of Action Major Mechanisms of ... development of vaccines and drugs that prevent and cure bacterial infections was one of the twentieth century's major contributions to human longevity and quality of life. Antibacterial...

Ngày tải lên: 08/07/2014, 02:20

... because of a marginally broader spectrum. Chapter 127. Treatment and Prophylaxis of Bacterial Infections (Part 2) Inhibition of Cell-Wall Synthesis One major difference between bacterial ... any stage of the synthesis, export, assembly, or cross-linking of peptidoglycan lead to inhibition of bacterial cell growth and, in most cases, to cell death. Peptidoglycan is composed of (1) ... enzymes (autolysins) that cleave peptidoglycan bonds in the normal course of cell growth. In the presence of antibacterial agents that inhibit cell-wall growth, autolysis proceeds without...

Ngày tải lên: 08/07/2014, 02:20

... Inhibition of Protein Synthesis Most of the antibacterial agents that inhibit protein synthesis interact with the bacterial ribosome. The difference between the composition of bacterial and ... several amino acids. Inhibition of folate synthesis leads to cessation of bacterial cell growth and, in some cases, to bacterial cell death. The principal antibacterial antimetabolites are sulfonamides ... synthetase by competing with bacterial isoleucine for its binding site on the enzyme and depleting cellular stores of isoleucine-charged tRNA. Inhibition of Bacterial Metabolism The antimetabolites...

Ngày tải lên: 08/07/2014, 02:20

... of Bacterial Infections (Part 4) Trimethoprim Trimethoprim is a diaminopyrimidine, a structural analogue of the pteridine moiety of folic acid. Trimethoprim is a competitive inhibitor of ... antimicrobial agents are inactivation of the compound, alteration or overproduction of the antibacterial target through mutation of the target protein's gene, acquisition of a new gene that encodes ... and its fluorinated derivatives (ciprofloxacin, levofloxacin, and moxifloxacin), are synthetic compounds that inhibit the activity of the A subunit of the bacterial enzyme DNA gyrase as well...

Ngày tải lên: 08/07/2014, 02:20

... dihydrofolate reductase for trimethoprim and an altered dihydropteroate synthetase for sulfonamides. Quinolones The most common mechanism of resistance to quinolones is the development of one ... efflux are also found in gram-positive bacteria. Chapter 127. Treatment and Prophylaxis of Bacterial Infections (Part 5) Vancomycin Clinically important resistance to vancomycin was first ... appears to be either mutation of the target isoleucine tRNA synthetase so that it is no longer inhibited by the antibiotic or plasmid-encoded production of a form of the target enzyme that binds...

Ngày tải lên: 08/07/2014, 02:20

... series of unrelated compounds. The construction of multiresistant strains by acquisition of multiple genes occurs by sequential steps of gene transfer and environmental selection in areas of high-level ... bacterium of resistance to multiple antibacterial agents is becoming increasingly common. The two major mechanisms are the acquisition of multiple unrelated resistance genes and the development of ... 127. Treatment and Prophylaxis of Bacterial Infections (Part 6) Rifampin Bacteria rapidly become resistant to rifampin by developing mutations in the B subunit of RNA polymerase that render...

Ngày tải lên: 08/07/2014, 02:20

... efficacy. Chapter 127. Treatment and Prophylaxis of Bacterial Infections (Part 7) Distribution To be effective, concentrations of an antibacterial agent must exceed the pathogen's ... drugs, antibacterial agents are disposed of by hepatic elimination (metabolism or biliary elimination), by renal excretion of the unchanged or metabolized form, or by a combination of the two ... susceptible bacteria, but since most infections are extravascular, the antibiotic must also distribute to the site of the infection. Concentrations of most antibacterial agents in interstitial...

Ngày tải lên: 08/07/2014, 02:20

Ngày tải lên: 08/07/2014, 02:20

Ngày tải lên: 08/07/2014, 02:20

Ngày tải lên: 08/07/2014, 02:20

Ngày tải lên: 08/07/2014, 02:20

Ngày tải lên: 08/07/2014, 02:20

Ngày tải lên: 08/07/2014, 02:20

Ngày tải lên: 06/08/2014, 17:21

Ngày tải lên: 12/08/2014, 15:20

Ngày tải lên: 13/08/2014, 03:20

... follows: 5 lof10ìPCR buffer, 4 lof10mmol/ldNTPmix;1lof10mol/l 16s-a, 1 lof10mol/l 16s-b, 1 lof10mol/l 16s-c, 0.5 l of Tap polymerase, 1 μl of template and 36.5 μl of dd H 2 O. PCR was carried out ... 9:85 http://www.translational-medicine.com/content/9/1/85 Page 6 of 9 Preparation of bacterial DNA Bacteria suspension was prepared at a density of 1 ì 10 8 cfu/ml with 0.9% sterile normal saline. Then, 1 ml of bacterial suspension was ... Germany), 400 μl of the eluent were obtained and stored at -20°C for use. Amplification of single-stranded DNA and sequencing of four bacterial genes The mixture for PCR was as follows: 5 lof10ìPCR buffer,...

Ngày tải lên: 20/06/2014, 03:20