chemotherapy for metastatic colorectal cancer

... Severe hepatic sinusoidal obstruction associated with oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer Ann Oncol 2004, 15:460-466 Vauthey JN, Pawlik TM, Ribero D, Wu ... SA, Strasberg S, Saltz L, Adam R, Nordlinger B, Rougier P, Rosen LS: Neoadjuvant chemotherapy for metastatic colon cancer: a cautionary note J Clin Oncol 2005, 23:9073-9078 Publish with Bio Med ... which serves as an autocrine factor for the induction of neovascularization Also it acts as a survival factor for tumour cells, protecting them from hypoxia, chemotherapy and radiotherapy In normal...

Ngày tải lên: 11/08/2014, 21:22

... recommended for the first-line treatment of metastatic colorectal cancer 1.2 Cetuximab in combination with irinotecan is not recommended for the secondline or subsequent treatment of metastatic colorectal ... Bowel Cancer Cancer Voices Cancerbackup Bowel Cancer UK (Colon Cancer Concern) CORE (Digestive Disorders Foundation) Long-term Medical Conditions Alliance Lynn’s Bowel Cancer Campaign Macmillan Cancer ... years of initial diagnosis) The 5-year survival rate for metastatic colorectal disease is 12% 2.4 The management of metastatic colorectal cancer is mainly palliative and involves a combination...

Ngày tải lên: 14/02/2014, 22:20

... therefore, candidates for palliative chemotherapy The role of chemotherapy as an integral part of the treatment of lung cancer has grown significantly, especially in the last few years In metastatic ... P: Estimating the world cancer burden: Globocan 2000 Int J Cancer 2001, 94:153-156 Non-small Cell Lung Cancer Collaborative Group: Chemotherapy in non small cell lung cancer: a meta-analysis ... treated carcinoma in situ of the uterine cervix; previous chemotherapy in an adjuvant setting or for metastatic disease No other anticancer treatments, with the exception of bisphosphonates and...

Ngày tải lên: 18/06/2014, 15:20

... metastatic colorectal cancer BMJ 1993, 306:752-755 Glimelius B, Hoffman K, Graf W, Pahlman L, Sjoden PO: Quality of life during chemotherapy in patients with symptomatic advanced colorectal cancer ... Gastrointestinal Tumor Adjuvant Therapy Group Cancer 1994, 73:556-562 Schoffski P, Kohne CH, Schellenberger U: Does effective chemotherapy for metastatic colorectal cancer (CC) improve HRQOL (QL)? Preliminary ... Organisation for the Research and Treatment of Cancer QLQ-C30: a HRQOL instrument for use in international clinical trials in oncology J Natl Cancer Inst 1993, 85:365-376 Page of (page number not for...

Ngày tải lên: 20/06/2014, 15:20

... contemplated Despite no further overt metastatic disease on CT, the patient was commenced on a course of chemotherapy (5 FU/Oxaliplatin) to treat presumed low volume metastatic colorectal disease and thus ... implications for the primary tumor treatment Cancer 1984, 53:982-992 Mazzaferri EL, Kloos RT: Clinical review 128: Current approaches to primary therapy for papillary and follicular thyroid cancer ... patterns of care for adenocarcinoma of the rectum, 1985–95 Cancer 1998, 83:2408-2418 O'Connell JB, Maggard MA, Ko CY: Colon cancer survival rates with the new American Joint Committee on Cancer sixth...

Ngày tải lên: 09/08/2014, 07:22

... modern combination chemotherapy including targeted drugs has been used to treat patients with metastatic colorectal cancer patients [24,25] Although these drugs might be effective for symptomatic ... role of RT and defined the effectiveness of chemotherapy combined with palliative RT in patients with a symptomatic pelvic mass of metastatic colorectal cancer Methods From August 1995 to December ... pelvic mass of metastatic colorectal cancer who were treated with palliative RT at Samsung Medical Center All patients had disease outside the pelvis and consulted a radiation oncologist for symptomatic...

Ngày tải lên: 09/08/2014, 09:20

... constitute colorectal cancer formation and metastasis We find marked differences between primary and metastatic tumors and show that chromothripsis rearrangements occur frequently in colorectal cancer ... tumors as well as their relevance for metastasis formation is currently unclear Here, we describe pairwise genomic analyses of matched primary and metastatic colorectal cancer samples from four patients ... events drive colorectal tumor development and metastasis Keywords Chromosome shattering, structural variation, colorectal cancer, metastasis, somatic mutations Background Colorectal cancer develops...

Ngày tải lên: 09/08/2014, 23:20

... or without biologic agents for metastatic breast cancer Crit Rev Oncol Hematol 76(2):99-111 Andreopoulou E, Hortobagyi GN: Prognostic factors in metastatic breast cancer: successes and challenges ... Efficacy and Safety of Bevacizumab In Combination with Chemotherapy for Second-Line Treatment of HER2-Negative Metastatic Breast Cancer Cancer Res 2009, 69:42, (24_MeetingAbstracts) 27 Miller ... three Randomized trials of Bevacizumab (BV) and first-line Chemotherapy as treatment for Metastatic Breast Cancer (MBC) European Society for Medical Oncology (ESMO): 2010; Milan (ITALY) Annals of...

Ngày tải lên: 10/08/2014, 10:21

... all sites of cancer, breast cancer was the most frequent representing 36.1%, followed by lung cancer (25.5%) and cervical cancer (12.6%) [2] Worldwide, breast cancer is the first cancer in women ... that allow for appropriate treatment, especially for women with very limited income According to the figures released by the International Agency for Research on Cancer [11], breast cancer is ... public cancer centres treating patients with breast cancer In this case, the total number of women suffering from breast cancer is obtained by adding the numbers of patients with localized breast cancer...

Ngày tải lên: 13/08/2014, 11:22

... serum tumor marker for colorectal cancer Clin Cancer Res.2005; 11(18):6550-7 31 Ma Y, Peng J, Huang L, Liu W, Zhang P, Qin H Searching for serum tumor markers for colorectal cancer using a 2-D ... blood screening for colorectal cancer Results for first 107,349 subjects Lancet.1989; 1:1160-4 Kronborg O, Fenger C, Olsen J, et al Randomised study of screening for colorectal cancer with faecal-occult-blood ... in colorectal cancer patients by MALDI-TOF MS We used WCX magnetic beads to screen potential serum biomarkers for colorectal cancer detection A total of 264 serum samples from colorectal cancer...

Ngày tải lên: 25/10/2012, 11:18

... CDKs is required for successful cell cycle progression [28,29]; for example, the correct formation of cyclin D/CDK complex is required for pRb hyper-phosphorylation, in order for it to release ... Zhang, R (2001) Antisense anticancer oligonucleotide therapeutics Curr Cancer Drug Targets 1, 177–196 Cho-Chung, Y.S (2002) Antisense DNAs as targeted therapeutics for cancer: no longer a dream Curr ... washed twice in ice-cold NaCl/Pi, before fixing in 2% (v/v) formaldehyde and 0.2% (v/v) glutaraldehyde Cells were then washed twice in ice-cold NaCl/Pi, before overnight incubation at 37 °C in...

Ngày tải lên: 07/03/2014, 15:20

... screening and surveillance for early detection of colorectal polyps and cancer: update 1997 American Cancer Society Detection and Treatment Advisory Group on Colorectal Cancer CA: Cancer J Clin 1997;47:154–60 ... surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and ... potential to image both cancer and polyps, whereas cancer detection tests have low sensitivity for polyps and typically lower sensitivity for cancer compared with that in cancer prevention tests...

Ngày tải lên: 15/03/2014, 01:20

... leucovirin for Metastatic Colorectal Cancer N Engl J Med 2004, 350:2335-42 Van Cutsem E, Kohne CH, Mitre E, et al.: Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer ... containing codon 12 an 13 The PCR reaction was as follows: 95°C for min, 35 cycles of 94°C for 10 sec, 58°C for 10 sec, 72°C for sec, and 72°C for The PCR reaction buffer (KAPA2 Fast Hot start, Resnova, ... treatment of metastatic colorectal cancer J Clin Oncol 2007, 20:5225-5232 Colucci G, Giuliani F, Mattioli R, et al.: FOLFOX4 + Cetuximab in untreated patients with advanced colorectal cancer A phase...

Ngày tải lên: 18/06/2014, 16:20

... intraperitoneal chemotherapy for ovarian cancer Int J Gynecol Cancer 2008, 18(Suppl 1):26-28 Helm CW: The role of hyperthermic intraperitoneal chemotherapy (HIPEC) in ovarian cancer Oncologist ... advanced ovarian cancer: pharmacokinetics and cisplatin-DNA adduct formation in patients and ovarian cancer cell lines Eur J Cancer 1998, 34:148-154 Trimble EL, Christian MC: National Cancer Institute-United ... growth of orthotopic metastatic prostate cancer and peritoneal metastatic ovarian cancer [24,25] The mechanism of arsenic-induced cell death in vitro is suggested to include formation of oxidative...

Ngày tải lên: 20/06/2014, 07:20

... of first-line chemotherapy (anthracycline- and/or taxane-containing regimen versus other); previous line of hormonotherapy administered in metastatic setting before the first-line chemotherapy ... status Table Significant predictive factors for PFS duration after a first line chemotherapy Table Predictive factors for OS duration after a first line chemotherapy Int J Med Sci 2008, 103 Figure ... treatment status DISCUSSION The search for prognostic and predictive factors that could influence the survival of patients treated for metastatic breast cancer has already been the subject of...

Ngày tải lên: 08/08/2014, 17:20

... rectal cancer Int J Colorectal Dis 2009, 24:1097-1109 Umar A, Boland CR, Terdiman JP, Syngal S, de la CA, Ruschoff J, et al: Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer ... [hereditary nonpolyposis colorectal cancer (HNPCC)] Fam Cancer 2005, 4:219-225 35 Anaya DA, Chang GJ, Rodriguez-Bigas MA: Extracolonic manifestations of hereditary colorectal cancer syndromes Clin ... superficial layers of cuboidal cells that were immunopositive for TTF-1 and EMA, as well as stromal cells positive for TTF-1 expression, and some also for neuroendocrine markers such as neuron-specific...

Ngày tải lên: 09/08/2014, 01:25

... (preoperative and postoperative) chemotherapy for locally advanced gastric cancer [3] Up to this point, many neoadjuvant chemotherapy treatments for gastric cancer have been used with varying ... postoperative morbidity and mortality Neoadjuvant chemotherapy with the FOLFOX regimen for local advanced gastric cancer has been performed for years in our centre The current retrospective study ... receiving neoadjuvant chemotherapy for gastric cancer If neoadjuvant chemotherapy is to be considered as a therapeutic option in patients with locally advanced gastric cancer, it is necessary...

Ngày tải lên: 09/08/2014, 02:21

... the study and was informed that they could withdraw at any time Inclusion criteria for chemoembolization were: 1) A confirmed diagnosis of liver dominant metastatic colorectal cancer (by either ... TACE for improving survival and achieving local control in patients with liver metastases from colorectal cancer[ 24] Two hundred and seven patients with liver metastases from colorectal cancer ... from colorectal cancer Int J Colorectal Dis 2006, 21:33-37 Abramson RG, Rosen MP, Perry LJ, Brophy DP, Raeburn SL, Stuart KE: Cost-effectiveness of hepatic arterial chemoembolization for colorectal...

Ngày tải lên: 09/08/2014, 04:21

... potentially curative resection for colorectal cancer Ann Surg 2004, 240:255-259 Jessup JM, Stewart A, Greene FL, Minsky BD: Adjuvant chemotherapy for stage III colon cancer: implications of race/ethnicity, ... of vogue"; it might be true for complicated diverticulitis, but probably not for the emergency management of left-sided colorectal cancer- the original indication for this time-honoured operation ... (left colon vs rectum); mode of presentation (obstructive vs perforated); TNM stage; and mode of dissemination for metastatic cancers (peritoneal vs liver) 3) Modalities of HP (first stage);...

Ngày tải lên: 09/08/2014, 07:21

... preservation in pyriform sinus cancer: preliminary results of a European Organization for Research and Treatment of Cancer phase III trial EORTC Head and Neck Cancer Cooperative Group J Natl Cancer Inst ... preservation Chemotherapy Chemotherapy included cisplatin +/- 5-fluorouracil In the CCRT arm, 15 patients had cisplatin weekly (30 mg/ m2) for up to cycles or tri-weekly (60-80 mg/m2) for cycles ... conducted for significant prognostic factors with Coxregression method Analysis of the data was performed using SPSS 12 software Results Survival The median follow-up was 19.4 months for all patients,...

Ngày tải lên: 09/08/2014, 08:23