characteristics practical diagnostic and treatment approaches
báo cáo khoa học: "Different patterns of NF-B and Notch1 signaling contribute to tumor-induced lymphangiogenesis of esophageal squamous cell carcinoma" ppt
... ZC and HL conceived of the study; CS, YS, YL, YL and BZ performed experiments; ZC and LC analyzed data and prepared the figures; CS, ZC and HL drafted the manuscript All authors have read and ... NFB and Notch signaling to tumor-induced lymphangiogenesis of ESCC, we here assessed the expression of NF-B and Notch1 in ESCC tissues and evaluated their association with various clinical characteristics, ... tumor-node-metastasis (TNM) classification, and differentiation (well, moderate, or poor grade) of tumor cells in ESCC Lymphangiogenetic characteristics and their associations with NF-B and Notch1 signaling were...
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báo cáo khoa học: "DOF-binding sites additively contribute to guard cell-specificity of AtMYB60 promoter" potx
... lines harbouring the -1,307::GUS (-1,307 A and B), 619::GUS (-619 A and B), -472::GUS, -366::GUS (-366 A and B), -262::GUS (-262 A and B) or 205::GUS (-205 A and B) constructs Two lines for each construct ... respectively an intermediate (b and f), a weak (c and g) and no GUS activity (d and h) Scale bars represent mm (a-d) or 0.1 mm (e-h) Figure - Oligomerisation of the 57 bp sequence and 3’ deletions of the ... transformation and drafted the manuscript EC, AA and LC did transgenic Arabidopsis analysis FF carried out cdf mutant analysis CT, MG, and GC conceived the study, participated in its design and coordination...
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Báo cáo y học: " Does a new polyomavirus contribute to Merkel cell carcinoma" pot
... concatemer, and two additional tumors had an indeterminate integration pattern For one tumor with a monoclonal integration pattern, both primary and metastatic tumor tissue was available, and both ... waves: early and late The early-expressed genes, including large and small T antigens, bind to host proteins to force the cell into S phase (the cell-cycle phase when the DNA is replicated) and facilitate ... primase, topoisomerase I, and RPA (Figure 1) [17] SV40 large T antigen also binds cellular growth regulators including the tumor suppressors pRb and p53, to promote cell growth and entry into S phase...
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báo cáo hóa học:" Characterization of the tumor marker muc16 (ca125) expressed by murine ovarian tumor cell lines and identification of a panel of cross-reactive monoclonal antibodies" docx
... conducted the RT-PCR and western blot ananlysis and was assisted in these experiments by JAB and JAAG MM and CR helped in designing appropriate Muc16 primers JC assisted in obtaining and maintaining ... human and murine forms of the mucin MUC16 is both expressed on the cell surface and shed from the cell in soluble forms Muc16, on the other hand, is detected primarily in the spent media and in ... donation from Jean McKenzie, and start-up funds from the Department of Obstetrics and Gynecology to MSP We are deeply grateful to Kathy Schell for her advice and help and acknowledge the support...
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báo cáo khoa học: "A nanocomplex that is both tumor cell-selective and cancer gene-specific for anaplastic large cell lymphoma" ppt
... are very costly and only available for a limited number of ligands Thus, scientists have searched for other ligand molecules that are easier to produce Aptamers, short single-stranded oligonucleotides ... 299 and Jurkat reporter cells that stably express eGFP and luciferase gene were utilized [43] The cells were treated with nanocomplexes containing the CD30 aptamer and eGFP siRNA for days, and ... luciferase-specific siRNA nanocomplexes and days post -treatment, luciferin was added to the cell cultures and luciferase activity detected by bioluminescence scanning Treatment with the nanocomplex selectively...
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Báo cáo khoa học: Do bacterial genotoxins contribute to chronic inflammation, genomic instability and tumor progression? pot
... ssDNA ends and modulates the activity of effectors, such as BRCA2 and Rad51, which execute the recombination process by performing strand invasion and Holliday junction formation and resolution ... pro-inflammatory (TNF-a, IFN-c and Cox-2, IL-6 and TGF-a) and anti-apoptotic (Bcl-2 and Bcl-XL) genes, as well as upregulation of hepatic mRNA levels of components of the NF-jB pathway (p65 and p50) [70] The ... membrane rafts [14,20], and cholesterol depletion by methyl-b-cyclodextrin reduces the ability of both AaCDT and HdCDT to bind to Jurkat and HeLa cell lines, respectively, and prevents intoxication...
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Báo cáo y học: "Interactions between IL-32 and tumor necrosis factor alpha contribute to the exacerbation of immune-inflammatory diseases" ppt
... IL32γ, and IL-32δ IL-32α is present in intracellular locations, and IL-32β is secreted from the cells IL-32α and IL-32β are thought to be the major expressed variants The sequences of IL-32β and ... variant and as a secreted protein from the cells, and the sequences of IL-32β and IL-32γ were basically similar [13] We demonstrated that IL-32 is expressed in various lymphoid cells, and in the ... (BM-hIL32) The expression and secretion of TNFα were increased in resting F4/80+ splenic macrophages of BM-hIL-32 mice, and the expression and secretion of TNFα, IL-1β, and IL-6 were increased...
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Evaluation of the Characteristics of Microorganisms that Contribute to Denitrification in the Paddy Drainage Treatment Apparatus by Quinone Composition Measurement
... Water treatment apparatus Fig - Outline of the experimental field and the water treatment apparatus - 422 - Journal of Water and Environment Technology, Vol 8, No.4, 2010 Paddy field The characteristics ... plant was Akita-Komachi Rice, and the planting rate was 0.30 m (ridge pitch) and 0.15 m (planting pitch) The paddling and transplanting were conducted on June and June 8, and the inundation began ... Journal of Water and Environment Technology, Vol 8, No.4, 2010 The contribution ratio of PC1 and PC2 were 43.8% and 18.6%, respectively, and the accumulated contribution ratio for PC1 and PC2 was...
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Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer ppt
... to ERBB3 and ERBB4 NRG1 and NRG2 bind to both ERBB3 and ERBB4, whereas NRG3 and NRG4 only bind to ERBB4 [3] Although these ligands show redundancy, heparinbinding-EGF is the only ligand whose ... relatively low, being 33, 24 and 28%, respectively regulin and epigen); (b) those that bind to EGFR and ERBB4 (including betacellulin, heparin-binding EGF and epiregulin); and (c) neuregulin (NRG) ... HER3 and ERBB4 ⁄ HER4 ERBB2, ERBB3 and ERBB4 show extracellular homologies, relative to the EGFR, of 44, 36 and 48%, respectively, while those for the tyrosine kinase domain are 82, 59 and 79%,...
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Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR-targeted anticancer therapy doc
... binding of ligand to EGFR induces receptor dimerization and consequent conformational changes that result in activation of the intrinsic tyrosine kinase, receptor autophosphorylation and a transient ... the receptor and thereby stabilize the interaction with EGF-TKIs signaling cascade, independently of EGFR activation Mutation of KRAS thus bypasses the need for ligand binding to EGFR and results ... adenocarcinoma, and in never-smokers, the same groups identified clinically as most likely to respond to treatment with EGFR-TKIs Several prospective clinical trials of gefitinib or erlotinib for treatment...
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Tài liệu Báo cáo khoa học: EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors docx
... ⁄ and the PI3K ⁄ Akt pathways results, in turn, in the inactivation of pro-apoptotic Bcl-2 proteins (e.g PUMA, Bax, Bim and Bad), Fas, and CDK inhibitors (e.g p27KIP1, p21WAF1 and p15INK4b), and ... both cell proliferation and survival Potential targets of these MAPK and PI3K ⁄ Akt signaling pathways include apoptosis-related molecules (Bcl-2 family members and Fas) and cell-cycle regulatory ... Takeuchi and F Ito 21, and PC-9, harboring a deletion (del746-750) in EGFR exon 19, are highly sensitive to gefitinib; and this sensitivity to gefitinib is associated with dependence on both Akt and...
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Tài liệu Báo cáo Y học: Bivalent cations and amino-acid composition contribute to the thermostability of Bacillus licheniformis xylose isomerase doc
... (i.e Q, N, S, and T) and an increase in charged amino-acid residues (i.e K, E, and R) in hyperthermophilic proteins As S and T can catalyze the deamination and backbone cleavage of Q and N residues ... 0.981, is based on the elution data of the 200, 150, and 66 kDa protein standards Linear regressions (1) and (2) give molecular masses of 200 and 177.5 kDa, respectively, for BLXI q FEBS 2001 ... cm) calibrated with blue dextran and protein standards of 443, 200, 150, and 66 kDa (Sigma Chemical Co., St Louis, MO, USA) The flow rate was 0.2 mL·min21 EDTA treatment The purified enzyme was...
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Báo cáo khoa học: "Entailment-based Text Exploration with Application to the Health-care Domain" pot
... service implements full-text and faceted search, and document indexing The data service handles data (e.g., documents) replication for clients The entailment service handles the logic of the entailment ... health and health care education Health Information & Libraries, 24:2–23 Ido Dagan, Bill Dolan, Bernardo Magnini, and Dan Roth 2009 Recognizing textual entailment: Rational, evaluation and approaches ... entailment graph and the taxonomy) The index server applies periodic indexing of new texts, and the exploration server serves the exploration application on querying, exploration, and data 83 Application...
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Báo cáo khoa học: Structural features in the C-terminal region of the Sinorhizobium meliloti RmInt1 group II intron-encoded protein contribute to its maturase and intron ppt
... green (P, L, I, V, M, F, W, Y and A); polar, purple (N, Q, S and T); and black (G and C) four putative a-helices, as in most group II IEPs [13], and a putative short b-strand in the C-tail The two ... into either double-stranded DNA or transiently singlestranded DNA target sites, and that priming may include random nonspecific opposite-strand nicks, a nascent leading strand or de novo initiation ... GE Healthcare) and 100 units of T4 polynucleotide kinase (New England Biolabs Inc., Ipswich, MA, USA) The double-stranded DNA substrates (dsDNA70) used in top-strand cleavage and reverse splicing...
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Báo cáo khoa học: Assessment of telomere length and factors that contribute to its stability potx
... FISH and Q-FISHFCM have further improved assays of telomere length Recent advances in these techniques and the advantages and limitations of the various assays are highly relevant to understanding ... varied [48] Telomere length analysis and DNA replicatory mechanisms are aspects directly involved and related to cell structure, function and integrity, and thus the use of these sophisticated ... [55] [55] T-OLA HUVEC Fibroblasts and lymphocytes HeLa (cervical cancer cell line) and U937 cells Fibroblasts, lymphocytes HeLa, and U937 cells Fibroblasts and lymphocytes < 90 < 90 < 90 Majority...
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Báo cáo khoa học: Detergent-resistant membrane fractions contribute to the total 1 H NMR-visible lipid signal in cell potx
... structure is more ordered giving it characteristics of being in the liquid-ordered (lo) phase [10] DRMs are rich in cholesterol and sphingolipids (including GM1 and GM3) and selectively retain a number ... Materials and methods Antibodies and reagents Phycoerythrin (PE)-conjugated anti-CD69/anti-CD25 and biotin-conjugated cholera toxin (CT-B) were purchased from Becton Dickinson (San Jose, CA, USA) and ... bovine serum and were either left unstimulated or were stimulated with PMA (30 ngÆmL)1) and ionomycin (300 ngÆmL)1) for 24 h Preparation and fractionation of plasma membranes Jurkat and CEM-T4...
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Báo cáo khoa học: Sendai virus N-terminal fusion peptide consists of two similar repeats, both of which contribute to membrane fusion ppt
... 7–17 and 21–31 of the consensus sequence Large unilamellar vesicles (LUV) were prepared from DOPtdCho, DOPtdEth, and Cho (1 : : 1) and when necessary with different amounts of Rho-PtdEth and NBDPtdEth, ... elements were taken from Jackson and Mantsch [41], mean values ± standard deviation are given Secondary Structure (%) Sample a helix Random coil Aggregated strands Other structures WT 1–33 G12A ... Biochem 269) 16 Epand, R.M (1998) Lipid polymorphism and protein–lipid interactions Biochim Biophys Acta 1376, 353–368 17 Peisajovich, S.G., Epand, R.F., Pritsker, M., Shai, Y & Epand, R.M (2000)...
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Greener Pastures How grass-fed beef and milk contribute to healthy eating ppt
... efficiencies and consumer prices depends on many factors These factors include the total supply of and demand for milk, the number of farms and cows on those farms, energy costs, and federal and state ... labels and in advertising The section ends with a review of the specific standards for nutrients and other substances found in milk and meat Organizations that set dietary standards Food and Nutrition ... transport feed from distant places to the feedlot and to monitor and move animals around the lot (Brown and Elliott 2005) Scientists in Missouri and Maryland also have noted that confinement-based dairies...
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Báo cáo khoa học: Structure and function of human a-lactalbumin made lethal to tumor cells (HAMLET)-type complexes pptx
... the side chains of asparagines 82, 84, 87 and 88 and lysine 79 [14] The a-helical domain contains three major ahelical (amino acids 5–11, 23–34 and 86–98) and two short 310-helical domains The smaller ... with histone H3 and weaker interactions with H4, H2A and H2B have been documented with isolated histones in nuclear extracts and by confocal microscopy Furthermore, histones and HAMLET have been ... vesicles, LC3 translocation and accumulation typical of macroautophagy were observed in tumor cells after HAMLET treatment and inhibition of macroautophagy by Beclin and Atg5 siRNAs significantly...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25