... Hypnotics and sedatives were used by 25% of aripiprazole patients and 21% of placebo patients At least adverse event was reported by 142 (76%) of the 186 patients in the placebo group and 154 (87%) of ... validity of psychiatric diagnosis perplexes the problem and makes the gathering of scientific data difficult, because the diagnosis of BD in particular is often made retrospectively and carries ... the role of the 5-HT-mediated systems in the mechanism of action of aripiprazole [33] Aripiprazole reaches peak concentration (Cmax) to h after ingestion, and has a bioavailability of 87% and half...
... double-blind and placebo-controlled clinical study, we sought to evaluate the efficacyandsafetyof 5-Loxin® in treatment of OA of the knee We assessed the effectiveness of 100 mg/day and 250 mg/ ... Haematological and biochemical evaluations For assessment ofsafetyof 5-Loxin®, several parameters were evaluated in serum, urine and whole blood of all patients at each visit of the study duration ... analyses using SAS software to evaluate the efficacyof two doses of 5-Loxin® in comparison with the placebo group in terms of improvement in pain and physical ability scores, and to assess biomolecular...
... Analysis of days of onset of common cold symptoms Shown are the numbers of patients for verum, placebo and total divided into groups with days of onset of common cold symptoms at the point of inclusion ... the principles of the Declaration of Helsinki, local drug law and standard operating procedures of the investigator, sponsor and CRO involved The study protocol and attached documentation (consent ... clear, colourless, odourless and free of particles Verum and placebo nasal sprays were identical in shape, size and colour to allow a double-blind design, and were randomized at the CRO Before...
... (breathlessness on a scale of to 4; cough, sputum production and wheezing on a scale of to 3), use of daily rescue medication and concomitant medication were recorded in the patient’s diary and reviewed by ... in favour of aclidinium for cough and sputum production (Week 1), breathlessness (Week 12), wheezing (Week 28) and use of daily rescue medication (Weeks 12 and 28) (p < 0.05 for all) Safety The ... Pneumology and Thoracic Surgery, Grosshansdorf, Germany 6Department of Oncology, Haematology and Respiratory Diseases, University of Modena and Reggio Emilia, Modena, Italy 7Division of Pulmonary...
... (maximum change of 57.0 mm) and 3.5 mm (-1.0, 20.0) with placebo (maximum change of 61.0 mm) Safety Adverse events were reported in 51.0% of patients treated with tiotropium, and 61.5% of patients ... all tiotropium studies [11-14] and supports the clinical relevance of the sustained efficacyof tiotropium and reduction of COPD exacerbations The actual magnitude of the reduction in rescue medication ... Pedersen OF, Peslin R, Yernault JC: Lung volumes and forced ventilatory flows Work Group on Standardization of Respiratory Function Tests European Community for Coal and Steel Official position of...
... the methods of implementation and technical characteristicsof the ventilation devices (Table 3) and regarding the definition and adequacy of criteria for ETI (Table 3) The analysis ofsafety issues ... practice and more challenging for clinicians to understand The aim of our study was to systematically review the evidence in order to answer key clinical questions about the efficacyandsafetyof ... analyze the impact of patients' baseline hypercapnia on the efficacyof CPAP and NPPV and to test a common clinical hypothesis about the advantage of NPPV when using higher levels of pressure support...
... experiments and data acquisition MV conducted experiments, interpretation of data, and manuscript drafting GB performed study conception and design, statistical analysis and interpretation of data, and ... Care Vol 10 No Livigni et al A variety of recent studies have investigated the efficacyandsafetyof pumpless arterovenous devices to remove CO2 [1417], which offer several advantages over ECMO: ... cannulation, increase of left-to-right shunt (thus excluding patients with cardiac failure), and no direct blood flow control Our study was designed to evaluate the efficacyandsafetyof a veno-venous...
... pharmacology of drugs, a safety system in standard treatment would help to solve the black box ofsafetyandof unknown relationship between the dosage and actions of drugs (e.g effectiveness and side ... including both standardized measurements of blood concentrations of psychotropic drugs and the documentation ofefficacyand side effects of the medication For practical reasons, the use of an internet ... situation of lower standards of drug -safety for children continues, due the lack of paediatric pharmacokinetic and -dynamic trials and nonexisting data The European Agency for the Evaluation of Medicinal...
... PRESS INC Efficacy andSafetyof Pregabalin in GAD Figure Efficacyof Pregabalin as Measured by Unadjusted Mean HAM-A Total Score by Week and Treatment Group Versus Placebo (analysis of covariance)a,b,c ... Hospital Anxiety and Depression Scale48 (patient rated) consisting of the anxiety subscale (HADS-A) and the depression subscale (HADS-D) Safetyand Tolerability Analyses Safetyand tolerability ... efficacy variable of the study) were compared between each dose of pregabalin and placebo, as well as between venlafaxine and placebo and (in post hoc analyses) between each pregabalin dose and...
... actuarial rate of HC and HN were 62,4% and 37,6%, respectively, and the 5-year actuarial rate were 81,2% and 55,4%, respectively (Figures and 2) Table Distribution of results of radiological ... pre and post-radiosurgical GH and IGF-1 levels were, respectively, 5.8 and 2.9 ng/ml and 688.5 and 361.5 ng/ ml; the median pre- and post-radiosurgircal prolactin levels were, respectively, 55 and ... the effects of Gamma Knife RS on the growth and endocrinological response and its safety in the treatment of pituitary adenomas Materials and methods Patient population Forty-two out of the first...
... suffered in 20% of cases of paroxysmal, in 37% of persistent, and in 41% of cases of long standing persistent AF There was no statistical significant correlation in between type of AF and diagnosis ... without the need of large thermal gradients and without jeopardizing adjacent structures (Figure 1) [6] The purpose of this study was to evaluate the efficacyof left atrial HIFU ablation of AF with ... Diagnosis and classification of AF were established by standard ECG and holter ECG in all patients prior to admission AF was defined paroxysmal in 29%, persistent in 31% and long standing persistent...
... olanzapine to compare efficacyandsafetycharacteristics between black and white patients Methods Study Design Data were pooled from similarly designed, randomized, double-blind studies of olanzapine ... all-cause time to discontinuation and PANSS Total score between white, black, and Hispanic subgroups Another study looked at the impact of race on the efficacyandsafetyof long-acting risperidone ... Ciliberto N, Bossie CA, Urioste R, Lasser RA: Lack of impact of race on the efficacyandsafetyof long-acting risperidone versus placebo in patients Page 11 of 11 27 28 29 30 31 32 33 34 35 36 37 38...
... comparative efficacyand tolerability of 5-Loxin® and Aflapin® in the treatment of OA of the knee Materials and Methods Study materials BE-30 (5-Loxin) is a novel Boswellia serrata extract standardized ... Hematological and biochemical evaluations For assessment ofsafetyof 5-Loxin® and Aflaseveral parameters were evaluated in serum, urine and whole blood of all subjects at each visit of the study ... software to evaluate the efficacyof 5-Loxin® and Aflapin® in comparison with the placebo group in terms of improvement in pain and physical function scores at baseline and on days 7, 30, 60 and...
... Comparison of resveratrol content of Swiss wines from organic and integrated viticulture (1997 grape harvest).55 Dossier Quality andSafetyof Organic Products Secondary metabolite content of organic and ... variety of direct parameters such as loss of water and substance, accumulation of harmful substances and microorganisms, and physiological parameters such as respiration, and enzymatic, defence and ... biodiversity and landscape, soil, water, climate and air, and also to energy consumption In short, organic is better for people, animals and the environment 22 Quality andSafetyof Organic Products...
... http://www.jiasociety.org/content/9/4/7 Respectively, 47% and 53% of patients were at CDC stages B and C Seven of the patients at CDC stage C had a history of pulmonary tuberculosis, and had a history of extrapulmonary tuberculosis ... 14:1601-1610 Abstract Gerstoft J, Kirk O, Obel N, et al.: Low efficacyand high frequency of adverse events in a randomized trial of the triple nucleoside regimen abacavir, stavudine and didanosine AIDS ... real baseline characteristicsof most Senegalese patients We observed a high frequency of peripheral neuropathies relative to other studies of the same combination,[6-8] but Gerstof and colleagues[9]...
... However, there are no data on the effectiveness andsafetyof this combination We assessed virologic, immunologic, and clinical benefits andsafetyof this combination in HIV-infected Indian patients ... developed IRIS on TDF/FTC/EFV (8 cases of tuberculosis, of cytomegalovirus vitreitis, of hepatitis B virus, of Pneumocystis jiroveci pneumonia, of herpes zoster, andof cryptococcal meningitis) One ... Gallant JE, Staszewski S, Pozniak A, et al.: Efficacyandsafetyof tenofovir DF vs stavudine in combination therapy in antiretroviral naive patients: a year randomized trial JAMA 2004, 292:191-201...
... one aspect of EM efficacyEfficacyof EM for critical care and procedures Efficacyof EM for efficiency or cost of care Efficacyof EM for public health and preventive medicine Efficacyof EM for ... accuracy of reading films, etc.) Efficacyof EM for trauma and airway management Efficacyof EM for using ultrasound Efficacyof EM faculty Efficacyof EM residencies Overviews and editorials of EM efficacy ... efficacy or value of EM or aspects of EM delivered care Case reports and case series of successful clinical care in the Emergency Department (ED) were not included (there are of course thousands...
... predictor of seedling quality at the time of lifting and often, but not always [42], correlates well with survival [36, 37, 38] Several less time-consuming tests have also been investigated and, of ... practice in Ireland (10–20% of seedlings are now cold stored) and has managerial and practical benefits [24, 26] The typically mild and moist climatic conditions found in Ireland may result in ... at the nursery site is a sandy loam (pH 5.7, organic content 6–8%, and sand, silt and clay fractions 66, 19 and 15% respectively) Plants received monthly additions of nitrogen at 14 kg N ha–1...
... depletion and were reversible within months of drug withdrawal The pharmacokinetic profile of one or two doses of belimumab was dose proportional and consistent with a fully human mAb A half-life of ... initiation of phase II studies investigating the safetyand clinical activity of belimumab in patients with SLE and rheumatoid arthritis Competing interests JZ, WC, and WF were all employees of Human ... 0) and on days 14, 28, 42, 56, and 84 for patients in single-dose cohorts, and at screening and on days 0, 14, 21, 35, 49, 63, 77, and 105 for patients in double-dose cohorts Absolute counts of...
... established its efficacy in treatment of ADHD [10] Tricyclic antidepressants and bupropion are other non-stimulants which are effective in treatment of ADHD [11] Efficacyof both methylphenidate and atomoxetine ... form Title, year of publication, total number of participants, age of participants, design of study (parallel vs crossover), blinding, name and dose of drug, number who dropped out and outcome measures ... out using the randomeffects model of DerSimonian and Laird [25] The presence of heterogeneity between studies was tested using We included all published randomized, open label and double blind...