characteristic surfaces and domain of dependence

Ngày tải lên: 05/08/2014, 09:46

... listed in the second column of Figure 1.1, and 2) the possible sizes of D are given in the third column of Figure 1.1 We will leave the proof of (2) in Section 1.4 Proof of Proposition 1.9 (1) Consider ... proof of Theorem 1.5 AMPLENESS OF −KX ¯ 1.5 17 Ampleness of −KX ¯ In the proof of Theorem 1, for each weighted graph of C + D in Figure 1.6, we ¯ constructed a normal projective surface X of ... and ∆S is of one of the following types: A1 ⊕ A17 , A3 ⊕ A15 , A5 ⊕ A13 , A7 ⊕ A11 , A9 ⊕ A9 Moreover, all of them are realizable 3) If I(Z) = 3, then (S, g) ≃ (S3 , g3 ), and ∆S is of one of...

Ngày tải lên: 11/09/2015, 10:14

... intersection form is even: then S is a connected sum of copies of P1 × P1 and of a K3 surface if the signature is negative, C C and of copies of P1 × P1 and of a K3 surface with reversed orientation C ... SPACES OF SURFACES AND REAL STRUCTURES 591 and V Kharlamov for a useful conversation, V Kulikov and Sandro Manfredini for pointing out some nonsense, Sandro again for the nice picture, and finally ... with an action of G, and the product action of G on C × C is free if and only if, defining c, c by the properties abc = a b c = 1, and letting Σ be the union of the conjugates of the cyclic subgroups...

Ngày tải lên: 14/02/2014, 16:20

... deletion of KIND1; DKIND2, deletion of KIND2; DKIND1 + 2, deletion of both KIND1 and KIND2; DRasN, deletion of RasN; DGEF, deletion of RasGEF; KIND1, KIND1 domain; KIND2, KIND2 domain (B) KIND2 domain ... KIND domains of Spir-2 and PTPN13 were generated by RT-PCR and inserted into pEGFP-C1 and pGEX-4T-2 The N- and C-terminal regions of the v-KIND KIND2 and the MAP2 CD were generated by PCR and ... in dendrites of cultured hippocampal neurons Fig S4 Domain structure of MAP2 and the alignment of v-KIND-binding core (BD) region of MAP2 CD2 domain (702–744 aa) in human, mouse and Gallus This...

Ngày tải lên: 14/02/2014, 19:20

... arithmetic genus and is a flat limit of rational normal curves in Pn 343 THE K OF DEGENERATIONS OF SURFACES We will often consider two particular kinds of trees Tn : a chain Rn of length n and the fork ... number of irreducible components of double curves in X; • fn : the number of n-faces of G, i.e the number of En -points of X, for n 3; • f := n fn , the number of faces of G, i.e the total number of ... singularities of the total space X of a degeneration of surfaces at a good Zappatic singularity of its central fibre X0 = X (cf also [23] and [24]) Indeed, in Section 6, the local analysis of minimal and...

Ngày tải lên: 16/02/2014, 06:20

... five authors: it is the risk of exploitation within relationships of dependence and interdependence that society must deal with and manage Interdependence and the Fear of Exploitation The five chapters ... regard to the development of a culture of ethics Development of a Culture of Ethics The development of an ethical community of professionals, of commercial actors, or of bureaucrats does not involve ... Association of Law Teachers), Alison Harvison Young (Canadian Council of Law Deans), and Roderick Macdonald (Law Commission of Canada) Personal Relationships of Dependence and Interdependence...

Ngày tải lên: 18/02/2014, 05:20

... composed of two rigid domains [domain (residues 1119) and domain (residues 151245)] linked by an interdomain hinge (residues 120150) Interestingly, the connection between the two domains and the ... composed of two six-stranded b-barrel domains with the nature of its collective structural dynamics being attributed to interdomain hinge-bending motions [16,20,21] Due to the location of the active ... hydrolysis of the acyl-enzyme intermediate, followed by formation and breakdown of a second tetrahedral intermediate (EP2)TET2, and liberation of the reactions second product with restoration of the...

Ngày tải lên: 19/02/2014, 05:20

... C-terminal SH2 domain of PLC-r; pYELE, pYIDI and pYVDV for the N-terminal SH2 domain of PLC-r; and pYIXV, pYVXI, pYVXL and pYVXP for the N-terminal SH2 domain of SHPTP2 The different SH2 domain binding ... 271) Ó FEBS 2004 Fig Comparison of amino acid sequences of SH2 domains from Src and the mouse Grb4, and expression and purification of the Grb4 SH2 and RGS3 PDZ domains (A) Secondary structural ... binding of the PDZ domain of PDZRGS3 affects binding of the Grb4 SH2 domain to phosphorylated peptides, through studies of ternary interactions among the PDZ domain, the phosphotyrosine peptide and...

Ngày tải lên: 19/02/2014, 12:20

... is deleted, the expression of Abd-B is controlled by iab-6 in both A6 and A7, resulting in the transformation of A7 into a duplicated copy of A6, while the identity of the more posterior segments ... their proper target promoter in the viscous environment of the nucleus Somatic pairing of chromosomes and the regulation of Abd-B A peculiarity of Drosophila is the fact that the homologous chromosomes ... for the reorganization of intramolecular interactions and the correction of an inappropriate looping structure in later stages of development If the uninterrupted pairing of homologs is considered...

Ngày tải lên: 20/02/2014, 01:20

... harmful drinkers Alcohol dependence affects 4% of people aged between 16 and 65 in England (6% of men and 2% of women), and over 24% of the English population (33% of men and 16% of women) consume alcohol ... assessment and management of harmful drinking and alcohol dependence in adults and in young people aged 10–17 years This is one of three pieces of NICE guidance addressing alcohol-related problems and ... [TASI]), and cover the following areas: consumption, dependence features and patterns of drinking comorbid substance misuse (consumption and dependence features) and associated problems mental and...

Ngày tải lên: 21/02/2014, 11:20

... S6 and the GST-tag (C) Immunoblot analysis of the phosphorylation status of p70S6K and S6 in Paskin+ ⁄ + and Paskin) ⁄ ) MEFs (D) Immunoblot analysis of the phosphorylation status of p70S6K and ... group within its PAS domain [5] Subsequent to de-repression by ligand binding, autophosphorylation in trans results in the ‘switch-on’ of the kinase domain of FixL A similar mode of activation has ... Targets and stimulation of PASKIN P Schlafli et al ¨ Introduction In lower organisms, the Per-Arnt-Sim (PAS) domain is found often in environmental protein sensors involved in the perception of light...

Ngày tải lên: 06/03/2014, 00:21

... for the open and closed conformers of the C-terminal domain of human eRF1 Fig S3 NOE map of the minidomain (residues 329– 372) of human eRF1 NMR structure and function of the eRF1 C -domain Fig ... 0.19 residues of the minidomain (330–332, at the beginning of the central b-strand) and residues 343 and 351, model was selected as the best For residues 357–359 of the minidomain and for several ... b-structure of the minidomain and the corresponding tilt of the loop (residues 357–367) between a3 and b5 (Fig 3B,C) In one of the conformers (closed; Fig 3C,E), the side chain of His356 is on the top of...

Ngày tải lên: 06/03/2014, 11:20

... far- and near-UV CD spectra of Tma-RNase HI, Tma-CD and Tma-ND were measured at 20 °C and pH 9.0, and comparisons are shown in Fig The farand near-UV CD spectra of Tma-CD are similar to those of ... domain of reverse transcriptase Retroviral RNases H are required for the conversion of single-stranded genomic RNA into double-stranded DNA, which is an initial step of viral proliferation, and ... that removal of the HBD does not significantly affect the structure of the RNase H domain of Tma-RNase HI The far- and near-UV CD spectra of Tma-ND were significantly different from those of Tma-RNase...

Ngày tải lên: 06/03/2014, 22:21

Ngày tải lên: 07/03/2014, 02:20

... structure and dynamics of eRF1 middle domain A B Fig 1H,15N-HSQC spectra of the M domain of human eRF1 The numbering of the residues corresponds to that of the full eRF1 protein (A) The Gly region of ... H, N-HSQC spectrum of the M domain of human eRF1 recorded at 278 K (B) The superposition of the 1H,15N-HSQC spectra of wild-type (red) and G183A mutant (blue) of the M domain of human eRF1 recorded ... structure of the M domain of the human eRF1 [3] is superimposed on the same set of atoms in the representative solution structure and is shown in red (B) The topology of the M domain of human eRF1 and...

Ngày tải lên: 07/03/2014, 05:20

... using a bandwidth of nm and a response time of s, and 10 data points per nanometer were collected Each spectrum is the average of three scans Far-UV CD spectra of CTC in the presence of phospholipid ... unfolding of CTC in the absence and presence of phospholipid vesicles The temperature dependence of specific heat capacity at constant pressure, Cp, in the absence (A) and presence (B) of different ... envelope between 11 and 26 charges (m ⁄ z 4982–2108) was observed, and for hexamers and nonamers, complete envelopes between 20 and 35 charges (m ⁄ z 5480–3132) and between 28 and 37 charges (m...

Ngày tải lên: 07/03/2014, 05:20

... domain (N -domain) that serves as a docking site for various adaptor proteins [6–10] ClpA consists of three domains: an N -domain and two ATP-binding domains referred to as the D1 and D2 domains ... regarding the role of the ClpB N -domain (which shares a common fold with the N -domain of ClpA) in substrate selection [15–17] One difficulty in understanding the role of the N -domain of ClpA stems ... of this substrate class requires specific interaction between ClpS and the N -domain of ClpA Consequently, dramatic changes to the structure of the N -domain of ClpA would inhibit ClpS binding and...

Ngày tải lên: 07/03/2014, 05:20

... spectra of the two domains permitted the full sequence-specific assignments, the identification of the spin systems and the assignment of 398 and 252 of the NOESY cross-peaks of the a- and b -domain, ... interesting and unexpected picture of the Cu(I) binding to the two single domains Results and Discussion Cu(I) titration of Zn4aMT-1 and Zn3bMT-1 As both the structure of native Zn7MT-1 was known, and ... vitro folding of the two domains of copper MTs [27] Replacement of Zn(II) by Cu(I) led to the proposal of the formation of Cu,Zn-MT intermediates and that, during the last steps of copper titration,...

Ngày tải lên: 07/03/2014, 09:20

... level of structure Modeling indicates that tetramer formation depends upon contact of b-strand 10 from the C-terminal extensions of monomers A and D with b-strands and in the a-crystallin domain of ... dimers, with monomers A and B in dimer and C and D in dimer (Fig 8) The a-crystallin domain of each monomer is composed of nine b-strands (labeled b2–b10), with the b6 strand situated in a large ... C and B, respectively (Fig 8) A more prominent dimer–dimer interface occurs with b-strand of monomer B interacting with loop L5 ⁄ of monomer C, and b-strand of monomer C reacting with L5 ⁄ of...

Ngày tải lên: 07/03/2014, 12:20

... and B are shown in red and blue, respectively (C) Overlap (stereo view) of CH1 and CH2 subdomains of pleABD/2a molecule A with the CH1 subdomain of utrophin molecule A and the CH2 subdomain of ... human plectin and lowest with fimbrin (Table 3) The nearly identical conformations of the pleABD/2a structure and the corresponding subdomains of the A and B molecules of utrophin and dystrophin ... which the CH1 and CH2 subdomains were facing each other through helices a1 and a5, and helices a10 (including the subsequent loop) and a11 Molecules A and B in the asymmetric unit of the pleABD/2a...

Ngày tải lên: 07/03/2014, 15:20